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| 1 | Targeted methylation sequencing reveals dysregulated Wnt signaling in Parkinson disease显示文摘Parkinson disease(PD) is a progressive neurodegenerative movement disorder. Both environmental and genetic factors play important roles in PD etiology. A number of environmental toxins cause parkinsonism in human and animal models. Genetic studies of rare early onset familial PD cases resulted in identification of disease-linked mutations in multiple genes. Nevertheless, the potential interaction between environment and genetics in PD pathogenesis remains largely unknown. We hypothesized that environmental factors induce abnormal epigenetic regulation that is involved in the pathogenesis of both familial and sporadic PD. We determined the global methylation status of 80,000e110,000 Cp G sites in each of the five sporadic PD patient brains and five age and postmodern interval matched control brains utilizing bisulfite padlock sequencing. Multiple genes involved in neurogenesis, particularly the ones in the Wnt signaling pathway, were hypermethylated in PD brains compared to their matched control brains. Consistent with the DNA methylation changes, marked reduction of protein expression was observed for four Wnt and neurogenesis related genes(FOXC1, NEURG2, SPRY1, and CTNNB1) in midbrain dopaminergic(DA) neurons of PD. The treatment of low concentration of 1-methyl-4-phenylpyridinium(MPPt) for cells resulted in downregulation of Wnt related genes. The study revealed an important link between the epigenetic disregulation of Wnt signaling and the pathogenesis and progression of PD. | Lusi Zhang Jie Deng Qian Pan Yan Zhan Jian-Bing Fan Kun Zhang Zhuohua Zhang | 2016 | Journal of Genetics and Genomics2016，43，10： | 5 |
| 2 | Human lipoprotein lipase complementary DNA sequence 显示文摘 | WION K L KIRCHGESSNER T G LUSIS A J | 1987 | Science1987，235，： | 1 |
| 3 | The Sequence of cDNA encoding lipoprotein lipase 显示文摘 | Kirchgessner T G Svenson K L Lusis A J | 1987 | J Biol Chem1987，262，18： | 1 |
| 4 | Atherosclerosis 显示文摘 | Lusis AJ | 2000 | Nature2000，407，6801： | 1 |
| 5 | Atherosclerosis 显示文摘 | Lusis AJ | 2000 | Nature2000，407，6801： | 1 |
| 6 | Human lip- oprotein lipase complementary DNA sequence 显示文摘 | WION K L KIRCHGESSNER T G LUSIS A J | 1987 | Science1987，235，4796： | 1 |
| 7 | Innovative electrochemical approach for an early detection of microRNAs显示文摘 | Lusi E A Passamano M Guarascio P | 2009 | Anal Chem2009，81，7： | 1 |
| 8 | Loss of the lysophosphatidylcholine effector, G2A, ameliorates aortic atherosclerosis in low-density lipoprotein receptor knockout mice显示文摘 | Parks BW Lusis A J Kabarowski JH | 2006 | Arterioscler Thromb Vasc Biol2006，26，： | 1 |
| 9 | Atherosclerosis显示文摘 | Lusis AJ | 2000 | Nature2000，407，6801： | 1 |
| 10 | Atherosclerosis显示文摘 | Lusis AJ | 2000 | Nature2000，407，： | 1 |
| 11 | Atherosclerosis显示文摘 | Lusis AJ | 2000 | Nature2000，407，： | 1 |
| 12 | Loss of tumor suppre- ssor in lung cancer-1 (TSLC1) expression in meningioma cor- relates with increased malignancy grade and reduced patient survival显示文摘 | Surace EI Lusis E Murakami Y | 2004 | J Neuropathol Exp Neurol2004，63，10： | 1 |
| 13 | Atheroscle~is显示文摘 | Lusis AJ | 2000 | Nature20002000，，： | 1 |
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| 15 | Atherosclerosis显示文摘 | Lusis AJ | 2000 | Nature2000，407，： | 1 |
| 16 | Atherosclerosis 显示文摘 | Lusis AJ | 2000 | Nature2000，407，6801： | 1 |
| 17 | Atheroselerosis显示文摘 | Lusis A J | 2000 | Nature2000，407，： | 1 |
| 18 | Loss of tumor sup pressor in lung cancer 1 (TSLC1) expression inmeningioma cor relateswith in-creasedmalignancy grade and reduced patient sur- vival 显示文摘 | Surace EI Lusis E Murakami Y | 2004 | Neuro pathol Exp Neuro2004，63，10： | 1 |
| 19 | Human lipoprotein lipase complementary DNA sequence 显示文摘 | Wion KL Kirchgessner T G Lusis AJ | 1987 | Science1987，235，4796： | 1 |
| 20 | Innovative electrochemical approach for an early detection of microRNAs显示文摘 | Lusi EA Passamano M Guarascio P | 2009 | Anal Chem2009，81，7： | 1 |
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