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| 1 | Review:Acute lung injury/acute respiratory distress syndrome (ALI/ARDS): the mechanism,present strategies and future perspectives of therapies显示文摘Acute lung injury/acute respiratory distress syndrome (ALI/ARDS), which manifests as non-cardiogenic pulmonary edema, respiratory distress and hypoxemia, could be resulted from various processes that directly or indirectly injure the lung. Extensive investigations in experimental models and humans with ALI/ARDS have revealed many molecular mechanisms that offer therapeutic opportunities for cell or gene therapy. Herein the present strategies and future perspectives of the treatment for ALI/ARDS, include the ventilatory, pharmacological, as well as cell therapies. | LUH Shi-ping CHIANG Chi-huei | 2007 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2007，8，1： | 53 |
| 2 | Video-assisted thoracic surgery―the past, present status and the future显示文摘Video-assisted thoracic surgery (VATS) has developed very rapidly in these two decades, and has replaced conven-tional open thoracotomy as a standard procedure for some simple thoracic operations as well as an option or a complementary procedure for some other more complex operations. In this paper we will review its development history, the present status and the future perspectives. | LUH Shi-ping LIU Hui-ping | 2006 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2006，7，2： | 26 |
| 3 | Video-assisted thoracoscopic surgery (VATS) for bilateral primary spontaneous pneumothorax显示文摘目的将由帮助录像的 thoracoscopic 外科(大桶) 考察我们双边的主要自发的气胸(PSP ) 的治疗的经验。回顾的图表评论被在诊所上或电话会见跟随的材料和方法。病人们被在乎为由在四个医学中心的一位胸的外科医生或在北、中央的台湾的社区医院。有双边的 PSP 的 13 个病人从 1994 年 7 月同时或顺序经历了双边的大桶到 2005 年 12 月。结果与从 15 ~ 36 年(平均数 23.1 年)的年龄, 12 男性和男性女性同时为双边的 PSP 与大桶被对待,在双边的 pneumothoracis 的指示下面(n=4 ) 或顺序(n=9 ) 。在为非同时的 PSP 病人的第一和第二个相反地侧面的大桶过程之间的间隔从 7 d 到 6 年。13 个病人(84.6%) 中的十一个有突出的肺的 bullae/blebs,并且与机械或化学的 pleurodesis 经历了 bullae 切除术。吝啬的起作用的时间是( 45.6 ±1 8.3 ) min (范围 25 ~9 6 min )并且( 120.6 ±2 8.7 ) min (范围 84 ~1 66 min )分别地为非同时(为在第一个大桶以后的相反地侧面的方面的复发的第二个大桶)并且同时(双边的大桶在里面一操作)过程。没有手术后的死亡。然而,延长了漏气(>7 d ) 在在保守治疗以后恢复了的一个病人(7.7%) 发生了。胸试管排水的吝啬的持续时间是 3.1 d 并且中部在时期上面列在后面是 3.4 年。结论大桶是在双边的 PSP 的治疗的一个安全、有效的过程。因为甚至与可见 bullae,复发的发生不在我的组并且在某以前的文学那么高,双边的大桶仅仅与同时双边的 PSP 为病人被推荐。在一个仰卧的位置的双边的大桶应该仅仅在选择情况中被使用,因为可能的肋膜的粘附或在以后的方面上隐藏 bullae。 | Yi-jen CHEN Shi-ping LUH Kun-yen HSU Cheng-ren CHEN Thomas Chang-yao TSAO Jia-yuh CHEN | 2008 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2008，9，4： | 20 |
| 4 | Diagnosis and treatment of primary spontaneous pneumothorax显示文摘Primary spontaneous pneumothorax(PSP) commonly occurs in tall,thin,adolescent men.Though the pathogenesis of PSP has been gradually uncovered,there is still a lack of consensus in the diagnostic approach and treatment strategies for this disorder.Herein,the literature is reviewed concerning mechanisms and personal clinical experience with PSP.The chest computed tomography(CT) has been more commonly used than before to help understand the pathogenesis of PSP and plan further management strategies.The development of video-assisted thoracoscopic surgery(VATS) has changed the profiles of management strategies of PSP due to its minimal invasiveness and high effectiveness for patients with these diseases. | Shi-ping LUH | 2010 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2010，11，10： | 9 |
| 5 | Organ preconditioning: the past, current status, and related lung studies显示文摘Preconditioning (PC) has emerged as a powerful method for experimentally and clinically attenuating various types of organ injuries. In this paper related clinical and basic research issues on organ preconditioning issues were systemically reviewed. Since lung injuries, including ischemia-reperfusion and others, play important roles in many clinical results, including throm-boembolism, trauma, thermal injury, hypovolemic and endotoxin shock, reimplantation response after organ transplantation, and many respiratory diseases in critical care. It is of interest to uncover methods, including the PCs, to protect the lung from the above injuries. However, related studies on pulmonary PC are relatively rare and still being developed, so we will review previous literature on experimental and clinical studies on pulmonary PC in the following paragraphs. | LUH Shi-ping YANG Pan-chyr | 2006 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2006，7，5： | 7 |
| 6 | Value of video-assisted thoracoscopic surgery in the diagnosis and treatment of pulmonary tuberculoma:53 cases analysis and review of literature显示文摘Tuberculoma of the lung is one of manifestations in tuberculosis and usually presents as a solitary pulmonary nodule(SPN).It is difficult to differentiate tuberculoma from SPN by other benign or malignant diseases.At present,the crucial role of video-assisted thoracoscopic surgery(VATS) in diagnosis and treatment of pulmonary diseases has been well acknowledged.Here,we reported 53 patients undergoing VATS resection for tuberculomas in our series.No postoperative mortality was found and only two patients experienced prolonged air-leakage(>7 d) and two had minor wound infections that were recovered after anti-tuber-culosis or antibiotic treatment.Anti-tuberculosis chemotherapy from 6 to 12 months was routinely used postoperatively.We conclude that VATS is a satisfactory tool for the diagnosis and treatment of tuberculoma and can also establish a reliable diagnosis for all patients with SPNs. | Kun-Yen HSUDepartment of Thoracic Medicine Chia-Yi Christian Hospital Hwa-Chan LEE Chien-Chih OU Shi-ping LUH | 2009 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2009，10，5： | 7 |
| 7 | GADD45β基因表达诱导对不同p53状态的肝癌细胞作用显示文摘目的:体外合成GADD45β基因全序列表达质粒后,研究GADD45β基因表达诱导对呈不同p53状态的肝癌细胞的作用及可能机制。方法:采用RT-PCR法获得GADD45β基因全序列,插入pDrive穿梭克隆载体和pIRES2-EGFP荧光表达载体后大量扩增获得DNA,结合p53全基因表达质粒pp53-EGFP转染HepG2、Hep3B细胞后,以[3H]胸腺嘧啶脱氧核苷掺入法(3H-Tdr)和细胞克隆形成法分析DNA合成变化及细胞生长能力;以双抗体夹心ELISA法测定TGF-β1表达变化。结果:成功合成GADD45β基因全序列和表达质粒,通过流式细胞仪收集转染阳性的荧光表达细胞能显著提高转染效率;转染GADD45β后,具有野生型p53基因的HepG2细胞的细胞克隆形成能力和DNA合成能力明显受到抑制,细胞凋亡明显增加,TGF-β1的表达亦明显受抑。与之相反,缺失p53基因的Hep3B需要同时共转染p53基因后,方出现抑制效应。结论:GADD45β基因能够有效抑制肝癌细胞的生长,其功能需要完整p53基因的辅助和(或)调控。GADD45表达和(或)功能异常,导致p53介导的DNA损伤修复途径异常或阻断,是肝脏细胞恶性转化及形成肿瘤的可能机制。 | 邱伟华 Dana Darwish Peiguo G.Chu Frank Luh 陈皓 邓侠兴 沈柏用 杨卫平 李宏为 Yun Yen | 2005 | 外科理论与实践2005，10，2： | 6 |
| 8 | STAT3在SAMe抑制HepG2细胞VEGF表达中的作用显示文摘目的研究肝癌细胞(HepG2)和正常胎肝细胞(CL-48)血管内皮生长因子(VEGF)和信号转导与转录激活因子3(STAT3)的表达状态,以及S-腺苷甲硫氨酸(SAM e)对其的干预作用,为HepG2和CL-48的不同调控途径提供功能性依据。方法在对数生长期的CL-48和HepG2细胞中加入不同浓度的SAM e(0、0.5、1.0 mmol/L)作用72 h,分别采用Northern印迹法、实时荧光定量PCR、W estern印迹法以及[3H]胸腺嘧啶脱氧核苷掺入法(3H-Tdr)和细胞克隆形成法,观察VEGF和STAT3表达的变化趋势,分析DNA合成及细胞生长能力的变化。结果SAM e作用前(SAM e 0 mmol/L),HepG2和CL-48均呈现VEGF和STAT3高表达状态。SAM e作用后:HepG2的VEGF和STAT3表达明显降低,并呈现剂量-效应关系,DNA合成和细胞生长能力明显受限;CL-48的STAT3表达虽然受到抑制,但VEGF的高表达状态无明显降低趋势,且DNA合成和细胞生长能力无显著变化。结论虽然HepG2和CL-48均呈现VEGF和STAT3的高表达,但二者具有不同的调控途径;SAM e通过抑制STAT3的组成性活化而降低VEGF的高表达状态,可能是SAM e的肝脏保护机制之一。 | 邱伟华 Bingsen Zhou Dana Darwish Peiguo G.Chu Frank Luh 陈皓 杨卫平 李宏为 Yun Yen | 2006 | 上海交通大学学报(医学版)2006，26，6： | 6 |
| 9 | Primary tuberculous infection of breast:experiences of surgical resection for aged patients and review of literature显示文摘Primary mammary tuberculosis is a rare entity that usually occurs in female of reproductive age. Herein three such patients including two males with ages over 80 years, who underwent surgical resection, are reported. Fine needle biopsy failed to achieve specific diagnosis before surgical operation. All of their conditions got satisfactory improvement and anti-tuberculosis chemotherapy was administered postoperatively. Previous literature related to the epidemiology, diagnosis and treatment for mammary tuberculosis will be also reviewed. Mammary tuberculosis is usually related to breast feeding women and is extremely rare in aged man. The possible mechanisms resulting in this disease in our three patients, including direct extension, reactivation, or transmitted by staffs or peers of the nursing home, would also be discussed. | LUH Shi-ping HSU Jeng-dong LAI Yih-shyong | 2007 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2007，8，8： | 5 |
| 10 | 护士工作满意度研究进展显示文摘目前护士的短缺和高转行流动率在许多国家引起了广泛关注,因为它对所有医疗保健系统的效率产生了冲击。护士的招募及留任一直是与工作满意度相关的。该文分析了近年来与护士工作满意度相关的文献并得出结论:需要对目前已经确认的诸多影响工作满意度的因素进行更多的研究以理解其重要性,由于缺少一个包含组织、专业和个人的变量的原始原因模型,制约了改进护士留任措施的发展。该文介绍了学者对护士工作满意度及其相关因素的研究。 | LuH WhileAE Barriball KL 王雪莲(摘) 蔡虻(摘) 程显山(校) | 2007 | 国际护理学杂志2007，26，2： | 4 |
| 11 | Advanced Strategies to Improve Performances of Molybdenum-Based Gas Sensors显示文摘Molybdenum-based materials have been intensively investigated for high-performance gas sensor applications.Particularly,molybdenum oxides and dichalcogenides nanostructures have been widely examined due to their tunable structural and physicochemical properties that meet sensor requirements.These materials have good durability,are naturally abundant,low cost,and have facile preparation,allowing scalable fabrication to fulfill the growing demand of susceptible sensor devices.Significant advances have been made in recent decades to design and fabricate various molybdenum oxides-and dichalcogenides-based sensing materials,though it is still challenging to achieve high performances.Therefore,many experimental and theoretical investigations have been devoted to exploring suitable approaches which can significantly enhance their gas sensing properties.This review comprehensively examines recent advanced strategies to improve the nanostructured molybdenum-based material performance for detecting harmful pollutants,dangerous gases,or even exhaled breath monitoring.The summary and future challenges to advance their gas sensing performances will also be presented. | Angga Hermawan Ni Luh Wulan Septiani Ardiansyah Taufik Brian Yuliarto Suyatman Shu Yin | 2021 | Nano-Micro Letters2021，13，12： | 3 |
| 12 | Experiences and benefits of positron emitted tomography-computed tomography (PET-CT) combined with video-assisted thoracoscopic surgery (VATS) in the diagnosis of Stage 1 sarcoidosis显示文摘Background: The purpose of this study was to describe our experiences and analyze the benefits of video-assisted thoracoscopic surgery (VATS) combined with positron emitted tomography (PET)-computed tomography (CT) in the diagnosis of patients with early (Stage 1) sarcoidosis. Methods: From 1995 to 2006, seven patients (two males, five females), with ages ranging from 26 to 58 years, were impressed with Stage 1 sarcoidosis (mediastinal or hilar lymph nodes involvements without lung in- volvement) by histological examination of intrathoracic lymph nodes (LNs) and/or lung parenchyma taken from VATS biopsy. Three of them received PET or PET-CT evaluation. VATS was approached from the right and left side in one and six patients, respectively, according to the locations of their lesions. Results: All the VATS biopsied LNs or lung specimens were adequate for establishing diagnosis. Mediastinal LNs were taken from Groups 3, 4 in four, Group 7 in two, and Groups 5, 6 in one of them. Hilar LNs biopsies were performed in four cases. Lung biopsy was performed in all but two cases. All of them were expressed pathologically or radiologically as Stage 1 sarcoidosis. PET-CT revealed high emission signals over these affected LNs. These patients received oral steroid treatment or follow up only. All of them were followed up from 5 months to 11 years with satis- factory results. Conclusion: VATS biopsy is a minimally invasive, safe and effective procedure. It can be used as a diagnostic alternative of transbronchial lung biopsy (TBLB), and can harvest larger and more areas of specimens than mediastinoscopy for staging patients with sarcoidosis. PET-CT can provide us more accurate information about the characteristics and localization of these lesions before biopsy. VATS combined with PET-CT can provide more accurate and earlier diagnosis of patients with unknown intrathoracic lesions, including the sarcoidosis. | LUH Shi-ping WU Tzu-chin WANG Yao-tung TSAO Thomas Chang-yao CHEN Jia-yuh | 2007 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2007，8，6： | 3 |
| 13 | Video-assisted thoracoscopic surgery (VATS) for the treatment of hepatic hydrothorax:report of twelve cases显示文摘Background:Hepatic hydrothorax is defined as a significant pleural effusion in patients with liver cirrhosis and without underlying cardiopulmonary diseases. Treatment of hepatic hydrothorax remains a challenge at present. Methods:Herein we share our experiences in the treatment of 12 patients with hepatic hydrothorax by video-assisted thoracoscopic surgery(VATS) . Repair of the diaphragmatic defects,or pleurodesis by focal pleurectomy,talc spray,mechanical abrasion,electro-cauterization or injection was administered intraoperatively,and tetracycline intrapleural injection was used postoperatively for patients with prolonged(>7 d) high-output(>300 ml/d) pleural effusion. Results:Out of the 12 patients,8(67%) had uneventful postoperative course and did not require tube for drainage more than 3 months after discharge. In 4(33%) patients the pleural effusion still recurred after discharge due to end-stage cirrhosis with massive ascites. Conclusion:We conclude that the repair of the diaphragmatic defect and pleurodesis through VATS could be an alternative of transjugular intrahepatic portal systemic shunt (TIPS) or a bridge to liver transplantation for patients with refractory hepatic hydrothorax. Pleurodesis with electrocauterization can be an alternative therapy if talc is unavailable. | Shi-ping LUH Chi-yi CHEN | 2009 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2009，10，7： | 2 |
| 14 | A fuzzy optimization-based method for integrated power system scheduling and inter-utility power transaction with uncertainties 显示文摘 | Yan H Luh P B | 1997 | IEEE Transactions on Power Systems1997，12，2： | 2 |
| 15 | Primary leiomyosarcoma of the nipple-areola complex:Report of a case and review of literature显示文摘Primary leiomyosarcoma of the nipple-areola complex is extremely rare. Less than ten such cases have been reported in English literature so far. Herein we describe a 52-year-old female presenting with a 1.5 cm×1.1 cm×0.7 cm nodular lesion over her left nipple, and leiomyosarcoma was proved by pathological examination of the excised specimen. Positron emitted tomogram (PET) revealed no abnormal signal other than the primary site. Microscopically, this poorly circumscribed tumor was composed of interlacing bundles of smooth muscle cells with bizarre and pleomorphic nuclei, as well as prominent nucleoli. Its mitotic count was up to 7 mitoses per 10 high power fields (HPF). Immunohistochemical study of tumor cells revealed positive stain for α-smooth muscle actin and vimentin; and negative for cytokeratin, CD34 and S-100. Left simple mastectomy was undertaken and no residual mass lesion was noted on the resected specimen. Related literatures about the diagnosis and treatment for breast leiomyosarcoma will be presented here. | Lai-ching WONG Po-chi HUANG Shi-ping LUH Chiun-sheng HUANG | 2008 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2008，9，2： | 2 |
| 16 | Steel-making process schedul- ing using Lagrangian relaxation显示文摘 | Tang L X Luh P B Liu J Y | 2002 | International Journal of Pro- duction Research2002，40，1： | 1 |
| 17 | Direct Sum of J-rings and Zero Rings显示文摘 | Ligh S Luh J | 1989 | Amer Math Monthly1989，96，： | 1 |
| 18 | Antimicrobial aitivities of six new oral cephem antibiotics显示文摘 | Chang SC Hsien WC luh K T | 1990 | J Formos Med Assoc1990，89，8： | 1 |
| 19 | Joint toque control by a direct feedback for industrial robots显示文摘 | LUH J Y S FISHER W D RICHARD P C P | 1995 | IEEE Trans on Aut Contl1995，64，20： | 1 |
| 20 | Schedule generation and reeonfiguration for parallel machines显示文摘 | LUH P B HOITOMT D J MAX E | 1990 | IEEE Transactions on Robotics and Automation1990，6，6： | 1 |
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