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| 1 | Cellular and molecular mechanisms in the pathogenesis of liver fibrosis:An update显示文摘There have been considerable recent advances towards a better understanding of the complex cellular and molecular network underlying liver fibrogenesis.Recent data indicate that the termination of fibrogenic processes and the restoration of deficient fibrolytic pathways may allow the reversal of advanced fibrosis and even cirrhosis.Therefore,efforts have been made to better clarify the cellular and molecular mechanisms that are involved in liver fibrosis.Activation of hepatic stellate cells(HSCs)remains a central event in fibrosis,complemented by other sources of matrix-producing cells,including portal fibroblasts,fibrocytes and bone marrow-derived myofibroblasts.These cells converge in a complex interaction with neighboring cells to provoke scarring in response to persistent injury.Defining the interaction of different cell types,revealing the effects of cytokines on these cells and characterizing the regulatory mechanisms that control gene expression in activated HSCs will enable the discovery of new therapeutic targets.Moreover,the characterization of different pathways associated with different etiologies aid in the development of disease-specific therapies.This article outlines recent advances regarding the cellular and molecular mechanisms involved in liver fibrosis that may be translated into future therapies.The pathogenesis of liver fibrosis associated with alcoholic liver disease,non-alcoholic fatty liver disease and viral hepatitis are also discussed to emphasize the various mechanisms involved in liver fibrosis. | Gülsüm ?zlem Elpek | 2014 | World Journal of Gastroenterology2014，20，23： | 82 |
| 2 | Thrombospondin-1 expression correlates with angiogenesis in experimental cirrhosis显示文摘AIM:To investigate the significance of Thrombospondin-1 (TSP-1) expression and its relationship with angiogenesis during experimental fibrosis. METHODS:Cirrhosis was induced in male Wistar rats by intraperitoneal administration of diethyl nitrosamine (DEN). The serial sections from liver tissues were stained with anti-CD34 and anti-TSP-1 antibodies before being quantitated by light microscopy. RESULTS:Our results showed that of TSP-1 expression gradually increases according to the severity of fibrosis (GroupⅠvs group Ⅱ, Group Ⅲ and Group Ⅳ;Group Ⅱ vs group Ⅲ and group Ⅳ;group Ⅲ vs group Ⅳ, P < 0.05). Moreover, TSP-1 expression was found to be correlated with angiogenesis (P < 0.05). CONCLUSION:The correlative evidence of the link between TSP-1 and fibrosis or angiogenesis provided by this study suggests that besides its role as a strong promoter of transforming growth factor-β1 (TGF-β1), TSP-1 might have an additional role in liver fibrogenesis by stimulating angiogenesis and this protein could be a potential target to prevent fibrogenesis in chronic inflammatory diseases of the liver. | Gülsüm zlem Elpek Güzide Ayse Gkhan Sevgi Bozova | 2008 | World Journal of Gastroenterology2008，14，14： | 7 |
| 3 | Influence of lead acetate on soil microbial biomass and community structure in two different soils with the growth of Chinese cabbage (Brassica chinensis)显示文摘 | Liao M Chen CL Zeng LS Huang CY | 2007 | 中国生物学文摘2007，21，7： | 5 |
| 4 | Survival factors after resection of small hepatocellular carcinoma显示文摘Early resection of hepatocellular carcinoma is a key measure to prolong the survival of patients. This study was designed to summarize our experience in surgical resection of small hepatocellular carcinoma (HCC), and to analyze the factors influencing the postoperative survival of patients. METHODS:The clinicopathologic data of 105 patients with small HCC after resection from 1986 through 2003 were analyzed ; the patients had been followed up for more than half a year (median 33 months). Nine clinicopathologic factors, preoperative α-fetoprotein (AFP) level, liver cirrhosis, Child-Pugh score, tumor size (>2cm vs.≤2 cm) and number (single vs. multiple), capsule formation, portal vein tumor thrombi (PVTT), Edmondson tumor grade and surgical method, were analyzed by the log-rank test and the Cox proportional harzards model analysis. RESULTS:The cumulative 1-,3- and 5-year survival rates after the operation were 86.5%, 70.3% and 55.2%, respectively, and the 1-, 3- and 5-year disease-free survival rates were 78%, 58. 9% and 45. 6%, respectively. One patient died from esophagogastric varices hemorrhage in 2 weeks after reoperation. Thirty-six patients had intrahepatic recurrence or metastasis postoperatively and 34 patients died. The Kaplan-Meier method and the Cox proportional harzards model analysis indicated that poor Child-Pugh score, tumor more than 2 cm in diameter, PVTT and multiple lesions (including satellitic lesions) were adverse factors affecting postoperative survival. The Cox proportional harzards model analysis indicated that tumor size, PVTT and multiple lesions were the factors influencing postoperative disease-free survival. CONCLUSIONS:Limited hepatectomy with a margin more than 1 cm is an appropriate surgical approach. Adverse preoperative Child-Pugh score and postoperative intrahepatic recurrences are the main factors leading to the death of patients with small HCC. | Departments of Surgical Oncology (Wu FS, Zhao WH, Ma ZM, Teng LS and Wang M) and General Surgery ( Liang TB and Zheng SS) , First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China | 2005 | Hepatobiliary & Pancreatic Diseases International2005，4，3： | 5 |
| 5 | 散瞳对人工晶状体屈光度数计算的影响(英文)显示文摘目的:研究散瞳对人工晶状体屈光度数计算的影响。方法:前瞻性研究。选取梅尔辛大学医学院诊断为白内障需接受白内障超声乳化联合人工晶状体植入术的患者45例52眼作为研究对象。散瞳前后,所有患者均接受术前角膜地形图测量,自动角膜曲率测量和生物特征测定。结果:与散瞳前数值相比,散瞳后,自动角膜曲率计测得的水平曲率(Kh)明显更大,且生物超声波测定的前房深度明显更深。使用散瞳后测量计算得出的屈光度数植入人工晶状体屈光正常的几率明显较高。比较正视眼和屈光不正眼发现正视眼的前房深度明显更深。结论:在人工晶状体屈光度计算中,角膜曲率测量与生物特征测量比公式计算更重要。如果采用接触技术进行生物超声波测定,须注意避免角膜压迫。在检测时,注意前房深度应随访,且可通过利用人工晶状体屈光度计算中的最大值将误差最小化。 | Gülsüm Egemen Erkayhan Ufuk Adigüzel | 2016 | 国际眼科杂志2016，16，8： | 3 |
| 6 | An unusual cause of cholecystitis:Heterotopic pancreatic tissue in the gallbladder显示文摘Gallbladder localization of heterotopic pancreas (HP) is uncommon and very rarely gives rise to symptoms. Herein we report a case of HP found in the gallbladder neck presented with signs and symptoms of cholecystitis. The patient was a 40-year old male, suffering from epigastric pain, abdominal fullness and fever. On physical examination, the right upper abdomen was tender with a positive Murphy’s sign. Ultrasonographic examination showed a hydropic gallbladder without stones and he underwent a cholecystectomy. Pathological examination revealed an intramural nodule (9 mm) in the neck region which is consisted of acini, ducts and islet cells of an aberrant pancreatic tissue. Although HP is encountered rarely in the gallbladder and is found incidentally during pathological studies, this case emphasizes that HP might cause symptoms and present clinically as cholecystitis. For this reason, in patients presenting with symptomatic gallbladder diseases, including cholecystitis without any other pathology, HP should be taken into consideration before it is diagnosed as 'idiopathic’’. | Glsm zlem Elpek Sevgi Bozova Gkben Y■d■r■m Kpesiz Mehmet ■■ | 2007 | World Journal of Gastroenterology2007，13，2： | 2 |
| 7 | Turner RT effects of orbital spaceflight on human osteoblastic cell physiology and gene expression显示文摘 | Harris SA Zhang M Kidder LS | 2000 | Bone2000，26，4： | 2 |
| 8 | Excitatory glycine receptors containing the NR3 family of NMDA receptor subunits显示文摘 | Chatterton JE Awobuluyi M Premkumar LS | 2002 | Nature2002，415，： | 2 |
| 9 | Predictors of survival in systemic lupus erythematosus显示文摘 | Magder LS Petri M | 2006 | Medicine (Baltimore)2006，85，3： | 1 |
| 10 | Safety,pharmacokinetics,and efficacy of AMG 706,an oral multikinase inhibitor,in patients with advanced solid tumors显示文摘 | ROSEN LS KURZROCK R MULAY M | 2007 | J Clin Oncol2007，25，： | 1 |
| 11 | Predictors of survival in systemic lupus erythematosus显示文摘 | Kasitanon N Magder LS Petri M | 2006 | Medicine(Baltimore)2006，85，14： | 1 |
| 12 | Proteins complexed to the P1 adhesinofMycoplasmapneumoniae显示文摘 | Gerlinde LS Alexandre P Matthias M | 2000 | Microbiology2000，146，： | 1 |
| 13 | Thrombospondin 1-a regulator of adenoma growth and carcinoma progression in the APC (Min/+ ) mouse model显示文摘 | Gutierrez LS Suckow M Lawler J | 2003 | Carcinogenesis2003，24，2： | 1 |
| 14 | Interleukin-1 induces transcription of keratin K6 in human epidermal keratinocytes显示文摘 | Komine M Rao LS Freedberg IM | 2001 | J Invest Dermatol2001，116，2： | 1 |
| 15 | Firsthand cigarette smoke alters fibroblast migration and survival: implications for impaired healing 显示文摘 | Wong LS Martins-Green M | 2004 | Wound Repair Regen2004，12，： | 1 |
| 16 | Atypical entero- pathogenic Escherichla coli infection and prolonged diarrhea in children显示文摘 | Nguyen RN Taylor LS Tauschek M | 2006 | Emerg Infect Dis2006，12，： | 1 |
| 17 | Do blood concentrations of neurone specific enolase and S-100 beta protein reflect cognitive dysfunction after abdominal surgery显示文摘 | Rasrnussen LS Christiansen M Rasmussen H | 2000 | Br J Anaesth2000，84，2： | 1 |
| 18 | Cardiac arrest resuscitation evaluation in LosAngeles: CARELA显示文摘 | Eckstein M Stratton SJ Chan LS | 2005 | Ann Emerg Med2005，45，5： | 1 |
| 19 | Thyroid cancer in childhood: management strategy, including dosimetry and long- term resuhs显示文摘 | Luster M Lassmann M Freudenberg LS | 2007 | Hormones (Athens)2007，6，： | 1 |
| 20 | Stress and the brain: from adaptation to disease显示文摘 | De Kloet E R Jo?ls M Holsboer F | 2005 | Nature Reviews Neuroscience2005，6，6： | 1 |
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