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| 1 | Translational pain research: Evaluating analgesic effect in experimental visceral pain models显示文摘Deep visceral pain is frequent and presents major challenges in pain management, since its pathophysiology is still poorly understood. One way to optimize treatment of visceral pain is to improve knowledge of the mechanisms behind the pain and the mode of action of analgesic substances. This can be achieved through stand-ardized experimental human pain models. Experimental pain models in healthy volunteers are advantageous for evaluation of analgesic action, as this is often diff icult to assess in the clinic because of confounding factors such as sedation, nausea and general malaise. These pain models facilitate minimizing the gap between knowledge gained in animal and human clinical studies. Combining experimental pain studies and pharmacokinetic stud- ies can improve understanding of the pharmacokinetic-pharmacodynamic relationship of analgesics and, thus, provide valuable insight into optimal clinical treatment of visceral pain. To improve treatment of visceral pain, it is important to study the underlying mechanisms of pain and the action of analgesics used for its treatment. An experimental pain model activates different modalities and can be used to investigate the mechanism of action of different analgesics in detail. In combination with pharmacokinetic studies and objective assessment such as electroencephalography, new information re-garding a given drug substance and its effects can be obtained. Results from experimental human visceral pain research can bridge the gap in knowledge between animal studies and clinical condition in patients suffering from visceral pain, and thus constitute the missing link in translational pain research. | Anne Estrup Olesen Trine Andresen Lona Louring Christrup Richard N Upton | 2009 | World Journal of Gastroenterology2009，15，2： | 3 |
| 2 | The impact of an electronic monitoring and reminder device on patient compliance with antihypertensive therapy:a randomized controlled trial显示文摘 | Ame Christensen Lona Louring Christrup Paul Erik Fabricius | 2010 | Journal of Hypertension2010，，28： | 1 |
| 3 | Inherited AD- AMTS13 deficiency ( Upshaw-Schulman syndrome ) : A short review 显示文摘 | Perez-Roddguez A Loures E Rodriguez-Trillo A | 2014 | Thromb Res2014，134，6： | 1 |
| 4 | Thermomechanical stress analysis of superplastic forming tools显示文摘 | Gao C Y Lours P Bernhart G | 2005 | Journal of Materials Processing Technology2005，，169： | 1 |
| 5 | Amplitude to phase conversion of InGaAs pin photo-diodes for femtosecond lasers microwave signal generation 显示文摘 | Zhang W Li T Lours M | 2012 | Applied physics B2012，106，： | 1 |
| 6 | Oxidation and Oxide Spallation of Heat Resistant Cast Steels for Super Plastic Forming Dies 显示文摘 | Baleix S Bernhart G Lours P | 2002 | Materials Science and Engineering2002，327，： | 1 |
| 7 | Influence of Heat Treatment on the Fracture Toughness and Crack Propagation in 5%Cr Martensitic Steel显示文摘 | Souki I Delagnes D Lours P | 2011 | Procedia Engineering2011，，10： | 1 |
| 8 | High resolution frequency standard dissemination via optical fiber metropolitan network 显示文摘 | NARBONNEAU F LOURS M BIZE S | 2006 | Review of Scientific Instruments2006，77，6： | 1 |
| 9 | Sensory dis-turbances and pain complaints after brachial plexus root injury: aprospective study involving 150 adult patients显示文摘 | Bertelli J A Ghizoni M F Loure Iro Chaves D P | 2011 | Microsurgery2011，31，2： | 1 |
| 10 | Reservoir porosity inference显示文摘 | Loures L Moraes F | 2002 | 72nd Ann Internat Mtg Soc of Expl Geophys2002，，： | 1 |
| 11 | Sensory disturbances and pain complaints after brachial plexus root injury:a prospective study involving 150 adult patients显示文摘 | Bertelli JA Ghizoni MF Loure Iro Chaves DP | 2011 | Microsurgery2011，31，2： | 1 |
| 12 | Prospective com-parison of 6 comorbidity indices as predictors of 1-yearpost-hospital discharge institutionalization,readmission,and mortality in elderly individuals显示文摘 | Zekry D Loures Valle BH Graf C | 2012 | J Am Med Dir As-soc2012，13，3： | 1 |
| 13 | Percutaneous mitral balloon valvuloplasty in pregnant women with mitral stenosis显示文摘 | Nercolini DC da Rocha Loures Bueno R Eduardo Guerios E | 2002 | Catheter Cardiovasc Interv2002，57，： | 1 |
| 14 | Post industrial landscapes as drivers for urban redevelopment: publicversus expert perspectives towards the benefits and barriers of the reuse of postindustrial sites in urban areas 显示文摘 | Loures | 2015 | Habitat International2015，7281，： | 1 |
| 15 | High resolution fre-quency standard dissemination via optical fiber metropolitannetwork显示文摘 | Narbonneau F Lours M Bize S | 2006 | Review of Scientific Instruments2006，77，6： | 1 |
| 16 | Optimal exploitation of an unknown reverse 显示文摘 | Lour G C | 1978 | Review of Economic Studies1978，45，3： | 1 |
| 17 | High resolution frequency standard dissemination via optical fiber metro-politan network 显示文摘 | Narboonneau F Lours M Bize S | 2006 | Review of Scientific Instruments2006，77，06： | 1 |
| 18 | Ultrastructural localization of basic proteins in cytoplasmic granules of rat eosinophils and mast cell 显示文摘 | Pimenta P F P Loures M A L Souza W | 1980 | Histochem Cytochem1980，28，： | 1 |
| 19 | Strength and breaking mechanism of multi-walled carbon Nanotubes under tensile load 显示文摘 | Oleg Loure Mark J | 2000 | Science2000，287，： | 1 |
| 20 | Analysis on quality of life of patients with osteoarthrosis undergoing total hip arthroplasty显示文摘 | de Araújo Loures E Leite IC | 2015 | Rev Bras Ortop2015，47，4： | 1 |
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