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| 1 | Does physical therapy and rehabilitation improve outcomes for diabetic foot ulcers?显示文摘One of the most common and serious complications of diabetes mellitus is ulceration of the foot. Among persons with diabetes, 12%-25% will present to a healthcare institution for a foot disorder during their lifespan. Despite currently available medical and surgical treatments, these are still the most common diabetes-related cause of hospitalization and of lower extremity amputations. Thus, many adjunctive and complementary treatments have been developed in an attempt to improve outcomes. We herein review the available literature on the effectiveness of several treatments, including superficial and deep heaters, electro-therapy procedures, prophylactic methods, exercise and shoe modifications, on diabetic foot wounds. Overall, although physical therapy modalities seem to be useful in the treatment of diabetic foot wounds, further randomized clinical studies are required. | Yasemin Turan Bulent M Ertugrul Benjamin A Lipsky Kevser Bayraktar | 2015 | World Journal of Experimental Medicine2015，5，2： | 7 |
| 2 | 无弧限流式混合断路器显示文摘本文介绍一种名为混合限流式断路器(H—CLID)的简化的直流/交流混合断路器。当主触头处于闭合位置时其两端的电压降与机械式断路器为同一数量级,然而限流能力和电流分断能力却几乎与强迫换流的无触点晶闸管断路器相同。和可实现接通和分断功能的混合断路器相比,H—CLID的设计却简化多了。在H—CLID中使用了可更换触头,这样H—CLID又相当于一个熔断器。 开发了两个H—CLID模型,一个为物理模型,其额定参数为4OOA/380VAC,一个为工业模型,其额定参数为1600A/500VDC,对这些模型进行了一系列实验,这些实验包括:在低压系统中进行预期电流达75kA(有效值)的交流电流分断;在低压配电屏上分断交流/直流于扰电弧;在低压系统中分断由发电机或换流器提供的直流电流,其为实际非限流的预期电流和分断高感性电路中的直流负荷电流(恒流电抗器)。 以上所有试验都证实了H—CLID可进行无弧分断,并且几乎完全消除了短路电流及干扰电弧的破坏作用。H—CLID最好的使用场合是低压AC/DC开关设备中的“寿命保护”,它可以用来对二极管、晶闸管变换器中的内部故障进行快速保护,这样就可以省去在变换器电路中保护半导体的熔断器了。 | J. Zyborski, T. Lipski, J. Czucha, R. Partyka, M. Pikon, J. Piotrowski (85-952 Gdansk) Technical University of Gdansk, Poland | 1998 | 低压电器1998，，1： | 5 |
| 3 | Competition between TRAF2 and TRAF6 Regulates NF-κB Activation in Human B Lymphocytes显示文摘Objective To investigate the role of TNF receptor-associated factor 2 (TRAF-2) and TRAF6 in CD40-induced nuclear factor-κB (NF-κB) signaling pathway and whether CD40 signaling requires TRAF2. Methods Human B cell lines were transfected with plasmids expressing wild type TRAF2 or dominant negative TRAF2,TRAF2-shRNA,or TRAF6-shRNA. The activation of NF-κB was detected by Western blot,kinase assay,transfactor enzyme-linked immunosorbent assay (ELISA),and fluorescence resonance energy transfer (FRET). Analysis of the role of TRAF-2 and TRAF-6 in CD40-mediated NF-κB activity was examined following stimulation with recombinant CD154. Results TRAF2 induced activity of IκB-kinases (IKKα,IKKi/ε),phosphorylation of IκBα,as well as nuclear translocation and phosphorylation of p65/RelA. In contrast,TRAF6 strongly induced NF-κB activation and nuclear translocation of p65 as well as p50 and c-Rel. Engagement of CD154-induced nuclear translocation of p65 was inhibited by a TRAF6-shRNA,but conversely was enhanced by a TRAF2-shRNA. Examination of direct interactions between CD40 and TRAFs by FRET documented that both TRAF2 and TRAF6 directly interacted with CD40. However,the two TRAFs competed for CD40 binding. Conclusions These results indicate that TRAF2 can signal in human B cells,but it is not essential for CD40-mediated NF-κB activation. Moreover,TRAF2 can compete with TRAF6 for CD40 binding,and thereby limit the capacity of CD40 engagement to induce NF-κB activation. | Wen Zhang Xuan Zhang Xiao-li Wu Liu-sheng He Xiao-feng Zeng Amrie C. Grammer Peter E. Lipsky | 2010 | Chinese Medical Sciences Journal2010，25，1： | 5 |
| 4 | Serotonin Transporter Promoter Gain-of-Function Genotypes Are Linked to Obsessive-Compulsive Disorder显示文摘 | Xian-Zhang Hu Robert H. Lipsky Guanshan Zhu Longina A. Akhtar Julie Taubman Benjamin D. Greenberg Ke Xu Paul D. Arnold Margaret A. Richter James L. Kennedy Dennis L. Murphy David Goldman | 2006 | The American Journal of Human Genetics2006，，5： | 2 |
| 5 | Analysis of the functional capabilities of CD3+CD4-CD8- and CD3+CD4+CD8+ human T cell clones显示文摘 | Patel SS Wacholtz MC Duby AD Thiele DL Lipsky PE | 1989 | J Immunol1989，143，4： | 2 |
| 6 | 原发性高血压患者血清和尿液中肿瘤坏死因子浓度与早期器官损害的关系显示文摘高血压被认为是一种低度炎症性疾病。因此,炎症细胞因子浓度可能在高血压患者体内升高,包括肿瘤坏死因子(tumor necrosis factor,TNF)„该研究由年龄18-65岁的参与者96人组成:原发性高血压患者76例和20名健康对照人群。用诊室和动态血压监测(ambulatory blood pressure monitoring,ABPM)测量血压,采集血液进行实验室检查[TNF,TNF受体(TNF receptor 1,TNFR1)],收集24h尿以评估蛋白尿和TNF浓度。 | 陈嘉睿(译) 叶鹏(审校) Puszkarska A Niklas A Giuszek J Lipski D Niklas K | 2019 | 中华高血压杂志2019，27，11： | 2 |
| 7 | Treatment for diabetic foot ulcers 显示文摘 | Cavanagh PR Lipsky BA Bradbury AW | 2005 | Lancet2005，366，9498： | 1 |
| 8 | Effects of dilution on fine particle mass and partitioning of semivolatile organics in diesel exhaust and wood smoke显示文摘 | LIPSKY E M ROBINSON A L | 2006 | Environmental Science and Technology2006，40，1： | 1 |
| 9 | Unresolved issues in the role of cyclooxygenase-2 in normal physiologic processes and disease显示文摘 | Brooks P Crofford L | 2000 | Arch Intern Med2000，160，： | 1 |
| 10 | For the Infectious Diseases Society of America,diagnosis and treatment of diabetic foot infections显示文摘 | Lipsky B A Berendt A Deery H G | 2004 | Clin Infect Dis2004，39，7： | 1 |
| 11 | The IL-1 receptor accessory protein (AcP)is required for IL-33 signaling and soluble AcP enhances the ability of soluble ST2 to inhibit IL-33显示文摘 | Palmer G Lipsky BP Smithgall MD | 2008 | Cytokine2008，42，3： | 1 |
| 12 | Cutting edge: Stromal cell derived factor(SDF) - 1 is a co- stimulator for CD4^+ T cell activation显示文摘 | Nanki T Lipsky P | 2000 | J Immunol2000，164，10： | 1 |
| 13 | The effect of heroin and multiple drug abuse on the electrocardiogram显示文摘 | Lipski J Stimmel B Donoso E | 1973 | Am Heart J1973，86，5： | 1 |
| 14 | Incomplete information in relational databases显示文摘 | IMIELINSKI T LIPSKI J W | 1984 | Journal of the ACM1984，31，4： | 1 |
| 15 | Prevent in foot ulcers in patkn with diabetes显示文摘 | Singh N Annstron IX Lipsky BA | 2005 | JAMA2005，293，2： | 1 |
| 16 | Preventing foot ulcers in patients with diabetes显示文摘 | Singh N Armstrong DG Lipsky BA | | 0，，2： | 1 |
| 17 | Does this coughing adolescent or adult patient have pertussis?显示文摘 | Cornia PB Hersh AL Lipsky BA | 2010 | JAMA2010，304，8： | 1 |
| 18 | A potential new treatment for rheumatoid arthritis : thunder god vine 显示文摘 | Lipsky PE Tao XL | 1997 | Semin Arthritis Rheum1997，26，5： | 1 |
| 19 | Stable-isotope-based labe- ling of styrene degrading microorganisms in biofilters 显示文摘 | ALEXANDRINO M KNIEF C LIPSKI A | 2001 | Appl Environ Microbio12001，67，： | 1 |
| 20 | Infliximab and methotrexate in the treatment of rheumatoid arthritis显示文摘 | Lipsky P E Van der Heijde D M St clair E W | 2000 | N Eng J Med2000，343，： | 1 |
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