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| 1 | 三萜类化合物对化学损伤原代培养大鼠肝细胞的保护作用显示文摘目的:研究三萜类化合物对半乳糖胺(D-GalN)和四氯化碳(CCl4)损伤原代培养大鼠肝细胞的保护作用及其机制。方法:两步灌流法分离大鼠肝细胞进行原代培养,评价积雪草酸(asiaticacid,AA)和β-甘草次酸(β-glycyrrhetinicacid,GA)对D-GalN和CCl4损伤原代培养肝细胞的保护作用。光镜评价细胞生长形态,MTT法测定细胞活性,测定细胞上清天冬氨酸氨基转移酶(AST)和乳酸脱氢酶(LDH);并以荧光分光光度法测定细胞中活性氧(ROS),细胞上清活性氮终产物(NOx)和细胞内谷胱甘肽(GSH)含量;用JC-1法测定细胞线粒体膜电位(ΔΨm)。结果:AA和GA均可显著抑制D-GalN所致的AST和LDH升高(P<0.05),AA尚能提高细胞存活率(P<0.05);AA和GA也能显著抑制CCl4所致的LDH释放(P<0.05)。AA和GA均显著减少两种化学损伤细胞ROS生成和NOx释放,明显改善D-GalN所致细胞线粒体ΔΨm的降低;AA尚显著抑制两种化学损伤细胞内GSH降低。结论:三萜类化合物对D-GalN和CCl4致原代培养大鼠肝细胞损伤有保护作用,其机制与抑制细胞ROS、NOx生成和GSH降低相关,对D-GalN损伤尚有改善线粒体膜电位作用。 | 马葵芬 张相宜 齐罗扬 王燕 周长新 Nina Artanti Novik Nurhidayat Lince Yarni 楼宜嘉 | 2007 | 浙江大学学报(医学版)2007，36，3： | 10 |
| 2 | Valence reduction process from solgel V205 toVO2 thin film显示文摘 | Yuan N Li J LinC | 2002 | ApplSurfSci2002，191，14： | 1 |
| 3 | Formulation and optimization of cubic polynomial joint trajectories for industrial robots显示文摘 | LINC S CHANGPR LUH JY S | 1983 | IEEE Trans on Automatic Control1983，28，12： | 1 |
| 4 | Coordinate descent method for large-scale L2-1oss linear support vector machines显示文摘 | CHANG Kai-wei HSIEH C J LINC J | 2008 | Journal of Machine Learning Research2008，9，7： | 1 |
| 5 | Diffuse intraperitoneal- metastasis after spontaneous of hepatoeel-lular carcinoma显示文摘 | LINC C CHENC H TSANG YM | 2006 | J Formos Med Assoc2006，105，： | 1 |
| 6 | A systematic review of clinical studies on hereditary factors in pelvic organ pro- lapsed 显示文摘 | Lince SL Vierhout ME Kluivers KB | 2012 | Int Urogynecol J2012，23，： | 1 |
| 7 | Crystallinity of rf-sputtered MoS2 films显示文摘 | LINCE J R FLEISCHAUER P D | 1987 | Journal of Materials Research1987，2，： | 1 |
| 8 | Early enteral nutrition in gastrointestinal surgery:A pilot study显示文摘 | Velez JP Lince LF Restrepo JI | 1997 | Nutrition1997，13，5： | 1 |
| 9 | LeverageandInvestmentunderaStateownedBankLendingEnvironment:EvidencefromChina显示文摘 | FirthM LinC WongS | 2008 | JournalofCorporateFinance2008，，14： | 1 |
| 10 | Auditpartnertenure,auditfirmtenureanddiscretionaryaccruals:doeslongauditortenureimpairearningsquality显示文摘 | ChenC LinC LinY | 2008 | ContemporaryAccountingResearch2008，25，2： | 1 |
| 11 | Metal incorporation in sputter - deposited MoS2 films studied by extended X - ray absorption fine structure 显示文摘 | Lince J R Hilton M R Bommannavar A S | 1995 | Journal of Materials Research1995，10，： | 1 |
| 12 | Crystallinity of rf-sputtered MoS2 films 显示文摘 | Lince J R Fleischauer P D | 1987 | Journal of Materials Research1987，，2： | 1 |
| 13 | A comparison of oxidation and oxygen substitution in MoS2 solid film lubricants显示文摘 | FLEISCHAUER P D LINCE J R | 1999 | Tribology International1999，32，： | 1 |
| 14 | Phy- scial and sensory properties of yogurt stabilized with milk proteins 显示文摘 | MODLER H W LAARMOND M E LINC S | 1983 | Journal of Dairy Science1983，66，3： | 1 |
| 15 | Micro - tribological performance of MoS2 lubricants with varying Au content显示文摘 | Pantcho Stoyanov J Zachary Fishman Jeffrey R Lince | 2008 | Surface & Coatings Technology2008，203，： | 1 |
| 16 | Formulation and optimization of cubic polynomial joint traiectories for industrial robots显示文摘 | LinCS ChangPR Luh J YS | 1983 | IEEE Trans Automat Contr1983，，12： | 1 |
| 17 | , The integrated secondary route network design model in the hierarchical hub-and-spoke network for dual express services 显示文摘 | LinC C | 2010 | International Journal of Production Economics2010，123，1： | 1 |
| 18 | Hierarchical MADM with fuzzy integral for evaluating enterprise intranet web sites显示文摘 | Tzeng G H Ou Yang Y P LinC T | 2005 | Information Sciences2005，169，34： | 1 |
| 19 | Impalpibleeryptorchidism,areviewof170tstes显示文摘 | LinCS ChinTW WeiCF | 2002 | 中华医学杂志2002，65，： | 1 |
| 20 | Momordica charantia ameliorates insulin resistance and dyslipidemia with altered hepatic glucose production and fatty acid synthesis and AMPK phosphorylation in high-fat-fed mice显示文摘 | SHINC C SHLAUM T LINC H | 2014 | Phytotherapy Research:Ptr2014，，3： | 1 |
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