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| 1 | Portal vein thrombosis in cirrhotic patients-it is always the small pieces that make the big picture显示文摘Portal vein thrombosis(PVT) is a frequent and serious complication in patients with liver cirrhosis(LC). Recently, a new classification of PVT was proposed, although the functional component was not completed included. The status of liver disease(compensated/decompensated) should be added to this classification. Reduced portal flow velocity and the acquired hypercoagulable status associated with LC are the main risk factors for PVT development, although endothelial dysfunction may play an important role that needs to be further evaluated. The European Association for the Study of the Liver and the American Association for the Study of Liver Disease recommend that the anticoagulant treatment should be consider in cirrhotic patients with PVT. Low molecular weight heparin and vitamin K antagonists proved their efficacy and relatively safety in PVT treatment, although in addition to recanalization rates, more complex endpoints such as mortality and decompensation rate should be evaluated. The new oral anticoagulant therapies offers the advantage of oral administration in the absence of laboratory monitoring, however, there are a few reports regarding their use in cirrhotic patients, most of them referring to compensated isolated cases. Transjugular intrahepatic portosystemic shunt could be an alternative if thrombosis progresses despite anticoagulatant therapy and/or when PVT is associated with portal hypertension complications. The aim of this editorial is to discuss the different aspects of pathophysiology, clinical relevance, diagnosis and management of PVT in patients with LC. | Irina Girleanu Anca Trifan Carol Stanciu Cǎtǎlin Sfarti | 2018 | World Journal of Gastroenterology2018，24，39： | 6 |
| 2 | 新辅助放化疗联合全直肠系膜切除术后接受辅助化疗不能改善Ⅱ/Ⅲ期直肠癌患者的无复发生存率显示文摘目的:目前,NCCN指南建议对局部进展期Ⅱ/Ⅲ期直肠癌先行新辅助放化疗(nCRT),然后行全直肠系膜切除术(TME)和辅助化疗。辅助化疗的肿瘤学获益尚未得到进一步证实。本研究的目的是评估nCRT+TME手术后接受辅助化疗的直肠癌患者肿瘤复发和生存情况。方法:本研究是在南加州的14家医院和相关诊所完成的回顾性研究,研究对象为2005年1月1日至2016年12月31日接受手术治疗的862例Ⅱ/Ⅲ期直肠癌患者,无论是否行辅助化疗,纳入研究的患者均接受了新辅助化疗以及全直肠系膜切除术。主要终点是无复发生存率。 | 李来元 VOSS R K LIN J C ROPER M T | 2020 | 结直肠肛门外科2020，26，2： | 5 |
| 3 | 欧洲和中国的心脏与肾脏远程缺血预适应研究:一项随机对照试验显示文摘远程缺血预适应(remote ischemic preconditioning,RIPC)对经皮冠状动脉介入治疗(percutaneous coronary intervention,PCI)术后造影剂肾病(contrast-induced nephropathy,CIN)的潜在保护作用尚待确定。该研究为双盲、随机、安慰剂对照的多中心研究,纳入年龄〈85岁,肾清除率为30~60mL/(min·1.73m^2)的有临床适应证的患者,除了直接PCI外均按1∶1给予RIPC或标准治疗。主要终点是CIN的发生率。次要终点是围手术期心肌梗死(peri-procedural myocardial infarction,PMI)的发生率。 | 刘青 叶鹏 Moretti C Cerrato E Cavallero E Lin S Rossi ML Picchi A Sanguineti F Ugo F Palazzuoli A Bertaina M Presbitero P Shao-Liang C Pozzi R Giammaria M Limbruno U Lefèvre T Gasparetto V Garbo R OmedèP Sheiban I Escaned J Biondi-Zoccai G Gaita F Perl L D'Ascenzo F | 2018 | 中华高血压杂志2018，26，4： | 3 |
| 4 | Satellite sensor image classification using cascaded architecture of neural fuzzy network显示文摘 | Lin C T Lee Y C Pu P H | 2000 | IEEE Transactions on Geoscience and Remote Sensing2000，38，2： | 2 |
| 5 | 显示文摘 | Cheng H F Lin T F Hu C T | 1993 | J Am Ceram Soc1993，76，4： | 2 |
| 6 | Combined contrast-enhanced power Doppler and real-time sonoelastography performed during EUS, used in the differential diagnosis of focal pancreatic masses (with videos)显示文摘 | Adrian S?ftoiu Sevasti?a Iordache Dan Ionu? Gheonea Carmen Popescu Anca Malo? Florin Gorunescu Tudorel Ciurea Alexandru Iordache Gabriel Lucian Popescu Cǎtǎlin Manea | 2010 | Gastrointestinal Endoscopy2010，，4： | 2 |
| 7 | Screw Dislocation Dipole Near an Internal Crack显示文摘 | Lin K M Hu C T Lee S B | 1993 | Engineering Fracture Mechanics1993，45，： | 1 |
| 8 | Suppression of lipopolysaccharide- induced nuclear factor- kappaB activity by theaflavin-3,3'-digallate from black tea and other polyphenols through down-regulation of IkappaB kinase activity in macrophages 显示文摘 | Pan M H Lin-shiau S Y Ho C T Lin J H Lin J K | 2000 | Biochem Pharm2000，59，： | 1 |
| 9 | A note on Platt's probabilistic outputs for support vector machines显示文摘 | Lin H T Lin C J Weng R C | 2007 | Machine Learning2007，68，3： | 1 |
| 10 | Predictors for extraintestinal infectiom of non-typhoidal Salmonella in patients without AIDS 显示文摘 | Chiu C H Lin T Y Qu J T | 1999 | Hat J Clin Pract1999，53，： | 1 |
| 11 | Acetyl danshenxinkun a from Salvia miltiorrhiza 显示文摘 | Lin Y L Liu C Y Chen T H etal | 2003 | J Chin Med2003，14，： | 1 |
| 12 | A concise survey of scheduling with time-dependent processing times显示文摘 | Cheng T C E Ding Q Lin B M T | 2004 | European Journal of Operational Research2004，152，： | 1 |
| 13 | Lysophosphatidic aeid up- regulates vascular endothelial growth factar-C and tube formation in human endothelial cells through LPA ( 1/3 ), COX-2, and NF-kappaB activation and EGFR transactivation-dependent mechanisms显示文摘 | Lin C I Chen C N Huang M T | 2008 | Cell Signal2008，20，10： | 1 |
| 14 | Satellite observations of modulation of surface winds by typhoon-induced upper ocean cooling显示文摘 | LIN I I LIU W T WU C C | 2003 | Geophysical Research Letters2003，30，3： | 1 |
| 15 | Automatic generation of NC cutter path from massive data points显示文摘 | LIN A C LIU H T | 1998 | Computer-Aided Design1998，30，1： | 1 |
| 16 | Structure of the channel catfish (Ictalurus punctatus) growth hormone gene and its evolutionary implication显示文摘 | Lin C M Chen T T | 1993 | Mol Mar Bio Biotechnol1993，2，： | 1 |
| 17 | Effect of brain e dema on infarct volume in a focal cerebral ischemia model in rats显示文摘 | Lin T N He Y Y Wu G Khan M Hsu C Y | 1993 | Stroke1993，24，： | 1 |
| 18 | Modeling and Performance of a Static Frequency Converter Starting a 300MV·A Synchronous Machine显示文摘 | LIU T H LIN C Y | 1996 | Electric Power Systems Research1996，，37： | 1 |
| 19 | Thermal stability of sputtered copper films containing dilute insoluble tungsten: thermal annealing study 显示文摘 | Lin C H Chu J P Mahalingam T | 2003 | Mater Res2003，18，6： | 1 |
| 20 | Genetic diversity and biogeography of Cunninghamia konishii ( Cupressaeeae ) , an island species in Taiwan:a comparison with Cunninghamia lanceolata, a mainland species in China显示文摘 | Chung J D Lin T P Tan Y C | 2004 | Molecular Phy- logeneties and Evolution2004，33，： | 1 |
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