|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Simple and sensitive determination of sparfloxacin in pharmaceuticals and biological samples by immunoassay显示文摘Plasma quinolone concentrations are not routinely measured in clinical practice.However,in order to optimize quinolone treatment,monitoring of plasma concentrations could sometimes be useful particularly in critically ill patients.In this study,anti-sparfloxacin antibody was obtained by immunizing rabbits with sparfloxacin conjugated with bovine serum albumin using isobutyl chloroformate method.After the assay procedure was optimized,the standard curve of sparfloxacin was established.The practical measuring range of the competitive ELISA extended from 5 ng/mL to 2 mg/mL.The recovery rates and coefficients of variation for rat plasma,urine and tissues were 87.7-106.2% and 4.8-15.3%,respectively.To demonstrate the potential of the ELISA,a preliminary pharmacokinetics and tissue distribution study of sparfloxacin in rats and quantitative analysis of sparfloxacin in several pharmaceuticals were performed and compared with high-performance liquid chromatography(HPLC).The experimental data indicated that the proposed method would be a valuable tool in therapeutic drug monitoring(TDM) for sparfloxacin. | Hua-Jin Zenga,Ran Yangb,Bing Liub,Li-Fang Leib,Jian-Jun Lib,Ling-Bo Qub,c,n aSchool of Pharmaceutical Sciences,Zhengzhou University,Zhengzhou 450001,China bDepartment of Chemistry,Zhengzhou University,Zhengzhou 450001,China cSchool of Chemistry & Chemical Engineering,Henan University of Technology,Zhengzhou 450001,China | 2012 | Journal of Pharmaceutical Analysis2012，2，3： | 2 |
| 2 | Influence of mass-flow ratio of inner to outer secondary air on gas-particle flow near a swirl burner显示文摘The influence of mass-flow-rate ratio of inner to outer secondary air on gas-particle flow characteristics was determined in the near-burner region of a centrally fuel-rich swirl coal combustion burner.Velocity and particle volume flux profiles and normalized particle number concentrations were obtained.Peaks in tangential mean velocity and three-dimensional root-mean-square fluctuation velocities were found to decrease as the mass-flow-rate ratio increased.Moreover,the peaks in the mean axial velocities and particle volume flux near the wall increased,whereas those near the chamber axis decreased.Simultaneously,both recirculation zone and swirl number decreased as the mass-flow-rate ratio increased. | Jianping Jing Chunming Zhang Wei Suna Jieruo Ana Jinsheng Bia Zhengqi Lib | 2013 | Particuology2013，11，5： | 2 |
| 3 | A modified method of ecological footprint calculation and its application显示文摘 | SHENG ZHAO ZIZHEN LIB WENLONG LIA | 2005 | Ecological Modeling2005，185，： | 1 |
| 4 | Analysis of genetic variation in selected stocks of hatchery flounder, Paralichthys olivaceus, using AFLP markers 显示文摘 | LIU Y G CHEN S L LIB F | 2005 | Biochemical Systematics and Ecology2005，33，10： | 1 |
| 5 | Shrinkage tuning parameter selection with a diverging number of parameters 显示文摘 | WANG H LIB L LENG C | 2009 | J Roy Stat Soc B2009，71，3： | 1 |
| 6 | The effects of Na2WO4 concentration on the properties of microarc oxidation coatings on aluminum alloy显示文摘 | ZHENGA H Y WANGA Y K LIB B S | 2005 | Materials Letters2005，59，： | 1 |
| 7 | On uniqueness of entire functions in C^n and their partial differential polynomials显示文摘 | BERNSTEIN C A CHANG D C LIB Q | 1996 | Forum Math1996，8，： | 1 |
| 8 | Direct liquefaction of sawdust under syngas with and without catalyst 显示文摘 | WANG G LI W LIB Q | 2007 | Chemical Engineering and Processing2007，46，3： | 1 |
| 9 | BML-Ill, a lipoxin receptor agonist, protects haemorrhagic shock-induced acute lung injury in rats 显示文摘 | Gong J Guo S Li liB | 2012 | Resuscitation2012，83，7： | 1 |
| 10 | Mechanical characteriza-tion of high aspect ratio silicon nanolines 显示文摘 | LIB HUANG H ZHAO Q | 2008 | MaterialsResearch Society2008，1086，： | 1 |
| 11 | Bcl-2 expression and triple negative profile in breast carcinoma显示文摘 | Kallel-I3ayoudh I I-Iassen liB Khabir A | 2011 | Med Oncol2011，28，1： | 1 |
| 12 | Seed rain dynamics reveals strong dispersal limitation,different reproductive strategies and responses to climate in a temperate forest in northeast China显示文摘 | LIB H HAO Z Q BIN Y | 2011 | Journal of Vegetation Science2011，23，2： | 1 |
| 13 | Update on the epidemi- ology gastro-oesophageal reflux disease ; a systematic review 显示文摘 | Ei-Serag liB Sweet S Winchester CC | 2014 | Gut2014，63，6： | 1 |
| 14 | Biometric Evidence That Sexual Selection Has Shaped the Hominin Face 显示文摘 | Weston EM Friday AE Lib P | 2007 | PLOS One2007，2，8： | 1 |
| 15 | Estimation of effect of voids on frequency response of mountain tunnellining based on microtremor method显示文摘 | GAO Y JIANG Y LIB | 2014 | Tunnelling and Underground Space Technology2014，42，： | 1 |
| 16 | An investigation on the hydrogen storage characteristics of the melt-spun nanoerystalline and amorphous Mg20-xLaxNil0 (x = 0, 2)hydrogen storage alloys显示文摘 | ZHANG Y H LIB W REN H P | 2009 | Materials Chemistry and Physics2009，115，1： | 1 |
| 17 | The efficacy of a Salonellatyphi Vi conjugate vaccine in two to five year old children显示文摘 | Lin FY Ho VA Khiem liB | 2001 | N Engl J Med2001，344，： | 1 |
| 18 | Study on flavonoids in Quercus dentata Thunb显示文摘 | ZhouYJ(周应军) LiB(李波) LiangJN(梁建宁) eta1 | | 中草药0，，： | 1 |
| 19 | Frequent phosphodiesterase 11A gene (PDE11A) defects in patients with Carney complex (CNC) caused by PRKAR1A mutations: PDE11A may contribute to adrenal and testicular tumors in CNC as a modifier of the phenotype显示文摘 | Libé R Horvath A Vezzosi D | 2011 | J Clin Endocrinol Met2011，96，1： | 1 |
| 20 | Repetitive transeranial magnetic stimulation treatment of comorbid in post- traumatic stress disorder and major depression 显示文摘 | Rosenberg PB Mehnd Iratta liB | 2002 | J Neuro Psychiatry Clin Neurosci2002，14，3： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员