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| 1 | Estrogen deficiency leads to telomerase inhibition, telomere shortening and reduced cell proliferation in the adrenal gland of mice显示文摘雌激素缺乏调停变老,但是内在的机制尚待充分坚定。我们这里报导 aromatase 的指向的混乱在老鼠引起的雌激素缺乏在 vivo 在肾上腺导致 telomerase 活动的重要抑制。基因表示分析证明当雌激素不在时, telomerase 颠倒 transcriptase (TERT ) 基因表示在肾上腺外皮和肾的萎缩与损害房间增长联合被减少。在 c 工具包积极的干细胞被识别在肾的外皮的实质占据。telomeres 的分析表明那雌激素缺乏比那在肾的外皮导致显著地更短的 telomeres 在野类型(WT ) 控制鼠标。为了推进,建立雌激素的原因的效果,我们在这些雌激素缺乏的动物进行了雌激素代替治疗。为 3 个星期的雌激素的管理在雌激素缺乏的老鼠恢复 TERT 基因表示, telomerase 活动和房间增长。因此,我们第一次,那雌激素缺乏在 vivo 在鼠标的肾上腺引起 TERT 基因表示, telomerase 活动, telomere 维护,和房间增长的抑制的数据表演,建议那 telomerase 抑制并且 telomere 弄短可以调停在肾上腺的房间增长拘捕,因此贡献雌激素在生理的条件下面的导致缺乏的老化。 | Sharyn Bayne Margaret EE Jones He Li Alex R Pinto Evan R Simpson Jun-Ping Liu | 2008 | Cell Research2008，18，11： | 6 |
| 2 | A major pathway for carbon and nitrogen losses-Gas emissions during storage of solid pig manure in China显示文摘This study investigated the carbon(C) and nitrogen(N) gas emissions(N_2O,NH_3,CO_2 and CH_4) from solid pig manure management in China.Gas emissions were quantified from static piles over 60 days during summer in China's Yangtze River Basin,using Drager-Tube and static chamber-gas chromatography techniques.High emissions of NH_3 and N_2 O were observed at the early stage of storage,but high emission of CH_4 occured later during storage.Overall,62% of the total C in the original pile was lost; CO_2 and CH_4 emissions accounted for 57 and 0.2% of C lost respectively.Over the same time,41% of the total N in the original pile was lost; NH_3 and N_2 O emissions accounted for 15 and 0.3% of N lost respectively.The volatilization of NH_3 during storage in summer was 4.56 g NH_3 per kg dry weight.The total greenhouse gas(GHG) emissions during storage accounted for 67.93 g CO_2 equivalent per kg dry weight; N_2 O and CH_4 contributed to 46 and 55% of total GHG emissions respectively.Given China's major role in pig production,further attention should given to pig manure management to mitigate its contribution to atmospheric pollution. | SHAN Nan LI Hu LI Jian-zheng Ee Ling Ng MA Yan WANG Li-gang CHEN Qing | 2019 | Journal of Integrative Agriculture2019，18，1： | 3 |
| 3 | Infl uence of nitrate concentrations on EH40 steel corrosion aff ected by coexistence of Desulfovibrio desulfuricans and Pseudomonas aeruginosa bacteria显示文摘Nitrate addition is a common bio-competitive exclusion(BCE)method to mitigate corrosion in produced water reinjection systems,which can aff ect microbial community compositions,especially nitrate and sulfate reducing bacteria,but its eff ectiveness is in controversy.We investigated the infl uence of nitrate concentrations on EH40 steel corrosion aff ected by coexistence of Desulfovibrio vulgaris and Pseudomonas aeruginosa bacteria.Results demonstrate that only mixed bacteria or nitrate had little eff ect on EH40 steel corrosion,and nitrate could accelerate the corrosion of EH40 steel through the action of microorganisms.The corrosion promotion of nitrate was dependent on its concentrations,which increased from 0 to 5 g/L and decreased from 5 to 50 g/L.These diff erences were believed to be related to the regulation of nitrate in the growth of bacteria and biofi lms.Therefore,care must be taken to BCE method with nitrate when nitrate reducing bacteria with high corrosive activity are present in the environments. | Zhihua SUN Jiajia WU Dun ZHANG Ce LI Liyang ZHU Ee LI | 2022 | Journal of Oceanology and Limnology2022，40，4： | 2 |
| 4 | Improved biological performance of Ti implants due to surface modi- fication by micro - arc oxidation显示文摘 | Long - Hao Li Young - Min Kong Hae - Won Kim Young - Woon Kim Hyoun - Ee Kim Seong - Joo Heo Jai - Young Koak | 2004 | Biomaterials2004，25，： | 1 |
| 5 | Local expression of indoleamine 2,3-dioxygenase protects engraftment of xenogeneic skin substitute显示文摘 | Tredqet EE Gaffari A | 2006 | J Invest Dermatol2006，126，： | 1 |
| 6 | Antagonism of orexin receptors significantly lowers blood pressure in spontaneously hypertensive rats显示文摘 | Li A Hindmarch CC Nattie EE | 2013 | J Physiol2013，591，17： | 1 |
| 7 | VEGF and P1GFpromote adult vasculogenesis by enhancing EPCrecruitment and vessel formation at the site of tumorneovascularization 显示文摘 | Li B Sharpe EE Maupin AB | 2006 | FASEB J2006，20，9： | 1 |
| 8 | Fairness from the Top:Perceived Procedural Justice and Collaborative Problem Solving in New Product Development显示文摘 | Li Hy Bingham JR Umphress EE | 2007 | Organization Science2007，18，2： | 1 |
| 9 | Activation of pro-death Bcl-2 family proteins and mitochondria apoptosis pathway in tumor necrosis factor-alpha-induced liver injury显示文摘 | Zhao Y Li S Childs EE | 2001 | J Biol Chem2001，276，27： | 1 |
| 10 | Medullary serotonergic neurones modulate the ventilatory response to hypercapnia,but not hypoxia in conscious rats显示文摘 | Taylor NC Li A Nattie EE | 2005 | J Physiol2005，566，2： | 1 |
| 11 | Myeloma light chains induce epithelial-mesenchymal transition inhuman renal proximal tubule epithelial cells Nephrol Dial 显示文摘 | Li M Hering-Smith KS Simon EE | 2008 | Transplant2008，23，3： | 1 |
| 12 | Surface and peripheral doses of dynamic and physical wedges 显示文摘 | Li Z Klein EE | 1997 | Int J Radiat Oncol Biol Phys1997，37，： | 1 |
| 13 | In vitro anti-hepatitis B virus activities of 5'-O-myristoyl analogue derivatives 3'-fluoro-2', 3'-dideoxythymidine ( FLT ) and 3'-atido-2', 3'-dideoxythymidine (AZT) 显示文摘 | Parang K Wiebe LI Knaus EE Huang JS Tyrrell DL | 1998 | J Pharm Sci1998，1，3： | 1 |
| 14 | Force decomposition model for tool-wear in turning with grooved cutting tools 显示文摘 | Ee K C Balaji A K Li P X | 2002 | Wear2002，249，： | 1 |
| 15 | A COLIAl Spl binding site polymorphism predisposes to osteoporotic fracture by affecting bone density and quality 显示文摘 | Mann V Hobson EE Li B | 2001 | J Clin Invest2001，107，7： | 1 |
| 16 | Comparison of matrix metal- loproteinase 9 and brain natriuretic peptide as clinical biomarkers in chronic heart failure显示文摘 | Vorovich EE Chuai S Li M | 2008 | Am Heart J2008，155，6： | 1 |
| 17 | Ectopic expression of fibroblast growth factor receptor 3 promotes myeloma cell proliferation and prevents apoptosis显示文摘 | Plowright EE Li Z Bergsagel PL | 2000 | Blood2000，95，3： | 1 |
| 18 | Fc gamma receptors: structure, function and role as genetic risk factors in SLE 显示文摘 | Li X Ptacek TS Brown EE | 2009 | GenesImmun2009，10，： | 1 |
| 19 | Comparison of matrix metanoproteinase 9 and brain natriuretie peptide as clinical biomarkers in chronic heart failure显示文摘 | Vorovich EE Chuai S Li M | 2008 | Am Heart J2008，155，6： | 1 |
| 20 | VEGF and PIGF promote adult vasculogenesis by enhancing EPC recruitment and vessel formation at the site of tumor neovascularization 显示文摘 | Li B Sharpe EE Maupin AB | 2006 | FASEB J2006，20，9： | 1 |
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