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| 1 | Late Mesozoic crust-mantle interaction in southeastern Fujian——Isotopic evidence from the Pingtan igneous complex显示文摘UNDERPLATING Of mantle-derived basaltic magma and interacting with the lower crust materials are believed to be an important mechanism for the growth and transformation of the crust. | Dong, CW Zhou, XM Li, HM Ren, SL Zhou, XH | 1997 | Chinese Science Bulletin1997，42，6： | 23 |
| 2 | Tumor size as a prognostic factor in patients with advanced gastric cancer in the lower third of the stomach显示文摘AIM: To explore the impact of tumor size on outcomes in patients with advanced gastric cancer in the lower third of the stomach. METHODS: We retrospectively analyzed the clinical records of 430 patients with advanced gastric cancer in the lower third of the stomach who underwent distal subtotal gastrectomy and D2 lymphadenectomy in our hospital from January 1998 to June 2004. Receiver-operating characteristic (ROC) curve analysis was used to determine the appropriate cutoff value for tumor size, which was measured as maximum tumor diameter. Based on this cutoff value, patients were divided into two groups: those with large-sized tumors (LSTs) and those with small-sized tumors (SSTs). The correlations between other clinicopathologic factors and tumor size were investigated, and the 5-year overall survival (OS) rate was compared between the two groups. Potential prognostic factors were evaluated by univariate KaplanMeier survival analysis and multivariate Cox's propor-tional hazard model analysis. The 5-year OS rates in the two groups were compared according to pT stage and pN stage. RESULTS: The 5-year OS rate in the 430 patients with advanced gastric cancer in the lower third of the stomach was 53.7%. The mean ± SD tumor size was 4.9 ± 1.9 cm, and the median tumor size was 5.0 cm. ROC analysis indicated that the sensitivity and specificity results for the appropriate tumor size cutoff value of 4.8 cm were 80.0% and 68.2%, respectively (AUC=0.795, 95%CI: 0.751-0.839, P=0.000). Using this cutoff value, 222 patients (51.6%) had LSTs (tumor size ≥ 4.8 cm) and 208 (48.4%) had SSTs (tumor size<4.8 cm). Tumor size was significantly correlated with histological type (P=0.039), Borrmann type (P=0.000), depth of tumor invasion (P=0.000), lymph node metastasis (P=0.000), tumor-nodes metastasis stage (P=0.000), mean number of metastatic lymph nodes (P=0.000) and metastatic lymph node ratio (P=0.000). Patients with LSTs had a significantly lower 5-year OS rate than those with SSTs (37.1% vs 63.3%, P=0.000). Univariate analysis showed that depth of tumor invasion (c 2=69.581, P=0.000), lymph node metastasis (c 2=138.815, P=0.000), tumor size (c 2=78.184, P=0.000) and metastatic lymph node ratio (c 2=139.034, P=0.000) were significantly associated with 5-year OS rate. Multivariate analysis revealed that depth of tumor invasion (P=0.000), lymph node metastasis (P=0.019) and tumor size (P=0.000) were independent prognostic factors. Gastric cancers were divided into 12 subgroups: pT2N0; pT2N1; pT2N2; pT2N3; pT3N0; pT3N1; pT3N2; pT3N3; pT4aN0; pT4aN1; pT4aN2; and pT4aN3. In patients with pT2-3N3 stage tumors and patients with pT4a stage tumors, 5-year OS rates were significantly lower for LSTs than for SSTs (P<0.05 each), but there were no significant differences in the 5-year OS rates in LST and SST patients with pT23N0-2 stage tumors (P > 0.05). CONCLUSION: Using a tumor size cutoff value of 4.8cm, tumor size is a prognostic factor in patients with pN3 stage or pT4a stage advanced gastric cancer located in the lower third of the stomach. | Hong-Mei Wang, Chang-Ming Huang, Chao-Hui Zheng, Ping Li, Jian-Wei Xie, Jia-Bin Wang, Jian-Xian Lin, Jun Lu, Department of Gastric Surgery, Affiliated Union Hospital of Fujian Medical University, Fuzhou 350001, Fujian Province, China Author contributions: Wang HM and Huang CM conceived of the study, analyzed the data, and drafted the manuscript Zheng CH, Li P and Xie JW helped revise the manuscript critically for important intellectual content Wang JB, Lin JX and Lu J helped collect data and design the study and all authors read and approved the final manuscript. | 2012 | World Journal of Gastroenterology2012，18，38： | 15 |
| 3 | The effect of retinoic acid on Ito cell proliferation and content of DNA and RNA显示文摘 | Gao ZL Li DG Lu HM Gu XH | 1999 | World Journal of Gastroenterology1999，5，5： | 13 |
| 4 | Crucial role of the sarcoplasmic reticulum in the developmental regulation of Ca2+ transients and contraction in cardiomyocytes derived from embryonic stem cells显示文摘 | Fu JD Li J Tweedie D Yu HM Chen L Wang R Riordon DR Brugh SA Wang SQ Boheler KR Yang HT | 2006 | 中国生物学文摘2006，20，7： | 9 |
| 5 | Zircon U-Pb dating of Shuiquangou alkaline complex intrusives, northwestern Hebei Province显示文摘SUPER large gold deposits related to alkaline intrusions have been found in America,Canada,Australia,Papua New Guinea and elsewhere.Dongping gold deposit with superlarge potentialhas also been found in Shuiquangou alkaline complex intrusions,northwestern Hebei Province,China.One of the keys to resolving the possible genetic relationship between gold deposits andore-host alkaline intrusions is to determine their formation ages.This note dates the Shuiquan-gou intrusions with zircon U-Pb method. | Mo, CH Liang, HY Wang, XZ Cheng, JP Li, HM | 1997 | Chinese Science Bulletin1997，42，9： | 6 |
| 6 | 基于原发肿瘤表观扩散系数直方图分析预测高级别浆液性卵巢癌患者铂类药物化疗敏感性显示文摘高级别浆液性卵巢癌(HGSOC)是最常见和最致命的卵巢癌组织学亚型,初始肿瘤细胞减灭术后进行一线铂类药物化疗是其标准的治疗方法,但其治疗后复发率高达75%。运用间隔6个月有无复发这一非常简单有效的方法对铂敏感及铂耐药患者进行分类,并能为后续的个体化治疗方案选择提供客观依据。弥散加权成像(DWI)可以利用表观扩散系数(ADC)检测细胞和细胞膜的完整性,以量化水分子在组织中的扩散程度,而基于ADC分析的直方图则可分析肿瘤的生物异质性。该研究通过治疗前阶段HGSOC原发病变全肿瘤区域和全实性肿瘤区域ADC直方图分析,对患者铂类药物的化疗反应予以预测。 | Lu J Li HM Cai SQ 毛咪咪(编译) | 2022 | 中华医学杂志2022，102，3： | 5 |
| 7 | A Model for Liquid-Diffusion Catalytically Grown Fibrous Carbon Material显示文摘A mechanism for the catalytically growth of vapor grown fibrous carbon (VGFC) preparing from the floating catalyst method has been proposed, in which liquid diffusion-determined diffusionof carbon atoms through catalyst particles is described mathematically, and the physical andchemical properties of the catalyst particIes during the growth process are taken into account.From the model the growth rate and grown length of VGFC are calculated theoretically whichcoincides with the experimental datal and the necessity of reducing gas such as hydrogen inpreparing VGFC is explained as to reduce Fe3C, which acts as intermediate catalyst shown bythe model. Fe3C formed on the surface of γ-Fe will stop the growth of carbon fiber if they cannot be reduced at once. Additionally, the growth temperature and diameter of VGFC are alsodiscussed in the paper. | Zhang, WG Cheng, HM Su, G Fan, YY Li, F Shen, ZH Zhou, BL | 1999 | Journal of Materials Science & Technology1999，15，1： | 2 |
| 8 | Epidemiology of Heli cobacter pylori in Southern China:identification of early childhood as the critical period for acquisition显示文摘 | Mitchell HM Li YY Hu PJ | 1992 | J Infect Dis1992，166，： | 1 |
| 9 | 显示文摘 | Li LY Shih HM Liu MY | 2001 | J Biol Chem2001，276，27： | 1 |
| 10 | Neuroendoerine differentiation in 32 cases of cocalled sclerosing hemangioma of the lung: identified by immunohistochemical and ultrastrustructural study 显示文摘 | Xu HM Li WH Hou N | 1997 | Am J Surg Pathol1997，21，9： | 1 |
| 11 | Occurrence of antibiotics and antibiotic resistance genes in a sewage treatment plant and its ef?uent-receiving river 显示文摘 | Xu J Xu Y Wang HM Guo CS Qiu HY He Y Zhang Y Li XC Meng W | 2015 | Chemosphere2015，119，： | 1 |
| 12 | HIV in cadence among men who have sec with men in China:A meta-analysis of publishen studies显示文摘 | Li HM Peng RR Li J | 2011 | PLo S One2011，6，23： | 1 |
| 13 | Identification of two pigments and a hydroxystilbene antibiotic from Photorhabdus luminescens显示文摘 | Chen GH Wu HM | 1995 | Applied and Environmental Microbiology1995，61，： | 1 |
| 14 | Coupling between neuronal nitric oxide synthase and glutamate receptor 6-medialed c- Jun N-terwinai kinase signaling pathway via S-nitrosylation contributes to ischemia neuronal death 显示文摘 | Yu HM Xu J Li C | 2008 | Neuroscience2008，155，4： | 1 |
| 15 | Quick response policy with Bayesian information updates 显示文摘 | Choi TM Li D Yan HM | 2006 | European Journal of Operational Research2006，170，3： | 1 |
| 16 | Computerized classification study on 680 clinical confirmed SARS patients in Xiao Tang Shan Hospital 显示文摘 | Dong J Cao XT Liu ZM Xu HM Li YP Sun X Wang L Zhou YC | 2004 | Chinese Journal of Evidence-Based Medicine2004，4，5： | 1 |
| 17 | Chinese SF-36 Health Survey:translation,culture,adaptation,validation,and normalization显示文摘 | Li L Wang HM Shen Y | 2003 | J Epidemiol Community Health2003，57，： | 1 |
| 18 | Lysyl oxidase:properties,specificity,and biological roles inside and outside of the cell显示文摘 | Kagan HM Li W | 2003 | J Cell Biochem2003，88，4： | 1 |
| 19 | Chinese SF-36 Health Survey translation, cultural adaptation, validation, and normaliza tion显示文摘 | Li L Wang HM Shen Y | 2003 | J Epidemiol Community Health2003，57，4： | 1 |
| 20 | Co-detection in the pathogenesis of severe hand-foot-mouth disease 显示文摘 | Liu LJ Xu HM Li XJ | 2012 | Arch Virol2012，157，11： | 1 |
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