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| 1 | Association between MDM2-SNP309 and hepatocellular carcinoma in Taiwan Residents population显示文摘AIM:To investigate the risk association and compare the onset age of hepatocellular carcinoma(HCC) patients in Taiwan with different genotypes of MDM2- SNP309. METHODS:We analyzed MDM2-SNP309 genotypes from 58 patients with HCC and 138 cancer-free healthy controls consecutively.Genotyping of MDM2-SNP309 was conducted by restriction fragment length polymor- phism assay. RESULTS:The proportion of homozygous MDM2- SNP309 genotype(G/G)in cases and cancer-free healthy controls was similar(17.2%vs 16.7%).Multi-variate analysis showed that the risk of G/G genotypeof MDM2-SNP309 vs wild-type T/T genotype in patients with HCC was not significant(OR=1.265,95% CI=0.074-21.77)after adjustment for sex,hepatitis B or C virus infection,age,and cardiovascular disease/ diabetes.Nevertheless,there was a trend that GG genotype of MDM2-SNP309 might increase the risk in HCC patients infected with hepatitis virus(OR=2.568, 95%CI=0.054-121.69).Besides,the homozygous MDM2-SNP309 genotype did not exhibit a significantly earlier age of onset for HCC. CONCLUSION:Current data suggest that the asso- ciation between MDM2-SNP309 GG genotype and HCC is not significant,while the risk may be enhanced in patients infected by hepatitis virus in Taiwan. | Jyh-Der Leu I-Feng kin Ying-Fang Sun Su-Mei Chen Chih-Chao Liu Yi-Jang Lee | 2009 | World Journal of Gastroenterology2009，15，44： | 6 |
| 2 | Gonadotrophin-releasing hormone-Ⅰ and -Ⅱ stimulate steroidogenesis in prepubertal murine Leydig cells in vitro显示文摘瞄准:在鼠科的 Leydig 房间 steroidogenesis 上学习释放 gonadotrophin 荷尔蒙(GnRH ) 的效果和机制。方法:净化的鼠科的 Leydig 房间与 GnRH 被对待 -- 我 and-II 收缩筋,和睾丸激素生产和 steroidogenic 酶表情被决定。结果:GnRH -- 我 and-II 收缩筋显著地刺激了鼠科的 Leydig 房间 steroidogenesis 60%80% 在剂量 -- 并且时间依赖者举止(P <
0.05 ) 。steroidogenic 的 mRNA 表情尖锐规章(星) 蛋白质, P450scc, 3 β-hydroxysteroid 脱氢酶(HSD ) ,然而并非 17 α-hydroxylase 或 17 β-HSD,被两 GnRH 收缩筋显著地随 1.5-to 3 褶层增加刺激(P <
0.05 ) 。然而, 3 仅仅 β-HSD 蛋白质表示被两 GnRH 收缩筋导致,随 1.6-to 2 褶层增加(P <
0.05 ) 。结论:GnRH 直接由激活 3 β-HSD 酶表示刺激了鼠科的 Leydig 房间 steroidogenesis。 | Yung-Ming Lin Ming-Yie Liu Song-Ling Poon Sew-Fen Leu Bu-Miin Huang | 2008 | Asian Journal of Andrology2008，10，6： | 6 |
| 3 | Sitagliptin protects rat kidneys from acute ischemia- reperfusion injury via upregulation of GLP-1 and GLP-1 receptors显示文摘Aim: Sitagliptin, an oral glucose-lowering agent, has been found to produce cardiovascular protection possibly via anti-inflammatory and anti-atherosclerotic activities of glucagon-like peptide-1 receptor (GLP-1). The aim of this study was to investigate whether sitagliptin protected the kidney function from acute ischemia-reperfusion (IR) injury in rats. Methods: Adult male SD rats were categorized into 4 groups: sham control, IR injury, IR+sitagliptin (300 mg/kg) and IR+sitagliptin (600 mg/kg). Acute renal IR injury of both kidneys was induced by clamping the renal pedicles for I h. The drug was orally administered at 1, 24 and 48 h after acute IR. Blood samples and 24-h urine were collected before and at 72 h after acute IR. Then the rats were sacrificed, and the kidneys were harvested for biochemical and immunohistochemical studies. | Meng-wei CHANG Chih-hung CHEN Yi-ching CHEN Yin-chun WU Yen-yi ZHEN Steve LEU Tzu-hsien TSAI Sheung-fat KO Pei-hsun SUNG Chih-chau YANG Hsin-ju CHIANG Hsueh-wen CHANG Yen-ta CHEN Hon-kan YIP | 2015 | Acta Pharmacologica Sinica2015，36，1： | 6 |
| 4 | Apoptotic Effect of Cisplatin and Cordycepin on OC3 Human Oral Cancer Cells显示文摘Objective:To evaluate apoptotic effects of cisplatin and cordycepin as single agent or in combination with cytotoxicity in oral cancer cells.Methods:The influences of cisplatin(2.5μg/mL)and/or cordycepin treatment(10 or 100μmol/L)to human OC3 oral cancer cell line were investigated by morphological observation for cell death appearance,methylthiazoletetrazolium(MTT)assay for cell viability,flow cytometry assay for cell apoptosis,and Western blotting for apoptotic protein expressions.Results:Data demonstrated that co-administration of cisplatin(2.5μg/mL)and cordycepin(10 or 100μmol/L)resulted in the enhancement of OC3 cell apoptosis compared to cisplatin or cordycepin alone treatment(24 h),respectively(P<0.05).In flow cytometry assay,percentage of cells arrested at subG1 phase with co-treatment of cordycepin and cisplatin(30%)was significantly higher than cisplatin(5%)or cordycepin(12%)alone group(P<0.05),confirming a synergistically apoptotic effect of cordycepin and cisplatin.In cellular mechanism study,co-treatment of cordycepin and cisplatin induced more stress-activated protein kinase/Jun terminal kinase(JNK),the expressions of caspase-7,and the cleavage of poly ADP-ribose polymerase(PARP)as compared to cisplatin or cordycepin alone treatment(P<0.05).Conclusion:Cisplatin and cordycepin possess synergistically apoptotic effect through the activation of JNK/caspase-7/PARP pathway in human OC3 oral cancer cell line. | CHEN Ying-hui HAO Lyh-Jyh HUNG Chih-peng CHEN Jung-wei LEU Sew-fen HUANG Bu-miin | 2014 | Chinese Journal of Integrative Medicine2014，20，8： | 3 |
| 5 | Cirrhotic patients at increased risk of peptic ulcer bleeding: a nationwide population‐based cohort study显示文摘 | J.‐C. Luo H.‐B. Leu M.‐C. Hou C.‐C. Huang H.‐C. Lin F.‐Y. Lee F.‐Y. Chang W.‐L. Chan S.‐J. Lin J.‐W. Chen | 2012 | Aliment Pharmacol Ther2012，，6： | 3 |
| 6 | 3D bioprinting of stem cells and polymer/bioactive glass composite scaffolds for bone tissue engineering显示文摘A major limitation of using synthetic scaffolds in tissue engineering applications is insufficient angiogenesis in scaffold interior.Bioactive borate glasses have been shown to promote angiogenesis.There is a need to investigate the biofabrication of polymer composites by incorporating borate glass to increase the angiogenic capacity of the fabricated scaffolds.In this study,we investigated the bioprinting of human adipose stem cells(ASCs)with a polycaprolactone(PCL)/bioactive borate glass composite.Borate glass at the concentration of 10 to 50 weight%,was added to a mixture of PCL and organic solvent to make an extrudable paste.ASCs suspended in Matrigel were ejected as droplets using a second syringe.Scaffolds measuring 10×10×1 mm^3 in overall dimensions with pore sizes ranging from 100–300μm were fabricated.Degradation of the scaffolds in cell culture medium showed a controlled release of bioactive glass for up to two weeks.The viability of ASCs printed on the scaffold was investigated during the same time period.This 3D bioprinting method shows a high potential to create a bioactive,highly angiogenic three-dimensional environment required for complex and dynamic interactions that govern the cell’s behavior in vivo. | Caroline Murphy Krishna Kolan Wenbin Li Julie Semon Delbert Day Ming Leu | 2017 | International Journal of Bioprinting2017，3，1： | 3 |
| 7 | Synthesis,characterization and catalytic performance of Mo based metal-organic frameworks in the epoxidation of propylene by cumene hydroperoxide显示文摘Two types of Mo containing metal-organic frameworks,denoted as Mo@COMOC-4 and PMA@MIL-101(Cr),were synthesized respectively by a post-synthetic modification and a ship-in-bottle approach.The catalytic performance of both compounds in the epoxidation of propylene using cumene hydroperoxide(CHP) as oxidant was compared with MoO_3@SiO_2.A higher conversion(46.2%) and efficiency(87.4%) of CHP was observed for Mo@COMOC-4,whereas the heteropoly acids supported MIL-101 resulted in the decomposition of CHP due to its strong acidic character.Regenerability tests demonstrated that Mo@COMOC-4 could be reused for multiple runs without significant loss in both activity and stability. | Xiao-Lei Ni Jing Liu Ying-Ya Liu Karen Leus Hannes Depauw An-Jie Wang Pascal Van Der Voort Jian Zhang Yong-Kang Hu | 2017 | Chinese Chemical Letters2017，28，5： | 2 |
| 8 | In the name of the rose:a roadmap for rose research in the genome era显示文摘The recent completion of the rose genome sequence is not the end of a process,but rather a starting point that opens up a whole set of new and exciting activities.Next to a high-quality genome sequence other genomic tools have also become available for rose,including transcriptomics data,a high-density single-nucleotide polymorphism array and software to perform linkage and quantitative trait locus mapping in polyploids.Rose cultivars are highly heterogeneous and diverse.This vast diversity in cultivated roses can be explained through the genetic potential of the genus,introgressions from wild species into commercial tetraploid germplasm and the inimitable efforts of historical breeders.We can now investigate how this diversity can best be exploited and refined in future breeding work,given the rich molecular toolbox now available to the rose breeding community.This paper presents possible lines of research now that rose has entered the genomics era,and attempts to partially answer the question that arises after the completion of any draft genome sequence:‘Now that we have“the”genome,what’s next?’.Having access to a genome sequence will allow both(fundamental)scientific and(applied)breeding-orientated questions to be addressed.We outline possible approaches for a number of these questions. | Marinus J.M.Smulders Paul Arens Peter M.Bourke Thomas Debener Marcus Linde Jan De Riek Leen Leus Tom Ruttink Sylvie Baudino Laurence Hibrant Saint-Oyant Jeremy Clotault Fabrice Foucher | 2019 | Horticulture Research2019，6，1： | 2 |
| 9 | Sweep-envelope differential equation algorithm and its application to NC machining verification 显示文摘 | Blackmore D Leu M Wang L | 1997 | Computer Aided Design1997，29，9： | 2 |
| 10 | Error analysis for four-axis side milling of undevelopable ruled surfaces 显示文摘 | Yang Bo Leu M C Zhou Ji | 1998 | Control Engineering Practice1998，6，4： | 2 |
| 11 | Superplastic elongation characteristic of fine grained magnesium alloy ZK60显示文摘This paper employs simple rolling process plus annealing to refine the grain size of magnesium alloy ZK60.This goal is effectively achieved,obtaining grains as fine as ~3.7 μm.Such a specimen shows an elongation of 642%,and its ultimate fracture surface exhibits intergranular separation and significant grain growth.Additionally,the effects of the specimen's geometry and tensile test axis with respect to the rolling direction on superplastic elongation is studied,which has not been done before. | LEE Shyong CHIANG Chihte LEU Jyhshyan CHEN Yunghung | 2010 | Rare Metals2010，29，4： | 2 |
| 12 | On the merits and pitfalls of critical chain scheduling显示文摘 | Herroelen Roel Leus | 2001 | Journal of Operations Management2001，19，： | 1 |
| 13 | Heterogeneous chemistry of HONO on liquid sulfuric acid : A new mechanism of chlorine activation on stratospheric sulfate aerosols 显示文摘 | Zhang R Y Leu M-T Keyser L F | 1996 | The Journal of Physical Chemistry1996，10，： | 1 |
| 14 | Hyperbranched poly (ether ketone) with carboxylic acid terminal groups synthesis, characterization, derivatization显示文摘 | Shu C F Leu C M | 1999 | Macromolecules1999，32，1： | 1 |
| 15 | Interleukin-6-induced STAT3 and AP-1 amplify hepatocyte nuclear factor 1-mediated transactivation of hepatic genes, an adaptive response liver injury显示文摘 | Crissey MA Leu JP | 2001 | Mol Cell Biol2001，21，2： | 1 |
| 16 | 显示文摘 | Leu M S Chin T S | 1997 | J Appl Phys1997，81，： | 1 |
| 17 | Electroforming process and application to micro/macro manufacturing 显示文摘 | McGeough J A Leu M C Rajurkar K P | 2001 | Annals of the CIRP2001，50，2： | 1 |
| 18 | Effect of rosuvastatin on plasma levels of asymmetric dimethylarginine in patients with hypercholesterolemia显示文摘 | Lu TM Ding YA Leu HB | 2004 | Am J Cardiol2004，94，2： | 1 |
| 19 | activates Bak and causes disruption of a Bak-Mcll complex 显示文摘 | Leu J I Dumont P Mitochondrial p53 Hafey M | 2004 | Nat Cell Biol2004，6，5： | 1 |
| 20 | Loss of estrogen receptor signaling triggers epigenetic silencing of downstream targets in breast cancer 显示文摘 | Leu YW Yan PS Fan M | 2004 | Cancer Res2004，64，22： | 1 |
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