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| 1 | Calcium signaling and T-type calcium channels in cancer cell cycling显示文摘Regulation of intracellular calcium is an important signaling mechanism for cell proliferation in both normal and cancerous cells. In normal epithelial cells, free calcium concentration is essential for cells to enter and accomplish the S phase and the M phase of the cell cycle. In contrast, cancerous cells can pass these phases of the cell cycle with much lower cytoplasmic free calcium concentrations, indicating an alternative mechanism has developed for fulfilling the intracellular calcium requirement for an increased rate of DNA synthesis and mitosis of fast replicating cancerous cells. The detailed mechanism underlying the altered calcium loading pathway remains unclear; however, there is a growing body of evidence that suggests the T-type Ca2+ channel is abnormally expressed in cancerous cells and that blockade of these channels may reduce cell proliferation in addition to inducing apoptosis. Recent studies also show that the expression of T-type Ca2+ channels in breast cancer cells is proliferation state dependent, i.e. the channels are expressed at higher levels during the fast-replication period, and once the cells are in a non-proliferation state, expression of this channel isminimal. Therefore, selectively blocking calcium entry into cancerous cells may be a valuable approach for preventing tumor growth. Since T-type Ca2+ channels are not expressed in epithelial cells, selective T-type Ca2+ channel blockers may be useful in the treatment of certain types of cancers. | James T Taylor Xiang-Bin Zeng Jonathan E Pottle Kevin Lee Alun R Wang Stephenie G Yi lennifer A S Scruggs Suresh S Sikka Ming Li | 2008 | World Journal of Gastroenterology2008，14，32： | 12 |
| 2 | 实施新生儿复苏项目减少中国新生儿出生窒息死亡显示文摘中国作为增速领先的世界经济力量不断向前发展,妇幼健康状况取得了显著的成效。5岁以下儿童死亡率的降低提前实现了千年发展目标,但是新生儿死亡所占比例仍较高。在相对较高的新生儿死亡率背后,存在农村地区的地理环境不利于提供医疗服务、医疗机构的医疗条件存在差异、基层医务人员技术能力较低等因素。为了解决新生儿死亡问题,尤其是减少新生儿出生窒息的发生率和死亡率,在过去十年间,主要的相关各方已经着手在中国实施新生儿复苏项目。这些努力在临床保健方面已经显现成效,而且在未来会进一步发挥作用,从而改善儿童的长期健康结局。 | 薛艳萍 Xu T Niermeyer S Lee H | 2017 | 中国妇幼卫生杂志2017，8，3： | 5 |
| 3 | Clinical outcomes following salvage Gamma Knife radiosurgery for recurrent glioblastoma显示文摘Glioblastoma multiforme(GBM) is the most common malignant primary brain tumor with a survival prognosis of 14-16 mo for the highest functioning patients. Despite aggressive, multimodal upfront therapies, the majority of GBMs will recur in approximately six months. Salvage therapy options for recurrent GBM(r GBM) are an area of intense research. This study compares recent survival and quality of life outcomes following Gamma Knife radiosurgery(GKRS) salvage therapy. Following a Pub Med search for studies usingGKRS as salvage therapy for malignant gliomas, nine articles from 2005 to July 2013 were identified which evaluated rG BM treatment. In this review, we compare overall survival following diagnosis, overall survival following salvage treatment, progression-free survival, time to recurrence, local tumor control, and adverse radiation effects. This report discusses results for rG BM patient populations alone, not for mixed populations with other tumor histology grades. All nine studies reported median overall survival rates(from diagnosis, range:16.7-33.2 mo; from salvage, range:9-17.9 mo). Three studies identified median progression-free survival(range:4.6-14.9 mo). Two showed median time to recurrence of GBM. Two discussed local tumor control. Six studies reported adverse radiation effects(range:0%-46% of patients). The greatest survival advantages were seen in patients who received GKRS salvage along with other treatments, like resection or bevacizumab, suggesting that appropriately tailored multimodal therapy should be considered with each rG BM patient. However, there needs to be a randomized clinical trial to test GKRS for rG BM before the possibility of selection bias can be dismissed. | Erik W Larson Halloran E Peterson Wayne T Lamoreaux Alexander R MacKay Robert K Fairbanks Jason A Call Jonathan D Carlson Benjamin C Ling John J Demakas Barton S Cooke Christopher M Lee | 2014 | World Journal of Clinical Oncology2014，5，2： | 5 |
| 4 | Tumor Antigen Specific Activation of Primary Human T-Cells Expressing a Virally Encoded Chimeric T-Cell Receptor Specific for p185HER2显示文摘We have developed and tested chimeric T-cell receptors (TCR) specific for p185HER2. In these experiments, retroviral vectors expressing the N29γ or N29ζ receptors were constructed in pRET6. Amphotropic viral producer cells were established in the GALV-based PG13 packaging cell line. Ficoll purified human peripheral blood lymphocytes (PBL) were virally transduced using an optimized protocol incorporating activation with immobilized anti-CD3/anti-CD28 monoclonal anti- bodies, followed by viral infection in the presence of fibronectin fragment CH296. Transduced cells were co-cultured with human tumor cell lines that overexpress (SK-OV-3) or underexpress (MCF7) p185HER2 to assay for antigen specific im- mune responses. Both CM+ and CD8+ T-cells transduced with the N29γ or N29ζ chTCR demonstrated HER2-specific anti- gen responses, as determined by release of Th1 like cytokines, and cellular cytotoxicity assays. Our results support the fea- sibility of adoptive immunotherapy with genetically modified T-cells expressing a chTCR specific for p185HER2. | 杨建民 Michael S FRIEDMAN Christopher M REYNOLDS Marianne T HUBEN Lee WILKE Jennifer FULLER 李桥 Zelig ESHHAR James J MULE Kevin T MCDONAGH | 2004 | Journal of Microbiology and Immunology2004，2，4： | 5 |
| 5 | 血根碱对肉鸡生长性能、相对器官重量、盲肠菌群、血清胆固醇水平以及肉品质的影响显示文摘研究旨在探索日粮添加血根碱(SGV)对肉鸡生长性能、相对器官重量、盲肠菌群、血清胆固醇水平和腿肌丙二醛含量的影响。选用840日龄雄性肉鸡(罗斯品种)饲养于28个稻草垫上,随机分为4个处理:玉米-豆粕型基础对照日粮、基础日粮中添加卑霉素10 ppm作为生长促进剂(AGP)、基础日粮中添加SGV 20 ppm(SGV20)和50 ppm(SGV50)。与饲喂基础日粮的肉鸡相比,基础日粮中添加AGP组、SGV20组和SGV50组的肉鸡最终体重(BW)、日增重、饲料转化率(FCR)显著改善(P<0.05)。与对照组相比,SGV20喂养组的肉鸡相对空肠重量显著降低(P<0.05),所有添加SGV组肉鸡相对空肠或回肠长度显著升高(P<0.05)。SGV20组较对照组肉鸡肠道菌群有所改变,尤其是盲肠乳酸菌数增加,但AGP组无改变。SGV20组或SGV50组肉鸡的总胆固醇水平较对照组显著降低(P<0.05),控制饮食物显著降低(P<0.05)。添加SGV后,作为脂质过氧化反应指示剂的腿肌丙二醛含量显著降低(P<0.05)。研究表明,在肉鸡日粮中补充SGV 20或50 ppm可以提高肉鸡生长性能,改变多种生物和生理参数,如相对器官重量、血清胆固醇水平、肠道菌群和肉品质。 | Lee K W Kim J S Oh S T Kang C W An B K | 2015 | 饲料博览2015，0，3： | 2 |
| 6 | A potential based panel method for the analysis of a two-dimensional super or partially cavitating hydrofoil 显示文摘 | LEE C S KIM Y G LEE J T | 1992 | J of Ship Res1992，36，2： | 2 |
| 7 | 卒中介入治疗培训指南:国际多学会共识文件显示文摘1背景
缺血性卒中是全球人口死亡和残疾的首要原因。很多急性大血管闭塞(emergent large vesselocclusion,ELVO)患者都会遗留长期残疾。事实上,这些颅内大动脉闭塞经常会导致大面积脑损伤,进而造成患者死亡或严重致残。 | Lavine SD Cockroft K Hoh B Bambakidis N Khalessi AA Woo H Riina H Siddiqui A Hirsch JA Chong W Rice H Wenderoth J Mitchell P Coulthard A Signh TJ Phatorous C Khangure M Klurfan P ter Brugge K Iancu D Gunnarsson T Pongpech S Rodesch G Soderman M Taylor A Krings T Orbach D Picard L Suh DC Zheng HQ Jansen O Muto M Szikora I Pierot L Brouwer P Gralla J Renowden S Andersson T Fiehler J Turjman F White P Januel AC Spelle L Kulcsar Z Chapot R Biondi A Dima S Taschner C Szajner M Krajina A Sakai N Matsumaru Y Yoshknura S Ezura M Fujinaka T Iihara K Ishii A Higashi T Hirohata M Hyodo A Ito Y Kawanishi M Kiyosue H Kobayashi E Kobayashi S Kuwayama N Matsumoto Y Miyachi S Murayama Y Nagata I Nakahara I Nemoto S Niimi Y Oishi H Satomi J Satow T Sugiu K Tanaka M Terada T Yamagami H Diaz O Lylyk P Jayaraman MV Patsalides A Gandhi CD Lee SK Abruzzo T Albani B Ansari SA Arthur AS Baxter BW Bulsara KR Chen M Almandoz JE Fraser JF Heck DV Hetts SW Hussain MS Klucznik RP Leslie-Mawzi TM Mack WJ McTaggart RA Meyers PM Mocco J Prestigiacomo CA Pride GL Rasmussen PA Starke RM Sunenshine PJ Tarr RW Frei DF Pabo M Nogueira RG Zaidat OO Jovin T Linfante I Yavagal D Liebeskind D Novakovic R Pongpech S 许岩 孙瑞 郭芮兵 | 2017 | 国际脑血管病杂志2017，25，5： | 2 |
| 8 | Nucleation in foam extrusion显示文摘 | Lee S T | 2001 | Journal of Cellular Plastics2001，37，3： | 2 |
| 9 | Image representation using 2D gabor wavelets 显示文摘 | Lee T S | 1996 | IEEE Transactions on Pattern Analysis and Machine Intelligence1996，18，10： | 2 |
| 10 | Shear effects on thermoplastic foam nucleation显示文摘 | Lee S T | 1993 | Polymer Engineering and Science1993，33，7： | 2 |
| 11 | Telomerase activity in pleural effusions diagnostic significance显示文摘 | CHENG T Y LEE M H LAN R S | 1998 | J Clin Oncol1998，16，4： | 2 |
| 12 | Tracking design of uncertain nonlinear SISO systems:adaptive fuzzy approach显示文摘 | CHEN B S LEE T S CHANG Y C | 1994 | IEEE Transactions on Fuzzy Systems1994，4，2： | 2 |
| 13 | The potential role of resistin in atherogenesis 显示文摘 | BURNETT M S LEE C W KINNAIRD T D | 2005 | Atherosclerosis2005，182，： | 1 |
| 14 | Screw Dislocation Dipole Near an Internal Crack显示文摘 | Lin K M Hu C T Lee S B | 1993 | Engineering Fracture Mechanics1993，45，： | 1 |
| 15 | Drop on Demand Solder Droplet Jetting System for Fabricating Microstructure显示文摘 | LEE T M KANG T G YANG J S | 2008 | Electronics Packaging Manufacturing2008，31，3： | 1 |
| 16 | Effects of thermal and chemical surface-flame interaction on flame quenching显示文摘 | KIM K T LEE D H KWON S | 2006 | Combust and Flame2006，146，： | 1 |
| 17 | 显示文摘 | Lee T H Oh C S Lee C G | 2004 | Scripta Materialia2004，5，50： | 1 |
| 18 | Adsorption and diffusion of aromatics in AIPO4-5显示文摘 | CHIANG A S T LEE C K CHANG Z H | 1991 | Zeolites1991，11，4： | 1 |
| 19 | Granulocyte colony-stimulating factor induces sensorimotor recovery in intracerebral hemorrhage显示文摘 | Park H K Chu K Lee S T | 2005 | Brain Res2005，1041，2： | 1 |
| 20 | Characteristics of nitrile--butadiene rubber layered silicate nanocomposites with silane coupling agent 显示文摘 | Kim J T Lee D Y Oh T S | 2003 | J Appl Polym Sci2003，89，10： | 1 |
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