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| 1 | Do statins reduce hepatitis C RNA titers during routine clinical use?显示文摘AIM: To compare hepatitis C virus (HCV) titers in patients with chronic hepatitis C with and without exposure to 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins).METHODS: Medical records were reviewed for 6463 patients with documented HCV infection at a single center between March 2004 and September 2006. Patients with confi rmed viremia and meeting inclusion criteria were assigned to one of three groups: Group A (n = 50), dyslipidemic patients with statin usage during HCV RNA polymerase chain reaction (PCR) determination; Group B (n = 49), dyslipidemic patients with prior or future statin usage but not at the time of HCV RNA PCR determination; and Group C (n = 102), patients without statin usage during the study period. The primary analysis explored the effect of statin therapy on HCV viremia. Secondary analyses assessed class effect, dose response, and effect of other lipid-lowering therapies on HCV viral titers.RESULTS: Median HCV RNA titers did not signif icantly differ among the three groups (Group A: 4 550 000 IU/mL, Group B: 2 850 000 IU/mL, Group C: 3 055 000 IU/mL).For those subjects with longitudinal assessment of HCV viremia prior to and while on statins, there were no signif icant differences between pre- and post-HCV viral titers. Additionally, no differences in HCV titers were observed at any dose level of the most prescribed statin, simvastatin. However, hypertriglyceridemia independently correlated with HCV titers, and niacin exposure was associated with signif icantly lower viral titers (P < 0.05).CONCLUSION: There was no apparent effect of statins on HCV viral replication in this analysis. Further investigation is warranted to explore the possible antiviral properties of triglyceride-lowering agents and their potential role as adjuncts to standard HCV therapy. | Kimberly A Forde Connie Law Rose O’Flynn David E Kaplan | 2009 | World Journal of Gastroenterology2009，15，40： | 2 |
| 2 | Control by homoeo-logous group 1 chromosomes of the high-molecular-weight subunits of glutenin,a major protein of wheat endosperm显示文摘 | Payne P I Law C N Mudd E E | 1980 | Theor Appl Genet1980，58，： | 2 |
| 3 | Photosynthetic efficiency optimization studies with the macroalga Gracilaria tikvihae: implications for CO2 emission control from power plants显示文摘 | Berning J L | 1991 | Bioresource Technology1991，37，： | 1 |
| 4 | Advances in electrostatic crop spraying of conductive pesticides 显示文摘 | Law S E Cooper S C Oetting R D | 1992 | Transactions of ASAE1992，11，4： | 1 |
| 5 | Overvoltage protection of shunt-capacitor banks using MOV arresters显示文摘 | Granaghan M F Reid W E Law S W | 1984 | IEEE Trans on Power Apparatus and System1984，103，8： | 1 |
| 6 | Expressionof LM02 is associated with t(14;18)/IGH-BCL2 fusion but notBCL6 translocations in diffuse large B-cell lymphoma 显示文摘 | DURNICK D K LAW M E MAURER M J | 2010 | Am J Clin Pathol2010，134，2： | 1 |
| 7 | Introduction to unconventional petroleum system显示文摘 | Law B E Curtis J B | 2002 | AAPG Bulletin2002，86，： | 1 |
| 8 | Conceptual model for origin of abnor mally pressured gas accumulation in low-permeability reservoirs显示文摘 | Law B E Dickinson W W | 1985 | AAPG Bulletin1985，69，8： | 1 |
| 9 | Reactiva-tion of peroxi-some proliferator- activated receptora is associat-ed with contractile dysfunction in hypertrophied rat heart 显示文摘 | YOUNG M E LAWS F A GOODWIN G W | 2001 | JBiol Chem2001，276，44： | 1 |
| 10 | Large-eddy simulation of starting buoyant jets显示文摘 | Wang R Q Law A W K Adams E E | 2011 | Environmental Fluid Mechanics2011，11，6： | 1 |
| 11 | Nonalcoholic fatty liver disease显示文摘 | Law K Brunt E M | | 0，，04： | 1 |
| 12 | Introduction to unconventional petroleum systems显示文摘 | Law B E | 2002 | AAPG Bulletion2002，86，11： | 1 |
| 13 | Battery performance enhancement with additions of bismuth显示文摘 | Law L T Demacro R | 1994 | Journal of Power Source1994，，2： | 1 |
| 14 | Overvoltage pro-tection of shunt-capacitor banks using MOV arresters显示文摘 | Granaghan M F Reid W E Law S W et a1 | 1984 | IEEETransactions on Power Apparatus and System1984，103，8： | 1 |
| 15 | Epigallocatechin gallate,a constituent of green tea,Represses hepatic glucose production显示文摘 | Mary E Law Wahner Wang X H | 2002 | J Biological Chem2002，277，34： | 1 |
| 16 | Clinical and neuroanatomi- cal predictors of cerebellar mutism syndrome 显示文摘 | Law N Greenberg M Bouffet E | 2012 | Neuro Oncol2012，14，10： | 1 |
| 17 | Nutrient- and light-limited growth of Thalassiosira fluviatilis in continuous culture, with im-plications for phytoplankton growth in the ocean 显示文摘 | LAWS E A BANNISTER T T | 1980 | Limnol Oceanogr1980，25，3： | 1 |
| 18 | Transforming growth factor beta-regulated gene expression in a mouse mammary gland epithelial cell line 显示文摘 | Xie L Law B K Aakre M E | 2003 | Breast Cancer Research2003，5，： | 1 |
| 19 | Carbon and water vapor exchange of an open-canopied ponderosa pine ecosystem显示文摘 | Anthoni P M Law B E Unsworth M H | 1999 | Agricultural and Forest Meteorology1999，95，3： | 1 |
| 20 | Lymphocyte activation antigen CD70 expressed by renal cell carcinoma is a potential therapeutic target /or anti-CD70 anti- body-drug conjugates 显示文摘 | Law C L Gordon K A Toki B E | 2006 | Cancer Res2006，66，： | 1 |
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