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| 1 | Adjusting CA19-9 values to predict malignancy in obstructive jaundice:Influence of bilirubin and C-reactive protein显示文摘AIM:To find a possible relationship between inflammation and CA19-9 tumor marker by analyzing data from patients with benign jaundice(BJ) and malignant jaundice(MJ).METHODS:All patients admitted for obstructive jaundice,in the period 2005-2009,were prospectively enrolled in the study,obtaining a total of 102 patients.On admission,all patients underwent complete standard blood test examinations including C-reactive protein(CRP),bilirubin,CA19-9.Patients were considered eligible for the study when they presented obstructive jaundice confirmed by instrumental examinations and increased serum bilirubin levels(total bilirubin > 2.0 mg/dL).The standard cut-off level for CA19-9 was 32 U/mL,whereas for CRP this was 1.5 mg/L.The CA19-9 level was adjusted by dividing it by the value of serum bilirubin or by the CRP value.The patients were divided into 2 groups,MJ and BJ,and after the adjustment a comparison between the 2 groups of patients was performed.Sensitivity,specificity and positive predictive values were calculated before and after the adjustment.RESULTS:Of the 102 patients,51 were affected by BJ and 51 by MJ.Pathologic CA19-9 levels were found in 71.7% of the patients.In the group of 51 BJ patients there were 29(56.9%) males and 22(43.1%) females with a median age of 66 years(range 24-96 years),whereas in the MJ group there were 24(47%) males and 27(53%) females,with a mean age of 70 years(range 30-92 years).Pathologic CA19-9 serum level was found in 82.3% of MJ.CRP levels were pathologic in 66.6% of the patients with BJ and in 49% with MJ.Bilirubin and CA19-9 average levels were significantly higher in MJ compared with BJ(P = 0.000 and P = 0.02),while the CRP level was significantly higher in BJ(P = 0.000).Considering a CA19-9 cut-off level of 32 U/mL,82.3% in the MJ group and 54.9% in the BJ group were positive for CA19-9(P = 0.002).A CA19-9 cut-off of 100 U/mL increases the difference between the two groups:35.3% in BJ and 68.6% in MJ(P = 0.0007).Adjusting the CA19-9 value by dividing it by serum bilirubin level meant that 21.5% in the BJ and 49% in the MJ group remained with a positive CA19-9 value(P = 0.003),while adjusting the CA19-9 value by dividing it by serum CRP value meant that 31.4% in the BJ group and 76.5% in the MJ group still had a positive CA19-9 value(P = 0.000004).Sensitivity,specificity,positive predictive values of CA19-9 > 32 U/mL were 82.3%,45% and 59.1%;when the cutoff was CA19-9 > 100 U/mL they were,respectively,68.6%,64.7% and 66%.When the CA19-9 value was adjusted by dividing it by the bilirubin or CRP values,these became 49%,78.4%,69.4% and 76.5%,68.6%,70.9%,respectively.CONCLUSION:The present study proposes CRP as a new and useful correction factor to improve the diag-nostic value of the CA19-9 tumor marker in patients with cholestatic jaundice. | Gaetano La Greca Maria Sofia Rosario Lombardo Saverio Latteri Agostino Ricotta Stefano Puleo Domenico Russello | 2012 | World Journal of Gastroenterology2012，18，31： | 20 |
| 2 | Laparo-endoscopic “Rendezvous” to treat cholecysto-choledocolithiasis: Effective,safe and simplifies the endoscopist’s work显示文摘AIM: To investigate our clinical experience with combined laparo-endoscopic Rendezvous (RV) for the treatment of patients affected by gallstones and common bile duct (CBD) stones and especially to study the never evaluated opinion of the endoscopist concerning the difficulty of the intraoperative endoscopic procedure during the RV in comparison with standard endoscopic retrograde cholangio-pancreatography (ERCP). METHODS: Eighty consecutive patients affected by cholecystolithiasis and diagnosed or suspected CBD stones were treated with a standardized 'tailored' RV. The relevant technical features, the feasibility, the effectiveness in stone clearance, the safety but also the simple evaluation of difficulty and agreement of the endoscopist were analyzed with a questionnaire. RESULTS: The feasibility was 97.5% and the effectiveness 100% concerning CBD clearance and solution of coexisting problems at the papilla. Minor morbidity was 3.3%, the operating time was prolonged by a mean of 14 min, the mean hospital stay was 3.8 d and only one stone’s recurrence occurred. The endoscopist evaluated the procedure to be simpler than standard ERCP-ES in 81.2% of the cases.CONCLUSION: Simultaneous RV carries higheffectiveness and safety at least comparable to those reported for other options. The endoscopist is very often satisfied with this approach because of the minimization of some steps of the endoscopic procedure and avoidance of relevant iatrogenic risk factors. If the mandatory collaboration between surgeons and endoscopists is guaranteed, this approach can often be preferable for the patient, the surgeon, the endoscopist and the hospital. | Gaetano La Greca Francesco Barbagallo Michele Di Blasi Andrea Chisari Rosario Lombardo Rosario Bonaccorso Saverio Latteri Andrea Di Stefano Domenico Russello | 2008 | World Journal of Gastroenterology2008，14，18： | 15 |
| 3 | Gastrointestinal stromal tumour of the rectum: Report of a case and review of literature显示文摘Gastrointestinal stromal tumour (GIST) is a rare tumour of the gastrointestinal tract which does not generally originate in the rectum. The authors describe a case of a 70-year-old man who underwent an anterior resection of the rectum for a low-risk GIST. The patient was not given adjuvant chemotherapy with imatinib and is still disease-free 30 mo after surgery. The authors conclude that although rectal GIST is extremely uncommon, it should be included in differential diagnosis when a tumour in the rectum is detected. Biopsy of the tumour is essential, since this makes it possible to reach a sure preoperative diagnosis based on the immunohistological features of the CD117 and CD34. Although complete surgical resection with negative tumour margins is the principal curative procedure for primary and non-metastatic tumours, further studies are still needed for the determination of the most effective treatment strategy for patients with rectal GIST. | Nello Grassi Calogero Cipolla Adriana Torcivia Stefano Mandalà Giuseppa Graceffa Alessandro Bottino Federica Latteri | 2008 | World Journal of Gastroenterology2008，14，8： | 6 |
| 4 | Analysis of epidermal growth factor receptor expression as a predictive factor for response to gefitinib (Iressa, ZD1839) in non-small-cell lung cancer显示文摘 | Parra HS Cavina R Latteri F | 2004 | Br J Cancer2004，91，2： | 1 |
| 5 | Seeding after radiofrequeney ablation of hepatocellular carcinoma in patients with cirrhosis: a prospective study 显示文摘 | Latteri F Sandonato L Di Marco V | 2008 | Dig Liver Dis2008，40，8： | 1 |
| 6 | Preoperative treatment with interleukin-2 in colorectal carcinoma显示文摘 | Vecchio R Latteri F Di Martino M | 1998 | G Chir1998，19，4： | 1 |
| 7 | Activity of a specific inhibitor, gefitinib (Iressa, ZD1839), of epicermal growth factor receptor in refractory non-small-cell lung cancer显示文摘 | Santoro A Cavina R Latteri F | 2004 | Ann Oncol2004，15，1： | 1 |
| 8 | Multimodal approaches to the treatment of hepatocellular carcinoma 显示文摘 | Cabibbo G Latteri F Antonucci M | 2009 | Nat Clin Pract Gastroenterol Hepatol2009，6，3： | 1 |
| 9 | Analysis of epidermal growth factor receptor expression as a predictive factor for response to gefitinib in non-small-cell lung Cancer显示文摘 | Parra HS Cavina R Latteri F | 2004 | Br J Cancer2004，91，2： | 1 |
| 10 | Analysis of epidermal growth factor receptor expression as a predictive factor for response to gefitinib('Iressa', ZD1839)in non-small-cell lung cancer 显示文摘 | Parra HS Cavina R Latteri F | 2004 | BrJ Cancer2004，91，2： | 1 |
| 11 | Activity of a specific inhibitor,gefitinib (Iressa,ZD1839),of epidermal growth factor receptor in refractory non-small-cell lung cancer显示文摘 | Santoro A Cavina R Latteri F | 2004 | Arm Oncol2004，15，1： | 1 |
| 12 | Analysis of epidermal growth factor receptor expression as a predictive factor for response to gefitinib('Iressa',ZD 1839)in non-small cell lung cancer显示文摘 | Parra HS Cavina R Latteri F | 2004 | Br J Cancer2004，91，2： | 1 |
| 13 | Analysis of epidermal growth factor receptor expression as a predictive factor for response to gefitinib ('Iressa',ZD1839) in non-small-cell lung cancer显示文摘 | Parra HS Cavina R Latteri F | 2004 | Br J Cancer2004，91，2： | 1 |
| 14 | Intrathoracic goiter:experience with 61 surgically treated cases显示文摘 | Latteri S Saita S Potenza E | 2000 | Chir Ita2000，52，2： | 1 |
| 15 | Multimodal ap- proaches to the treatment of hepatocellular carcinoma显示文摘 | Cabibbo G Latteri F Antonucci M | 2009 | Nat Clin Praet Gastroenterol Hepatol2009，6，3： | 1 |
| 16 | Analysis of epidermal growth factor receptor expression as a predictive factor for response to gefitinib ('Iressa', ZD1839) in non-small-cell lung cancer 显示文摘 | Parra H S Cavina R Latteri F | 2004 | Br J Cancer2004，91，2： | 1 |
| 17 | Combined regimen of cisplatin, doxorubicin ,and alpha-2b interferon in the treatment of advanced malignant pleural mesothelioma:a Phase Ⅱ multicenter trial of the ltalian Group on Rare Tumors (GITR) and the Italian Lung Cancer Task Force( FONICAP ) 显示文摘 | Parra HS Tixi L Latteri F | 2001 | Cancer2001，92，3： | 1 |
| 18 | Successful endoscopic repair of an unusual colonic perforation following polypectomy using an endoclip device显示文摘Colonic perforation during endoscopic diagnostic or therapeutic procedures,represents an uncommon occurrence even if,together with haemorrhage,it is still the most common complication of colonoscopy,with an incidence ranging between 0.1% and 2% of all colonoscopic procedures. The ideal treatment in these cases remains elusive as the endoscopist and the surgeon have to make a choice case by case,depending on many factors such as how promptly the rupture is identified,the condition of the patient,the degree of contamination and the evidence of peritoneal irritation. Surgical interventions both laparotomic and laparoscopic,and other medical non-operative solutions are described in the literature. Only three cases have been reported in the literature in which the endoscopic apposition of endoclips was used to repair a colonic perforation during colonoscopy. Ours is the first case that the perforation itself was caused by the improper functioning of a therapeutic device. | Francesco Barbagallo Giorgio Castello Saverio Latteri Emanuele Grasso Salvatrice Gagliardo Gaetano La Greca Michele Di Blasi | 2007 | World Journal of Gastroenterology2007，13，20： | 1 |
| 19 | Analysis of epidermal growth factor receptor expression as a predictive factor for response to gefitinib ('Iressa', ZD1839) in non-small-cell lung cancer 显示文摘 | ParraHS CavinaR Latteri F | 2004 | Br J Cancer2004，91，2： | 1 |
| 20 | Three -week versus four week schedule of cisplatin and gemcitabine: results of a randomized phase Ⅱ study 显示文摘 | Soto Parra H Cavina R Latteri F | 2002 | Ann 0ncol2002，13，7： | 1 |
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