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| 1 | It is safe to use transdermal glyceryl trinitrate to lower blood pressure in patients with acute ischaemic stroke with carotid stenosis显示文摘Background There is concern that blood pressure(BP)lowering in acute stroke may compromise cerebral perfusion and worsen outcome in the presence of carotid stenosis.We assessed the effect of glyceryl trinitrate(GTN)in patients with carotid stenosis using data from the Efficacy of Nitric Oxide in Stroke(ENOS)Trial.Methods ENOS randomised 4011 patients with acute stroke and raised systolic BP(140-220 mm Hg)to transdermal GTN or no GTN within 48 hours of onset.Those on prestroke antihypertensives were also randomised to stop or continue their medication for 7 days.The primary outcome was the modified Rankin Scale(mRS)at day 90.Ipsilateral carotid stenosis was split:<30%;30-<50%;50-<70%;≥70%.Data are ORs with 95%CIs adjusted for baseline prognostic factors.results 2023(60.5%)ischaemic stroke participants had carotid imaging.As compared with<30%,≥70%ipsilateral stenosis was associated with an unfavourable shift in mRS(worse outcome)at 90 days(OR 1.88,95%CI 1.44 to 2.44,p<0.001).Those with≥70%stenosis who received GTN versus no GTN had a favourable shift in mRS(OR 0.56,95%CI 0.34 to 0.93,p=0.024).In those with 50-<70%stenosis,continuing versus stopping prestroke antihypertensives was associated with worse disability,mood,quality of life and cognition at 90 days.Clinical outcomes did not differ across bilateral stenosis groups.Conclusions Following ischaemic stroke,severe ipsilateral carotid stenosis is associated with worse functional outcome at 90 days.GTN appears safe in ipsilateral or bilateral carotid stenosis,and might improve outcome in severe ipsilateral carotid stenosis. | Jason P Appleton Lisa J Woodhouse Andrew Belcher Daniel Bereczki Eivind Berge Valeria Caso Hui Meng Chang Hanne K Christensen Ronan Collins John Gommans Ann C Laska George Ntaios Serefnur Ozturk Gillian M Sare Szabolcs Szatmari Yongjun Wang Joanna M Wardlaw Nikola Sprigg Philip M Bath for the ENOS investigators | 2019 | Stroke & Vascular Neurology2019，4，1： | 6 |
| 2 | Long-term antidepressant treatment with Moclobemide for aphasia in acute stroke patients:a randomised,double-blind,placebo-controlled study显示文摘 | Laska AC von Arbin M Kahan T el al | 2005 | Cerebrovasc Dis2005，19，2： | 1 |
| 3 | Polyaniline as a suport for urease immobilization显示文摘 | Wlodarczyk J Zaborska W | 1999 | J Molecular Catalysis B:Enzymatic1999，6，： | 1 |
| 4 | Analog-to-informa- tion conversion via random demodulation显示文摘 | Kirolos S Laska J Wakin M | 2006 | Dallas ICAS Workshop on Design Applications Integration and Software2006，2006，2： | 1 |
| 5 | Evaluation of a Treponema pallidum Western immunoblot assay as a confirmatory test for syphilis显示文摘 | Byrne R E Laska S Bell M | 1992 | J Clin Microbiol1992，30，： | 1 |
| 6 | Polyaniline as a support for urease immobilization 显示文摘 | Laska J Wlodarczyk J Zaborska W | 1999 | Journal of Molec- ular Catalysis B : Enzymatic1999，6，6： | 1 |
| 7 | Relationships between en ergy balance knowledge and the home environment 显示文摘 | Slater M E Sirard J R Laska M N | 2011 | J Am Diet Assoc2011，111，4： | 1 |
| 8 | Nutrition label use partially mediates the re- lationship between attitude toward healthy eating and overall dietary quality among college students 显示文摘 | Graham DJ Laska MN | 2012 | Journal of the Academy of Nutri- tion and Dietetics2012，112，3： | 1 |
| 9 | A modified method for the isolation and determination of brain hista- mine using Bio-Rex 70 显示文摘 | Lewis S J Fennessy MR Laska FJ | 1980 | Inflamm Res1980，10，3： | 1 |
| 10 | Aphasia in acute strokeand relation to outcome显示文摘 | Laska AC Hellblom A Murray V | 2001 | J Intern Med2001，249，5： | 1 |
| 11 | Beyond Nyquist:efficient sampling of sparse bandlimited signals显示文摘 | Tropp J A Laska J N Duarte M F Romberg J K Baraniuk R G | 2010 | IEEE Transaction on Information Theory2010，58，1： | 1 |
| 12 | Expression of the RA! gene is conducive to apoptosis: studies of induction and interference显示文摘 | Laska MJ Strandbygard D Kjeldgaard A | 2007 | Exp Cell Res2007，313，12： | 1 |
| 13 | p53 and PPP1R13L (alias iASPP or RAI)form a feedbaek loop to regulate genotoxie stress responses 显示文摘 | Laska MJ Vogel UB Jensen UB | 2010 | Bioehim Biophys Aeta2010，1800，12： | 1 |
| 14 | Food preferences and nutrient composition in captive white-handed gibbons,Hylobates lar显示文摘 | Jildmalm R Amundin M Laska M | 2008 | International Journal of Primatology2008，29，： | 1 |
| 15 | Structure of understory shrub assemblages in adjacent secondary and old growth tropical wet forests, Costa Rica显示文摘 | Laska MS | 1997 | Biotropica1997，29，： | 1 |
| 16 | Water Soluble Polyaniline显示文摘 | Laska J Widlara J | 2003 | Synthetic Metals2003，135，4： | 1 |
| 17 | A modified method for the isolation and determination of brain histamine using Bio-Rex 70 显示文摘 | Lewis SJ Fennessy MR Laska FJ | 1980 | Agents Actions1980，10，3： | 1 |
| 18 | Beyond Nyquist: efficient sampling of sparse bandlimited signals 显示文摘 | Tropp J A Laska J N Duarte M F Romberg J K and Baraniuk R G | 2010 | IEEE Transactions on Information Theory2010，56，1： | 1 |
| 19 | Latent class analysis of life style characteristics and health risk behaviors among college youth显示文摘 | Laska M N Pasch K E Lust K | 2009 | Prev Sci2009，10，4： | 1 |
| 20 | Analysis of mercury and other heavy metals accumulated in lichen Usnea antarctica from James Ross Island, Antarctica 显示文摘 | Zverina O Laska K Cervenka R | 2014 | Environmental Monitoring and Assessment2014，186，12： | 1 |
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