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| 1 | JTE-522-induced apoptosis in human gastric adenocarinoma cell line AGS cells by caspase activation accompanying cytochrome C release,membrane translocation of Bax and loss of mitochondrial membrane potential显示文摘瞄准:在 JTE-522-induced apoptosis 调查 mitochondrial 小径的角色并且调查在细胞色素 C 版本, caspase 活动和 mitochondrial 膜潜力(Deltapsim ) 的损失之间的关系。方法:房间文化,数的房间, ELISA 试金, TUNEL,流动 cytometry,西方的污点和 fluorometric 试金被采用在 AGS 房间和相关分子的机制在房间增长和 apoptosis 上调查 JTE-522 的效果。结果:JTE-522 禁止了 AGS 细胞的生长并且导致了 apoptosis。Caspases 8 并且 9 在从 procaspase 和 caspase 活动由劈开产品的外观判定了劈开特定的 fluorogenic 底层的 apoptosis 期间被激活。阐明是否 caspases 的激活 8 和 9 为 apoptosis 正式就职被要求,我们在 apoptosis 上检验了 caspase 特定的禁止者的效果。结果证明 caspase 禁止者显著地禁止了 JTE-522 导致的 apoptosis。另外,与 Rhodamin 123 的举起的减少伴随的细胞色素 C 的 Bax 和 cytosolic 版本的膜 translocation,在 apoptosis 的一个早阶段被检测。而且, Bax translocation,细胞色素 C 版本,和 caspase 9 激活被 Z-VAD.fmk 和 Z-IETD-CHO 堵住。结论:现在的数据显示在 caspases 的激活之间的一个关键协会 8, 9,细胞色素 C 版本, Bax 的膜 translocation, Deltapsim 的损失和在 AGS 房间的 JTE-522-induced apoptosis。 | Hong-Liang Li Xiao-Hong Li Jun-Hua Lü Xian-Da Ren,Department of Pharmacology,Jinan University Pharmacy College,Guangzhou 510632,Guangdong Province,China Dan-Dan Chen,Department of Cardiology,First Affiliated Hospital,Zhongshan University,Guangzhou 510089,Guangdong Province,China Hai-Wei Zhang,Department of Pathology,Jinan University Medical College,Guangzhou 510632,Guangdong Province,China Cun-Chuan Wang,Department of laparoscopic surgery,First Affiliated Hospital,Jinan University Medical College,Guangzhou 510632,Guangdong Province,China | 2002 | World Journal of Gastroenterology2002，8，2： | 16 |
| 2 | Survival after laparoscopic surgery versus open surgery for colon cancer: long-term outcome of a randomised clinical trial 显示文摘 | Colon Cancer Laparoscopic or Open Resection Study Group Buunen M Veldkamp R | 2009 | Lancet Oncoi2009，10，1： | 1 |
| 3 | Preliminary resulm from a prospective analysis of 1194 laparoscopic - assisted colectomies显示文摘 | Bennett CL Stryker SJ Ferreira MR :The learning curve for laparoscopic colorectal surgery | 1997 | Arch Surg1997，132，： | 1 |
| 4 | Survival after laparoscopic surgery versus open surgery for colon cancer: long- term outcome of a randomised clinical trial 显示文摘 | Colon Cancer Laparoscopic or Open Resection Study Group Buunen M Veldkamp R Hop WC | 2009 | Lancet Oncol2009，10，： | 1 |
| 5 | Laparoscopic surgery versus open surgery for colon cancer: short-term outcomes of a randomised trial 显示文摘 | Veldkamp R Kuhry E Hop WC Colon Cancer Laparoscopic or Open Resection Study Group (COLOR) | 2005 | Lancet Oncol2005，6，7： | 1 |
| 6 | Minimally invasive liver resection for huge(≥10cm)tumors:an international multicenter matched cohort study with regression discontinuity analyses显示文摘Background:The application and feasibility of minimally invasive liver resection(MILR)for huge liver tumours(≥10 cm)has not been well documented.Methods:Retrospective analysis of data on 6,617 patients who had MILR for liver tumours were gathered from 21 international centers between 2009-2019.Huge tumors and large tumors were defined as tumors with a size≥10.0 cm and 3.0-9.9 cm based on histology,respectively.1:1 coarsened exact-matching(CEM)and 1:2 Mahalanobis distance-matching(MDM)was performed according to clinically-selected variables.Regression discontinuity analyses were performed as an additional line of sensitivity analysis to estimate local treatment effects at the 10-cm tumor size cutoff.Results:Of 2,890 patients with tumours≥3 cm,there were 205 huge tumors.After 1:1 CEM,174 huge tumors were matched to 174 large tumors;and after 1:2 MDM,190 huge tumours were matched to 380 large tumours.There was significantly and consistently increased intraoperative blood loss,frequency in the application of Pringle maneuver,major morbidity and postoperative stay in the huge tumour group compared to the large tumour group after both 1:1 CEM and 1:2 MDM.These findings were reinforced in RD analyses.Intraoperative blood transfusion rate and open conversion rate were significantly higher in the huge tumor group after only 1:2 MDM but not 1:1 CEM.Conclusions:MILR for huge tumours can be safely performed in expert centers It is an operation with substantial complexity and high technical requirement,with worse perioperative outcomes compared to MILR for large tumors,therefore judicious patient selection is pivotal. | Tan-To Cheung Xiaoying Wang Mikhail Efanov Rong Liu David Fuks Gi-Hong Choi Nicholas LSyn Charing CChong Iswanto Sucandy Adrian KHChiow Marco VMarino Mikel Gastaca Jae Hoon Lee TPeter Kingham Mathieu D’Hondt Sung Hoon Choi Robert PSutcliffe Ho-Seong Han Chung Ngai Tang Johann Pratschke Roberto ITroisi Brian KPGoh International Robotic and Laparoscopic Liver Resection Study Group Collaborators | 2021 | Hepatobiliary Surgery and Nutrition2021，10，5： | 1 |
| 7 | Survival after laparoscopic surgery versus open surgery for colon cancer; long-term outcome of a randomised clinical trial显示文摘 | Colon Cancer Laparoscopic or Open Resection Study Group Buunen M Veldkamp R | 2009 | Lancet Oncol2009，10，1： | 1 |
| 8 | Survival after laparoscopic Surgery versus open surgery for colon cancer, long - term outcome of a randomised clinical trial显示文摘 | Colon Cancer Laparoscopic or Open Resection Study Group guunen M Veldkamp R | 2009 | Lancet Oncol2009，10，1： | 1 |
| 9 | Survival after laparoscopic surgery versus open surgery for colon cancer:long-term outcome of a randomised clinical trial显示文摘 | Colon Cancer Laparoscopic or Open Resection Study Group Buunen M Veldkamp R | 2009 | Lancet Oncol2009，10，1： | 1 |
| 10 | Survival after Laparosopic surgery versus open surgery for colon cancer: Iamg term outcome of a randomized cLinicaL triaL显示文摘 | CoLon Cancer Laparoscopic or Open Resection Study Group Buunen M VeLdkamp R et aL | 2009 | Lancet OncoL2009，10，1： | 1 |
| 11 | Survival after laparoscapic surgery versus open surgery for colon cancer: long-term outcome of a randomised clinical trial显示文摘 | Cohm Cancer Laparoscopic or Open Reseetion Study Group Buunen M Veldkamp R | 2009 | Lancet Oncol2009，10，1： | 1 |
| 12 | Survival after laparoscopic surgery versus open surgery for colon cancer:long-term outcome of a randomised clinical trial显示文摘 | Colon Cancer Laparoscopic or Open Resection Study Group Buunen M Veldkamp R | 2009 | Lancet Oncol2009，10，1： | 1 |
| 13 | a prospective follow 2up analy2sis显示文摘 | Bisgaard T Rosenberg J Kehlet H From acute to chronic pain after laparoscopic cholecystectomy | 2005 | Scand J Gaslzoenterol2005，40，11： | 1 |
| 14 | jejunal exclusion in the treatment of type 2 diabetes mellitus in patients with BMI<30 kg/m2 显示文摘 | Ramos AC Galvao Neto Laparoscopic duodenal- MP de Souza YM etal | 2009 | Obes Surg2009，19，： | 1 |
| 15 | Survival after laparoscopic surgery versus open surgery for colon cancer long-term outcome of a randomized clinical trial显示文摘 | Colon Cancer Laparoscopic or Open Resection Study Group Buunen M Veldkamp R | 2009 | Lancet Oncol2009，10，1： | 1 |
| 16 | 显示文摘 | Hare Wood LM Webb DR Pope AJ Laparoscopic ureterolithtomy the result of an initial series and a evaluation of its role in the management of ureteric calculi | 1994 | Br J Urol1994，74，： | 1 |
| 17 | Conservative management of ureteral endometriosis显示文摘 | Camanni M Laparoscopic Delpiano EM Bonino L | 2010 | Curr ODin Obstet Gynecol2010，22，4： | 1 |
| 18 | Survival after laparoscopicsurgery versus open surgery for colon cancer:long-termoutcome of a randomized clinical trial显示文摘 | Colon Cancer Laparoscopic or Open Resection Study Group Buunen M Veldkamp R | 2009 | Lancet Oncol2009，10，1： | 1 |
| 19 | Survival after laparoscopic surgery versus open surgery for colon cancer:long-term outcome of a randomised clinical trial显示文摘 | Colon Cancer Laparoscopic or Open Resection Study Group Buunen M Veldkamp R | 2009 | Lancet Oncol2009，10，1： | 1 |
| 20 | Survival after laparoscopic surgery versus open surgery for colon cancer: long-term outcome of a randomised clinical trial显示文摘 | Colon Cancer Laparoscopic or Open Resection Study Group Buunen M Veldkamp R | 2009 | Lancet Oncol2009，10，： | 1 |
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