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| 1 | 靶向Jak/Stat通路作为Akt/β-联蛋白诱导的肝细胞癌SP/CD44+肿瘤细胞的治疗策略显示文摘【据《J Hepatol》2019年9月报道】题:靶向Jak/Stat通路作为Akt/β-联蛋白诱导的肝细胞癌SP/CD44+肿瘤细胞的治疗策略(作者Toh TB等)肝切除和肝移植以及辅助放化疗是肝细胞癌(HCC)治疗的主要手段。由于其频繁复发和肝内转移,HCC患者5年生存率仍然很差。目前仅索拉非尼和仑伐替尼被批准用于晚期、非切除的HCC的一线治疗,但其生存获益有限。因此需要确定新的治疗靶点以改进目前HCC治疗方式。 | 丁梦梦 高沿航 TOH TB LIM JJ HOOI L | 2020 | 临床肝胆病杂志2020，36，3： | 16 |
| 2 | Gastroenterology in developing countries:Issues and advances显示文摘Developing countries shoulder a considerable burden of gastroenterological disease. Infectious diseases in particular cause enormous morbidity and mortality. Diseases which afflict both western and developing countries are often seen in more florid forms in poorer countries. Innovative techniques continuously improve and update gastroenterological practice. However, advances in diagnosis and treatment which are commonplace in the West, have yet to reach many developing countries. Clinical guidelines, based on these advances and collated in resource-rich environments,lose their relevance outside these settings. In this two-part review, we first highlight the global burden of gastroenterological disease in three major areas: diarrhoeal diseases, hepatitis B, and Helicobacter pylori . Recent progress in their management is explored, with consideration of future solutions. The second part of the review focuses on the delivery of clinical services in developing countries. Inadequate numbers of healthcare workers hamper efforts to combat gastroenterological disease. Reasons for this shortage are examined, along with possibilities for increased specialist training. Endoscopy services, the mainstay of gastroenterology in the West, are in their infancy in many developing countries. The challenges faced by those setting up a service are illustrated by the example of a Nigerian endoscopy unit. Finally, we highlight the limited scope of many clinical guidelines produced in western countries. Guidelines which take account of resource limitations in the form of 'cascades' are advocated in order to make these guidelines truly global. Recognition of the different working conditions facing practitioners worldwide is an important step towards narrowing the gap between gastroenterology in rich and poor countries. | Kate L Mandeville Justus Krabshuis Nimzing Gwamzhi Ladep Chris JJ Mulder Eamonn MM Quigley Shahid A Khan | 2009 | World Journal of Gastroenterology2009，15，23： | 8 |
| 3 | A high-density, multi-parental SNP genetic map on apple validates a new mapping approach for outcrossing species显示文摘Quantitative trait loci(QTL)mapping approaches rely on the correct ordering of molecular markers along the chromosomes,which can be obtained from genetic linkage maps or a reference genome sequence.For apple(Malus domestica Borkh),the genome sequence v1 and v2 could not meet this need;therefore,a novel approach was devised to develop a dense genetic linkage map,providing the most reliable marker-loci order for the highest possible number of markers.The approach was based on four strategies:(i)the use of multiple full-sib families,(ii)the reduction of missing information through the use of HaploBlocks and alternative calling procedures for single-nucleotide polymorphism(SNP)markers,(iii)the construction of a single backcross-type data set including all families,and(iv)a two-step map generation procedure based on the sequential inclusion of markers.The map comprises 15417 SNP markers,clustered in 3 K HaploBlock markers spanning 1267 cM,with an average distance between adjacent markers of 0.37 cM and a maximum distance of 3.29 cM.Moreover,chromosome 5 was oriented according to its homoeologous chromosome 10.This map was useful to improve the apple genome sequence,design the Axiom Apple 480 K SNP array and perform multifamily-based QTL studies.Its collinearity with the genome sequences v1 and v3 are reported.To our knowledge,this is the shortest published SNP map in apple,while including the largest number of markers,families and individuals.This result validates our methodology,proving its value for the construction of integrated linkage maps for any outbreeding species. | Erica A Di Pierro Luca Gianfranceschi Mario Di Guardo Herma JJ Koehorst-van Putten Johannes W Kruisselbrink Sara Longhi Michela Troggio Luca Bianco Hélène Muranty Giulia Pagliarani Stefano Tartarini Thomas Letschka Lidia Lozano Luis Larisa Garkava-Gustavsson Diego Micheletti Marco CAM Bink Roeland E Voorrips Ebrahimi Aziz Riccardo Velasco François Laurens W Eric van de Weg | 2016 | Horticulture Research2016，3，1： | 3 |
| 4 | 外科减肥手术后高血压缓解和复发的预测因素显示文摘目前,只有很少量研究涉及外科减肥手术后高血压得到缓解和复发的影响因素,没有可用于预测高血压复发相关因素的信息。该研究的目的是评估在外科减肥手术后第1年和第3年里高血压的缓解情况和复发率,并寻找可能的预测因素。 | Benaiges D Sagué M Flores-Le Roux JA Pedro-Botet J Ramón JM Villatoro M Chillarón JJ Pera M Más A Grande L Goday A 陈云 | 2016 | 中华高血压杂志2016，24，9： | 2 |
| 5 | The pathogenesis of coronary artery disease and the acute coronary syndromes显示文摘 | Fuster V Badimon L Badimon JJ | 1992 | N Engl J Med1992，326，4： | 2 |
| 6 | Human adrenomedullin gene delivery protects against cardiac hypertrophy, fibrosis,and renal damage in hypertensive dahl salt-sensitive rats显示文摘 | Zhang JJ Yoshida H Ch L | 2000 | Hum Gene Ther2000，11，13： | 2 |
| 7 | Altered expression patterns of group Ⅰ and Ⅱ metabotropic glutamate receptors in multiple sclerosis显示文摘 | Geurts JJ Wolswijk G Bo L | 2003 | Brain2003，126，8： | 1 |
| 8 | Cryopreservation of adherent human embryonic stem cells显示文摘 | Ji L Pablo JJ Palecek SP | 2004 | Biotechnol Bioeng2004，88，3： | 1 |
| 9 | Increased mortality after dronedarone therapy for severe heart failure 显示文摘 | Kober L Torp-Pedersen C McMurray JJ | 2008 | N Engl J Med2008，358，25： | 1 |
| 10 | Serotonin 2C receptor agonistsimprove type 2 diabetes via melanocortin-4 receptor signaling pathways显示文摘 | Zhou L Sutton GM Rochford JJ | 2007 | Cell Metab2007，6，5： | 1 |
| 11 | The pathogenesis of coronary artery disease and the acute coronary syndromes显示文摘 | Fuster V Badimon L Badimon JJ | 1992 | N Engl J Med1992，326，5： | 1 |
| 12 | Depletion of human stratum corneum vitamin E:an early and sensitive in vivo marker of UV induced photooxidation显示文摘 | Thiele JJ Traver MG Packer L | 1998 | J Invest Dermatol1998，110，： | 1 |
| 13 | Effect of age on adult stereoacuity as measured by different type of stereotests显示文摘 | Garmham L Sloper JJ | 2006 | Br J Ophthalmol2006，90，1： | 1 |
| 14 | Orientation-dependent and sequence-specific expansions of CTG/CAG trinueleotide repeats in Saccharomyces cerevisiae 显示文摘 | MMiret JJ Pessoa-Brandao L Lahue RS | 1998 | PNAS1998，95，12： | 1 |
| 15 | Studies on the structure and dynamics of the human telomeric G quadruplex by single- molecule fluorescence resonance energy transfer显示文摘 | Ying L Green JJ Li H | 2003 | Proc Natl Acad Sci USA2003，100，14： | 1 |
| 16 | Mitochondrial permeability transition: a common pathway to necrosis and apoptosis 显示文摘 | Kim JS He L Lemasters JJ | 2003 | Biochem Biophys Res Commun2003，304，3： | 1 |
| 17 | The pathogencsis of coronary arlery disease and the acute coronary syndromes显示文摘 | Fuster V Badin on L Badin on JJ | 1992 | N Engl J Med1992，326，： | 1 |
| 18 | Differentially expressed proteins in the pancreas of diet-induced diabetic mice 显示文摘 | Qiu L List EO Kopehick JJ | 2005 | Mol Cell Proteomies2005，4，9： | 1 |
| 19 | EuroFlow antibody panels for standardized n-dimensional flow cytometric immunophenotyping of normal,reactive and malignant leukocytes显示文摘 | van Dongen JJ Lhermitte L B(o)ttcher S | 2012 | Leukemia2012，26，： | 1 |
| 20 | Atorvastatin and the dyslipidemi of early renalfailure显示文摘 | Soy RC Kastelein JJ Arisz L | | 0，，： | 1 |
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