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| 1 | Platelet thromboxane(11-dehydro-Thromboxane B_2) and aspirin response in patients with diabetes and coronary artery disease显示文摘Aspirin(ASA) irreversibly inhibits platelet cyclooxygenase-1(COX-1) leading to decreased thromboxane-mediated platelet activation. The effect of ASA ingestion on thromboxane generation was evaluated in patients with diabetes(DM) and cardiovascular disease. Thromboxane inhibition was assessed by measuring the urinary excretion of 11-dehydro-thromboxane B2(11dhTxB2), a stable metabolite of thromboxane A2. The mean baseline urinary 11dhTxB2 of DM was 69.6% higher than healthy controls(P = 0.024): female subjects(DM and controls) had 50.9% higher baseline 11dhTxB2 than males(P = 0.0004), while age or disease duration had no influence. Daily ASA ingestion inhibited urinary 11dhTxB2 in both DM(71.7%) and controls(75.1%, P < 0.0001). Using a pre-established cut-off of 1500 pg/mg of urinary 11dhTxB2, there were twice as many ASA poor responders(ASA 'resistant') in DM than in controls(14.8% and 8.4%, respectively). The rate of ASA poor responders in two populations of acute coronary syndrome(ACS) patients was 28.6 and 28.7%, in spite of a significant(81.6%) inhibition of urinary 11dhTxB2(P < 0.0001). Both baseline 11dhTxB2 levels and rate of poor ASA responders were significantly higher in DM and ACS compared to controls. Underlying systemic oxidative inflammation may maintain platelet function in atherosclerotic cardiovascular disease irrespective of COX-1 pathway inhibition and/or increase systemic generation of thromboxane from non-platelet sources. | Luis R Lopez Kirk E Guyer Ignacio Garcia De La Torre Kelly R Pitts Eiji Matsuura Paul RJ Ames | 2014 | World Journal of Diabetes2014，5，2： | 13 |
| 2 | Cytogenetie evalua- tion of two nitroimidazole derivatives显示文摘 | Lopez NMM Palermo AM Mudry MD | 2003 | Toxicol In Vitro2003，17，1： | 1 |
| 3 | Insertion and use of the LMA Supreme in the prone position显示文摘 | Lopez AM Valero R Brimacombe 1 | 2010 | Anaesthesia2010，65，2： | 1 |
| 4 | Lipolysis, proteolysis and sensory characteristics of a Spanish fermented dry - cured meat product ( salchichon ) with oregano essential oil used as surface mold inhibitor 显示文摘 | Matin - Sanchez AM Chaves - lopez C Sendra E | 2011 | Meat Science2011，89，1： | 1 |
| 5 | Quality of life and breast cancer:relationship to psychosocial variables显示文摘 | Shapiro SL Lopez AM Schwartz GE | 2001 | J Clin Psychol2001，57，4： | 1 |
| 6 | Skin tear prevention and management among patients in the acute aged care and reha- bilitation units in the Australian Capital Territory :a best prac- tice implementation project显示文摘 | Lopez V Dunk AM Parke J | 2011 | Int J Evid Based Healthc2011，9，： | 1 |
| 7 | Awake intubation using the LMA CTrach in patients with difficult airways显示文摘 | Lopez AM Valero R Pons M | 2009 | Anaesthesia2009，64，4： | 1 |
| 8 | Ethnic identity and cultural awareness among the offspring of Mexican interethnic marriages显示文摘 | De Snyder NS Lopez CM Padilla AM | 1982 | J Early Adolescence1982，，3： | 1 |
| 9 | Biological evaluation of Cuban plants显示文摘 | Jimenez Misas CA Rojas Hernandez NM Lopez Abraham AM | 1979 | Rev Cubana Med Trop1979，31，1： | 1 |
| 10 | Aztreonam/clavulanic acid in the treatment of serious infections caused by Stenotrophomonas maltophilia in neutropenic patients:case reports显示文摘 | 8,Garcia Sanchez JE Vazquez Lopez ML Blazquez de Castro AM | 1997 | J Chemother1997，9，3： | 1 |
| 11 | Increased nitric oxide synthesis and inducible nitric oxide synthase expression in patients with alcoholic and non - alcoholic liver cirrhosis显示文摘 | Sanchez Rodriguez A Criado M Roudriguez Lopez AM | 1998 | Clin Sci1998，，94： | 1 |
| 12 | Mechanical stretch up-regu- lates microRNA-26a and induces human airway smooth muscle hy- pertrophy by suppressing glycogen synthase kinase-3β 显示文摘 | Mohamed JS Lopez MA Boriek AM | 2010 | J Biol Chem2010，285，29： | 1 |
| 13 | Ethnic identity and cultural awareness among the offspring of Mexican interethnic marriages显示文摘 | De Snyder NS Lopez CM Padilla AM | 1982 | J Early Adolescence1982，，3： | 1 |
| 14 | Restoring treatment with continuous insulin infusion pump(BICI) 显示文摘 | Mendez Lopez AM | 2008 | Rev Enferm2008，31，6： | 1 |
| 15 | Interactions between toxic (As,Cd,Hg and Pb) and nutritional essential (Ca,Co,Cr,Cu,Fe,Mn,Mo,Ni,Se,Zn) elements in the tissues of cattle from NW Spain 显示文摘 | Lopez AM Prieto MF Miranda M | 2004 | Biometals2004，17，： | 1 |
| 16 | Percutaneous toxicity of uranyl nitrate:its effect in terms of exposure area and time显示文摘 | Lopez R Diaz Sylvester PL Ubios AM et a1 | 2000 | Health Phys2000，78，4： | 1 |
| 17 | Adrenal ganglioneuroma:A diagnostic challenge显示文摘 | Alramadan M Lopez Martinez S Cerezo Arillo AM | | 0，，： | 1 |
| 18 | Hepatic entrapment of esterified cholesterol drives continual expansion of whole body sterol pool in lysosomal acid lipase-deficient mice 显示文摘 | Aqul A Lopez AM Posey KS | 2014 | Am J Physiol Gastrointest Liver Physiol2014，307，8： | 1 |
| 19 | TCRmu recombination and transcription relative to the conventional TCR during postnatal development in opossums显示文摘 | Parra ZE Baker ML Lopez AM | 2009 | Immunol2009，182，： | 1 |
| 20 | Quality of life and breast cancer: relationship to psychosocial variables 显示文摘 | Shapiro SL Lopez AM Schwartz GE | 2001 | J Clin Psychol2001，57，4： | 1 |
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