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| 1 | No difference in mortality among ALPPS,two-staged hepatectomy,and portal vein embolization/ligation:A systematic review by updated traditional and network meta-analyses显示文摘Background:There is an ongoing debate on the feasibility,safety,and oncological efficacy of the associating liver partition and portal vein ligation for staged hepatectomy(ALPPS)technique.The aim of this study was to compare ALPPS,two-staged hepatectomy(TSH),and portal vein embolization(PVE)/ligation(PVL)using updated traditional meta-analysis and network meta-analysis(NMA).Data sources:Electronic databases were used in a systematic literature search.Updated traditional metaanalysis and NMA were performed and compared.Mortality and major morbidity were selected as primary outcomes.Results:Nineteen studies including 1200 patients were selected from the pool of 436 studies.Of these patients,315(31%)and 702(69%)underwent ALPPS and portal vein occlusion(PVO),respectively.Ninetyday mortality based on updated traditional meta-analysis,subgroup analysis of the randomized controlled trials(RCTs),and both Bayesian and frequentist NMA did not demonstrate significant differences between the ALPPS cohort and the PVE,PVL,and TSH cohorts.Moreover,analysis of RCTs did not demonstrate significant differences of major morbidity between the ALPPS and PVO cohorts.The ALPPS cohort demonstrated significantly more favorable outcomes in hypertrophy parameters,time to operation,definitive hepatectomy,and R0 margins rates compared with the PVO cohort.In contrast,1-year disease-free survival was significantly higher in the PVO cohort compared to the ALPPS cohort.Conclusions:This study is the first to use updated traditional meta-analysis and both Bayesian and frequentist NMA and demonstrated no significant differences in 90-day mortality between the ALPPS and other hepatic hypertrophy approaches.Furthermore,two high quality RCTs including 147 patients demonstrated no significant differences in major morbidity between the ALPPS and PVO cohorts. | Paschalis Gavriilidis Robert P Sutcliffe Keith J Roberts Madhava Pai Duncan Spalding Nagy Habib Long R Jiao Mikael H Sodergren | 2020 | Hepatobiliary & Pancreatic Diseases International2020，19，5： | 6 |
| 2 | Th1 cytokines promote T-cell binding to antigen-presenting cells via enhanced hyaluronan production and accumulation at the immune synapse显示文摘Hyaluronan(HA)production by dendritic cells(DCs)is known to promote antigen presentation and to augment T-cell activation and proliferation.We hypothesized that pericellular HA can function as intercellular‘glue’directly mediating T cell–DC binding.Using primary human cells,we observed HA-dependent binding between T cells and DCs,which was abrogated upon pre-treatment of the DCs with 4-methylumbelliferone(4-MU),an agent which blocks HA synthesis.Furthermore,T cells regulate HA production by DCs via T cell-derived cytokines in a T helper(Th)subset-specific manner,as demonstrated by the observation that cell-culture supernatants from Th1 but not Th2 clones promote HA production.Similar effects were seen upon the addition of exogenous Th1 cytokines,IL-2,interferon c(IFN-c)and tumor necrosis factor a(TNF-a).The critical factors which determined the extent of DC–T cell binding in this system were the nature of the pre-treatment the DCs received and their capacity to synthesize HA,as T-cell clones which were pre-treated with monensin,added to block cytokine secretion,bound equivalently irrespective of their Th subset.These data support the existence of a feedforward loop wherein T-cell cytokines influence DC production of HA,which in turn affects the extent of DC–T cell binding.We also document the presence of focal deposits of HA at the immune synapse between T-cells and APC and on dendritic processes thought to be important in antigen presentation.These data point to a pivotal role for HA in DC–T cell interactions at the IS. | Paul L Bollyky Stephen P Evanko Rebecca P Wu Susan Potter-Perigo S Alice Long Brian Kinsella Helena Reijonen Kelly Guebtner Brandon Teng Christina K Chan Kathy R Braun John A Gebe Gerald T Nepom Thomas N Wight | 2010 | Cellular & Molecular Immunology2010，7，3： | 3 |
| 3 | The potential for resistance to Botrytis cinerea by kiwifruit显示文摘 | Wurms K V Long P G Sharrock K R | 1999 | Crop Protection1999，18，： | 1 |
| 4 | Measurement of leaf and canopy photosynthetic C02 exchange in the field显示文摘 | Farageand P K Garcia R L | 1996 | Journal of Experimental Botany1996，47，304： | 1 |
| 5 | Facts & figures chemical R & D显示文摘 | Brennan M B Long J R Zurer P R | 1997 | C & EN1997，75，35： | 1 |
| 6 | Multiclass linear dimension reduction by weighted Pairwise Fisher criteria显示文摘 | Long M Duin R P W Haeb- Umbach R | 2001 | IEEE Transactions on Pattern Analysis and Machine Intelligence2001，23，7： | 1 |
| 7 | Nuclear Magnetic Resonance studies of water mobility in bread during storage 显示文摘 | Chen P L Long Z Ruan R | 1997 | LWT- Food Science and Technology1997，30，2： | 1 |
| 8 | Improving photosynthetic effi ciency for greater yield 显示文摘 | Zhu X G Long S P Ort D R | 2010 | Annual Review of Plant Biolo gy2010，61，1： | 1 |
| 9 | Kondo Resonance in a Single-molecule Transistor显示文摘 | LIANG W SHORES M P BOCKRATH M LONG J R PARK H | 2002 | Nature (London)2002，417，： | 1 |
| 10 | Monitoring electrical resistance of concretes containing alternative cementitious materials to assess their resistance to chloride penetration显示文摘 | Basheer P A M Gilleece P R V Long A E | 2002 | Cement and Concrete Composites2002，24，5： | 1 |
| 11 | Nuclear magneticresonance studies of water mobility in bread duringstorage显示文摘 | Chen P L Long Z Ruan R | 1997 | Lebensmittel-Wissenschafl und-Technologie1997，30，2： | 1 |
| 12 | Improving photosynthetic efficiency for greater yield 显示文摘 | Zhu X G Long S P Ort D R | 2010 | Ann Rev Plant Biol2010，61，： | 1 |
| 13 | Group 4 metal olefin polymerization catalysts stabilized by bidentate O,Pligands显示文摘 | Long R J Gibson V C White A J P | | 0，，： | 1 |
| 14 | Can improvement in photosynthesis increase crop y eldsV显示文摘 | Long S P Zhu X G Naidu S L Ort D R | 2006 | Plant Cell Environment2006，29，3： | 1 |
| 15 | Fast ion conduction in an acid doped pentaglycerine plastic crystal显示文摘 | Howlett P C MacFarlane D R | 2006 | Solid State Ionics2006，177，7： | 1 |
| 16 | Reversible middle cerebral artery occlusion without craniotomy in rats显示文摘 | Long E Z Weinstein P R Carlson S | 1989 | Stroke1989，20，1： | 1 |
| 17 | Porous media equivalents for networks of discontinuous fractures显示文摘 | Long J C S Remer J S Wilson C R Witherspoon P A | 1982 | Water Resources Research1982，18，3： | 1 |
| 18 | Lagands-unsupported metal-metal(M = Cu, Ag) interactions between closed-shell d^10 trinuclear systems显示文摘 | Singh K Long J R Stavropoulos P | 1997 | JAm Chem Soc1997，119，： | 1 |
| 19 | Chlorophyll fluorescence as a probe of the photosynthetic competence of leaves in the field:a review of current instrumentation显示文摘 | Bolhar-Nordenkampf H R Long S P Baker N R | 1989 | Funct Ecol1989，3，： | 1 |
| 20 | Structural stud- ies of secondary crystallization products of the Fe23 B6 - type in a nano- crystalline FeCoB - based alloy 显示文摘 | Long J G Ohodnicki P R Laughlin D E | 2007 | Journal of Applied Physics2007，101，9： | 1 |
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