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| 1 | A preliminary validation of the Brief COPE instrument for assessing coping strategies among people living with HIV in China显示文摘Background:The Brief COPE instrument has been utilized to conduct research on various populations,including people living with HIV(PLWH).However,the questionnaire constructs when applied to PLWH have not been subjected to thorough factor validation.Methods:A total of 258 PLWH were recruited from two provinces of China.They answered questions involving the scales of three instruments:the Brief COPE,the Perceived Social Support Scale,and the Perceived Discrimination Scale for PLWH.Confirmatory factor analysis(CFA)and exploratory factor analysis(EFA)were conducted.Results:The CFA found a poor goodness of fit to the data.The subsequent EFA identified six preliminary factors,forming subscales with Cronbach’s alphas,which ranged from 0.61 to 0.80.Significant correlation coefficients between the subscales and measures of perceived social support and perceived discrimination were reported,giving preliminary support to the validity of the new empirical factor structure.Conclusion:This study showed that the original factor structure of the Brief COPE instrument,when applied to PLWH in China,did not fit the data.Thus,the Brief COPE should be applied to various populations and cultures with caution.The new factor structure established by the EFA is only preliminary and requires further validation. | Xiao-you Su Joseph TF Lau Winnie WS Mak KC Choi Tie-jian Feng Xi Chen Chu-liang Liu Jun Liu De Liu Lin Chen Jun-min Song Yan Zhang Guang-lu Zhao Zhang-ping Zhu Jin-quan Cheng | 2015 | Infectious Diseases of Poverty2015，4，1： | 2 |
| 2 | Total synthesis of taxol 显示文摘 | NICOLAOU KC YANG Z LIU JJ | 1994 | Nature1994，367，： | 1 |
| 3 | Detection of HCV RNA in sativa urine seminal fluid and as cites显示文摘 | Liu TC Chang TT Young KC | 1992 | JMAD Virus1992，37，： | 1 |
| 4 | Expression of autophagy-related protein beclin-1 in malignant canine mammary tumors显示文摘 | Liu JL Chang KC Lo CC | 2013 | BMC Vet Res2013，9，1： | 1 |
| 5 | Autoimmunity in the pathogenesis and treatment of keratocoryunctivitis sicca显示文摘 | LIU KC HUYNH K GRUBBS J DAVIS RM | 2014 | Curr Allergy Asthma fiep2014，14，1： | 1 |
| 6 | Outcome of emergency ERCP for acute eholangitis in patients 90 years of age and older 显示文摘 | Hui CK Liu CL Lai KC | 2004 | Aliment Pharmacol Ther2004，19，11： | 1 |
| 7 | Laser diffraction methods for high-temperature strain-measurements显示文摘 | PIH H LIU KC | 1991 | Experimental Mechanics1991，31，： | 1 |
| 8 | Herpes simplex virus gene Products required for viral inhibition of expression of Gl phase functions显示文摘 | Song B Yeh KC Liu J | 2001 | J Virol2001，290，2： | 1 |
| 9 | Pluronic L-81 ameliorates diabetic symptoms in db/db mice through transcriptional regulation of microsomal triglyceride transfer protein显示文摘AIM: To test whether oral L-81 treatment could im-prove the condition of mice with diabetes and to investigate how L-81 regulates microsomal triglyceride transfer protein (MTP) activity in the liver. METHODS: Genetically diabetic (db/db) mice were fed on chow supplemented with or without L-81 for 4 wk. The body weight, plasma glucose level, plasma lipid profile, and adipocyte volume of the db/db mice were assessed after treatment. Toxicity of L-81 was also evaluated. To understand the molecular mecha-nism, HepG2 cells were treated with L-81 and the effects on apolipoprotein B (apoB) secretion and mRNA level of the MTP gene were assessed.RESULTS: Treatment of db/db mice with L-81 sig-nificantly reduced and nearly normalized their body weight, hyperphagia and polydipsia. L-81 also markedly decreased the fasting plasma glucose level, improved glucose tolerance, and attenuated the elevated levels of plasma cholesterol and triglyceride. At the effective dosage, little toxicity was observed. Treatment of HepG2 cells with L-81 not only inhibited apoB secretion, but also signif icantly decreased the mRNA level of the MTP gene. Similar to the action of insulin, L-81 exerted its effect on the MTP promoter. CONCLUSION: L-81 represents a promising candidate in the development of a selective insulin-mimetic mol-ecule and an anti-diabetic agent. | Wo-Shing Au Li-Wei Lu Sidney Tam Otis King Hung Ko Billy KC Chow Ming-Liang He Samuel S Ng Chung-Man Yeung Ching-Chiu Liu Hsiang-Fu Kung Marie C Lin | 2009 | World Journal of Gastroenterology2009，15，24： | 1 |
| 10 | The multiple roles for Sox2 in stem cell maintenance and tumorigenesis 显示文摘 | Liu KC Lin BS Zhao M | 2013 | Cell Signal2013，25，5： | 1 |
| 11 | Diallyl trisulfide (DATS) inhibits mouse colon tumor in mouse CT-26 cells allograft model in vivo 显示文摘 | Wu PP Liu KC Huang WW | 2011 | Phytomedicine2011，18，89： | 1 |
| 12 | Auto-processing of very Fine-Scale Composite Materials by Chaotic Mixing of Melts显示文摘 | Zumbrunnen DA Miles KC Liu YH | 1996 | Composites part A1996，27，： | 1 |
| 13 | A long noncoding RNA maintains active chromatin to coordinate homeotic gene expression 显示文摘 | Wang KC Yang YW Liu B | 2011 | Nature2011，472，7341： | 1 |
| 14 | A long noncoding RNA maintains active chromatin to coordinate homeotic gene expression 显示文摘 | Wang KC Yang YW Liu B | 2011 | Nature2011，472，： | 1 |
| 15 | Differential regulation of gonadotropin receptors(fshr and lhcgr) by epidermal growth factor (EGF) in the zebrafish ovary显示文摘 | Liu KC Ge W | 2013 | Gen Comp Endocrinol2013，18，： | 1 |
| 16 | Triptolide induces apoptosis in human adrenal cancer NCI-H295 cells through a mitochondrial-dependent pathway 显示文摘 | Wu PP Liu KC Huang WW | 2011 | OncolRep2011，25，2： | 1 |
| 17 | APC in the regulation of intestinal cmpt fission显示文摘 | Wasan HS Park HS Liu KC | 1998 | J Pathol1998，185，： | 1 |
| 18 | Killer Ig-like receptor haplotype analysis by gene content:evidence for genomic diversity with a minimum of six basic framework haplotypes,each with multiple subsets显示文摘 | Hsu KC Liu XR Selvakumar A | 2002 | J Immunol2002，169，： | 1 |
| 19 | Tumor-associated macrophages pro-mote oral cancer progression through activation of the AXL signalingpathway 显示文摘 | Lee CH Liu SY Chou KC | 2014 | Ann Surg Oncol2014，21，3： | 1 |
| 20 | Long noncoding RNA programs active chromatin domain to coordinate homeotic gene activation显示文摘 | Wang KC Yang yw Liu B | 2011 | Nature2011，472，7341： | 1 |
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