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| 1 | Research advances on the multiple uses of Moringa oleifera: a sustainable alternative for socially neglected population显示文摘Moringa oleifera Lam(Moringaceae) is a plant with high nutritional and medicinal value. Native to India, it is now widely distributed throughout tropical and subtropical regions of the world. Its different parts are sources of proteins, vitamins and minerals and present different pharmacological and biotechnological potential. Moreover, M. oleifera seeds are widely used in water and effluent treatment, for their coagulation, flocculation and sedimentation properties, their ability of improving water quality, by reducing organic matter and microbial load, with special applicability in intensive animal production systems, such as aquaculture. In addition, due to its high nutritional value and several medicinal properties, this tree may act as a nutritional and medical alternative for socially neglected populations. In this context, this review gathers information on M. oleifera, emphasizing its chemical constituents, nutritional, pharmacological and antimicrobial properties, applications in the treatment of water effluents, and ecological and social aspects. | Raimunda Samia Nogueira Brilhante Jamille Alencar Sales Vandbergue Santos Pereira Débora de Souza Collares Maia Castelo-Branco Rossana de Aguiar Cordeiro Célia Maria de Souza Sampaio Manoel de Araújo Neto Paiva Joao Bosco Feitosa dos Santos JoséJúlio CostaSidrim Marcos Fábio Gadelha Rocha | 2017 | Asian Pacific Journal of Tropical Medicine2017，10，7： | 10 |
| 2 | Relationship between Th17 immune response and cancer显示文摘Cancer is the second leading cause of death worldwide and epidemiological projections predict growing cancer mortality rates in the next decades.Cancer has a close relationship with the immune system and,although Th17 cells are known to play roles in the immune response against microorganisms and in autoimmunity,studies have emphasized their roles in cancer pathogenesis.The Th17 immune response profile is involved in several types of cancer including urogenital,respiratory,gastrointestinal,and skin cancers.This type of immune response exerts pro and antitumor functions through several mechanisms,depending on the context of each tumor,including the protumor angiogenesis and exhaustion of T cells and the antitumor recruitment of T cells and neutrophils to the tumor microenvironment.Among other factors,the paradoxical behavior of Th17 cells in this setting has been attributed to its plasticity potential,which makes possible their conversion into other types of T cells such as Th17/Treg and Th17/Th1 cells.Interleukin(IL)-17 stands out among Th17-related cytokines since it modulates pathways and interacts with other cell profiles in the tumor microenvironment,which allow Th17 cells to prevail in tumors.Moreover,the IL-17 is able to mediate pro and antitumor processes that influence the development and progression of various cancers,being associated with variable clinical outcomes.The understanding of the relationship between the Th17 immune response and cancer as well as the singularities of carcinogenic processes in each type of tumor is crucial for the identification of new therapeutic targets. | Hanna Santos Marques Breno Bittencourt de Brito Filipe Antônio França da Silva Maria Luísa Cordeiro Santos Júlio César Braga de Souza Thiago Macêdo Lopes Correia Luana Weber Lopes Nayara Silva de Macêdo Neres Rafael Santos Dantas Miranda Dórea Anna Carolina Saúde Dantas Lorena Lôbo Brito Morbeck Iasmin Souza Lima Amanda Alves de Almeida Maiara Raulina de Jesus Dias Fabrício Freire de Melo | 2021 | World Journal of Clinical Oncology2021，12，10： | 5 |
| 3 | Menopause and cognitive impairment:A narrative review of current knowledge显示文摘A severe impairment of cognitive function characterizes dementia.Mild cognitive impairment represents a transition between normal cognition and dementia.The frequency of cognitive changes is higher in women than in men.Based on this fact,hormonal factors likely contribute to cognitive decline.In this sense,cognitive complaints are more common near menopause,a phase marked by a decrease in hormone levels,especially estrogen.Additionally,a tendency toward worsened cognitive performance has been reported in women during menopause.Vasomotor symptoms(hot flashes,sweating,and dizziness),vaginal dryness,irritability and forgetfulness are common and associated with a progressive decrease in ovarian function and a subsequent reduction in the serum estrogen concentration.Hormone therapy(HT),based on estrogen with or without progestogen,is the treatment of choice to relieve menopausal symptoms.The studies conducted to date have reported conflicting results regarding the effects of HT on cognition.This article reviews the main aspects of menopause and cognition,including the neuroprotective role of estrogen and the relationship between menopausal symptoms and cognitive function.We present and discuss the findings of the central observational and interventional studies on HT and cognition. | Délio Marques Conde Roberto Carmignani Verdade Ana L R Valadares Lucas F B Mella Adriana OrcesiPedro Lucia Costa-Paiva | 2021 | World Journal of Psychiatry2021，11，8： | 3 |
| 4 | Oral refeeding in mild acute pancreatitis:An old challenge显示文摘Although the idea that pancreas rest has long been considered as a very relevant topic in acute pancreatitis (AP)therapy,the right time and type of diet to be offered to patients recovering from an acute attack are a great challenge to clinicians who treat this condition.Fortunately,the last decade was noted for several trials looking for the best answer to the question:'when and how to start oral refeeding in AP?'It is well known that 80%of patients present with mild disease characterized by usually uncomplicated clinical course are managed with pancreatic rest through nil per oral;while the use of specific nutritional intervention is an exception.Therefore,mild AP has been the most investigated form of AP and researchers have tried different kind of meals to offer calories and reduce costs by shortening hospitalization time.Usually in mild AP,the oral refeeding is introduced between the first 3 d and 7 d after hospitalization but,the type of diet and patients’tolerance have been scrutinized in detail with mixed results.Although 20%to 25%have pain recurrence requiring nutritional support and greater time of hospitalization,most patients seem to tolerate oral refeeding well.We propose analyzing the most recent investigations of this matter and their conclusions to develop a better understanding of the management of AP. | Júlio Maria F Chebli Pedro D Gaburri Liliana A Chebli | 2011 | World Journal of Gastrointestinal Pathophysiology2011，2，6： | 2 |
| 5 | Association between C1019T polymorphism of connexin37 and acute myocardial infarction: a study in patients from Sicily显示文摘 | Listi F Candore G Lio D | 2005 | Int J Cardiol2005，102，2： | 1 |
| 6 | Adsorption of chromium (VI) ion from aqueous solution by succinylated mercerized cellulose functionalized with quaternary ammonium groups显示文摘 | Leandro Vinícius Alves Gurgel Júlio César Perin de Melo Jorge Carvalho de Lena Laurent Frédéric Gil | 2009 | Bioresource Technology2009，，13： | 1 |
| 7 | The LISA technology package dynamics and control 显示文摘 | Bortoluzzi D Lio M D Dolesi R | 2003 | Classical and Quantum Gravity2003，20，10： | 1 |
| 8 | Single sheet functionalized graphene by oxidation and thermal expansion of graphite显示文摘 | Mcallister M J Lio J L Adamson D H | 2007 | Chem Mater2007，19，18： | 1 |
| 9 | Association between C 1019T pol- ymorphism of connexin37 and acute myocardial infarction : a study in patients from Sicily显示文摘 | VListi F C andore G Lio D | 2005 | Int J Cardiol2005，102，2： | 1 |
| 10 | Connexin37 1019 gene polymor- phism in myocardial infarction patients and centenarians显示文摘 | Listi F Candore G Lio D | 2007 | Ath- erosclerosis2007，191，2： | 1 |
| 11 | Parameter Estimations for Generalized Exponential Distribution under Progressive Typo-I Interval Censoring 显示文摘 | Chen D G Lio Y L | 2010 | Computational Statistics and Data Analysis2010，，54： | 1 |
| 12 | In vitro treatment with interleukin-2 normalizes type- 1 cytokine production by lymphocytes from elderly 显示文摘 | Lio D Balistreri CR Candore G | 2000 | Immuno - pharmacol Immunotoxicol2000，22，： | 1 |
| 13 | MOLECULAR IMAGING OF THERMOCHROMIC CARBOHYDRATE-MODIFIED POLYDIACETYLENE THIN FILMS显示文摘 | Lio A Reichert A Ahn D J | | 0，，： | 1 |
| 14 | Inflammation, genetics, and longevity: further studies on the pro- tective effects in men of IL-10-1082 promoter SNP and its interaction with TNF-alpha-308 promoter SNP 显示文摘 | Lio D Scola L Crivello A | 2003 | J Med Genet2003，40，4： | 1 |
| 15 | Genotype frequencies of the+874T->A single nucleotide polymorphism in the first intron of the interferon-gamma gene in a sample of Sicilian patients affected by tuberculosis显示文摘 | Lio D Marino V Serauto A | 2002 | Eur J Immunogenet2002，29，5： | 1 |
| 16 | 1267 HSP70-2 poly-morphism as a risk factor for carotid plaque rapture and cerebral ischaemia in old type 2 diabetes-atherosclerotic patients 显示文摘 | Giacconi R Caruso C Lio D | 2005 | Mech Ageing Dev2005，126，8： | 1 |
| 17 | Inflammation, ageing and cancer 显示文摘 | Vasto S Carruba G Lio D Colonna-Romano G Di-Bona D Candore G | 2009 | Mech Ageing Dev2009，130，12： | 1 |
| 18 | Surgical management ofLeiomyomata during pregnanacy 显示文摘 | Lios D Zikopoulos K Paraskevaidis E | 1994 | Int J Gynecol Obstet1994，44，1： | 1 |
| 19 | Human RadS1C deficien- cy destabilizes XRCC3, impairs recombination, and radiosensitizes S/G2-phase cells显示文摘 | Lio YC Schild D Brermeman MA | 2004 | J Biol Chem2004，279，42： | 1 |
| 20 | The chemokine fractalkine inhibits Fas-mediated cell death of brain microglia显示文摘 | Boehme SA Lio FM Maciejewski-Lenoir D | 2000 | J Immunol2000，165，1： | 1 |
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