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| 1 | 肥大细胞源性组织蛋白酶G在狭窄主动脉瓣不良改变中的可能作用显示文摘Aims: Aortic stenosis(AS) is characterized by extensive remodelling of the valves, including infiltration of inflammatory cells, extracellular matrix degradation, and fibrosis. The molecular mechanisms behind this adverse remodelling have remained obscure. In this article, we study whether cathepsin G, an angiotensin Ⅱ(Ang Ⅱ)forming elastolytic enzyme, contributes to progression of AS. Methods and results: Stenotic aortic valves(n=86) and control valves(n=17) were analysed for cathepsin G, transforming growth factor-β1(TGF-β1), and collagens I and Ⅲ with RT-PCR and immunohistochemistry. Valvular collagen/elastin ratio was quantified by histochemistry. In stenotic valves, cathepsin G was present in mast cells and showed increased expression(P< 0.001), which correlated positively(P< 0.001)with the expression levels of TGF-β1 and collagens I and Ⅲ. TGF-β1 was also present in mast cell rich areas and cathepsin G induced losartan-sensitive TGF-β1 expression in cultured fibroblasts. Collagen/elastin ratio was increased in stenotic valves(P< 0.001) and correlated positively with smoking(P=0.02). Nicotine in cigarette smoke activated mast cells and induced TGF-β1 expression in cultured fibroblasts. Fragmented elastin was observed in stenotic valves containing activated cathepsin G-secreting mast cells and in normal valves treated with cathepsin G. Conclusion: In stenotic aortic valves, mast cell-derived cathepsin G may cause adverse valve remodelling and AS progression. | Helske S. Syvranta S. Kupari M. K.A. Lindstedt 郭俊 | 2006 | 世界核心医学期刊文摘(心脏病学分册)2006，，12： | 7 |
| 2 | Sperm chromatin struc- ture assay as an independent predictor of fertility in vivo :acase - con- trol study 显示文摘 | G iwercman A Lindstedt L Larsson M | 2010 | International Journal of Andrology2010，33，1： | 1 |
| 3 | Osmotic pumping as a release mechanism for membrane-coated drug formulations 显示文摘 | Lindstedt B Raguarsson G Hj/irtstam J | 1989 | IntJPharm1989，56，3： | 1 |
| 4 | Use of variable-numbertandem repeats to examine genetic diversity of Neisseria meningitidis显示文摘 | Yazdznkhah SP Lindstedt BA Caugant DA | 2005 | J Clin Microbiol2005，43，4： | 1 |
| 5 | Treatment of hereditary tyrosinaemia type I by inhibition of 4-hydroxyphenylpyrurvate diox- ygenase 显示文摘 | Lindstedt S Holme E Lock EA | 1992 | Lancet1992，340，8823： | 1 |
| 6 | Women with Polycystic ovary syndrome wedge resected in 1956 to 1965 : along-term follow- uP focusing on natural history and circulating hormones显示文摘 | Dahlgren E Johansson S Lindstedt G | 1992 | Fertil Steril1992，57，3： | 1 |
| 7 | Transported PDF modelling with detailed chemistry of pre- and auto-ignition in CH 4 /air mixtures显示文摘 | K. Gkagkas R.P. Lindstedt | 2006 | Proceedings of the Combustion Institute2006，，1： | 1 |
| 8 | Time resolved velocity and turbulence measurements in turbulent gaseous explosions显示文摘 | LINDSTEDT R P SAKTHITHARAN V | 1998 | Combustion and Flame1998，114，： | 1 |
| 9 | Pharmacological correction of neonatal lethal hepatic dysfunction in a routine model of hereditary tyrosinaemia type I 显示文摘 | Grompe M Lindstedt S AI-Dhalimy M | 1995 | Nat Genet1995，10，4： | 1 |
| 10 | Persistent subretinal fluid after surgery for rhegmatogenous retinal detachment:hypothesis and review显示文摘 | Veckeneer M Derycke L Lindstedt EW | | 0，，： | 1 |
| 11 | Use of variable-number tandem repeats to examine genetic diversity of Neisseria meningitides显示文摘 | Yazdankhah SP Lindstedt BA Caugant DA | 2005 | J Clin Microbiol2005，43，4： | 1 |
| 12 | Increased circulating concentrations and augmented myocardial extraction of osteoprotegerin in heart failure due to left ventricular pressure overload显示文摘 | Helske S Kovanen PT Lindstedt KA | 2007 | Eur J Heart Fail2007，9，5： | 1 |
| 13 | Octaplex PCR and fluorescence-based capillary electrophoresis for identification of human diarrheagenic Escherichia coli and Shigella spp 显示文摘 | Lin TB Lindstedt BA Lena A | 2007 | J Microbiol Methods2007，68，2： | 1 |
| 14 | Mast cell chymase induces smooth muscle cell apoptosis by a mechanism involving fibronectin degradation and disruption of focal adhesion显示文摘 | Leskinen M Lindstedt KA Wang YF | 2003 | Arteroscler Thromb Vasc Biol2003，23，： | 1 |
| 15 | TSH and TPOAb should be the first to analyze in suspected dysfunction of thyroid gland显示文摘 | Lindstedt G Lundberg PA Sundbeck G | 2000 | Lakartidningen2000，97，36： | 1 |
| 16 | Identification of a circulatory and oocytic avian apolipoprotein D显示文摘 | Vieira V Lindstedt K Schneider W | 1995 | Mol Rep Dev1995，42，： | 1 |
| 17 | CIM + T cells have a key instructive role in educating dendriticcells in allergy显示文摘 | Larsson K Lindstedt M Lundberg K | 2009 | Int Arch Allergy hnmunol2009，149，1： | 1 |
| 18 | Quantitation of seven low-dosage antipsychotic drugs in human postmortem blood using LC-MS-MS 显示文摘 | Roman M Kronstrand R Lindstedt D | 2008 | J Anal Toxicol2008，32，2： | 1 |
| 19 | Independent relationship between microalbuminuria and plasminogen activator inhibitor-1 activity (PAI - 1 ) activity in clinically healthy 58-year-old men 显示文摘 | Agewall S Lindstedt G Fagerberg B | 2001 | Atherosclerosis2001，157，1： | 1 |
| 20 | Regulation of cytoplasmic,surface and soluble forms of CD40 ligand in mouse B cells显示文摘 | Wykes M Poudrier J Lindstedt R | 1998 | EurJ Immunol1998，2，： | 1 |
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