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| 1 | Effect of Helicobacter pylori on gastric epithelial cells显示文摘The gastrointestinal epithelium has cells with features that make them a powerful line of defense in innate mucosal immunity. Features that allow gastrointestinal epithelial cells to contribute in innate defense include cell barrier integrity, cell turnover, autophagy, and innate immune responses. Helicobacter pylori(H. pylori) is a spiral shape gram negative bacterium that selectively colonizes the gastric epithelium of more than half of the world's population. The infection invariably becomes persistent due to highly specialized mechanisms that facilitate H. pylori 's avoidance of this initial line of host defense as well as adaptive immune mechanisms. The host response is thus unsuccessful in clearing the infection and as a result becomes established as a persistent infection promoting chronic inflammation. In some individuals the associated inflammation contributes to ulcerogenesis or neoplasia. H. pylori has an array of different strategies to interact intimately with epithelial cells and manipulate their cellular processes and functions. Among the multiple aspects that H. pylori affects in gastric epithelial cells are their distribution of epithelial junctions, DNA damage, apoptosis, proliferation, stimulation of cytokine production, and cell transformation. Some of these processes are initiated as a result of the activation of signaling mechanisms activated on binding of H. pylori to cell surface receptors or via soluble virulence factors that gain access to the epithelium. The multiple responses by the epithelium to the infection contribute to pathogenesis associated with H. pylori. | Shatha Alzahrani Taslima T Lina Jazmin Gonzalez Irina V Pinchuk Ellen J Beswick Victor E Reyes | 2014 | World Journal of Gastroenterology2014，20，36： | 15 |
| 2 | Immune evasion strategies used by Helicobacter pylori显示文摘Helicobacter pylori(H. pylori) is perhaps the most ubiquitous and successful human pathogen, since it colonizes the stomach of more than half of humankind. Infection with this bacterium is commonly acquired during childhood. Once infected, people carry the bacteria for decades or even for life, if not treated. Persistent infection with this pathogen causes gastritis, peptic ulcer disease and is also strongly associated with the development of gastric cancer. Despite induction of innate and adaptive immune responses in the infected individual, the host is unable to clear the bacteria. One widely accepted hallmark of H. pylori is that it successfully and stealthily evades host defense mechanisms. Though the gastric mucosa is well protected against infection, H. pylori is able to reside under the mucus, attach to gastric epithelial cells and cause persistent infection by evading immune responses mediated by host. In this review, we discuss how H. pylori avoids innate and acquired immune response elements, uses gastric epithelial cells as mediators to manipulate host T cell responses and uses virulence factors to avoid adaptive immune responses by T cells to establish a persistent infection. We also discuss in this review how the genetic diversity of this pathogen helps for its survival. | Taslima T Lina Shatha Alzahrani Jazmin Gonzalez Irina V Pinchuk Ellen J Beswick Victor E Reyes | 2014 | World Journal of Gastroenterology2014，20，36： | 7 |
| 3 | Identification of wheat alien chromosome addition lines for breeding wheat with high phosphor- us efficiency显示文摘 | Shiwen W Lina Y Hiroyuki T | 2010 | Breeding Sei2010，60，： | 1 |
| 4 | Development of new features of ant colony optimization for flowshop scheduling显示文摘 | LUB C Y SHYUC S J | 2008 | International Journal of Production Economics2008，112，2： | 1 |
| 5 | Attenuation relations of Arias intensity based on the Chi-Chi Taiwan earthquake data 显示文摘 | HWANGA H LINA C K YEHB Y T CHENGB S N CHENC K C | 2004 | Soil Dynamics and Earthquake Engineering2004，24，7： | 1 |
| 6 | Nanosized ALPO4-5 molecular sieves and ultrathin films prepared by microwave synthesis 显示文摘 | Mintova S Bein T Lina L | 1998 | Chemistry of Materials1998，10，： | 1 |
| 7 | Novel anti-inflammatory actions of nobiletin, a citrus polymethoxy flavonoid, on human synovial fibroblasts and mouse macrophages 显示文摘 | Lina N Satoa T Takayamaa Y | 2003 | Biochem Pharm2003，65，12： | 1 |
| 8 | A case study in a two-stage hybrid flow shop with setup time and dedicated machines显示文摘 | LINA H T LIAO C J | 2003 | International Journal of Production Economics2003，86，： | 1 |
| 9 | Shear and elongational flow properties of contents and degrees of polymerization显示文摘 | Lina C A Kub T H | 2008 | Journal of Materials Processing Technology2008，200，2： | 1 |
| 10 | Analysis of the genetic variability of genes encoding the RNA hi-activating compo- nents Agr and TRAP in a population of Staphylococcus aureus strains isolated from cows with mastitis 显示文摘 | Gilot P Lina G Cochard T | 2002 | J Clin Microbi- ol2002，40，11： | 1 |
| 11 | Comparison of EKF, Pseudomeasurement and Particle Filters for a Bearing-only Target Tracking Problem 显示文摘 | X Lina T Kirubarajan Y BarSha-kloma | 2002 | Signal and Data Processing of Small Tar- gets2002，4728，： | 1 |
| 12 | Compu- tation of minimal event bases that ensure diagnosability显示文摘 | BASILIO J C LINA S T S LAFORTUNE S etal | 2012 | Discrete Event Dynamic Synst2012，，： | 1 |
| 13 | Novel anti- inflammatory actions of nobiletin, a citrus polymethoxy flavonoid, on human synovial fibroblasts and mouse macrophages显示文摘 | LINA N SATOA T TAKAYAMAA Y | 2003 | Biochem Pharmacol2003，65，12： | 1 |
| 14 | A Two-Machine Flow Shop Problem with Processing Time-Dependent Buffer Constraints-An Application in Multimedia Presentations显示文摘 | Feng-Cheng Lina Jen-Shin Hong Bertrand M T Lin | 2009 | Computers and Operations Research2009，36，11： | 1 |
| 15 | Analysis of the geneticvariability of genes encoding the RNA III-activating compo-nents agr and TRAP in a population of Staphylococcus aureusstrains isolated from cows with mastitis显示文摘 | Gilot P Lina G Cochard T | 2002 | J Clin Microbiol2002，40，11： | 1 |
| 16 | Mycobacterium tuberculosis infects dendritic cells with high frequency and impairs their function in vivo 显示文摘 | Wolf AJ Linas B Trevejo-Nunez GJ Kincaid E Tamura T Takatsu K Ernst JD | 2007 | Immunol2007，179，： | 1 |
| 17 | Physicochemical properties and antitumor activities of water-soluble native and sulfated hyperbranched mushroom polysaccharides显示文摘 | Yon Z T Lina Z h Peter C K | 2006 | Carbohydr Res2006，341，： | 1 |
| 18 | 查看详情显示文摘 | Lina G Jarraud S Ji G Greenland T Pedraza A Etienne J Novick R.P.:Vandenesch F | | 0，，： | 1 |
| 19 | Pathophysiology of hypertension during preeclampsia linking placental ischemia with endothelial dysfunction显示文摘 | Granger J P Alexander B T Linas M T | 2001 | Hypertension2001，38，32： | 1 |
| 20 | 查看详情显示文摘 | Lina L Weichen L Takayama t | | 0，，： | 1 |
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