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| 1 | Up-regulation of PIK3CA promotes metastasis in gastric carcinoma显示文摘AIM:To explore expressions of PIK3CA in the progression of gastric cancer from primary to metastasis and its effects on activation of phosphatidylinositol 3-kinase(PI3K)/Akt pathway.METHODS:mRNA and protein levels of PIK3CA were assessed,respectively,by real-time quantitative polymerase chain reaction and immunohistochemistry in specimens of normal gastric mucosa,primary foci and lymph node and distant metastasis of gastric cancer.Akt and phosphorylated Akt protein were also examined by Western blotting in these tissues,in order to analyze the effect of PIK3CA expression level changes on the activation of PI3K/Akt signaling pathway.RESULTS:PIK3CA mRNA in lymph node metastasis were approximately 5 and 2 folds higher,respectively,than that in the corresponding normal gastric mucosa and primary gastric cancer tissues(P<0.05),while no statistical significance was found compared with distant metastasis.Immunohistochemically,PIK3CA protein expression was discovered in 7(35%)specimens of 20 primary foci vs 10(67%)of 15 of lymph node metastasis or 11(61%)of 18 of distant metastasis(35%vs 67%,P=0.015;35%vs 61%,P=0.044).With the increased level of PIK3CA expression,the total Akt protein expression remained almost unchanged,but p-Akt protein was upregulated markedly.CONCLUSION:Increased expression of PIK3CA is expected to be a promising indicator of metastasis in gastric cancer.Up-regulation of PIK3CA may promote the metastasis of gastric cancer through aberrant activation of PI3K/Akt signaling. | Liu JF Zhou XK Chen JH Yi G Chen HG Ba MC Lin SQ Qi YC. | 2010 | World Journal of Gastroenterology2010，16，39： | 20 |
| 2 | 急性缺血性脑卒中后低脉压与不良预后相关显示文摘众所周知,脉压与心脏功能、动脉僵硬度、体液状态和血管事件有关。该研究旨在探讨基于中国台湾地区脑卒中登记资料的急性缺血性脑卒中(acute ischemic stroke,AIS)患者入院时脉压的预后作用。 | 刘莉 叶鹏 Tang SC Yin JH Liu CH Sun MH Lee JT Sun Y Hsu CS Sun MC Lin CH Chen CH Lien LM Muo CH Jeng JS Hsu CY | 2017 | 中华高血压杂志2017，25，7： | 5 |
| 3 | Altered PTEN expression as a diagnostic marker for the earliest endometrial precancers显示文摘 | Mutter GL Lin MC Fitzgerald JT | 2000 | J Natl Cancer Insr2000，92，11： | 2 |
| 4 | Biodegradation kinetics and microbial communities associated with methyl tert-butyl ether removal in a biotrickling filter显示文摘 | Lin CW Lin NC Liu MC | 2007 | 中国生物学文摘2007，21，7： | 2 |
| 5 | Increased frequency of angiotensin-converting enzyme DD genotype in patients with type 2 diabetes in Taiwan 显示文摘 | Heieh MC Lin SR Hsieh TJ | 2000 | Nephrol Dial Transplant2000，15，7： | 1 |
| 6 | Insulin and glucagon independent effects of calcitonin gene-related peptide in the conscious dog显示文摘 | Lin DW Colburn CA | 1999 | Metabolism1999，48，5： | 1 |
| 7 | Outcome of Pulmonary Multidrug-Resistant Tuberculosis: a 6-yr Follow-up Study显示文摘 | Chiang CY Enarson DA Yu MC Bai KJ Huang RM Hsu CJ Suo J Lin TP | 2006 | Eur Respir J2006，28，5： | 1 |
| 8 | Altered PTEN expression as a diagnostic marker for the earliest endometrial precancers显示文摘 | Mutter GL Lin MC Fitzgerald JT | 2000 | J Natl Cancer Insr2000，92，： | 1 |
| 9 | Manifested strabismus in a case of Apert syndrome显示文摘 | Hsu CM Lin MC Sheu SJ | 2011 | J Chin Med Assoc2011，74，2： | 1 |
| 10 | Oral health knowledge, attitudes, and practices of Chinese adults显示文摘 | Lin HC Wong MC Wang ZJ | 2001 | J Dent Res2001，80，5： | 1 |
| 11 | Phase Ⅱ trial of lapatine for brain metastases in patients with human epidermal growth factor receptor-2 positive with breast cancer 显示文摘 | Lin NU Carey LA Liu MC | 2008 | J Clin Oncol2008，26，12： | 1 |
| 12 | Altered PTEN epression as a diagnostic marker for the earlist endometrial precancers 显示文摘 | Mutter GL Lin MC Fitzgerald JT | 2000 | J Natl Cancer Inst2000，92，11： | 1 |
| 13 | Worldwide Nanotech- nology Development: A Comparative Study of USPTO, EPO, and JPO Patents ( 1976 - 2004) 显示文摘 | Li X Lin Y Chen H Roco MC | 2007 | Journal of Nanoparticle Research2007，9，6： | 1 |
| 14 | Mortality risk factors in patients with Acinetobacter baumannii ventilator-associated pneumonia显示文摘 | Chang HC Chen YC Lin MC | 2011 | J Formos Med Assoc2011，110，9： | 1 |
| 15 | Apigenin induces apoptosis through proteasomal degradation of HER2/neu in HER2/neu-overexpressing breast cancer cells via the phosphatidy-linositol 3-kinase/Akt-dependent pathway显示文摘 | Way TD Kao MC Lin JK | 2004 | J Biol Chem2004，279，6： | 1 |
| 16 | Diaphragm sarcolemmal injury is induced by sepsis and alleviated by nitric oxide synthase inhibition显示文摘 | Lin MC Ebihara S El Dwairi Q | 1998 | Am J Respir Crit Care Med1998，158，51： | 1 |
| 17 | Antiangiogenic potential of three triterpenic acids in human liver cancer cells显示文摘 | Lin CC Huang CY Mong MC | 2011 | J Agric Food Chem2011，59，2： | 1 |
| 18 | Phase Ⅱ trial of lapa- tinib for brain metastases in patients with HER2-positive breast cancer显示文摘 | Lin NU Carey LA Liu MC | 2006 | J Clin Oncol2006，24，318： | 1 |
| 19 | Serum uric acid levels inpatients with cirrhosis : a reevaluation 显示文摘 | Lee WC Lin HC Hou MC | 1999 | J Clin Gastroenterol1999，29，3： | 1 |
| 20 | Relationships between factor Ⅷ: Ag and factor Ⅷ in recombinant and plasma-derived factor Ⅷ concentrates 显示文摘 | Lin Y Yang X Chevrier MC | 2004 | Haemophilia2004，10，5： | 1 |
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