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| 1 | Systematic review and meta-analysis of esophageal cancer in Africa:Epidemiology, risk factors, management and outcomes显示文摘BACKGROUND Esophageal cancer(EC)is associated with a poor prognosis,particularly so in Africa where an alarmingly high mortality to incidence ratio prevails for this disease.AIM To provide further understanding of EC in the context of the unique cultural and genetic diversity,and socio-economic challenges faced on the African continent.METHODS We performed a systematic review of studies from Africa to obtain data on epidemiology,risk factors,management and outcomes of EC.A non-systematic review was used to obtain incidence data from the International Agency for Research on Cancer,and the Cancer in Sub-Saharan reports.We searched EMBASE,PubMed,Web of Science,and Cochrane Central from inception to March 2019 and reviewed the list of articles retrieved.Random effects metaanalyses were used to assess heterogeneity between studies and to obtain odds ratio(OR)of the associations between EC and risk factors;and incidence rate ratios for EC between sexes with their respective 95%confidence intervals(CI).RESULTS The incidence of EC is higher in males than females,except in North Africa where it is similar for both sexes.The highest age-standardized rate is from Malawi(30.3 and 19.4 cases/year/100000 population for males and females,respectively)followed by Kenya(28.7 cases/year/100000 population for both sexes).The incidence of EC rises sharply after the age of 40 years and reaches a peak at 75 years old.Meta-analysis shows a strong association with tobacco(OR 3.15,95%CI:2.83-3.50).There was significant heterogeneity between studies on alcohol consumption(OR 2.28,95%CI:1.94-2.65)and on low socioeconomic status(OR 139,95%CI:1.25-1.54)as risk factors,but these could also contribute to increasing the incidence of EC.The best treatment outcomes were with esophagectomy with survival rates of 76.6%at 3 years,and chemo-radiotherapy with an overall combined survival time of 267.50 d.CONCLUSION Africa has high incidence and mortality rates of EC,with preventable and nonmodifiable risk factors.Men in this setting are at increased risk due to their higher prevalence of tobacco and alcohol consumption.Management requires a multidisciplinary approach,and survival is significantly improved in the setting of esophagectomy and chemoradiation therapy. | Akwi W Asombang Nathaniel Chishinga Alick Nkhoma Jackson Chipaila Bright Nsokolo Martha Manda-Mapalo Joao Filipe G Montiero Lewis Banda Kulwinder S Dua | 2019 | World Journal of Gastroenterology2019，25，31： | 9 |
| 2 | 抑制平滑肌的张力收缩:一种治疗勃起功能障碍的新途径显示文摘阴茎海绵体血管的收缩及张力的维持是由钙敏感的RhoA/Rho激酶信号传导途径介导的。以Y 2 76 32抑制海绵体平滑肌细胞的Rho激酶信号系统可促进阴茎勃起 ,表现为海绵体内压 (ICP)明显升高 ,而平均动脉压 (MAP)变化不显著。为什么在血管收缩信号很强的情况下性刺激仍能引发阴茎勃起反应 ?我们设想体内一氧化氮 (NO)能直接抑制RhoA/Rho激酶途径的活性 ,减少血管张力 ,促使血管舒张 ,勃起发生 ,使用Y 2 76 32可以恢复性腺功能低下和高血压病动物ED模型的阴茎勃起功能 ,这表明抑制Rho激酶活性药物具有临床应用的前景。此外 ,我们的结果显示阴茎表面使用Rho激酶抑制剂可能为ED治疗的有效方法之一。 | 戴玉田 Thomas M MILLS Ronald W LEWIS RClinton WEBB | 2002 | 中华男科学杂志2002，8，6： | 8 |
| 3 | Epidemiology of Sexual dysfunction in Asia compared to the rest of the world显示文摘在那里,一小部分流行病学的研究从亚洲在人在性混乱上被出版了。这篇论文试图估计流行病学的研究用包含了亚洲国家的英语语言出版了的性机能障碍的报告。关键点从用英语语言被出版的亚洲在性机能障碍上从九篇流行病学的论文在这篇论文被总结。七为到达至少 10 的一个 Prins 分数或更多的基于证据的研究满足了标准。在这份报告包括的报纸在同伴评论杂志来自国家、地区性的代表性的研究。在九份报纸的性机能障碍的这些结果在亚洲国家在男人和女人为各种各样的性机能障碍被总结。在这些中的三个,世界范围的数据在在流行率上与亚洲数据允许比较的一样的纸被介绍。从每这些研究的详细描述在段形式被介绍。可勃起的机能障碍(编辑) 上的更多的详细数据在一种平坦形式被介绍。一起,似乎是对在所有从亚洲的性混乱的国家特定、人口特定的进一步描述、分析的流行病学的研究的需要。这份批评评论报纸应该帮助为到达基于证据的文学标准指导这些研究。 | Ronald W Lewis | 2011 | Asian Journal of Andrology2011，13，1： | 6 |
| 4 | Pancreatic cancer: Are 'liquid biopsies' ready for prime-time?显示文摘Pancreatic cancer is a disease that carries a poor prognosis. Accurate tissue diagnosis is required. Tumours contain a high content of stromal tissue and therefore biopsies may be inconclusive. Circulating tumour cells(CTCs) have been investigated as a potential 'liquid biopsy' in several malignancies and have proven to be of prognostic value in breast, prostate and colorectal cancers. They have been detected in patients with localised and metastatic pancreatic cancer with sensitivities ranging from 38%-100% using a variety of platforms. Circulating tumour DNA(ct DNA) has also been detected in pancreas cancer with a sensitivity ranging from 26%-100% in studies across different platforms and using different genetic markers. However, there is no clear consensus on which platform is the most effective for detection, nor which genetic markers are the most useful to use. Potential roles of liquid biopsies include diagnosis, screening, guiding therapies and prognosis. The presence of CTCs or ct DNA has been shown to be of prognostic value both at diagnosis and after treatment in patients with pancreatic cancer. However, more prospective studies are required before this promising technology is ready for adoption into routine clinical practice. | Alexandra R Lewis Juan W Valle Mairead G Mc Namara | 2016 | World Journal of Gastroenterology2016，22，32： | 5 |
| 5 | Intensive blood pressure reduction in acute cerebral haemorrhage trial (INTERACT): a randomised pilot trial显示文摘 | Craig S Anderson Yining Huang Ji Guang Wang Hisatomi Arima Bruce Neal Bin Peng Emma Heeley Christian Skulina Mark W Parsons Jong Sung Kim Qing Ling Tao Yue Chun Li Jian Dong Jiang Li Wen Tai Jin Li Zhang En Xu Yan Cheng Stephane Heritier Lewis B Morgenste | 2008 | Lancet Neurology2008，，5： | 4 |
| 6 | 艾滋病的心肌病变:致病机理探讨显示文摘艾滋病的心肌病变正日益为人重视,本研究就128例尸检及原位杂交结果,结合文献复习,提出艾滋病心肌炎和充血性心肌病(C0CM)与人免疫缺陷病毒(HIV)直接感染心肌有关,抗逆转录病毒药物治疗也参与了艾滋病C0CM的发病过程。 | Lewis W 李武 | 1993 | 国外医学(心血管疾病分册)1993，20，2： | 2 |
| 7 | Necessary and sufficient for delayindependent stability of linear autonomous system显示文摘 | LEWIS R W ANDSON B D O | 1980 | IEEE Trans on Automat Contr1980，25，： | 2 |
| 8 | Adaptive fuzzy logic control of discrete-time dynamical systems 显示文摘 | Jagannathan A Vandegrift M W Lewis F L | 2000 | Automatica2000，36，2： | 2 |
| 9 | Synthesis of new bis (acetylide)-substituted fluorene derivatives and their bimetallic and polymeric complexes显示文摘 | Lewis J Raithby P R Wong W Y | 1998 | J Organomet Chem1998，556，： | 1 |
| 10 | New Triterpenoid Extractives from Lemaireocereus chichipe显示文摘 | Khong P W Lewis K G | 1975 | Aust J Chem1975，28，： | 1 |
| 11 | Metal enrichment in bauxites by deposition of chemically mature aeoli- an dust 显示文摘 | Brimhall G H Lewis X J Ague J J Detroit W E Hanpel J Rix P | 1988 | Nature1988，333，： | 1 |
| 12 | Dynamic relaxation analysis of the non- linear static response of pretensioned cable roofs 显示文摘 | Lewis W J | 1984 | Computer and Structures1984，18，6： | 1 |
| 13 | Monitoring the total phenolic/antioxidant levels in wine using flow injection analysis with acidic potassium permanganate chemiluminescence detection 显示文摘 | COSTIN J W BARNETT N W LEWIS S W | 2003 | AnalChimActa2003，499，： | 1 |
| 14 | Light-induced vegetative anthoeyanin pigmentation in Petunia显示文摘 | Albett N W Lewis D H Zhang H | 2009 | J Exp Bot2009，60，7： | 1 |
| 15 | Active magnetic control of oscillatory axial shaft vibrations in ship shaft transmission systems part 1 : System natural frequencies and Laboratory scale model显示文摘 | LEWIS D W ALLAIRE P E | 1989 | Tribology transactions1989，32，2： | 1 |
| 16 | Knee joint motion and ligament forces before and after ACL reconstruction 显示文摘 | Lewis J L Lew W D Hill J A | 1989 | Journal of Biomechanical Engineering1989，111，： | 1 |
| 17 | Associated and non-associated visco-plasticity and plasticity in soil mechanics显示文摘 | Zienkiewicz O C Humpheson C Lewis R W | 1975 | Geostechnique1975，25，4： | 1 |
| 18 | A New Autoregressive Time Series Model in Exponential Variables (NEAR (1) 显示文摘 | LAWRANCE A J LEWIS P A W | 1981 | Advances in Applied Probability1981，13，： | 1 |
| 19 | A finite element model of the squeeze casting process 显示文摘 | Lewis R W Ravindran K | 2006 | International Journal of Numerical Methods for Heat & FluidFlow2006，16，5： | 1 |
| 20 | The Effect of Ceramic Fiber Coatings on the Room-Temperature Mechanical Behavior of Ceramic?Fiber Composites显示文摘 | R W Rice J R Spann D Lewis | 1984 | Ceramic Engineering and Science Proceedings1984，5，78： | 1 |
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