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| 1 | Dynamic chromatin states in human ES cells reveal potential regulatory sequences and genes involved in pluripotency显示文摘Pluripotency,一个细胞的能力区分并且产生所有胚胎的系,定义象胚胎的茎(ES ) 那样的哺乳动物的细胞类型的一个小数字细胞。当它通常被保持了时,那 pluripotency 是 transcriptional 的产品激活并且维持关键干细胞基因的表达式的规章的网络,积累的证据在建立并且保卫 ES 房间的 pluripotency 为 epigenetic 进程正在指向一个关键角色,象维持区分的房间类型的身份一样。以便更好在 pluripotency 理解 epigenetic 机制的角色,我们检验了在经历区别进一个 mesendodermal 系的人的 ES 房间(hESCs ) 染色体宽的染色质修正的动力学。我们发现在倡导者的染色质修正在区别期间仍然保持大部分不变,除了在在在 H3K27 的 acetylation 和 methylation 之间的一个动态开关标记在基因表示的激活和 silencing 之间的转变的倡导者的一个小数字,建议在在大多数差别上的房间命运承诺的一个层次表示了基因。我们也在 50 000 潜在的 enhancers 上印射,并且在染色质修正,特别 H3K4me1 和 H3K27ac 观察了大得多的动力学,它与他们的潜在的目标基因的表示相关。这些 enhancers 的进一步的分析揭示了 pluripotency 和可以在 hESCs 授与发展胜任的一个平衡状态的一口染色质签名陈述语气的潜在地关键的 transcriptional 管理者。我们的结果提供在定义 enhancers 和 pluripotency 支持染色质修正的角色的新证据。 | R David Hawkins Gary C Hon Chuhu Yang Jessica E Antosiewicz-Bourget Leonard K Lee Que-Minh Ngo Sarit Klugman Keith A Ching Lee E Edsall Zhen Ye Samantha Kuan Pengzhi Yu Hui Liu Xinmin Zhang Roland D Green Victor V Lobanenkov Ron Stewart James A Thomson Bing Ren | 2011 | Cell Research2011，21，10： | 6 |
| 2 | Season of the year influences infection rates following total hip arthroplasty显示文摘AIM To research the influence of season of the year on periprosthetic joint infections.METHODS We conducted a retrospective review of the entire Medicare files from 2005 to 2014. Seasons were classified as spring, summer, fall or winter. Regional variations were accounted for by dividing patients into four geographic regions as per the United States Census Bureau(Northeast, Midwest, West and South). Acute postoperative infection and deep periprosthetic infections within 90 d after surgery were tracked. RESULTS In all regions, winter had the highest incidence of periprosthetic infections(mean 0.98%, SD 0.1%) and was significantly higher than other seasons in the Midwest, South and West(P < 0.05 for all) but not the Northeast(P = 0.358). Acute postoperative infection rates were more frequent in the summer and were significantly affected by season of the year in the West.CONCLUSION Season of the year is a risk factor for periprosthetic joint infection following total hip arthroplasty(THA). Understanding the influence of season on outcomes following THA is essential when risk-stratifying patients to optimize outcomes and reduce episode of care costs. | Samuel Rosas Alvin C Ong Leonard T Buller Karim G Sabeh Tsun yee Law Martin W Roche Victor H Hernandez | 2017 | World Journal of Orthopedics2017，8，12： | 4 |
| 3 | 青少年甘油磷酸胆碱代谢和心血管病的危险因素:一项队列研究显示文摘甘油磷酸胆碱(glycerophosphocholine,GPC)代谢物可调节动脉粥样硬化,从而导致心血管病风险。临床前期心血管病可能从青春期就开始。研究人员应用靶向血清脂质组学鉴定一组新的GPC,并测试在青春期时这些GPC中的任何一种是否与心血管病传统危险因子,如过量内脏脂肪、升高的血压、胰岛素抵抗和致动脉粥样硬化血脂异常相关。 | Syme C Czajkowski S Shin J Abrahamowicz M Leonard G Perron M Richer L Veillette S Gaudet D Strug L Wang Y Xu H Taylor G Paus T Bennett S Pausova Z 刘莉 叶鹏 | 2016 | 中华高血压杂志2016，24，10： | 3 |
| 4 | Overexpression of ErbB2 enhances ethanol-stimulated intracellular signaling and invasion of human mammary epithelial and breast cancer cells in vitro显示文摘 | Ma C Lin H Leonard SS | 2003 | Oncogene2003，22，34： | 2 |
| 5 | Sentinel node localization should be interpreted with caution in midline vulvar cancer显示文摘 | Louis-Sylvestre C Evangelista E Leonard F | 2005 | Gynecol Oncol2005，97，： | 1 |
| 6 | Widespread origins of domestic horse lineages显示文摘 | VILA C LEONARD J A GOTHERSTROM A | 2001 | Science2001，291，5503： | 1 |
| 7 | Mesoscopic structureand viscoelastic properties of β-1actoglobulin gels at low pH and low ionic strength 显示文摘 | Leonard M C Cecile V Renate G | 2002 | Food Hydrocolloids2002，16，3： | 1 |
| 8 | Patent duetus arteriosus and its treatment as risk factors for neonatal and neurodevelopmental morbidity显示文摘 | Chorne N Leonard C Piecueh R | 2007 | Pediatrics2007，119，： | 1 |
| 9 | Resveratrol scavenges reactive oxygen species and effects radical-induced cellular responses显示文摘 | Leonard SS Xia C Jiang BH | 2003 | Biochem Biophys Res Commun2003，309，： | 1 |
| 10 | Polyvinyl alcohol-coated macroporous polystyrene particles as stationary phases for the chromatography of protein 显示文摘 | Leonard M Fournier C Dellacherie E | 1995 | Journal of Chromatography B1995，664，： | 1 |
| 11 | An assessment of the effects of central interleukin-Ibeta,-2,-6and tumor necrosis factor-alpHa administration on some behavioural,neurochemical,endocrine and immune parameters in the rat显示文摘 | Connor TJ Song C Leonard BE et a1 | 1998 | Neuroscience1998，84，3： | 1 |
| 12 | Fibrilassemblies in aqueous whey protein mixtures显示文摘 | Bolder S G Hendrickx H Leonard M C S | 2006 | Journal of Agricultural and Food Chemistry2006，54，12： | 1 |
| 13 | Subpicosecond spin relaxation in GaAsSb multiple quantum wells显示文摘 | Hall K C Leonard S W Direl H M | 1999 | Appl Phys Lett1999，75，： | 1 |
| 14 | Derivatives of β-phenylethylamines显示文摘 | Buck J Leonard C Rhodanines I | | 0，，： | 1 |
| 15 | Efficacy of preoperative autologous blood donation for elective posterior lumbar spinal surgery显示文摘 | Kennedy C Leonard M Devitt A | | 0，，1976： | 1 |
| 16 | Regulation of nitrite reductase 显示文摘 | Subhash C Gupta Leonard Beevers | 1987 | Plant Physiology1987，，83： | 1 |
| 17 | Cyclic AMP-dependent protein kinase and protein kinase C phosphorylate N-methyl-D-aspartate receptors at different sites显示文摘 | Leonard C Hell JW | 1997 | J Biol Chem1997，272，12： | 1 |
| 18 | An assess-ment of the effects of central interleukin-1茁,-2,-6and tumornecrosis factor alpha administration on some behaviouralneurochemical endocrine and immune parameters in the rat显示文摘 | CONNOR T J SONG C LEONARD B E | 1998 | Neuroscience1998，84，3： | 1 |
| 19 | Rapid detection of the staphylococcal mecA gene from BACTEC blood culture bottles by the polymerase chain reaction 显示文摘 | Carroll K C Leonard R B Newcomb-Gayman P L | 1996 | Am J Clin Pathol1996，106，5： | 1 |
| 20 | Potentiation of glueocortieoid activity in hypoxia through induction of the glucocorticoid receptor 显示文摘 | Leonard NO Godson C Brady HR | 2005 | J Immunol2005，174，4： | 1 |
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