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| 1 | Development of hepatorenal syndrome in bile duct ligated rats显示文摘AIM: To evaluate in bile duct ligated rats whether there were progressive alterations of renal function without changes in histopathology. METHODS: Male Wistar rats were submitted to sham-surgery or bile duct ligation (BDL) and divided according to the post-procedure time (2, 4 and 6-wk). To determine renal function parameters, rats wereplaced in metabolic cages and, at the end of the experiment, blood and urine samples were obtained. Histology and hydroxyproline content were analyzed in liver and renal tissue. RESULTS: Rats with 2 wk of BDL increased free water clearance (P = 0.02), reduced urinary osmolality (P = 0.03) and serum creatinine (P = 0.01) in comparison to the sham group. In contrast, rats at 6 wk of BDL showed features of HRS, including signif icant increase in serum creatinine and reductions in creatinine clearance, water excretion and urinary sodium concentration. Rats with 4 wk of BDL exhibited an intermediate stage of renal dysfunction. Progressive hepatic f ibrosis according to post-procedure time was confirmed by histology. The increased levels of liver hydroxyproline contrasted with the absence of structural changes in the kidney, as assessed by histology and unchanged hydroxyproline content in renal tissue. CONCLUSION: Our data show that BDL produced progressive renal dysfunction without structural changes in the kidney, characterizing HRS. The present model will be useful to understand the pathophysiology of HRS. | Regina M Pereira Robson AS dos Santos Eduardo A Oliveira Virgínia HR Leite Filipi LC Dias Alysson S Rezende Lincoln P Costa Lucíola S Barcelos Mauro M Teixeira Ana Cristina Sim■es e Silva | 2008 | World Journal of Gastroenterology2008，14，28： | 2 |
| 2 | Probabilistic wind farms generation model for reliability studies applied to brazilian sites显示文摘 | Leite A P Borges C L T Falcao D M | 2006 | IEEE Trans on Power Systems2006，21，4： | 1 |
| 3 | Fewer thymic changes in MuSK antibody-positive than in MuSK antibody-negative MG 显示文摘 | Leite MI Strobel P Jones M | 2005 | Ann Neurol2005，57，3： | 1 |
| 4 | Preparation and characterization of ethanol-treated silk fibroin dense membranes for biomaterials application using waste silk fibers as raw material显示文摘 | NOGUEIRA G M RODAS A C D LEITE C A P | 2010 | Bio-Resource Technology2010，101，21： | 1 |
| 5 | Biosorption of copper by Paenibacillus polymyxa cells and their exopolysaccharide 显示文摘 | ACOSTA M P VALAMAN E LEITE S G F | 2005 | World Jouranal of Microbiology & Biotechnology2005，21，： | 1 |
| 6 | Symptomatic cysts of the cavum septi pellucidi and cavum vergae: The role of endoscopic neurosurgery in the treatment of four consecutive cases 显示文摘 | Fratzoglou M Grunert P Leite dos Santos A | 2003 | Minim Invasive Neurosurg2003，46，： | 1 |
| 7 | Seasonal dynamics of the Cayenne tick,Amblyomma cajennense on horses in Brazil显示文摘 | Oliveim P R Borges L M Leite R C | | 0，，04： | 1 |
| 8 | Evaluation of Mechanical Properties of Concrete with Copper Slag as Fine Aggregate 显示文摘 | Moura W A Goncalves J P Leite M B | 2009 | Rem-Revista Escola de Minas2009，62，2： | 1 |
| 9 | Disturbance decoupling in decentralized linear systems by nondynamic feedback of state or measurement 显示文摘 | LEITE V M P | 1985 | Int J Control1985，42，4： | 1 |
| 10 | The influence of sintering process and atmosphere on the non-ohmic properties of SnO2-based varistor 显示文摘 | Leite E R Nascimento A M Bueno P R | 1999 | J Mater Sci Mater Electr1999，10，： | 1 |
| 11 | Nutritional intake and bone mineral density in female adolescents显示文摘 | Leite M Padrao P | 2007 | Acta Med Port2007，20，4： | 1 |
| 12 | Biological and methodo- logical features of the measurement of S100B, a putative marker of brain injury显示文摘 | Goncalves C A Leite M C Nardin P | 2008 | Clin Biochem2008，41，1011： | 1 |
| 13 | The renin-angiotensin system in a rat model of hepatic fibrosis: evidence for a protective role of Angiotensin-(1-7) 显示文摘 | Pereira R M Dos Santos R A Teixeira M M Leite V H Costa L P da Costa Dias F L | 2007 | J Hepatol2007，46，： | 1 |
| 14 | Anti-inflammatory properties of extracts,fractions and lignans iso- lated from Phyllanthus arrtarus 显示文摘 | KASSUYA C A L LEITE D F P LUCILIA V D M | 2005 | Planta Medica2005，71，8： | 1 |
| 15 | Probabilistic Load Flow Techniques Applied to Power System Expansion Planning 显示文摘 | Leite da Silva A M Ribeiro S M P Allan R N | 1990 | IEEE Transactions on Power Systems1990，5，4： | 1 |
| 16 | Papillary thyroid carcinoma of childhood and adolescence: a 30-year experience at the Istituto Nazionale Tumori in Milan 显示文摘 | Collini P Massimino M Leite SF | 2006 | Pediatr Blood Cancer2006，46，3： | 1 |
| 17 | Biological and methodo-logical features of the measurement of S100B,aputative marker of brain injury显示文摘 | Gonalves C A Leite M C Nardin P | 2008 | Clin Biochem2008，41，1011： | 1 |
| 18 | The influence of sintering process and atmosphere on the nonOhmic properties of SnO2 based varistor 显示文摘 | Nascimento A M Bueno P R | 1999 | J Mater Sci Mater Electr1999，10，4： | 1 |
| 19 | Enhancing effect of lysine combined with other compounds on cephamycin C production in Streptomyces clavuligerus显示文摘 | Leite C A Cavallieri A P Araujo M | 2013 | BMC Microbiol2013，13，： | 1 |
| 20 | Online topology determination and bad data suppression in power system operation using artificial neural networks 显示文摘 | Souza J C S Leite da Silva A M Alves da Silva A P | 1998 | IEEE Transactions on Power Systems1998，13，3： | 1 |
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