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| 1 | Immunogenetic factors driving formation of ultralong VH CDR3 in Bos taurus antibodies显示文摘The antibody repertoire of Bos taurus is characterized by a subset of variable heavy(VH)chain regions with ultralong third complementarity determining regions(CDR3)which,compared to other species,can provide a potent response to challenging antigens like HIV env.These unusual CDR3 can range to over seventy highly diverse amino acids in length and form uniqueβ-ribbon‘stalk’and disulfide bonded‘knob’structures,far from the typical antigen binding site.The genetic components and processes for forming these unusual cattle antibody VH CDR3 are not well understood.Here we analyze sequences of Bos taurus antibody VH domains and find that the subset with ultralong CDR3 exclusively uses a single variable gene,IGHV1-7(VHBUL)rearranged to the longest diversity gene,IGHD8-2.An eight nucleotide duplication at the 3′end of IGHV1-7 encodes a longer V-region producing an extended Fβ-strand that contributes to the stalk in a rearranged CDR3.A low amino acid variability was observed in CDR1 and CDR2,suggesting that antigen binding for this subset most likely only depends on the CDR3.Importantly a novel,potentially AID mediated,deletional diversification mechanism of the B.taurus VH ultralong CDR3 knob was discovered,in which interior codons of the IGHD8-2 region are removed while maintaining integral structural components of the knob and descending strand of the stalk in place.These deletions serve to further diversify cysteine positions,and thus disulfide bonded loops.Hence,both germline and somatic genetic factors and processes appear to be involved in diversification of this structurally unusual cattle VH ultralong CDR3 repertoire. | Thaddeus C Deiss Melissa Vadnais Feng Wang Patricia L Chen Ali Torkamani Waithaka Mwangi Marie-Paule Lefranc Michael F Criscitiello Vaughn V Smider | 2019 | Cellular & Molecular Immunology2019，16，1： | 4 |
| 2 | Differential expression of S100 calcium-binding proteins characterizes distinct clinical entities in both WHO grade Ⅱ and Ⅲ astrocytic tumours显示文摘 | Camby I Lefranc F Titeca G | 2000 | Neuropathol Appl Neurobiol2000，26，1： | 2 |
| 3 | Monitoring the expression profiles of integrins and adhesion/growth-regulatory galeetins in adamantinomatous craniopharyngiomas: their ability to regulate tumor adhesiveness to surrounding tissue and their contribution to prognosis 显示文摘 | Lefranc F Mijatovic T Decaestecker C | 2005 | Neurosurgery2005，56，4： | 1 |
| 4 | 查看详情显示文摘 | Mijatovic T De Nève N Bruyère C Simon G Dewelle J Van Quaquebeke E Van Der A.E Van Vynckt F Lefranc F Kiss R | | 0，，： | 1 |
| 5 | Expression of members of the calcium-binding S-100 protein family in a rat model of cerebral basilar artery vasospasm显示文摘 | Lefranc F Golzarian J Chevalier C | 2002 | J Neurosurg2002，97，2： | 1 |
| 6 | Galectin-1:a small protein with major functions显示文摘 | Camby I Le Mercier M Lefranc F | 2006 | Glycobiology2006，16，11： | 1 |
| 7 | Galectin-l: a small protein with major functions显示文摘 | Camby I Le MM Lefranc F | 2006 | Glyeobiology2006，16，11： | 1 |
| 8 | Present and potential future adjuvant issues in high- grade astrocytic glioma treatment显示文摘 | LEFRANC F RYNKOWSKI M DEWITYE O | 2009 | Adv Tech Stand Neurosurg2009，34，： | 1 |
| 9 | Proautophagic drugs: a novel means to combat apoptosis-resistant cancers, with a special emphasis on glioblastornas 显示文摘 | LEFRANC F FACCHINI V KISS R | 2007 | Oncologist2007，12，12： | 1 |
| 10 | Naphthalimides and azonafides as promising anti-cancer agents显示文摘 | Ingrassia L Lefranc F Kiss R | 2009 | Curr Med Chem2009，16，10： | 1 |
| 11 | Epidural hematoma of the cervical spine:magnetic resonance imaging diagnosis and spontaneous resolution: case report 显示文摘 | Lefranc F David P Brotchi J | 1999 | Neurosurgery1999，44，： | 1 |
| 12 | Co-expression/co-location of S100 proteins (S100B,S100A1 and S100A2) and protein kinase C (PKC-beta,-eta and-zeta)in a rat model of cerebral basilar artery vasospasm显示文摘 | Lefranc F Decaestecker C Brotchi J | 2005 | Neuropathol ApplNeurobiol2005，31，6： | 1 |
| 13 | Targeting the alpha 1 subunit of the sodium pump to combol glioblastoma cells显示文摘 | Lefranc F Mijatovic T Kondo Y | 2008 | Nenrosurgery2008，62，1： | 1 |
| 14 | Proautophagic drugs: a novel means to combat apoptosis resistant cancers, with a special emphasis on glioblastomas 显示文摘 | Lefranc F Faechini V Kiss R | 2007 | Oncologist2007，12，2： | 1 |
| 15 | Differential expression of SIO0 calcium- binding proteins in epidermoid cysts, branchial cysts, craniopharyngiomas and cholesteatomas 显示文摘 | Pelc P Vanmuylder N Lefranc F | 2003 | Histopathology2003，42，4： | 1 |
| 16 | Galectin-1: a small protein with major functions显示文摘 | Camby I Le Mercier M Lefranc F | 2006 | Glycobiology2006，16，11： | 1 |
| 17 | Galectin-1: a small protein with major functions显示文摘 | Camby I Le Mercier M Lefranc F | 2006 | Glycobiology2006，16，11： | 1 |
| 18 | Anti-galectin compounds as potential anti-cancer drugs显示文摘 | Ingrassia L CambY I Lefranc F | 2006 | Curr Med Chem2006，13，： | 1 |
| 19 | The sodium pump alpha1 subunit as a potential target to combat apoptosis-resistant glioblastomas显示文摘 | Lefranc F Kiss R | 2008 | Neoplasia2008，10，3： | 1 |
| 20 | Characterization of the levels of expression of retinoic acid receptors, galectin-3, macrophage migration inhibiting factor, and p53 in 51 adamantinomatous craniopharyngiomas显示文摘 | Lefranc F Chevalier C Vinehon M | 2003 | J Neumsurg2003，98，1： | 1 |
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