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| 1 | Bis(7)-tacrine attenuates beta amyloid-induced neuronal apoptosis by regulating L-type calcium channels显示文摘 | Fu H Li W Lao Y Luo J Lee NT Kan KK Tsang HW Tsim KW Pang Y Li Z Chang DC Li M Han Y | 2006 | 中国生物学文摘2006，20，10： | 10 |
| 2 | Routine defunctioning stoma after chemoradiation and total mesorectal excision:A single-surgeon experience显示文摘AIM:To investigate the 10-year results of treating low rectal cancer by a single surgeon in one institution.METHODS:From Oct 1998 to Feb 2009,we prospectively followed a total of 62 patients with cT2-4 low rectal cancer with lower tumor margins measuring at 3 to 6 cm above the anal verge.All patients received neoadjuvant chemoradiation(CRT) for 6 wk.Among them,85% of the patients received 225 mg/m2/d 5-fluorouracil using a portable infusion pump.The whole pelvis received a total dose of 45 Gy of irradiation in 25 fractions over 5 wk.The interval from CRT completion to surgical intervention was planned to be approximately 6-8 wk.Total mesorectal excision(TME) and routine defunctioning stoma construction were performed by one surgeon.The distal resection margin,circumferential resection margin,tumor regression grade(TRG) and other parameters were recorded.We used TRG to evaluate the tumor response after neoadjuvant CRT.We evaluated anal function outcomes using the Memorial Sloan-Kettering Cancer Center anal function scores after closure of the defunctioning stoma.RESULTS:The median distance from the lower margin of rectal cancer to the anal verge was 5 cm:6 cm in 9 patients,5 cm in 32 patients,4 cm in 10 patients,and 3 cm in 11 patients.Before receiving neoadjuvant CRT,45 patients(72.6%) had a cT3-4 tumor,and 21(33.9%) patients had a cN1-2 lymph node status.After CRT,30 patients(48.4%) had a greater than 50% clinical reduction in tumor size.The final pathology reports revealed that 33 patients(53.2%) had a ypT3-4 tumor and 12(19.4%) patients had ypN1-2 lymph node involvement.All patients completed the entire course of neoadjuvant CRT.Most patients developed only Grade 1-2 toxicities during CRT.Thirteen patients(21%) achieved a pathologic complete response.Few post-operative complications occurred.Nearly 90% of the defunctioning stomas were closed within 6 mo.The local recurrence rate was 3.2%.Pathologic lymph node involvement was the only prognostic factor predicting disease recurrence(36.5% vs 76.5%,P = 0.006).Nearly 90% of patients recovered sphincter function within 2 year after closure of the defunctioning stoma.CONCLUSION:Neoadjuvant CRT followed by TME,combined with routine defunctioning stoma construction and high-volume surgeon experience,can provide excellent surgical quality and good local disease control. | Shao-Chieh Lin Po-Chuan Chen Chung-Ta Lee Hong-Ming Tsai Peng-Chan Lin Helen HW Chen Yuan-Hwa Wu Bo-Wen Lin Wen-Pin Su Jenq-Chang Lee | 2013 | World Journal of Gastroenterology2013，19，11： | 3 |
| 3 | Risk factors for failure to detect a cancer during clinical breast examination(United States)显示文摘 | BOBO jk Lawson HW Lee NC | 2003 | Cancer Causes Control2003，14，： | 1 |
| 4 | Cognitive effects of low-dose topiramate monotherapy in epilepsy patients: A 1-year follow-up 显示文摘 | Lee HW Jung DK Suh CK | 2006 | Epilepsy Behav2006，8，： | 1 |
| 5 | Improved outcome of adult recipients with a high model for end-stage liver disease score and a small-for-size graft显示文摘 | Yi NJ Suh KS Lee HW | 2009 | Liver Transpl2009，15，5： | 1 |
| 6 | Segmental lichen aureus: combination therapy with pentoxifylline and prostacyclin显示文摘 | Lee HW Lee DK Chang SE | 2006 | J Eur Acad Dermatol Venereol2006，20，10： | 1 |
| 7 | Inhibition of colon tumur progression and angiogenesis by the INK4a/Arf locus显示文摘 | Gibson SL Dai CY Lee HW | 2003 | Cancer Res2003，63，4： | 1 |
| 8 | Antidiabetic effects of chitosan oligosaccharides in neonatal streptozocin-induced noninsulin-dependent diabetes mellitus in rats显示文摘 | Lee HW Park YS Choi JW | 2003 | Biol Pharm Bull2003，26，8： | 1 |
| 9 | Typing of hantavirus from continents by polymerase chain reaction显示文摘 | Puthavathana P Lee HW Kang Cy | 1992 | Virus Res1992，26，1： | 1 |
| 10 | Hypoxia regulates basal and induced DNA synthesis and collagen type I production in human cardiac tlbroblasts: effects of transforming growth factor-betal, thyroid hormone, angiotensin II and basic fibroblast growth factor显示文摘 | Agocha A Lee HW Eghbali WM | 1997 | J Mol Cell Cardiol1997，29，8： | 1 |
| 11 | Inhibition of histone deacetylase attenuates hypoxia induced migration andinv asion of cancer cells via the restoration of RECK expression显示文摘 | Jeon HW Lee YM | 2010 | Mol Cancer Ther2010，9，5： | 1 |
| 12 | Decreased retinal ganglion cell layer thickness in patients with type 1 diabetes 显示文摘 | van Dijk HW Verbraak FD Kok PH Garvin M Sonka M Lee K | 2010 | Invest Ophthalmol Vis Sci2010，51，7： | 1 |
| 13 | Serum highmobility group box-1 ( HMGB1) is closely associatedwith the clinical and pathologic features of gastriccancer显示文摘 | Chung HW Lee SG Kim H | 2009 | J Transl Med2009，7，： | 1 |
| 14 | Telomere shortening and tumor formation by mouse cells lacking telomerase RNA显示文摘 | Blasco MA Lee HW Hande MP | | 0，，： | 1 |
| 15 | Hepatitis B virus X protein induces the expression of MTAI and HDACl, which enhances hypoxia signaling in hepatocellular carcinoma cells 显示文摘 | Yoo YG Na TY Seo HW Seong JK Park CK Shin YK Lee MO | 2008 | Oncogene2008，27，24： | 1 |
| 16 | Use of bone marrow stromal cells for tendon graft-to-bone healing:histological and immunohistochemical studies in a rabbit model显示文摘 | Ouyang HW Gob JC Lee EH | | 0，，2： | 1 |
| 17 | Statistical factorial anal- ysis on the material property sensitivity of the mechani- cal responses of the C4-C6 under compression, an- terior and posterior shear显示文摘 | Ng HW Teo EC Lee VS | 2004 | J Biomech2004，37，5： | 1 |
| 18 | Delivery of poorly soluble com- pounds by amolphous solid dispersions 显示文摘 | Lee 'IN~ Boersen NA Hui HW | 2014 | Cltrr Pharm Des2014，20，3： | 1 |
| 19 | Evaluation of solid breast lesions wiht power Doppler sonography显示文摘 | Kook SH Park HW Lee YR | 1999 | Clin Ultrasound1999，27，： | 1 |
| 20 | Investigation of inclusion complexation of paclitaxel by cyclohenicosakis-( 1 → 2 )-( β)-d-glucopyranosyl by cyclic-( 1 → 2 )-β-glucans ( cyclsophoranses ), and by cyclomahoheptaoses(β-cyclodextrins) 显示文摘 | Lee S Seo DH Kim HW | 2001 | Carbohydr Res2001，334，2： | 1 |
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