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| 1 | 人血浆硫氧化还原蛋白80随着年龄增长而增加,并在载脂蛋白E基因敲除小鼠中诱导炎症、血管生成和动脉粥样硬化显示文摘硫氧化还原蛋白(thioredoxin,TRX)1是一种普遍存在的12kD的蛋白质,可产生抗氧化和抗炎作用。由巨噬细胞产生的截断形式称为TRX80,其可诱导促炎细胞因子的上调。TRX80还促进小鼠腹膜和人巨噬细胞向促炎M1表型的分化。方法:使用特异性酶联免疫吸附试验测定血浆TRX1和TRX80水平。 | 刘莉 叶鹏 Couchie D Vaisman B Abderrazak A Mahmood DFD Hamza MM Canesi F Diderot V El Hadri K Nègre-Salvayre AE Le Page A Fulop T Remaley AT Rouis M | 2017 | 中华高血压杂志2017，25，6： | 9 |
| 2 | Studies on the Antibacterial Activity of the Extract of Stachytarpheta angusti folia显示文摘Objective : To investigate the scientific bases for the traditional use of Stachytarpheta angustifolia. Methods: In vitro antibacterial activity of the aqueous and ethanol extract of the plant was investigated using the agar cup plate diffusion method. Results: The ethanol extract of the plant shoued antibacterial activity against Escherichia coli , Streptococcus faecalis , Shigella dysenteriae ,Staphylococcus aureus ( S. Aureus ), Salmonella sp. , Pseudomonas aeruginosa and Neisseria gonorrhoeae, while the water extract was active against Escherichia coli, Streptococcus faecalis, Shigella dysenteriae, Staphylococcus aureus and. Pseudomonas aeruginosa. The ethanol extract exhibited higher antibacterial activity than the water extract. The minimum inhibitory concentration (MIC) and minimum bacterwidal concentration ( M BC ) of the ethanol extract were 0.65 mg / ml and 0.85 mg / ml , respectively, against S. Aureus. Treatment of the extract at higher temperature, 60 ℃ increased the sensitivity of the test organisms to the plant extract. Phytochemical analysis indicated that the plant possesses tannins, saponins as well as phenols. Conclusion: A scientific basis exists that the plant possesses antibacterial activity and it could be a probable source of therapeutic agent. | Yakubu M Bello Odama LE Nandita B De | 2003 | Journal of Nanjing Medical University2003，17，3： | 8 |
| 3 | 外耦合布拉格光栅 5μm量子级联激光器(英文)显示文摘窄带宽的 Al Ga As/ Ga As布拉格光栅耦合到 In P的半导体量子级联激光器从而产生稳定的激光频谱 ,其激光谱线宽度在 1纳米左右。如果不加光栅 ,非稳定的自由激射的激光器的谱线宽度有 3 0 nm左右。 | 彭川 LE H Q Sarangan A M Ishaug B Thompson L | 2003 | 重庆邮电学院学报(自然科学版)2003，15，3： | 4 |
| 4 | Perspectives on new biomarkers in gastric cancer: Diagnostic and prognostic applications显示文摘Gastric cancer is considered one of the most deadly tumors worldwide. Even with the decline in its incidence, the mortality rate of this disease has remained high, mainly due to its late diagnosis and to the lack of precise prognostic markers. The main purpose of this review is to present genetic, epigenetic and proteomic molecular markers that may be used in a diagnostic and prognostic manner and to discuss the pros and cons of each type of marker for improving clinical practice. In this sense, we observed that the use of genetic markers, especially mutations and polymorphisms, should be carefully considered, as they are strongly affected by ethnicity. Proteomic-based markers show promise, but the higher costs of the associated techniques con-tinue to make this approach expensive for routine use. Alternatively, epigenetic markers appear to be very promising, as they can be detected in bodily fluids as well as tissues. However, such markers must be used carefully because epigenetic changes may occur due to environmental factors and aging. Despite the advances in technology and its access, to date, there are few defined biomarkers of prognostic and diagnostic use for gastric tumors. Therefore, the use of a panel of several approaches(genetic, epigenetic and proteomic) should be considered the best alternative for clinical practice. | Danilo do Rosário Pinheiro Wallax Augusto Silva Ferreira Mariceli Baia Leo Barros Mariana Diniz Araújo Symara Rodrigues-Antunes Bárbara do Nascimento Borges | 2014 | World Journal of Gastroenterology2014，20，33： | 4 |
| 5 | Propofol and thiopental anesthesia:a comparision of the incidence of dreams and perioprative mood alterations 显示文摘 | Oxorn D Orser B Ferris LE | 1994 | Anesth Analg1994，79，3： | 2 |
| 6 | Competition between fusion-evaporation and multifragmentation in central collisions in ^(58)Ni+^(48)Ca at 25A MeV显示文摘The experimental data concerning the58Ni+48Ca reaction at Elab(Ni)=25A MeV,collected by using the CHIMERA 4π device,have been analyzed in order to investigate the competition among different reaction mechanisms for central collisions in the Fermi energy domain.As a main criterion for centrality selection we have chosen the flow angle(flow) method,making an event-by-event analysis that considers the shape of events,as it is determined by the eigenvectors of the experimental kinetic-energy tensor.For the selected central events(flow >60°) some global variables,good to characterize the pattern of central collisions have been constructed.The main features of the reaction products were explored by using different constraints on some of the relevant observables,like mass and velocity distributions and their correlations.Much emphasis was devoted,for central collisions,to the competition between fusion-evaporation processes with subsequent identification of a heavy residue and a possible multifragmentation mechanism of a well defined(if any) transient nuclear system.Dynamical evolution of the system and pre-equilibrium emission were taken into account by simulating the reactions in the framework of transport theories.Different approaches have been envisaged(dynamical stochastic BNV calculations + sequential SIMON code,QMD,CoMD,etc.).Preliminary comparison of the experimental data with BNV calculations shows reasonable agreement with the assumption of sequential multifragmentation emission in the mass region of IMFs close to the heavy residues.Possible deviations from sequential processes were found for those IMFs in the region of masses intermediate between the mass of heavy residues and the mass of light IMFs.Further simulations are in progress.The experimental analysis will be enriched also by information obtained inspecting the IMF-IMF correlation function,in order to elucidated the nature of space-time decay property of the emitting source associated with events having the largest IMF multiplicity. | FRANCALANZA L ABBONDANNO U AMORINI F BARLINI S BINI M BOUGAULT R BRUNO M CARDELLA G CASINI G AGOSTINO M D' De FILIPPO V De SANCTIS J GERACI E GIUSSANI A GRAMEGNA F GUIOT B KRAVCHUK V La GUIDARA E LANZALONE G Le NEINDRE N MAIOLINO C MARINI P MORELLI L OLMI A PAGANO A PAPA M PIANTELLI S PIRRONE S POLITI G POGGI G PORTO F RUSSOTTO P RIZZO F VANNINI G VANNUCCI L | 2013 | Nuclear Science and Techniques2013，24，5： | 2 |
| 7 | Osteonectin/SPARC is overexpressed in human hepatocellular carcinoma 显示文摘 | Le Bail B Faouzi S Boussarie L | 1999 | J Pathol1999，189，1： | 1 |
| 8 | Acute hemodynamic effects of biventricular DDD pacing in patients with end stage heart failure 显示文摘 | LECLERCG C CAZEAU L LE B H | 1998 | J Am Coil Cardiol1998，32，： | 1 |
| 9 | Influence of omeprazol on the antiplatelet action of clopidogrel associated to aspirin显示文摘 | Gilard M Amaud B Le Gal G | 2006 | American College of Cardiology2006，4，11： | 1 |
| 10 | Intracellular angiotensin II pro- duction in diabetic: rats is correlated with cardiomyocyte apoptosis, oxidative stress, and cardiac fibrosis 显示文摘 | Singh V P Le B Khode R | 2008 | Diabetes2008，57，12： | 1 |
| 11 | Regulation of the adenoma- tous polyposis coli gene by the miR - 135 family in colorectal cancer 显示文摘 | Nagel R le Sage C Diosdado B | 2008 | Cancer Res2008，68，14： | 1 |
| 12 | Interleukin-6 gene knockout influences energy balance regulating peptides in the hypothalamic paraventriculaR and supraoptic nuclei显示文摘 | Benrick A Schéle E Pinnock S B | 2009 | J Neuroendocrinol2009，21，7： | 1 |
| 13 | Combibing independent studies of a diagnostic test into a summary ROC curve: data-analytic approaches and some additional consideration 显示文摘 | Moses LE Shapiro D Littenberg B | 1993 | Statistics in Medicine1993，12，： | 1 |
| 14 | Andrews thoracoplasty as treatment of postpneumonectomy empyema: experience in 23 cases 显示文摘 | Icard P Ph lippe Le Rochais J Rubut B | 1999 | Ann Thorac Surg1999，68，： | 1 |
| 15 | LiFePO4 synthesis routes for enhanced electrochemical performance显示文摘 | Franger S Le Cras F Bourbon B | 2002 | Electrochem Solid State Lett2002，510，： | 1 |
| 16 | Theory of Explosive-Generated Water Waves显示文摘 | Le Mehaute B | 1988 | Princeton-New Jersey1988，，： | 1 |
| 17 | Multiple Rh messenger RNA isoforms are produced by alternative splicing显示文摘 | LE VAN K C CHERIF-ZAHAR B RAYNAL V | 1992 | Blood1992，80，： | 1 |
| 18 | VEGF-C is atrophic factor for neural progenitors in the vertebrate embryonic brain 显示文摘 | Le Bras B Barallobre MJ Homman-Ludiye J | 2006 | Nat Neurosci2006，9，： | 1 |
| 19 | Zeolites: new synergistic agents for intumescent fire retardant thermoplastic formulationscriteria for the choice of the zeolite 显示文摘 | Bourbigot S Le B M Brean P | 1996 | Fire and Materials1996，20，3： | 1 |
| 20 | l)evelopmenl and validation of a method tor fipronil residue determination in ovine using 96 well plate solid - phase extraction and gas chromatography - tandem mass spectrometry 显示文摘 | Biehon E Riehard CA Le Bizec B | 2008 | J of eharomatography A2008，1201，1： | 1 |
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