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| 1 | Intravenous vitamin C as adjunctive therapy for enterovirus/rhinovirus induced acute respiratory distress syndrome显示文摘We report a case of virus-induced acute respiratory distress syndrome(ARDS) treated with parenteral vitamin C in a patient testing positive for enterovirus/rhinovirus on viral screening. This report outlines the first use of high dose intravenous vitamin C as an interventional therapy for ARDS, resulting from enterovirus/rhinovirus respiratory infection. From very significant preclinical research performed at Virginia Commonwealth Universitywith vitamin C and with the very positive results of a previously performed phase Ⅰ safety trial infusing high dose vitamin C intravenously into patients with severe sepsis, we reasoned that infusing identical dosing to a patient with ARDS from viral infection would be therapeutic. We report here the case of a 20-year-old, previously healthy, female who contracted respiratory enterovirus/rhinovirus infection that led to acute lung injury and rapidly to ARDS. She contracted the infection in central Italy while on an 8-d spring break from college. During a return flight to the United States, she developed increasing dyspnea and hypoxemia that rapidly developed into acute lung injury that led to ARDS. When support with mechanical ventilation failed, extracorporeal membrane oxygenation(ECMO) was initiated. Twelve hours following ECMO initiation, high dose intravenous vitamin C was begun. The patient's recovery was rapid. ECMO and mechanical ventilation were discontinued by day-7 and the patient recovered with no long-term ARDS sequelae. Infusing high dose intravenous vitamin C into this patient with virus-induced ARDS was associated with rapid resolution of lung injury with no evidence of post-ARDS fibroproliferative sequelae. Intravenous vitamin C as a treatment for ARDS may open a new era of therapy for ARDS from many causes. | Alpha A Fowler Ⅲ Christin Kim Lawrence Lepler Rajiv Malhotra Orlando Debesa Ramesh Natarajan Bernard J Fisher Aamer Syed Christine DeWilde Anna Priday Vigneshwar Kasirajan | 2017 | World Journal of Critical Care Medicine2017，6，1： | 9 |
| 2 | 胆固醇结石病人肝脏脂质代谢异常的分子生物学研究显示文摘目的:研究导致胆石病人胆汁胆固醇过饱和的肝脏胆固醇和胆汁酸代谢途径中的分子生物学改变。方法:收集22例胆石病人和13例无胆石病的对照病人肝脏活检组织、胆囊胆汁和血浆。采用实时定量PCR检测肝脏基因表达,采用Western印迹法测定蛋白含量。结果:胆石病人较对照组ABCG5/ABCG8和LXRα基因的mRNA表达水平分别增加51%、59%和102%。肝脏SRBI的mRNA和蛋白含量均增加。结论:胆石病人ABCG5/ABCG8基因表达上调,可能与LXRα表达增加促进相关,这些异常是导致胆汁胆固醇过饱和的原因。此外,胆汁中过多的胆固醇可能来源于经肝脏高密度脂蛋白受体SRBI的摄取,而不是由于肝脏合成和酯化的异常。 | 蒋兆彦 姜翀弋 胡海 所广军 Paolo Parini Gsta Eggertsen Matthew A Davis Lawrence L Rudel Curt Einarsson 韩天权 张圣道 | 2007 | 外科理论与实践2007，12，5： | 4 |
| 3 | Efficacy and safety of canagliflozin versus glimepiride in patients with type 2 diabetes inadequately controlled with metformin (CANTATA-SU): 52 week results from a randomised, double-blind, phase 3 non-inferiority trial显示文摘 | William T Cefalu Lawrence A Leiter Kun-Ho Yoon Pablo Arias Leo Niskanen John Xie Dainius A Balis William Canovatchel Gary Meininger | 2013 | The Lancet2013，，： | 3 |
| 4 | Mammary gland growth and vascularity at parturition and during lactation in primiparous ewes fed differing levels of selenium and nutritional plane during gestation显示文摘Background: Objectives were to examine the effects of selenium(Se) supply and maternal nutritional plane during gestation on mammary gland growth, cellular proliferation, and vascularity at parturition and d 20 of lactation. Rambouillet primiparous ewes(n = 84) were allocated to treatments in a 2 x 3 factorial. Factors were dietary Se(adequate Se [ASe, 11.5 μg/kg BW] or high Se [HSe, 77.0 μg/kg BW]) and nutritional plane(60% [RES], 100% [CON], or 140% [EXC]). At parturition, lambs were removed and 42 ewes(7/treatment) were necropsied. Remaining ewes were fed a common diet meeting requirements for lactation and mechanically milked twice daily until necropsy on d 20. At both necropsy periods, mammary glands were dissected and tissues harvested. Samples were analyzed for RNA, DNA, and protein content, cell proliferation, and vascularity. Where interactions were present(P ≤ 0.05), least squares means from the highest-order interaction are presented. Results: Final body weight of ewes was least(P ≤ 0.002) in RES, intermediate for CON, and greatest for EXC, regardless of stage of the ewe at necropsy(parturition or d 20 of lactation). In ewes necropsied at parturition, mammary glands were heavier(P = 0.02) in EXC compared to RES, with CON intermediate. Concentration of RNA(mg/g) was decreased(P = 0.01) in EXC compared to CON at parturition. There was a tendency(P = 0.07) for a Se by nutrition interaction in percentage of cells proliferating where ASe-EXC ewes had greater(P ≤ 0.02) number of proliferating cells then all other treatments. Mammary vascular area tended(P = 0.08) to be affected by a Se by nutrition interaction where ASe-CON had less(P = 0.007) vascular area than HSe-CON ewes. In ewes necropsied at d 20 of lactation, the number of alveoli per area was decreased(P ≤ 0.05) in RES compared to CON and EXC-fed ewes. Conclusions: Results of this study indicate that proper maternal nutritional plane during gestation is important for mammary gland development, even out to d 20 of lactation. | Tammi L Neville Allison M Meyer Arshi Reyaz Pawel B Borowicz Dale A Redmer Lawrence P Reynolds Joel S Caton Kimberly A Vonnahme | 2013 | Journal of Animal Science and Biotechnology2013，4，4： | 3 |
| 5 | Central/peripheral nervous system and immune responses显示文摘 | David A Lawrence Dongsoo Kim | 2000 | Toxicology2000，，3： | 2 |
| 6 | 上游天然气及凝析物分配计量的基本方法及要点(英文)显示文摘来自陆上和海上的天然气、原油以及凝析物通常经公用管道输送到主要的处理厂和储运站。开采公司一般由石油公司所有或是授权给石油公司。在处理厂,烃类物质如天然气和凝析物经过处理以达到销售和盈利所需要的质量要求。接下来,天然气以标准体积(标准立方米)或燃烧热(焦耳)为单位卖给运输商。而凝析物以标准体积(标准立方米)或重量(公斤或吨)为单位卖给运输商。天然气和凝析物的销售是在这些主要的处理厂中完成的,同时销售收入应该返还给开采公司,并最终返还给每个生产井或油气田。当天然气来自两个及两个以上的地点(或者是两个及两个以上的公司)需要在公用管道、收集点或是处理厂中混合并处理时,或者是这些管道、收集点以及处理厂归属于不同的公司或处于不同的税率体系时,就急需一个天然气分配系统了。 | Philip A Lawrence | 2012 | 石油与天然气化工2012，41，2： | 2 |
| 7 | The reactions between Ca-based solids and gases representative of those found in a fluidized-bed incinerator显示文摘 | LAWRENCE A D BU J | 2000 | Chemical Engineering Science2000，55，24： | 2 |
| 8 | The effect of salinity on growth and survival of Penaeus vannamei, with observations on the interaction of IHHN virus and salinity 显示文摘 | Bray W A Lawrence A L Leung-Trujillo J R | 1994 | Aquaculture1994，122，23： | 1 |
| 9 | Contractual Relations,Control,and Quality in the Hog Sector显示文摘 | John D Lawrence | 1999 | Review of Agricultural Economics1999，2，1： | 1 |
| 10 | Relationship Quality in Services Selling:An Interpersonal Influence Perspective显示文摘 | CROSBY LAWRENCE A KENNETH R EVANS DEBORAH COWLES | 1990 | Journal of Marketing1990，，54： | 1 |
| 11 | Immunolocalization of type III collagen in human articular cartilage prepared by high- pressure eryofixation, freeze-substitution, and low-temperature embedding显示文摘 | Young R D Lawrence P A Duanee V C | 1995 | J Histochem Cytochem1995，43，4： | 1 |
| 12 | Resin transfer molding for affordable pri- mary structure 显示文摘 | Lawrence A G | 1995 | AIAA-95-38891995，，： | 1 |
| 13 | Mechanisms for the Cytotoxicity of eysteamine显示文摘 | Jeitner T M Lawrence D A | 2001 | Toxicological Sciences2001，63，1： | 1 |
| 14 | The amounts of NOx and N2O formed in a fluidized bed combustor during the buring of coal volatiles and also of char 显示文摘 | HayhurstA N Lawrence A D | 1996 | Combustion and Flame1996，，105： | 1 |
| 15 | Observation on the decline in sperm quality of Penaeus serilferus under laboratory conditions 显示文摘 | Leung T J R Lawrence A L | 1987 | Aquaculture1987，65，： | 1 |
| 16 | How Invest-ment Bankers Determine the Offer Price and Allocation of NewIssues显示文摘 | Benveniste Lawrence M and Paul A Spindt | 1989 | Journal of Financial Economics1989，，24： | 1 |
| 17 | Direct protein interaction underlies gene-for-gene specificity and coevolution of the flax resistance genes and flax rust avirulence genes显示文摘 | Dodds P N Lawrence G J Catanzariti A M | 2006 | Proc Natl Acad Sci USA2006，103，： | 1 |
| 18 | The effects of ω3 fatty acids and coenzyme Q10 on blood pressure and heart rate in chronic kidney disease: a randomized controlled trial显示文摘 | Trevor A Mori Valerie Burke Ian B Puddey Ashley B Irish Christine A Cowpland Lawrence J Beilin Gursharan K Dogra Gerald F Watts | 2009 | Journal of Hypertension2009，，9： | 1 |
| 19 | An overviewoftissue engineered bone显示文摘 | Charles A Vacanti MD Lawrence J | | 0，，： | 1 |
| 20 | The effects of feeding frequency on growth and reproduction in zebrafish (Danio rerio)显示文摘 | LAWRENCE C BEST J JAMES A | | 0，，368： | 1 |
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