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| 1 | MicroRNAs and liver cancer associated with iron overload:Therapeutic targets unravelled显示文摘Primary liver cancer is a global disease that is on the increase.Hepatocellular carcinoma(HCC)accounts for most primary liver cancers and has a notably low survival rate,largely attributable to late diagnosis,resistance to treatment,tumour recurrence and metastasis.MicroRNAs(miRNAs/miRs)are regulatory RNAs that modulate protein synthesis.miRNAs are involved in several biological and pathological processes including the development and progression of HCC.Given the poor outcomes with current HCC treatments,miRNAs represent an important new target for therapeutic intervention.Several studies have demonstrated their role in HCC development and progression.While many risk factors underlie the development of HCC,one process commonly altered is iron homeostasis.Iron overload occurs in several liver diseases associated with the development of HCC including Hepatitis C infection and the importance of miRNAs in iron homeostasis and hepatic iron overload is well characterised.Aberrant miRNA expression in hepatic fibrosis and injury response have been reported,as have dysregulated miRNA expression patterns affecting cell cycle progression,evasion of apoptosis,invasion and metastasis.In2009,miR-26a delivery was shown to prevent HCC progression,highlighting its therapeutic potential.Several studies have since investigated the clinical potential of other miRNAs with one drug,Miravirsen,currently in phaseⅡclinical trials.miRNAs also have potential as biomarkers for the diagnosis of HCC and to evaluate treatment efficacy.Ongoing studies and clinical trials suggest miRNA-based treatments and diagnostic methods will have novel clinical applications for HCC in the coming years,yielding improved HCC survival rates and patient outcomes. | Catherine M Greene Robert B Varley Matthew W Lawless | 2013 | World Journal of Gastroenterology2013，19，32： | 5 |
| 2 | Conjugated linoleic acid in bovine milk fat:a food -based approach to cancer chemoprevention 显示文摘 | M OShea F Lawless C Stanton R Devery | 1998 | Trends in Food Science & Technology1998，，9： | 1 |
| 3 | A wheat canopy model linking leaf area and phenology 显示文摘 | Lawless C Semenov M A Jamieson P D | 2005 | European Journal of Agronomy2005，22，： | 1 |
| 4 | Portfolio Restructuring and Limits to Hierarchical Govemance:The Effects of Environmental Uncertainty and Diversification Strategy显示文摘 | Bergh D D Lawless M W | | 0，，01： | 1 |
| 5 | Covariates and random effects in a Gamma process model with application to degradation and failure显示文摘 | Lawless J Crowder M | 2004 | Lifetime Data Analysis2004，10，3： | 1 |
| 6 | Covariates and random effects in a gamma process model with application to degradation and failure显示文摘 | Lawless J Crowder M | 2004 | Lifetime Data Analysis2004，10，3： | 1 |
| 7 | Fiber optic oxygen sensor based on phosphorescence quenching of erythrosine B trapped in Silica-gel glasses 显示文摘 | CHAN M A LAWLESS J L LAM S K | 2000 | Anal Chim Acta2000，408，12： | 1 |
| 8 | Surgical outcomes and safety of femtoseeond laser cataract surgery: a prospective study of 1 500 consecutive cases显示文摘 | Roberts TV Lawless M Bali SJ | 2013 | Ophthalmology2013，120，2： | 1 |
| 9 | Early experience with the femtosecond laser for cataract surgery显示文摘 | Bali SJ Hodge C Lawless M | 2012 | Ophthalmology2012，119，5： | 1 |
| 10 | Resistant starch from high-amylose maize increases insulin sensitivity in overweight and obese men显示文摘 | Maki K C Pelkman C L Finocchiaro E T Kelley K M Lawless A L Schild A L Rains T M | 2012 | The Journal of Nutrition2012，142，4： | 1 |
| 11 | Temperature threshold for burn injury:an oximeter safetystudy显示文摘 | GREENHALGH D G LAWLESS M B CHEW B B | 2004 | The Journal of Burn Care amp Rehabilitation2004，25，5： | 1 |
| 12 | Covariates and random effects in a Gamma process model with application to degradation and failure显示文摘 | Lawless J Crowder M | 2004 | Lifetime Data Analysis2004，10，3： | 1 |
| 13 | Computer modeling and biolog/cal learn- ing显示文摘 | Roth M W Lawless | 2001 | Educational Technology&Society2001，4，1： | 1 |
| 14 | A quantum metric of organizational performance:terrorism and counterterrorism显示文摘 | Bergman M Louca J | 2007 | Computational & Mathematical Organization Theory2007，13，： | 1 |
| 15 | Femtosecond cataract surgery:a review of current literature and the experience from an initial installation显示文摘 | Hodge C Bali SJ Lawless M | 2012 | Saudi J Ophthalmol2012，26，1： | 1 |
| 16 | Portfolio Restructuring and Limits to Hierarchical Governance: The Effects of Environmental Uncertainty and Diversifica- tion Strategy 显示文摘 | Bergh D D Lawless M W | 1998 | Organization Science1998，9，1： | 1 |
| 17 | Enrichment of the conjugated linoleic acid content of bovine milk fat by dry fractionation显示文摘 | O'Shea M Devery R Lawless F | 2000 | Int Dairy J2000，10，： | 1 |
| 18 | Temperature threshold for burn injury: an oximeter safetystudy显示文摘 | Greenhalgh D G Lawless M B Chew B B | 2004 | J Burn Care Rehabil2004，25，5： | 1 |
| 19 | Conjugated linoleic acid in bovine milk fat-a food-based approach to cancer chemoprevention显示文摘 | Oshea M Lawless F Stanton C | 1998 | Trends Food Sci technol1998，，9： | 1 |
| 20 | Femtosecond laser cataract surgery: technology and clinical practice显示文摘 | Roberts TV Lawless M Chan CC | 2013 | Clin Experiment Ophthalmol2013，41，2： | 1 |
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