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| 1 | Modulation of protein tyrosine phosphorylation in gastric mucosa during re-epithelization processes显示文摘AIM:To investigate the role of protein tyrosine phosphorylation in gastric wound formation and repair following ulceration. METHODS:Gastric lesions were induced in rats using restraint cold stress.To investigate the effect of oxidative and nitrosative cell stress on tyrosine phosphorylation during wound repair,total activity of protein tyrosine kinase(PTK),protein tyrosine phosphatase (PTP),antioxidant enzymes,nitric oxide synthase (NOS), 2',5'-oligoadenylate synthetase,hydroxyl radical and zinc levels were assayed in parallel. RESULTS:Ulcer provocation induced an immediate decrease in tyrosine kinase(40% in plasma membranes and 56% in cytosol,(P<0.05) and phosphatase activity (threefold in plasma membranes and 3.3-fold in cytosol),followed by 2.3-2.4-fold decrease (P<0.05) in protein phosphotyrosine content in the gastric mucosa. Ulceration induced no immediate change in superoxide dismutase (SOD) activity,30% increase (P<0.05) in catalase activity,2.3-fold inhibition (P<0.05) of glutathione peroxidase,3.3-fold increase (P<0.05) in hydroxyl radical content,and 2.3-fold decrease (P<0.05) in zinc level in gastric mucosa.NOS activity was three times higher in gastric mucosa cells after cold stress. Following ulceration,PTK activity increased in plasma membranes and reached a maximum on day 4 after stress (twofold increase,P<0.05),but remained inhibited(1.6-3-fold decrease on days 3,4 and 5,P<0.05) in the cytosol.Tyrosine phosphatases remained inhibited both in membranes and cytosol(1.5-2.4-fold,P< 0.05).NOS activity remained increased on days 1,2 and 3(3.8-,2.6-,2.2-fold,respectively,P<0.05).Activity of SOD increased 1.6 times(P<0.05)days 4 and 5 after stress.Catalase activity normalized after day 2. Glutathione peroxidase activity and zinc level decreased (3.3-and 2-fold,respectively,P<0.05)on the last day. Activity of 2',5'-oligoadenylate synthethase increased 2.8-fold (P<0.05) at the beginning,and 1.6-2.3-fold (P<0.05) during ulcer recuperation,and normalized on day 5,consistent with slowing of inflammation processes. CONCLUSION:These studies show diverse changes in total tyrosine kinase activity in gastric mucosa during the recovery process.Oxidative and nitrosative stress during lesion formation might lead to the observed reduction in tyrosine phosphorylation during ulceration. | Olena V Bogdanova Larysa I Kot Kateryna V Lavrova Volodymyr B Bogdanov Erica K Sloan Tetyana V Beregova Ludmyla I Ostapchenko | 2010 | World Journal of Biological Chemistry2010，1，11： | 2 |
| 2 | Enterovirus 71 isolated from cases of epidemic poliomyelitis-like disease in Bulgaria显示文摘 | M. Chumakov M. Voroshilova L. Shindarov I. Lavrova L. Gracheva G. Koroleva S. Vasilenko I. Brodvarova M. Nikolova S. Gyurova M. Gacheva G. Mitov N. Ninov E. Tsylka I. Robinson M. Frolova V. Bashkirtsev L. Martiyanova V. Rodin | 1979 | Archives of Virology (-)1979，，3： | 1 |
| 3 | Synthesis and biological activity of some 1-hydroxy-3- aminoalkyl adamantanes and their derivatives: 显示文摘 | Lavrova LN Indulen MK Ryazantseva GM | 1990 | Khimiko- FarmatevtiesM Zhurnal1990，24，1： | 1 |
| 4 | 显示文摘 | Lavrova G V Burgina E B Matvienko A A | 2006 | SOlid State Ionics2006，177，： | 1 |
| 5 | 显示文摘 | Lavrova G V Ponomareva V G | 2008 | Solid State Ionics2008，179，： | 1 |
| 6 | Enterovirus 71 isolated from cases of epidemic poliomyelitis-like disease in Bulgaria显示文摘 | M. Chumakov M. Voroshilova L. Shindarov I. Lavrova L. Gracheva G. Koroleva S. Vasilenko I. Brodvarova M. Nikolova S. Gyurova M. Gacheva G. Mitov N. Ninov E. Tsylka I. Robinson M. Frolova V. Bashkirtsev L. Martiyanova V. Rodin | 1979 | Archives of Virology1979，，3： | 1 |
| 7 | On the lateral instability of waves on the surface of a fmite-depth fluid 显示文摘 | Lavrova O T | 1983 | Iz-vestiya Atmospheric and Oceanic Physics1983，19，： | 1 |
| 8 | Bulk and surface properties of ionic salt CsH5(PO4)2显示文摘 | Lavrova G V Burgina E B Matvienko A A | 2006 | Solid State Ionics2006，177，1314： | 1 |
| 9 | Formation conditions of Kumdy-kol diamond deposit (north Kazakstan)显示文摘 | EKIMOVA T E LAVROVA L D NADEZHDINA E D | 1994 | GeolOrgDep1994，36，： | 1 |
| 10 | Composite protonie solid electrolytes in the CsHSO4-SiO2 system 显示文摘 | Ponomareva V G Uvarov N F Lavrova G V | 1996 | Solid State Ionics1996，90，： | 1 |
| 11 | Influence of dispersed TiO2 on protonic conductivity of CsHSO4显示文摘 | Ponomareva V G Lavrova G V | 1998 | Solid State Ionics1998，106，： | 1 |
| 12 | Effects of intermittenthypoxic training on orthostatic reactions of the cardiorespiratorysystem显示文摘 | Donina ZA Lavrova NI Tikhonov MA | 2008 | Bulletin of Experimental Biology and Medicine2008，145，6： | 1 |
| 13 | Ionization Pro- cesses in the Dielectric of Paper Capacitors under Direct Voltage显示文摘 | Renne V T Stepanov S I Lavrova D S | 1963 | Elektrichestvo1963，，： | 1 |
| 14 | The investigation of disordered phases in nanocomposite proton electrolytes based on MeHSO4(Me = Rb, Cs, K) 显示文摘 | Ponomareva V G Lavrova G V | 2001 | Solid State Ionics2001，145，： | 1 |
| 15 | Composite protonic solid electrolytes in the CsHSO4-SiO2 system显示文摘 | Ponomareva V G Uvarov N F Lavrova G V | 1996 | Solid State Ionics1996，90，1： | 1 |
| 16 | Role of low-grade inflammation markers and soluble cell adhesion molecules in patients with obstructive sleep apnea显示文摘 | Korzh O Krasnokutskiy S Lavrova E | 2007 | Sleep Medicine2007，81，： | 1 |
| 17 | Influence of dispersed TiO2 on protonic conductivity of CsHSO4显示文摘 | Ponomareva V G Lavrova G V | 1998 | Solid State Ionics1998，106，1： | 1 |
| 18 | Some l-hydroxy-3-aminoalkyladamantanes and their derivatives:synthesis and biological activity显示文摘 | Lavrova L N lndulen M K Ryazantseva G M | 1990 | Khimiko-Farrnatsevticheskii Zhurnal1990，24，1： | 1 |
| 19 | Enterovirus 71 isolated from cases of epidemic poliomyelitis-like disease in Bulgaria显示文摘 | M. Chumakov M. Voroshilova L. Shindarov I. Lavrova L. Gracheva G. Koroleva S. Vasilenko I. Brodvarova M. Nikolova S. Gyurova M. Gacheva G. Mitov N. Ninov E. Tsylka I. Robinson M. Frolova V. Bashkirtsev L. Martiyanova V. Rodin | 1979 | Archives of Virology (-)1979，，3： | 1 |
| 20 | Synthesis of thiamin, riboflavin and nicotinic acid in the rumen of sheep on a diet with feed hydrolysed sugar显示文摘 | Lavrova V N | 1981 | Byulleten'' Vsesoyuznogo Nauchno-Issledovatel'' Skogo Instituta Fiziologii Biokhimii Pitaniya Sel''Skokhozyaistvennykh Zhivotnykh1981，64，4： | 1 |
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