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| 1 | Effect of alcohol consumption on liver stiffness measured by transient elastography显示文摘AIM:To determine the evolution of transient elastography(TE) in patients with alcoholic liver disease according to alcohol cessation or continuation.METHODS:We retrospectively selected in our local database all patients who had two TE between June 2005 and November 2010 with chronic alcohol excessive consumption and excluded those with associated cause of liver disease.TE was performed at least one week apart by senior operator.TE examinations with less than ten successful measures or with an interquartile range above 30% were excluded.We retrospectively reviewed file of all patients to include only patient followed up by trained addictologist and for which definite information on alcohol consumption was available.Concomitant biological parameters [aspartate amino transferase(AST),alanine amino transferase and gamma-glutamyl transpeptidase(GGT)] within 4 wk of initial and final TE were recorded.Putative fibrosis score according to initial and final TE were determined with available cut-off for alcoholic liver disease and hepatitis C.Initial and final putative fibrosis score were compared according to alcohol consumption during follow-up.RESULTS:During the study period 572 patients had TE examination for alcoholic liver disease and 79 of them had at least two examinations.Thirty-seven patients met our criteria with a median follow-up of 32.5 wk.At the end of the study,13(35%) were abstinent,and 24(65%) relapsers.Eight patients had liver biopsy during follow-up.TE decreased significantly during follow-up in 85% of abstinent patients [median(range):-4.9(-6.1,-1.9)],leading to a modification of the putative fibrosis stage in 28%-71% of patient according to different cut-off value.In relapsers TE increased in 45% and decreased in 54% of patient.There was no statistical difference between initial and final TE in relapsers.In the overall population,using 22.6 kPa as cut-off for cirrhosis,4 patients had cirrhosis at initial TE and 3 patients had cirrhosis at final TE.Using 19.5 kPa as cut-off for cirrhosis,7 patients had cirrhosis at initial TE and 5 patients had cirrhosis at final TE.Using 12.5 kPa as cut-off for cirrhosis,16 patients had cirrhosis at initial TE and 15 patients had cirrhosis at final TE.Evolution of biological data was in accordance with the relapse or abstinent status:abstinence ratio(duration of abstinence/duration follow-up) was correlated with AST ratio(r =-0.465,P = 0.007) and GGT ratio(r =-0.662,P<0.0001).GGT was correlated with initial(r = 0.488,P = 0.002) and final TE(r = 0.49,P<0.005).Final TE was correlated with AST(r = 0.362,P<0.05).Correlation between TE ratio and AST ratio(r = 0.44,P = 0.01) revealed that TE varied proportionally to AST for all patients irrespective of their alcohol status.The same relationship was observed between TE ratio and GGT ratio(r = 0.65,P<0.0001).Evolution of TE was significantly correlated with the ratio of time of abstinence to observation time(r =-0.387,P = 0.016) and the evolution of liver enzymes.CONCLUSION:TE significantly decreased with abstinence.Results of TE in alcoholic liver disease cannot be interpreted without taking into account alcohol consumption and liver enzymes. | Edouard Bardou-Jacquet Ludivine Legros Draman Soro Marianne Latournerie Anne Guillygomarc'h Caroline Le Lan Pierre Brissot Dominique Guyader Romain Moirand | 2013 | World Journal of Gastroenterology2013，19，4： | 20 |
| 2 | Slit-Robo signaling induces malignant transformation through Hakai-mediated E-cadherin degradation during colorectal epithelial cell carcinogenesis显示文摘指导暗示的裂缝家庭绑在环岛(Robo ) 受体并且调制房间移植。我们这里报导 Slit2 的那宫外的表情和上皮的癌房间招募了的表示 Robo1 colorectal 的 Robo1 或 recombinant Slit2 处理为 E-cadherin (电子恶棍) ubiquitination 和 lysosomal 降级,上皮间充质的转变(EMT ) ,和肿瘤生长和肝转移的 ubiquitin ligase Hakai,它被救由 Hakai 击倒。相反,内长的 Robo1 或对 Robo1 有约束力的 Slit2 的特定的封锁击倒阻止的电子恶棍降级和颠倒的 EMT,导致减少的肿瘤生长和肝转移。Robo1 的宫外的表示也在 Slit2 积极的人的胚胎的肾触发了恶意的转变 293 个房间。重要地, Slit2 和 Robo1 的表示显著地在 colorectal 癌病人与增加的变形风险和更差的全面幸存被联系。我们断定由 Slit2 的 Robo1 的那个约会在 colorectal 期间通过调停 Hakai 的电子恶棍 ubiquitination 和 lysosomal 降级导致恶意的转变上皮的房间 carcinogenesis。 | Wei-Jie Zhou Zhen H Geng Shan Chi Wenli Zhang Xiao-Feng Niu Shu-Jue Lan Li Ma Xuesong Yang Li-Jing Wang Yan-Qing Ding Jian-Guo Geng | 2011 | Cell Research2011，21，4： | 14 |
| 3 | 关于痛风诊治决策的调查及相关因素分析显示文摘目的了解国内医生诊治痛风的决策并对相关因素进行分析。方法对197名医生进行了关于痛风诊治决策的现场问卷调查,同时收集答卷人的个人资料,通过双变量分析和多重Logistic回归分析模型,分析影响决策的相关因素。结果一共收回120份有效答卷。在诊断痛风时,94名医生(78.3%)认为应该检查患者的关节滑液。在治疗急性痛风发作时,如果患者肾功能良好,83名医生(69.2%)首选口服秋水仙碱;如果患者肾功能不全,50名医生(41.7%)首选皮质激素或促皮质激素。在降血尿酸治疗时,99名医生(82.5%)选择的指征不当,107名医生(89.2%)治疗开始得太早,92名医生(76.7%)用药的时间不够长。另外,在开始降血尿酸治疗的同时,仅有17名医生(14.2%)预防急性痛风的发作。多重Logistic回归分析发现痛风继续教育是医生采取正确诊断方法的相关因素。结论国内医生诊治痛风的决策与目前国际较为公认的意见并不一致,高质量的医学继续教育有可能提高医生诊治痛风的决策水平。 | 方卫纲 曾学军 李梦涛 Lan X Chen H Ralph Schumacher Jr 张奉春 | 2006 | 中华医学杂志2006，86，27： | 9 |
| 4 | 质子注入和快速退火对GaAs/AlGaAs量子阱红外探测器的影响显示文摘利用质子注入和快速退火技术改变GaAs/AlGaAs量子阱能级分布,使量子阱红外探测器的光电特性发生变化,在较大地移动了探测波长的同时,探测器的响应率、探测率以及暗电流特性也发生相应变化.在质子注入剂量为2.5×1015cm-2、快速退火条件为950℃、30s时,峰值探测波长移动2μm. | 李娜 陆卫 李宁 刘兴权 袁先漳 窦红飞 沈学础 FU Lan Tan H H C Jagadish M B Johnston M Gal | 2000 | 红外与毫米波学报2000，19，1： | 3 |
| 5 | Telomerase activity in pleural effusions diagnostic significance显示文摘 | CHENG T Y LEE M H LAN R S | 1998 | J Clin Oncol1998，16，4： | 2 |
| 6 | 显示文摘 | Chen L C Hsu C Y Lan W H | 2003 | Solid-State Electronics2003，47，： | 1 |
| 7 | Comprehensive analysis of microRNA expression patterns in renal biopsies of lupus nephritis patients显示文摘 | Dai Y Sui W Lan H | 2009 | Rheumatol Int2009，29，7： | 1 |
| 8 | Use of genetic mouse models in the study of diabetic nephropathy显示文摘 | Allen T J Cooper M E Lan H Y | 2004 | Curr Diab Rep2004，4，6： | 1 |
| 9 | Proteome analysis of human liver carcinoma Huh7 cells harboring hepatitis C virus subgenomic replicon显示文摘 | Fang C Yi Z Liu F Lan S Wang J Lu H Yang P Yuan Z | 2006 | Proteomics2006，6，2： | 1 |
| 10 | An EST-enriched comparative map of Brassica oleracea and Arabidopsis thaliana 显示文摘 | Lan T H DelMonte T A Reischmann K P | 2000 | Genome Research2000，10，： | 1 |
| 11 | Cross sections calculations for electron oxygen scattering using the polarized orbital close coupling theory 显示文摘 | Vo Ky Lan Feautrier N Le Dourneuf M Regemorter H Van | 1972 | J Phys B1972，5，： | 1 |
| 12 | Pdx-1 modulates Histone H4 aeetylation and insulin gene expression in terminally differentiated α- TC-1 cells 显示文摘 | Wang H W Breslin M B Lan M S | 2007 | Pancreas2007，34，2： | 1 |
| 13 | In-situ test of soil-root systems显示文摘 | Wu T H Beal P E Lan C | 1988 | Journal of Geotechnical Engineering ASCE1988，114，12： | 1 |
| 14 | Cyclic AMP stimulates SF- 1-dependent CYPllA1 expression through home- odomain-interacting protein kinase 3-mediated Jun N- terminal kinase and c-Jun phosphorylation 显示文摘 | Lan H C Li H J Lin G | 2007 | Molecu- lar and Cellular Biology2007，27，6： | 1 |
| 15 | Real-Time Noncrosstalk Sonar Sys|em by Short Optimized Pulse Position Modulation Sequences 显示文摘 | Meng Q H Lan S Y Yao Z J | 2009 | IEEE Transactions on Instrumentation and Measurement2009，58，10： | 1 |
| 16 | Ag/AgBr/TiO2 visible light photocatalyst for destruction of azodyes and bacteria显示文摘 | Hu C Lan Y Q Qu J H | 2006 | Journal of Physical Chemistry B2006，110，9： | 1 |
| 17 | Mea- suring internal electric fields in organic light - emitting diodes using electroabsorption spectroscopy 显示文摘 | CAMPBELL LAN H FERRARIS J P HAGLER T W | 1997 | Polym Advan Technol1997，8，： | 1 |
| 18 | PTEN activation contributes to tumor inhibition by trastuzumab,and loss of PTEN predicts trastuzumab resistance in patients显示文摘 | Nagata Y Lan K H Zhou X | | 0，，02： | 1 |
| 19 | Organic acids in two arsenic hyperaccumulators and a non-hyperaccumulator of Pteris exposed to elevated arsenic concentrations 显示文摘 | WANG H B WONG M H LAN C Y etal | 2011 | In- ternational Journal of Environmental and Analytical Chemis- try2011，91，3： | 1 |
| 20 | Dual lixiviant leaching process for extraction and re- covery of gold from ores at room temperature 显示文摘 | Zhang J T Shen S B Cheng Y Lan H F Hu X Wang F | 2014 | Hy- drometallurgy2014，144，145： | 1 |
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