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| 1 | 绕正方形排列的顺排的四个圆柱的流动研究显示文摘本文通过采用激光诱导荧关技术(LIF),对按正方形排列、边长间距比为4的顺排的四个圆柱的层流绕流进行了流动可视化研究;同时,在Re=200的情况下,对该流场进行了PIV流场测量,两种实验结果吻合良好,显示的都是只在下游圆柱的后面才有漩涡脱落。可是,采用两维有限体积法离散N-S方程计算该流场与实验结果完全不符合,原因尚不清楚。 | 李景银 K Lam K T Chan R M C So | 2004 | 工程热物理学报2004，25，1： | 14 |
| 2 | Novel role of STAT3 in microglia-dependent neuroinflammation after experimental subarachnoid haemorrhage显示文摘Background and purpose Signal transducer and activator of transcription 3(STAT3)may contribute to the proinflammation in the central nervous system diseases by modulating the microglial responses.Thus,this study was intended to investigate the effect of STAT3 on microglia-dependent neuroinflammation and functional outcome after experimental subarachnoid haemorrhage(SAH).Methods The SAH model was established by endovascular perforation in the mouse.Real-time PCR(RtPCR)and western blot were used to examine the dynamic STAT3 signalling pathway responses after SAH.To clarify the role of the STAT3 signalling pathway in the microglia-dependent neuroinflammation after SAH,the microglia-specific STAT3 knockout(KO)mice were generated by the Cre-LoxP system.The neurological functions were assessed by Catwalk and Morris water maze tests.Neuronal loss after SAH was determined by immunohistochemistry staining.Microglial polarisation status after STAT3 KO was then examined by RtPCR and immunofluorescence.Results The STAT3 and Janus kinase-signal transducer 2 activated immediately with the upregulation and phosphorylation after SAH.Downstream factors and related mediators altered dynamically and accordingly.Microglial STAT3 deletion ameliorated the neurological impairment and alleviated the early neuronal loss after SAH.To investigate the underlying mechanism,we examined the microglial reaction after STAT3 KO.STAT3 deletion reversed the increase of microglia after SAH.Loss of STAT3 triggered the early morphological changes of microglia and primed microglia from M1 to M2 polarisation.Functionally,microglial STAT3 deletion suppressed the SAH-induced proinflammation and promoted the anti-inflammation in the early phase.Conclusions STAT3 is closely related to the microglial polarisation transition and modulation of microglia-dependent neuroinflammation.Microglial STAT3 deletion improved neurological function and neuronal survival probably through promoting M2 polarisation and anti-inflammatory responses after SAH.STAT3 may serve as a promising therapeutic target to alleviate early brain injury after SAH. | Zhiyuan Vera Zheng Junfan Chen Hao Lyu Sin Yu Erica Lam Gang Lu Wai Yee Chan George K C Wong | 2022 | Stroke & Vascular Neurology2022，7，1： | 3 |
| 3 | Secure Group Communications Using Key Graphs显示文摘 | Wong C Gouda M Lam S | | 0，，： | 2 |
| 4 | Hospital lift system simulator: A performance Evaluator Predictor显示文摘 | Sydney C K Chu Lin C K Y Lam S S | 2003 | European Journal of Operational Research2003，146，1： | 1 |
| 5 | Degree of hydration and gel/space ratio of high volume fly ash/cement systems显示文摘 | LAM L WONG Y L POON C S | 2000 | Cement and Concrete Research2000，30，5： | 1 |
| 6 | Current approaches to the management of acute primary angle-closure glaucoma显示文摘 | LAM D S THAM C C LAI J S | 2007 | Curr Opin Opthalmol2007，18，2： | 1 |
| 7 | Compressive behavior of fiber reinforced high-performance concrete subjected to elevated temperatures 显示文摘 | POON C S SHUI Z H LAM L | 2004 | Cement and Concrete Research2004，34，12： | 1 |
| 8 | Framework of Success Criteria for Design Build Projects 显示文摘 | A P C Chan D Scott E W M Lam | 2002 | Journal of Management in Engineering2002，18，3： | 1 |
| 9 | Nimotuzumab in pediatric glioma 显示文摘 | Lam C Bouffet E Bartels U | 2009 | Future Oncol2009，5，9： | 1 |
| 10 | A fuzzy neural network approach for contractor prequalification 显示文摘 | LAM K C HU T THOMAS S N | 2001 | Journal of Construction Management and Economics2001，19，2： | 1 |
| 11 | Identification of brain-derived neurotrophic factor as a novel functional protein in hepatocellular carcinoma 显示文摘 | YangZ F HoDW Lam C T etal | 2005 | Cancer Res2005，65，1： | 1 |
| 12 | Physical and chemical analysis of plasma-treated cotton fabric subjected to wrinkle-resistant finish- ing显示文摘 | LAM Y L KAN C W YUEN C W M | 2011 | Cellulose2011，18，2： | 1 |
| 13 | Is customer participa- tion in value creation a double-edged sword? Evidence from professional financial services across cultures 显示文摘 | Chan K W Yim C K Lam S S K | 2010 | Journal of Marketing2010，74，3： | 1 |
| 14 | Teratoma in the region of adre- nal glanda unique entity masquerading as lipomatous adrenal tumor显示文摘 | LAM K Y LO C Y | 1999 | Surgery1999，126，： | 1 |
| 15 | Transport policy ap- praisal with equilibrium models I : generalized traffic and highway investment benefits 显示文摘 | Williams H C W L Lam W M | 1991 | Transportation Research Part B: Methodological1991，25，5： | 1 |
| 16 | Study on an ozone episode in hot season in Hong Kong and transboundary air pollution over Pearl River Delta region of China显示文摘 | Lam K S Wang T J Wu C L | 2005 | Atmospheric Environment2005，39，11： | 1 |
| 17 | Relation of arterial stiffness with gestational age and birth weight 显示文摘 | Cheung Y F Wong K Y Lam B C | 2004 | Arch Dis Child2004，89，3： | 1 |
| 18 | Soluble endoglincontributes to the pathogenesis of preeclampsia显示文摘 | Venkatesha S Toporsian M Lam C | 2006 | Nat Med2006，12，： | 1 |
| 19 | Epidemiologieal features of supracondylar fractures of the humerus in Chinese children显示文摘 | Cheng J C Lam T P Maffulli N | 2001 | Pediatr Orthop B2001，10，： | 1 |
| 20 | Fundamentals of alternative dispute resolution processes in construction显示文摘 | Sai On Cheung Henry C H Suen Tsun-Ip Lam | 2002 | Journal of Construction Engineering and Management2002，128，2： | 1 |
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