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| 1 | Multidisciplinary approach for multifocal, bilobar hepatocellular carcinoma: A case report and literature review显示文摘BACKGROUND Hepatocellular carcinoma(HCC) is the second most lethal malignancy worldwide. There has been virtually no change in the survivability of HCC in spite of improvement in therapies. Surgery is considered the ideal first, curative intervention, however most patients present in advanced stages with unresectable disease. Therefore, systemic and liver-directed non-operative therapies are initially offered to downstage the disease. To ensure optimal management, a multidisciplinary team approach is often warranted. Our case highlights the benefits of a multidisciplinary approach in a young woman with multifocal, bilobar HCC.CASE SUMMARY A 36-year-old Chinese woman with untreated hepatitis B was found to have large bilobar HCC during work up for abdominal pain. Her initial serum alphafetoprotein was significantly elevated to 311136 ng/mL. Computed tomography scan demonstrated bulky bilobar liver masses, consistent with intermediate stage HCC, Barcelona Clinic Liver Cancer Stage B. Her case was discussed and a personalized care plan was developed at the Multidisciplinary Center for Advanced Minimally Invasive Liver Oncologic Therapies at the University of Washington. She initially underwent bilobar transarterial chemoembolization with partial response of the left lobar tumor. Salvage hypofractionated proton beam radiation therapy was delivered to the right lobe followed by two additional transarterial chemoembolizations to the left lobe with good response.Finally, to remove left lobar residual disease, she was taken to the operating roomfor a left hepatectomy eleven months after her initial presentation. She continues to be without evidence of disease.CONCLUSION Coordinating the multiple HCC treatment modalities is complex and our case highlights the benefits of a multidisciplinary approach. | Kevin P Labadie Stephanie K Schaub Derek Khorsand Guy Johnson Smith Apisarnthanarax James O Park | 2019 | World Journal of Hepatology2019，11，1： | 2 |
| 2 | River basin network model for integrated water quantity/quality management 显示文摘 | Dai T Labadie J W | 2001 | Journal of Water Resources Planning and Management2001，127，5： | 2 |
| 3 | Soybean electrophysiology: effects of acid rain显示文摘 | Shvetsova T Mwesigwa J Labady A | 2002 | Plant Science2002，162，： | 1 |
| 4 | Optimal operation of multireservoir systems: state-of-the-art review 显示文摘 | LABADIE J | 2004 | Journal of Water Resources Planning and Managemem2004，130，2： | 1 |
| 5 | Contrast-enhanced harmonic endoscopic ultrasound in solid lesions of the pancreas: results of a pilot study显示文摘 | B. Napoleon M. Alvarez-Sanchez R. Gincoul B. Pujol C. Lefort V. Lepilliez M. Labadie J. Souquet P. Queneau J. Scoazec J. Chayvialle T. Ponchon | 2010 | Endoscopy2010，，07： | 1 |
| 6 | Treatment of benign positional vertigo using the semont maneuver:efficacy in patients presenting without nystagmus显示文摘 | Haynes DS Resser JR Labadie RF | 2002 | Laryngoscope2002，112，5： | 1 |
| 7 | Analysis of hormonal steroids in fish plasma and bile by coupling solid-phase extraction to GC/MS 显示文摘 | Budzinski H Devier M H Labadie P | 2006 | Anal Bioanal Chem2006，386，5： | 1 |
| 8 | Optimal design of water-distribution networks with GIS 显示文摘 | Taher S A Labadie W | 1996 | Journal of Water Resources and Management1996，，： | 1 |
| 9 | Stochastic soil moisture estimation and forecasting for irrigated fields显示文摘 | Aboitiz M Labadie J W Heermann D F | 1986 | Water Resources Research1986，22，2： | 1 |
| 10 | Host-range determinants on the PB2 protein of influenza A viruses control the interaction between the viral polymerase and nucleoprotein in human cells显示文摘 | Labadie K Dos Santos Afonso E Rameix-Welti MA | 2007 | Virology2007，362，2： | 1 |
| 11 | Optimal operation of multireservoir systems: State-of-the-art review显示文摘 | LABADIE J W | 2004 | Journal of Water Resources Planning anti Management2004，130，： | 1 |
| 12 | Optimal operation of multi reservoir systems:State of the art review显示文摘 | John W Labadie M ASCE | 2004 | Journal of Water Resources Planning and Management2004，130，2： | 1 |
| 13 | Inter-laboratory trial to evaluate the reproducibility of a new ELISA to detect rabies antibodies in vaccinated domestic and wild carnivores 显示文摘 | Servat A Labadie A Hamen A | 2008 | Biologicals2008，36，1： | 1 |
| 14 | Effect of different temperature upshifts on protein synthesis by the psychrotrophic bacterium Pseudomonas fragi显示文摘 | Michel V Labadie J Hebraud M | 1996 | Curr Microbiol1996，33，： | 1 |
| 15 | Optimal operation of multireservoir systems: State-of-the-art review 显示文摘 | Labadie J W | 2004 | Journal of Water Resources Planning and Management2004，130，2： | 1 |
| 16 | Treatment of benign positional vertigo using the semont maneuver:efficacy in patients presenting without nystagmus显示文摘 | HAYNES D S RESSER J R LABADIE R F | 2002 | Laryngoscope2002，112，： | 1 |
| 17 | DNA Sequencing on a Chip 显示文摘 | Wallraff G Labadie J Brock P | 1997 | Chemtech1997，，： | 1 |
| 18 | Avian antimicrobial proteins: structure, distribution and activity 显示文摘 | LABADIE O W PICMAN J HINCKE M T | 2007 | World Poultry Sci2007，63，： | 1 |
| 19 | Optimal operation of multi-reservoir systems: state-of-the-art review 显示文摘 | LABADIE J W | 2004 | Journal of Water Resources Planning and Management2004，130，2： | 1 |
| 20 | A Scatter Search for the Periodic Capaeitated Arc Routing Problem 显示文摘 | Chu F Labadi N Prins C | 2005 | European Journal of Operational Research (S0377-2217)2005，169，2： | 1 |
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