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| 1 | Murine model to study brain,behavior and immunity during hepatic encephalopathy显示文摘AIM:To propose an alternative model of hepatic encephalopathy(HE) in mice,resembling the human features of the disease.METHODS:Mice received two consecutive intraperitoneal injections of thioacetamide(TAA) at low dosage(300 mg/kg).Liver injury was assessed by serum transaminase levels(ALT) and liver histology(hematoxylin and eosin).Neutrophil infiltration was estimated by confocal liver intravital microscopy.Coagulopathy was evaluated using prolonged prothrombin and partial thromboplastin time.Hemodynamic parameters were measured through tail cuff.Ammonia levels were quantified in serum and brain samples.Electroencephalography(EEG) and psychomotor activity score were performed to show brain function.Brain edema was evaluated using magnetic resonance imaging.RESULTS:Mice submitted to the TAA regime developed massive liver injury,as shown by elevation of serum ALT levels and a high degree of liver necrosis.An intense hepatic neutrophil accumulation occurred in response to TAA-induced liver injury.This led to mice mortality and weight loss,which was associated with severe coagulopathy.Furthermore,TAA-treated mice presented with increased serum and cerebral levels of ammonia,in parallel with alterations in EEG spectrum and discrete brain edema,as shown by magnetic resonance imaging.In agreement with this,neuropsychomotor abnormalities ensued 36 h after TAA,fulfilling several HE features observed in humans.In this context of liver injury and neurological dysfunction,we observed lung inflammation and alterations in blood pressure and heart rate that were indicative of multiple organ dysfunction syndrome.CONCLUSION:In summary,we describe a new murine model of hepatic encephalopathy comprising multiple features of the disease in humans,which may provide new insights for treatment. | Lindisley Ferreira Gomides Pedro Elias Marques Bruno Engler Faleiros Rafaela Vaz Pereira Sylvia Stella Amaral Thais Reis Lage Gustavo Henrique Souza Resende Patricia Alves Maia Guidine Giselle Foureaux Fabíola Mara Ribeiro Fabiana Paiva Martins Marco Antonio Peliky Fontes Anderson José Ferreira Remo Castro Russo Mauro Martins Teixeira Márcio Flávio Moraes Antonio Lúcio Teixeira Gustavo Batista Menezes | 2014 | World Journal of Hepatology2014，6，4： | 2 |
| 2 | Digestion of biological materials using the microwave-assisted sample combustion technique 显示文摘 | Mesko M F Moraes D P Barin J S Dressler V L Knapp G Flores E M M | 2006 | Microchem Journal2006，82，： | 1 |
| 3 | Endotoxin-induced lung injury in mice : structural, functional, and biochemical responses显示文摘 | Rojas M Woods C R Mora A L | 2005 | Am J Physiol Lung Cell Mol Physiol2005，288，： | 1 |
| 4 | Characterization of my coviruses and analyses of chitinase secretion in the biocontrol fungus Metarhizium anisopliae显示文摘 | Gimenez-Pecci M de la Bogo P M R Santi L Moraes C K de Correa C T Vainstein M H Schrank A | 2002 | Current Microbiology2002，45，5： | 1 |
| 5 | Genome-wide analysis of gene expression associated with MYCN in human neuroblastoma显示文摘 | Alaminos M Mora J Cheung NK Smith A Qin J Chen L Gerald WL | 2003 | Cancer Res2003，63，8： | 1 |
| 6 | Stabilityof the ANAMMOX process in a gas - lift reactor and a SBR 显示文摘 | Dapena - Mora A Campos J L Mosquera - Corral A | 2004 | journal of Biotechnology2004，110，2： | 1 |
| 7 | Code validation for high-speed flow simulation over satellite launch vehicle 显示文摘 | Azevedo J L F Moraes P Jr | 1996 | Journal of Spacecraft and Rockets1996，30，1： | 1 |
| 8 | Three-dimensional grain growth : analytical approaches and computer simulations显示文摘 | Barrales Mora L A Gottstein G Shvindlerman L S | 2008 | Acta Materialia2008，56，20： | 1 |
| 9 | Application of microwave induced combustion in closed vessels for carbon black-containing elastomers decomposition 显示文摘 | Moraes D P Mesko M F Mello P A Paniz J N G Dressler V L Knapp G Flores E M M | 2007 | Spectrochim Acta : Part B2007，62，： | 1 |
| 10 | Prevalence of o- verweight and obesity, and associated factors in school children from urban area in Chilpancingo, Gurerrero, Mexico, 2004 显示文摘 | MORAES SA BELTRAN RJ MONDINI L | 2006 | Cad Saude Publica2006，22，6： | 1 |
| 11 | Regional approach for the estimation of low-frequency distribution of daily rainfall in the Languedoc-Roussillon region, France显示文摘 | Mora R D Bouvier C Neppel L | 2005 | Hydrolog Sci2005，50，1： | 1 |
| 12 | Failure of the mite-pathogenic fungus Neozygites tanajoae and the predatory mite Neoseiulus idaeus to control a population of the cassava green mite, Mononychellus tanajoa显示文摘 | Elliot S L Moraes G J de Mumford J D | 2008 | Experimental and applied acarology2008，，46： | 1 |
| 13 | Direct measurement of intra- abdominal pressure with a solid microtrandueer 显示文摘 | Pracca FF Biestre AA Moraes L | 2007 | J Clin Monit Comput2007，21，3： | 1 |
| 14 | Percutaneous vertebroplasty:a comparison between the procedure using the traditional and the new side-opening cannula for osteoporotic vertebral fracture显示文摘 | Figueiredo N Barra F Moraes L | 2009 | Arq Neuropsiquiatr2009，67，2： | 1 |
| 15 | Clays and oxide minerals as catalysts and nanocatalysts in Fenton-like reactions -Areview显示文摘 | Garrido-Ramirez E G B K G Theng M L Mora | 2010 | Applied Clay Science2010，47，34： | 1 |
| 16 | Efficacy of a topical suspension of bacterial antigens for the management of recurrent eczema in children 显示文摘 | Mora R Bellussi L Passali FM | 2004 | Med Sci Monit2004，10，9： | 1 |
| 17 | Secondary pulmonary hypertension in chronic heart failure: the role of the endothelium in pathophysiology and management 显示文摘 | Moraes D L Colucci W S Givertz M M | 2000 | Circulation2000，102，14： | 1 |
| 18 | Comparison of red chilli (Capsicum annuum) oleoresin and astaxanthin on rainbow trout (Oncorhyncus mykiss) fillet pigmentation 显示文摘 | Mora G Arredondo-Figueroa J L Ponce-Palafox J T | 2006 | Aquaculture2006，258，： | 1 |
| 19 | Granulocyte colony stimu lating factor induce neatrophil to secrete macrophage colony stimulating factor 显示文摘 | SANTIAGO E MORA L BAUTISTA M | 2001 | Cytokin2001，15，6： | 1 |
| 20 | Baseline cataract type and 10year mortality in the Italian - American case - control study of age - related cataract显示文摘 | Williams S L Ferrigno L Mora P | | American journal of epidemiology0，156，2： | 1 |
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