|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Multiple genetic alterations and behavior of cellular biology in gastric cancer and other gastric mucosal lesions:H.pylori infection,histological types and staging显示文摘AIM To investigate the expression of multiplegenes and the behavior of cellular biology ingastric cancer(GC)and other gastric mucosallesions and their relations to Helicobacter pylori(H.pylori)infection,tumor staging andhistological subtypes.METHODS Three hundred and twenty-sevenspecimens of gastric mucosa obtained viaendoscopy or surgical resection,and ABCimmunohistochemical staining were used todetect the expression of p53,p16,Bcl-2 andCOX-2 proteins.H.pylori was determined byrapid urea test combined with pathologicalstaining or14C urea breath test.Cellular image analysis was performed in 66 patients withintestinal metaplasia(IM)and/or dysplasia(Dys).In 30 of them,both cancer and theparacancerous tissues were obtained at the timeof surgery.Histological pattern,tumor staging,lymph node metastasis,grading ofdifferentiation and other clinical data werestudied in the medical records.RESULTS p16 expression of IM or Dys wassignificantly lower in positive H.pylori chronicatrophic gastritis(CAG)than those withnegative H.pylori(CAG:54.8% vs 88.0%,IM:34.4% vs 69.6%,Dys:23.8% vs 53.6%,allP<0.05),Bcl-2 or COX-2 expression of IM orDys in positive H.pylori cases was significantlyhigher than that without H.pylori(Bcl-2:68.8%vs23.9%,90.5% vs 60.7%;COX-2:50.0% vs10.8%,61.8% vs 17.8%;all P<0.05).Themean number of most parameters of cellularimage analysis in positive H.pylori group wassignificantly higher than that in negative H.pylori group(Ellipser:53±14,40±12μm,Area1:748±572,302±202 μm2,Area2:3050±1661,1681±1990 μm2,all P<0.05;Ellipseb:79±23,58±15 μm,Ratio1:22%±5%,13%±4%,Ratio2:79%±17%,53%±20%,all P<0.01).There was significant correlation between Bcl-2and histologic pattern of gastric carcinoma,andbetween COX-2 and tumor staging or lymph nodemetastasis(Bcl-2:75.0% vs 16.7%;COX-2:76.0% vs 20.0%,79.2% vs 16.7%;allP<0.05).CONCLUSION p1l6, Bcl-2, and COX-2 but not p53 gene may play a role in the early genesis/ progression of gastric carcinoma and are associated with H. pylori infection. p53 gene is relatively late event in gastric tumorigenesis and mainly relates to its progression. There is more cellular-biological behavior of malignant tumor in gastric mucosal lesions with H. pylori infection. Aberrant Bcl-2 protein expression appears to be preferentially associated with the intestinal type cancer. COX-2 seems to be related to tumor staging and lymph node metastasis. | Heng Jun Gao Lian Zhen Yu Jian Feng Bai Yan Shen Peng Gu Sun Han Lin Zhao Kun Miu Xiu Zhen Lü Xiao Yong Zhang Zhi Quan Zhao | 2000 | World Journal of Gastroenterology2000，6，6： | 52 |
| 2 | Modeling of Microstructure Evolution in 22MnB5 Steel during Hot Stamping显示文摘Automobile manufacturers have been increasingly adopting hot-stamped parts for use in newly designed vehicles to improve crash worthiness and fuel efficiency.However,the simulation of hot stamping is rather complex and challenging,and further research still needs to be done on hot stamping hardening mechanism.The microstructure evolution and hardening mechanisms during hot stamping of 22MnB5steel were thoroughly investigated,using information provided in the literatures as well as experimental results.New models were developed to predict the grain growth during heating and the flow stress of a manganese boron steel(22MnB5)with high hardenability by the Gleeble simulation experimental results.The deformed austenite decomposition during stamping and quenching was emphatically quantified based on the transformation thermodynamic and kinetic theories,and the relationship of microstructure to properties was analyzed.The results showed that the optimal process to obtain homogeneous and small lath martensite is heating at 900-950℃for 5min and then quenching at 50℃/s with a pressing time about 8s. | Li-juan ZHU Zheng-wei GU Hong XU Yi L Jiang CHAO | 2014 | Journal of Iron and Steel Research(International)2014，21，2： | 10 |
| 3 | New insights into p53 activation显示文摘肿瘤 suppressor p53 是一多功能,高度调整了,并且对 DNA 特别地敏感的倡导者特定的 transcriptional 因素发信号的损坏和细胞的应力。p53 由指导一个损坏房间的机制击倒小径遗体糟糕理解的房间生长拘捕或 apoptotic。证据建议在里面 p53 的 vivo 功能似乎与发生的损坏的类型和严厉平衡房间命运选择。antirepression 的概念,或通常在海湾保留 p53 的因素的抑制,帮助可以为 p53 激活解释生理的机制。这些因素也在怀有基因的一个野类型的拷贝的肿瘤为 p53 的复活提供新奇化学疗法的目标。 | Christopher L Brooks Wei Gu | 2010 | Cell Research2010，20，6： | 9 |
| 4 | Human CD39hi regulatory T cells present stronger stability and function under inflammatory conditions显示文摘 | Jian Gu Xuhao Ni Xiongxiong Pan Hao Lu Yunjie Lu Jie Zhao Song Guo Zheng Keli L Hippen Xuehao Wang Ling Lu | 2017 | Cellular & Molecular Immunology2017，14，6： | 6 |
| 5 | VEGF-specific siRNAs modified with 2′-deoxy effectively suppress VEGF expression and inhibit growth of nasopharyngeal carcinoma xenograft in a mouse model显示文摘Vascular endothelial growth factor (VEGF) is up-regulated in the vast majority of human tumors. The up-regulation of VEGF not only plays important roles in tumor angiogenesis, but also provides a target for tumor treatment with small interfering RNA (siRNA) that targets VEGF; however, it is unclear whether a quite high up-regulation of VEGF will affect the efficiency of RNA interference strategies targeting VEGF. A high level expression of VEGF was found in CNE cells from a nasopharyngeal carcinoma cell line. In this study, we investigate whether VEGF-specific siRNAs can effectively suppress VEGF expression in CNE cells, and study the methods for the use of VEGF-specific siRNAs as potential therapeutic agents. CNE cells with high VEGF expression induced by hypoxia were transfected with VEGF-specific siRNAs. The expression of VEGF was effectively suppressed by VEGF-specific siRNAs, measured by ELISA, Western blot analysis and RT-PCR. Furthermore, experiments in nude mice bearing nasopharyngeal carcinoma xenograft were initiated 5 d after injection of CNE cells. VEGF-specific siRNAs were modified with 2′-deoxy, then injected into the tumors, and a liposome-mediated siRNA transfection system and ultrasound exposure were used to help delivery of the siRNAs. Tumor growth was reduced significantly after 3 weeks' treatment. These studies suggest that VEGF-specific siRNAs still can effectively suppress VEGF expression even in tumor cell lines with a relatively high level of VEGF expression, such as CNE, and VEGF-specific siRNAs modified with 2′-deoxy can be used as potential agents for tumor therapy. | CHEN ShanYi1, GAO GuoFeng1, CHEN Wei1, Lü Qing2, TANG Shen2, HUA Zhong2, YE WenBin2, GU DaYong2, WANG ShaYan1 & ZHANG YaOu2 1 Shenzhen People’s Hospital, Clinical Medical College of Jinan University, Shenzhen 518020, China 2 Life Science Division, Graduate School at Shenzhen, Tsinghua University, Shenzhen 518055, China | 2008 | Science China(Life Sciences)2008，51，2： | 6 |
| 6 | Microelectronics-embedded channel bridging and signal regeneration of injured spinal cords显示文摘Due to the dificulty in spinal cord regeneration with biological methods,the microelectronic neural bridge,a new concept based on microelectronic technology,is presented.The microelectronic system has been realized in the forms of hybrid and integrated circuits.The integrated circuits forneural signal detection,stimulation,and regeneration are realized in a CMOS process.In animal experiments with 100 toads,48 rats,and 3 rabbits,nerve signals have been successfully detected from spinal cords and sciatic nerves,and functional electrical stimulation has been carried out for spinal cords and sciatic nerves.When the microelectronic system is bridged between the controlling and stimulated nerve,the relevant motion of legs and nerve signal waveforms,which are stimulated by the evoked or spontaneous nerve signal through such a system,have been observed.Therefore,the feasibility of the presented method was demonstrated. | Zhigong Wang Xiaosong Gu Xiaoying Lǔ Zhenglin Jiang Wenyuan Li Guangming Lǔ Yufeng Wang Xiaoyan Shen Xintai Zhao Huiling Wang Zhenyu Zhang Hongmei Shen Yang Wu Weixing Shen Jingyang Zhang Dong Chen Xiaoyi Mao Huaxiang Shen | 2009 | Progress in Natural Science:Materials International2009，19，10： | 5 |
| 7 | Comparison of gene expression between normalcolon mucosa and colon carcinoma by means of messenger RNA differential display显示文摘 | Wang L Lu W Chen YG Zhou XM Gu JR | 1999 | World Journal of Gastroenterology1999，5，6： | 4 |
| 8 | Identifying topologies and system parameters of uncertaintime-varying delayed complex networks显示文摘Node dynamics and network topologies play vital roles in determining the network features and network dynamical behaviors.Thus it is of great theoretical significance and practical value to recover the topology structures and system parameters of uncertain complex networks with available information. This paper presents an adaptive anticipatory synchronization-based approach to identify the unknown system parameters and network topological structures of uncertain time-varying delayed complex networks in the presence of noise. Moreover, during the identification process, our proposed scheme guarantees anticipatory synchronization between the uncertain drive and constructed auxiliary response network simultaneously. Particularly, our method can be extended to several special cases. Furthermore, numerical simulations are provided to verify the effectiveness and applicability of our method for reconstructing network topologies and node parameters. We hope our method can provide basic insight into future research on addressing reconstruction issues of uncertain realistic and large-scale complex networks. | WANG Xiong GU HaiBo WANG QianYao Lü JinHu | 2019 | Science China(Technological Sciences)2019，62，1： | 4 |
| 9 | Revisiting the Concentration Observations and Source Apportionment of Atmospheric Ammonia显示文摘While China’s Air Pollution Prevention and Control Action Plan on particulate matter since 2013 has reduced sulfate significantly,aerosol ammonium nitrate remains high in East China.As the high nitrate abundances are strongly linked with ammonia,reducing ammonia emissions is becoming increasingly important to improve the air quality of China.Although satellite data provide evidence of substantial increases in atmospheric ammonia concentrations over major agricultural regions,long-term surface observation of ammonia concentrations are sparse.In addition,there is still no consensus on whether agricultural or non-agricultural emissions dominate the urban ammonia budget.Identifying the ammonia source by nitrogen isotope helps in designing a mitigation strategy for policymakers,but existing methods have not been well validated.Revisiting the concentration measurements and identifying source apportionment of atmospheric ammonia is thus an essential step towards reducing ammonia emissions. | Yuepeng PAN Mengna GU Yuexin HE Dianming WU Chunyan LIU Linlin SONG Shili TIAN Xuemei LÜ Yang SUN Tao SONG Wendell WWALTERS Xuejun LIU Nicholas AMARTIN Qianqian ZHANG Yunting FANG Valerio FERRACCI Yuesi WANG | 2020 | Advances in Atmospheric Sciences2020，37，9： | 4 |
| 10 | Enzymatic hydrolysis of proteins from yellowfin tuna ( Thunnus albacares ) wastes using Alcalase显示文摘 | F Guérard L Dufossé D De La Broise A Binet | 2001 | Journal of Molecular Catalysis B Enzymatic2001，，4： | 3 |
| 11 | 环境铅暴露与血压的关系:2003-2010美国健康和营养调查显示文摘在铅暴露逐渐降低的环境下,该文通过分析2003-2010美国健康和营养调查资料,旨在研究血铅与血压、高血压的关系。纳入研究对象12 725人,其中非洲裔21.1%,西语裔20.5%,白人58.4%,女性48.7%。与非非洲裔比较,非洲裔的血压[126.5/71.9比123.9/69.6mm Hg(1mm Hg=0. | Hara A Thijs L Asayama K Gu YM Jacobs L Zhang ZY Liu YP Nawrot TS Staessen JA 刘莉 叶鹏 | 2014 | 中华高血压杂志2014，22，10： | 3 |
| 12 | Core muscle functional strength training for reducing the risk of low back pain in military recruits:An open-label randomized controlled trial显示文摘Background:Core muscle functional strength training(CMFST)has been reported to reduce injuries to the lower extremity.However,no study has confirmed whether CMFST can reduce the risk of low back pain(LBP).Objective:This study identified the effects of CMFST on the incidence of LBP in military recruits.Design,setting,participants and intervention:We performed a prospective,open-label,randomized,controlled study in a population of young healthy male naval recruits from a Chinese basic combat training program.Participants were randomly assigned to either the core group or the control group.In additional to normal basic combat training,recruits in the core group underwent a CMFST program for 12 weeks,while recruits in the control group received no extra training.Main outcome measures:At the beginning of the study and at the 12 th week,the number of participants with LBP was counted,and lumbar muscle endurance was measured.In addition,when participants complained of LBP,they were assessed using the visual analog scale(VAS)and Roland Morris Disability Questionnaire(RMDQ).Results:A total of 588 participants were included in the final analysis(295 in the core group and 293 in the control group).The incidence of LBP in the control group was about twice that of the core group over the 12-week study(20.8%vs 10.8%,odds ratio:2.161–2.159,P<0.001).The core group had better lumbar muscle endurance at 12 weeks than the control group([200.80±92.98]s vs[147.00±84.51]s,P<0.01).There was no significant difference in VAS score between groups,but the core group had a significantly lower RMDQ score at week 12 than the control group(3.33±0.58 vs 5.47±4.41,P<0.05).Conclusion:This study demonstrated that the CMFST effectively reduced the incidence of LBP,improved lumbar muscle endurance,and relieved the dysfunction of LBP during basic military training. | Xin Wang Wen-juan Song Yi Ruan Bing-chu Li Can Lü Nian Huang Fan-fu Fang Wei Gu | 2022 | Journal of Integrative Medicine2022，20，2： | 3 |
| 13 | TanSat Mission Achievements: from Scientific Driving to Preliminary Observations显示文摘The Chinese global carbon dioxide monitoring satellite(TanSat)was successfully launched in December 2016 and has completed its on-orbit tests and calibration.TanSat aims to measure the atmospheric Carbon Dioxide column-averaged dry air mole fractions(X_(CO_2))with a precision of 4 ppm at the regional scale,and further to derive the CO_2 global and regional fluxes.Progress toward these objectives is reviewed and the first scientific results from TanSat measurements are presented.During the design phase,Observation System Simulation Experiments(OSSE)on TanSat measurements performed prior to launch measurements using a nadir and a glint alternative mode when considering the balance of stable measurements and reduces the flux uncertainty(64%).The constellation measurements of two satellites indicate an extra 10%improvement in flux inversion if the satellite measurements have no bias and similar precision.The TanSat on-orbit test indicates that the instrument is stable and beginning to produce X_(CO_2)products.The preliminary TanSat measurements have been validated with Total Carbon Column Observing Network(TCCON)measurements and have inter-compared with OCO-2 measurements in an overlap measurement. | LIU Yi WANG Jing YAO Lu CHEN Xi CAI Zhaonan YANG Dongxu YIN Zengshan GU Songyan TIAN Longfei LU Naimeng L Daren | 2018 | 空间科学学报2018，38，5： | 2 |
| 14 | Berberine derivatives with a long alkyl chain branched by hydroxyl group and methoxycarbonyl group at 9-position show improved anti-proliferation activity and membrane permeability in A549 cells显示文摘Berberine(BBR)exhibits diverse bioactivities,including anticancer activity;but its poor druggability limits its applications.In this study,we designed and synthesized a series of 9-0 position modified BBR derivatives aiming to improve its cell permeability and anticancer activity,utilizing a long alkyl chain branched by hydroxyl group and methoxycarbonyl group.Among these compounds,B10 showed 3.6-fold higher intracellular concentration than BBR,as well as 60-fold increased anti-proliferation activity against human lung cancer A549 cells compared with BBR,Treatment with B10(1,2μM)induced apoptosis of A549 cells.Further investigations showed that B10 treatment dose-dependently affected mitochondrial functions,including oxygen consumption rate(OCR),mitochondrial membrane potential(MMP)and the morphology of mitochondria in A549 cells.Therefore,this work offers a new way for BBR structural modification through improving cell membrane permeability to affect mitochondrial functions and potential anti-tumor therapy in the future. | Yi Liu Ke-xin Zhu Lei Cao Zhi-fu Xie Min Gu Wei Lü Jing-ya Li Fa-jun Nan | 2020 | Acta Pharmacologica Sinica2020，41，6： | 2 |
| 15 | A comparative study on the electron microscopic enzymo-cytochemistry of Paramecium bursaria from light and dark cultures显示文摘 | Gu F K Chen L Ni B | 2002 | Europ J Protistol2002，38，： | 2 |
| 16 | Inhibition of extracellular signal-regulated kinase enhances Ischemia/Reoxygenation-induced apoptosis in cultured cardiac myocytes and exaggerated reperfusion injury in isolated peffusod heart 显示文摘 | Yue T L Wang C Gu J L | 2000 | Circ Res2000，86，6： | 2 |
| 17 | Effect of Contact Pressure during Quenching on Microstructures and Mechanical Properties of Hot-stamping Parts显示文摘An experimental apparatus with cooling system and pressure-adjustment assembly for simulating quenching was constructed to investigate the effect of contact pressure on the microstructures and mechanical properties of hotstamping parts.Qualitative and quantitative analyses of the microstructures of the as-quenched parts were conducted;moreover,hardness and tensile tests were performed to measure their mechanical properties.The results indicated that contact pressure during quenching strongly affected the structures and performances of hot-stamping components.An excessive low contact pressure led to insufficient martensitic transformation.The critical contact pressure for complete martensitic transformation for 4.0mm 22MnB5 steel was 0.4MPa when the temperature of the coolant was 20 ℃.However,in consideration of the efficiency of practical production,a contact pressure higher than 1.25 MPa is recommended. | Zheng-wei GU Meng-meng L Guan-han LU Xin LI Hong XU | 2015 | Journal of Iron and Steel Research(International)2015，22，12： | 2 |
| 18 | Evaluation of Petroleum System in Xihu Depression, East China Sea Shelf Basin显示文摘According to the theory of petroleum system and the characteristics of petroleum geology, the Xihu depression in the East China Sea shelf basin is divided into four petroleum systems: the Pinghu Formation as source rock and the Huagang Formation as reservoir rock, the Huagang Formation as source rock and reservoir rock, the Paleocene as source rock and the burial-hill as reservoir rock, and the Miocene as source rock and reservoir rock. The system with the Pinghu Formation as source rock and the Huagang Formation as reservoir rock is the most important one in the depression, which has high hydrocarbon generation and accumulation efficiency and is the most important object to hydrocarbon exploration at present. | Ye Jiaren L■ Delin Faculty of Earth Resources , China University of Geosciences, Wuhan 430074 Gu Huirong Planning & Designing Institute, Shanghai Offshore Petroleum Bureau, Shanghai 200120 | 2001 | Journal of China University of Geosciences2001，12，4： | 2 |
| 19 | Sierpiński-triangle fractal crystals with the C_(3v)point group显示文摘Self-similar fractals are of importance in both science and engineering. Metal-organic Sierpin′ ski triangles are particularly attractive for applications in gas separation, catalysis and sensing. Such fractals are constructed in this study by using 1208 V-shaped 4,400-dicyano-1,10:30,100-terphenyl molecules and Fe atoms on Au(1 1 1), and studied in detail by low-temperature scanning tunneling microscopy. Density functional theory calculations are employed to rationalize the invisible Fe atoms in STM images. Monte Carlo simulations are performed to understand the formation mechanism of the surface-supported fractal crystals. | Na Li Xue Zhang Gao-Chen Gu Hao Wang Damian Nieckarz Pawel Szabelski Yang He Yu Wang Jing-Tao Lü Hao Tang Lian-Mao Peng Shi-Min Hou Kai Wu Yong-Feng Wang | 2015 | Chinese Chemical Letters2015，26，10： | 2 |
| 20 | Meshless method: An overview and recent developments显示文摘 | Belytschko T Lu Y Y Gu L | 1996 | Computer Methods Appl Mech Engrg1996，139，： | 2 |
您所在的机构暂未开通此部分的功能，请联系管理员