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| 1 | A unique sequence in the N-terminal regulatory region controls the nuclear localization of KLF8 by cooperating with the C-terminal zinc-fingers显示文摘Kr 眉 p 像像素的因素 8 (KLF8 ) 抄写因素在房间周期前进起一个关键作用, oncogenic 转变,对间充质的转变和侵略上皮。然而,它的原子本地化信号(NLS ) 没被识别。有另外的 KLF monopartite NLS (mNLS ) 和 C2H2 锌手指(ZF ) 的 KLF8 份额,哪个被显示了是为一些另外的 KLF 的 NLS。在这份报告,用指导 PCR 的 mutagenesis 和 immunofluorescent 显微镜学,我们显示出 mNLSs,任何单个 ZF 的删除,或变化的那混乱 Zn2+ 有约束力或联系 DNA 主题没影响 KLF8 的原子本地化。删除 > 然而,从 C 终点的 1.5 ZF 引起了 KLF8 的细胞质的累积。令人惊讶地,氨基酸(aa ) 的删除 151-200 区域几乎从原子核消除了 KLF8。有 PKC 禁止者的 S165A, K171E 或 K171R 变化,或处理导致了部分细胞质的累积。Co-immunoprecipitation 证明 KLF8 与 importin- 交往了,这个相互作用要求了 ZF 主题。aa 1-150 或 201-261 区域的删除独自没改变原子本地化。BrdU 加入和 cyclin D1 倡导者酶试金作为野类型的 KLF8 证明在原子本地化的 KLF8 异种有缺陷者不能支持 DNA 合成或 cyclin D1 倡导者激活。一起拿,这些结果建议 KLF8 有二 NLS,一包围 S165 和 K171 并且另外的是二双人脚踏车 ZF,它为 KLF8 原子本地化和它的细胞的功能的规定是批评的。 | Tina S Mehta Heng Lu Xianhui Wang Alison M Urvalek Kim-Hang H Nguyen Farah Monzur Jojo D Hammond Jameson Q Ma Jihe Zhao | 2009 | Cell Research2009，19，9： | 10 |
| 2 | 未处理或上游法处理后精子的DNA碎片能否预测使用赠卵ICSI后的妊娠?显示文摘本研究比较了未处理的精子和上游法处理后精子中的DNA碎片值(SDF)预测使用赠卵ICSI后妊娠的可能性。总共81例不孕女性接受通过夫精和赠卵ICSI后的胚胎移植。这种方式排除了目前公认的影响精子DNA修复的女方因素。在ICSI受精时,同时使用DNA碎片率检测试剂盒(Halosperm)进行盲法检测未处理的和上游法处理后精液中的精子DNA碎片。经上游法处理后的精液样本中SDF值呈显著下降。有趣的是,未处理的或上游法处理后精液样本中的SDF值均能预测妊娠。通过ROC曲线和其衍生的约登指数计算得出未处理前和上游法处理后精子sDF的临界值分别是24.8%和17.5%。未处理精子SDF预测妊娠的敏感性和特异性分别为75%和69%,而上游法处理后的精子SDF预测妊娠的敏感性和特异性分别是78%和73%。虽然SDF值增高与生育呈负相关,但我们发现在精子筛选降低sDF值后再与赠卵进行ICSI并不能保证获得妊娠。这表明目前的技术手段对于一些DNA损伤仍无法探及,从而相对影响辅助生殖成功的机率。因此,我们认为对目前的“冰山模式”作一些修饰后可以用来解释SDF在生育中的作用。 | Jaime Gosálvez Pedro Caballero Carmen López-Fernández Leonor Ortega José Andrés Guijarro José Luís FernAndez Stephen D Johnston Rocio Nufiez-Calonge | 2013 | Asian Journal of Andrology2013，15，6： | 3 |
| 3 | Predictive clinical features of cardioembolic infarction in patients aged 85 years and older显示文摘Objective To assess predictive clinical factors of cardioembolic infarction in very old patients(85 years of age and older).Methods Prospective hospital-based stroke registry('The Sagrat Cor Hospital of Barcelona Stroke Registry')is an acute-care teaching hospital in Barcelona,Catalonia,Spain.From 956 first-ever cardioembolic stroke patients included in the stroke registry over a 24-year period,639 were younger than 85 years of age and 317 were 85 years or older(mean age:88.9 years).Demographics,clinical characteristics,risk factors and early outcome were compared.Predictors of cardioembolic infarction in the oldest age group were assessed by multivariate analyses.Results In a logistic regression model based on demographics,risk factors,clinical features and complications,female gender(odds ratio[OR]=1.74,95%confidence interval[CI]:1.27–2.39),heart failure(OR=2.27,95%CI:1.46–3.56),altered consciousness(OR=1.76,95%CI:1.28–2.42),and infectious complications(OR=2.01,95%CI:1.39–2.91)were predictors of cardioembolic stroke in the oldest age group.By contrast,heavy smoking,heart valve disease,hypertension,headache,early seizures,sensory deficit,and involvement of the posterior cerebral artery were independently associated with cardioembolic stroke in the younger group.Conclusions Identification of a differential clinical profile of cardioembolic stroke between patients aged 85 years or more and those younger than 85 years helps clinicians to the optimal management of ischemic infarction in the oldest segment of the population. | Ana Maria Carbajo-García Jonatan Cortés AdriàArboix Joan Massons Laura Díez Enric Vergés Jordi Arboix-Alió Luís García-Eroles | 2019 | Journal of Geriatric Cardiology2019，16，11： | 3 |
| 4 | In vivo chondrogenesis of adult bone-marrow-derived autologous mesenchymal stem cells显示文摘 | Chen J Wang C Lu S Wu J Guo X Duan C Dong L Song Y Zhang J Jing D Wu L Ding J Li D | 2006 | 中国生物学文摘2006，20，5： | 2 |
| 5 | Absence of association between HPV DNA,TP53 codon 72 polymorphism, and risk of oesophageal cancer in a high-risk area of China显示文摘 | Hsin Lu S Snijders P | 2001 | Cancer Lett2001，162，2： | 1 |
| 6 | New and emerging developments in solar energy显示文摘 | GOSWAMI D Y VIJAYARAGHAVAN S LU S | 2004 | Solar Energy2004，76，： | 1 |
| 7 | Sorption of the herbicide mefenacet in soils显示文摘 | Lu Y Han S K Zhang C D | 2001 | Environmental Contamination and Toxicology2001，66，1： | 1 |
| 8 | Diffusion-tensor MR im-aging of intracranial neoplasia and associated peritumoraledema:introduction of the tumor infiltration index显示文摘 | LU S AHN D JOHNSON G | 2004 | Radiol-ogy2004，232，1： | 1 |
| 9 | Storm wave reactivation of a submarine landslide显示文摘 | Prior D B Suhayda J N Lu N J Bomhold B D Keller G H Wiseman W J Wright L D Yang Z S | 1989 | Nature1989，341，： | 1 |
| 10 | Diffusion-tensor MR imaging of intracranial neoplasia and associated peritumoral edema:introduction of the tumor infiltration index显示文摘 | Lu S Ahn D Johnson G | 2004 | Radiology2004，232，1： | 1 |
| 11 | Eigenvalues and the one-dimensional p-Laplacian显示文摘 | AGARWAL R P LU H S O'REGAN D | 2002 | J Math Anal Appl2002，266，： | 1 |
| 12 | Drug delivery and transport to solid tumors显示文摘 | Jang S H Wientjes M G Lu D | 2003 | Pharmaceutical Research2003，20，9： | 1 |
| 13 | Diesel-like hydrocarbons from catalytic deoxygenation of stearic acid over supported Pd nanoparticles on SBA-15 catalysts显示文摘 | LESTARI S MAKI-ARVELA P ERANEN K BELTRAMINI J LU G MURZIN D Y | 2010 | Catal Lett2010，134，34： | 1 |
| 14 | Anal Chim Acta显示文摘 | Cao D S Hu Q N Xu Q S Yang Y N Zhao J C Lu H M Zhang L X Liang Y Z | 2011 | 692(1-2):502011，692，12： | 1 |
| 15 | High-level expressionof bioactive recombinant human lysozyme in the milkof transgenic mice using a modified human lactoferrinBAC显示文摘 | LIU S LI X Q LU D | 2012 | Transgenic Res2012，21，2： | 1 |
| 16 | A new family of deploy- able mechanisms based on the Hoekens linkage显示文摘 | Lu S Zlatanov D Ding X | 2014 | Mech anismand Machine Theory2014，73，13： | 1 |
| 17 | Expression of free fatty acid receptor GPR40 in the central nervous system of adult monkeys显示文摘 | Ma D Tao B Warashina S Kotani S Lu L Kaplamadzhiev DB Mori Y Tonchev AB Yamashima T | | 0，，04： | 1 |
| 18 | A maize stress-responsive NAC transcription factor, ZmSNAC1, confers enhanced tolerance to dehydration in transgenic Arabidopsis 显示文摘 | LU M YING S ZHANG D F | 2012 | Plant Cell Reports2012，31，9： | 1 |
| 19 | Entropy minimization for shadow removal 显示文摘 | FINLAYSON G D DREW M S LU C | 2009 | International Journal of Computer Vision2009，85，1： | 1 |
| 20 | Cyclovirobuxine D induces autophagy-associated cell death via the Akt/m TOR pathway in MCF-7 human breast cancer cells显示文摘 | Lu J Sun D Gao S | 2014 | J Pharmacol Sci2014，125，1： | 1 |
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