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| 1 | Extensively drug-resistant bacteria are an independent predictive factor of mortality in 130 patients with spontaneous bacterial peritonitis or spontaneous bacteremia显示文摘AIM: To evaluate the epidemiology and outcomes of culture-positive spontaneous bacterial peritonitis(SBP) and spontaneous bacteremia(SB) in decompensated cirrhosis.METHODS: We prospectively collected clinical, laboratory characteristics, type of administered antibiotic, susceptibility and resistance of bacteria to antibiotics in one hundred thirty cases(68.5% males) with positive ascitic fluid and/or blood cultures during the period from January 1, 2012 to May 30, 2014. All patients with SBP had polymorphonuclear cell count in ascitic fluid > 250/mm3. In patients with SB a thorough study did not reveal any other cause of bacteremia. The patients were followed-up for a 30-d periodfollowing diagnosis of the infection. The final outcome of the patients was recorded in the end of follow-up and comparison among 3 groups of patients according to the pattern of drug resistance was performed.RESULTS: Gram-positive-cocci(GPC) were found in half of the cases. The most prevalent organisms in a descending order were Escherichia coli(33), Enterococcus spp(30), Streptococcus spp(25), Klebsiella pneumonia(16), S. aureus(8), Pseudomanas aeruginosa(5), other Gram-negative-bacteria(GNB)(11) and anaerobes(2). Overall, 20.8% of isolates were multidrug-resistant(MDR) and 10% extensively drugresistant(XDR). Health-care-associated(HCA) and/or nosocomial infections were present in 100% of MDR/XDR and in 65.5% of non-DR cases. Meropenem was the empirically prescribed antibiotic in HCA/nosocomial infections showing a drug-resistance rate of 30.7% while third generation cephalosporins of 43.8%. Meropenem was ineffective on both XDR bacteria and Enterococcus faecium(E. faecium). All but one XDR were susceptible to colistin while all GPC(including E. faecium) and the 86% of GNB to tigecycline. Overall 30-d mortality was 37.7%(69.2% for XDR and 34.2% for the rest of the patients)(log rank, P = 0.015). In multivariate analysis, factors adversely affecting outcome included XDR infection(HR = 2.263, 95%CI: 1.005-5.095, P = 0.049), creatinine(HR = 1.125, 95%CI: 1.024-1.236, P = 0.015) and INR(HR =1.553, 95%CI: 1.106-2.180, P = 0.011).CONCLUSION: XDR bacteria are an independent lifethreatening factor in SBP/SB. Strategies aiming at restricting antibiotic overuse and rapid identification of the responsible bacteria could help improve survival. | Alexandra Alexopoulou Larisa Vasilieva Danai Agiasotelli Kyriaki Siranidi Sophia Pouriki Athanasia Tsiriga Marina Toutouza Spyridon P Dourakis | 2016 | World Journal of Gastroenterology2016，22，15： | 19 |
| 2 | Circulating lymphangiogenic growth factors in gastrointestinal solid tumors, could they be of any clinical significance?显示文摘Metastasis is the principal cause of cancer mortality, with the lymphatic system being the first route of tumor dissemination. The glycoproteins VEGF-C and VEGF-D are members of the vascular endothelial growth factor (VEGF) family, whose role has been recently recognized as lymphatic system regulators during embryogenesis and in pathological processes such as inflammation, lymphatic system disorders and malignant tumor metastasis. They are ligands for the VEGFR-3 receptor on the membrane of the lymphatic endothelial cell, resulting in dilatation of existing lymphatic vessels as well as in vegetation of new ones (lymphangiogenesis). Their determination is feasible in the circulating blood by immunoabsorption and in the tissue specimen by immunohistochemistry and reverse transcription polymerase chain reaction (RT-PCR). Experimental and clinicopathological studies have linked the VEGF-C, VEGF-D/VEGFR3 axis to lymphatic spread as well as to the clinical outcome in several human solid tumors. The majority of these data are derived from surgical specimens and malignant cell series, rendering their clinical application questionable, due to subjectivity factors and post-treatment quantification. In an effort to overcome these drawbacks, an alternative method of immunodetection of the circulating levels of these molecules has been used in studies on gastric, esophageal and colorectal cancer. Their results denotethat quantification of VEGF-C and VEGF-D in blood samples could serve as lymph node metastasis predictive biomarkers and contribute to preoperative staging of gastrointestinal malignancies. | Theodore D Tsirlis George Papastratis Kyriaki Masselou Christos Tsigris Antonis Papachristodoulou Alkiviadis Kostakis Nikolaos I Nikiteas | 2008 | World Journal of Gastroenterology2008，14，17： | 12 |
| 3 | Arsenic speciation in fish from Greek coastal areas显示文摘Arsenic speciation analysis was conducted on fish samples(sardine and anchovy) collected from six areas along the Greek coastline, i.e. Artemisium Straits, Thermaikos Gulf, Amvrakikos Gulf,Strymonian Gulf, Thracian Sea, and Elefsina Gulf. Total arsenic levels ranging from 11.8 to62.6 mg As/kg dry weight were determined. Arsenobetaine, a non-toxic form of arsenic, was found to be the main arsenic species, present at 8.6 to 58.8 mg As/kg dry weight, accounting for67–95% of the total arsenic. Also detected in all fish samples was dimethylarsinic acid, although at considerably lower concentrations, ranging from 0.072–0.956 mg As/kg dry weight.Monomethylarsonic acid was detected at low levels in all anchovy samples, and only in sardines from one area. Finally, inorganic arsenic in the form of arsenate was detected only in fish at one area, indicating the possible effect of an environmental parameter on its presence at detectable amounts. Statistical analysis revealed the environmental variables, such as salinity,total organic carbon and nitrogen, ammonium, phosphate, total phosphorus, dissolved oxygen and pressure index, are potentially correlated to As species concentrations. Furthermore, based on factor analysis, the biological parameters, such as fish weight, lipids, protein and ash content,that are correlated to As species concentrations of fish were also identified. The interrelationship of arsenobetaine and dimethylarsinic acid concentrations within each fish species was evaluated. | Ioanna Kalantzi Kyriaki Mylona Katerina Sofoulaki Manolis Tsapakis Spiros A.Pergantis | 2017 | Journal of Environmental Sciences2017，29，6： | 11 |
| 4 | Chylorrhea complicating D2+a gastrectomy: review of the literature and clarification of terminology apropos one case显示文摘 | John Griniatsos Nikoletta Dimitriou Despina Kyriaki Antigoni Velidaki Stavros Sougioultzis Paris Pappas | 2010 | Chinese Medical Journal2010，，16： | 4 |
| 5 | Association between magnesium concentration and HbA1c in children and adolescents with type 1 diabetes mellitus (儿童与青少年1型糖尿病患者的镁浓度与HbA1c之间的关系)显示文摘 | Assimina Galli‐Tsinopoulou Ioanna Maggana Ioannis Kyrgios Konstantina Mouzaki Maria G. Grammatikopoulou Charilaos Stylianou Kyriaki Karavanaki | 2014 | Journal of Diabetes2014，，： | 2 |
| 6 | Clinical decision support systems for brain tumor characterization using advanced magnetic resonance imaging techniques显示文摘In recent years, advanced magnetic resonance imaging(MRI) techniques, such as magnetic resonance spec-troscopy, diffusion weighted imaging, diffusion tensor imaging and perfusion weighted imaging have been used in order to resolve demanding diagnostic prob-lems such as brain tumor characterization and grading, as these techniques offer a more detailed and non-invasive evaluation of the area under study. In the last decade a great effort has been made to import and utilize intelligent systems in the so-called clinical deci-sion support systems(CDSS) for automatic processing, classification, evaluation and representation of MRI data in order for advanced MRI techniques to become a part of the clinical routine, since the amount of data from the aforementioned techniques has gradually inticle is two-fold. The first is to review and evaluate the progress that has been made towards the utilization of CDSS based on data from advanced MRI techniques. The second is to analyze and propose the future work that has to be done, based on the existing problems and challenges, especially taking into account the new imaging techniques and parameters that can be intro-duced into intelligent systems to significantly improve their diagnostic specificity and clinical application. | Evangelia Tsolaki Evanthia Kousi Patricia Svolos Efthychia Kapsalaki Kyriaki Theodorou Constastine Kappas Ioannis Tsougos | 2014 | World Journal of Radiology2014，6，4： | 2 |
| 7 | Hemodynamic interaction between portal vein and hepatic artery flow in small-for-size split liver transplantation显示文摘 | Vassilios Smyrniotis Georgia Kostopanagiotou Agathi Kondi Evangelos Gamaletsos Kassiani Theodoraki Dimitrios Kehagias Kyriaki Mystakidou John Contis | 2002 | Transplant International2002，，7： | 2 |
| 8 | Effects of seed moisture content, stratification and sowing date on the germination of Corylus avellana seeds显示文摘For Corylus avellana, pericarp permeability,seed desiccation tolerance, and the effect of warm and cold moist stratification combinations on germination and of outdoor sowing date on dormancy breaking and seedling emergence were investigated. Seeds with(intact fruit nut)and without the pericarp were subjected to an imbibition test, and water uptake was measured. After nuts had been stored for 5 months at 3–5℃, seeds and desiccated seeds were cold-stratified at 3–5 ℃(for 0, 1, 2 or 3 months),then tested for germination. Nuts were warm-stratified at 20–25℃(for 0, 1 or 2 months), then cold-stratified(for 0,1, 2 or 3 months) and tested for seed germination. The nuts were sown outdoors on three dates in the same year of their collection: 15 September(immediately after collection), 2 November, and 17 December, and emerged seedlings were counted the following spring. The pericarp was not a barrier to water uptake by the seed;however, the seeds imbibed water faster and had more mass when the pericarp was removed. Seeds tolerated desiccation;germinationpercentage was not reduced when seed moisture content was reduced to 8.71%. Germination of seeds without the pericarp(regardless of the moisture content) was the highest when the seeds were cold-stratified for 2 months.When seeds with the pericarp were tested for germination,2 months of warm stratification before a 2-month cold stratification maximized seed germination. For outdoor sowing of nuts, sowing date affected percentage of seedling emergence the following spring;early autumn sowing(immediately after collection) resulted in the best emergence. | Elias Pipinis Athanasios Stampoulidis Elias Milios Kyriaki Kitikidou Sofia Akritidou Stavroula Theodoridou Kalliopi Radoglou | 2020 | Journal of Forestry Research2020，31，3： | 2 |
| 9 | Predicting the fluid temperature at the exit of the vertical ground heat exchangers 显示文摘 | Michopoulos A Kyriakis N | 2009 | Applied Energy2009，86，10： | 1 |
| 10 | Use of TTS fentanyl as a single opioid for cancer pain relief:a safety and efficacy clinical Trial in patients na? ye to mild of strong opioids显示文摘 | Kyriaki M Sofia B Eleni T | 2002 | Oncology2002，62，： | 1 |
| 11 | Mammalian mitogen-activated protein ki-nase signal transduction pathways activated by stress and in-flammation显示文摘 | Kyriakis J M Avruch J | | 0，，02： | 1 |
| 12 | Evaluation of thin-layer drying models for describing drying kinetics of figs (Ficus eariea ) 显示文摘 | BABALIS S J PAPANICOLAOU E KYRIAKIS N | 2006 | Journal of Food Engineering2006，75，： | 1 |
| 13 | Possible implications of leptin, adiponectin and ghrelin in the regulation of energy homeostasis by thyroid hormond 显示文摘 | Kokkinos A Mourouzis I Kyriaki D | 2007 | Endocrine2007，32，1： | 1 |
| 14 | Mammalian mitogen-activated protein ki-nase signal trans duction pathways activated by stress and inflam-mation显示文摘 | Kyriakis JM Avruch J | 2001 | Physiol Rev2001，81，2： | 1 |
| 15 | Mammalian MAPK signal transduction pathways activated by stress and inflammation: a 10-year up- date 显示文摘 | Kyriakis JM Avruch J | 2012 | Physiol Rev2012，92，2： | 1 |
| 16 | The stress activated protein kinase subfamily of c-jun kinase显示文摘 | Kyriakis J M Banerjee P Nilolakaki E | | 0，，6476： | 1 |
| 17 | Mammalian mitogen-activated protein ki- nase signal transduetion pathways activated by stress and inflammation 显示文摘 | Kyriakis JM Avruch J | 2001 | Physiol Rev2001，81，2： | 1 |
| 18 | Mammalian mitogen_activated protein kinase signal transduction pathways activated by stress and inflammation显示文摘 | Kyriakis JM Avruch J | 2001 | Physiol Rev2001，81，： | 1 |
| 19 | Operation characteristics and experience of a ground source heat pump system with a vertical ground heat exehanger显示文摘 | MICHOPOULOS A ZACHARIADIS T KYRIAKIS N | 2013 | Energy2013，51，1： | 1 |
| 20 | Safety,immunogenicity and efficacy of poxvirus-based vector vaccines expressing the haemagglutinin gene of a highly pathogenic H5N1 avian influenza virus in pigs显示文摘 | KYRIAKIS C S DE VLEESCHAUWER A BARBE F | 2009 | Vaccine2009，27，16： | 1 |
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