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| 1 | A novel synthetic compound MCAP suppresses LPS- induced murine microglial activation in vitro via inhibiting NF-kB and p38 MAPK pathways显示文摘目的:调查新奇合成混合物的 anti-neuroinflammatory 活动,对在 vitro.Methods 的 导致LPS 的 microglial 激活的 7-methylchroman-2-carboxylic 酸N-( 2-trifluoromethyl ) phenylamide ( MCAP ):主要老鼠 microglia 和 BV2 microglia 房间暴露于 LPS ( 50 或 100 ng/mL )。iNOS 和 COX-2 的表示, proinflammatory cytokines, NF-κ B 和 p38 MAPK 发信号分子被 RT-PCR,西方的污点和 ELISA 分析。microglia 的词法变化和 NF-ĸ 的原子 translocation; B 用阶段对比和荧光显微镜学被设想, respectively.Results : 有 MCAP 的预告的处理(0.1, 1, 10 μ mol/L ) 在 BV2 microglia 房间的 iNOS 和 COX-2 的 dose-dependently 禁止的导致 LPS 的表示。类似的结果与 MCAP 在主要 microglia pretreated 被获得(0.1, 0.5 μ mol/L ) 。MCAP dose-dependently 消除了 TNF-α 的导致 LPS 的版本;, IL-6 和 IL-1β,并且 NF-κ 的减轻的导致 LPS 的激活;由减少 Iκ 的 phosphorylation 的 B; Bα在 BV2 microglia 房间。而且, MCAP 稀释了 p38 MAPK 的 导致LPS 的 phosphorylation SB203580 ,一个 p38 MAPK 禁止者, MEF-2 ( p38 MAPK 下游的一个抄写因素)的表示上的显著地加强的 引起MCAP 的抑制 .Conclusion : MCAP 由禁止 p38 MAPK 和 NF-κ 在 vitro 在鼠科的 microglia 施加反煽动性的效果; B 发信号小径和 proinflammatory 回答。MCAP 可以为治疗包含激活的 microglial 房间的疾病作为一个新奇代理人被开发。 | Byung-Wook KIM Sandeep Vasant MORE Yo-Sep YUN Hyun-Myung KO Jae-Hwan KWAK Heesoon LEE Kyoungho SUK In-Su KIM Dong-Kug CHOI | 2016 | Acta Pharmacologica Sinica2016，37，3： | 8 |
| 2 | OPTIMIZED MEANSHIFT TARGET REFERENCE MODEL BASED ON IMPROVED PIXEL WEIGHTING IN VISUAL TRACKING显示文摘The generic Meanshift is susceptible to interference of background pixels with the target pixels in the kernel of the reference model, which compromises the tracking performance. In this paper, we enhance the target color feature by attenuating the background color within the kernel through enlarging the pixel weightings which map to the pixels on the target. This way, the background pixel interference is largely suppressed in the color histogram in the course of constructing the target reference model. In addition, the proposed method also reduces the number of Meanshift iterations, which speeds up the algorithmic convergence. The two tests validate the proposed approach with improved tracking robustness on real-world video sequences. | Chen Ken Song Kangkang Kyoungho Choi Guo Yunyan | 2013 | Journal of Electronics(China)2013，30，3： | 4 |
| 3 | 3D-printed gelatin methacrylate (GelMA)/ silanated silica scaffold assisted by two-stage cooling system for hard tissue regeneration显示文摘Among many biomaterials,gelatin methacrylate(GelMA),a photocurable protein,has been widely used in 3D bioprinting process owing to its excellent cellular responses,biocompatibility and biodegradability.However,GelMA still shows a low processability due to the severe temperature dependence of viscosity.To overcome this obstacle,we propose a two-stage temperature control system to effectively control the viscosity of GelMA.To optimize the process conditions,we evaluated the temperature of the cooling system(jacket and stage).Using the established system,three GelMA scaffolds were fabricated in which different concentrations(0,3 and 10 wt%)of silanated silica particles were embedded.To evaluate the performances of the prepared scaffolds suitable for hard tissue regeneration,we analyzed the physical(viscoelasticity,surface roughness,compressive modulus and wettability)and biological(human mesenchymal stem cells growth,western blotting and osteogenic differentiation)properties.Consequently,the composite scaffold with greater silica contents(10 wt%)showed enhanced physical and biological performances including mechanical strength,cell initial attachment,cell proliferation and osteogenic differentiation compared with those of the controls.Our results indicate that the GelMA/silanated silica composite scaffold can be potentially used for hard tissue regeneration. | Eunjeong Choi Dongyun Kim Donggu Kang Gi Hoon Yang Bongsu Jung MyungGu Yeo Min-Jeong Park SangHyun An KyoungHo Lee Jun Sik Kim Jong Chul Kim Woonhyeok Jeong Hye Hyun Yoo Hojun Jeon | 2021 | Regenerative Biomaterials2021，8，2： | 2 |
| 4 | Kinetic and mechanistic study on the chemical vapor deposition of titanium dioxide thin films by in situ FT-IR using TTIP 显示文摘 | Alan KyoungHo Park YoungBae Park DongWha | 2003 | Surface and Coating Technology2003，171，： | 1 |
| 5 | Fastlock hybrid PLL combining fractional-N and Integer-N modes of differing bandwidths 显示文摘 | Kyoungho Woo Yong Liu Eunsoo Nam | 2008 | IEEE Solid-State Circuits2008，43，2： | 1 |
| 6 | Natural Autoantibody to Galectin-9 in Normal Human Sera显示文摘 | Kyoungho Suk Dae-Yeon Hwang Myung-Shik Lee | 1999 | Journal of Clinical Immunology1999，，3： | 1 |
| 7 | Controlled release of guest molecules from mesoporous silica particles based on a pH-responsive polypseudorotaxane motif 显示文摘 | Chiyoung Park Kyoungho Oh Chulhee Kim | 2007 | Angewandte Chemie2007，46，9： | 1 |
| 8 | A cloud middleware for assuring performance and high availability of soft real-time applications 显示文摘 | Kyoungho A Shashank S Faruk C | 2014 | Journal of System Architecture2014，60，9： | 1 |
| 9 | Controlled release of guest molecules from mesoporous silica particles based on a pH-responsive polypseudorotaxane motif 显示文摘 | Park Chiyoung Oh Kyoungho Lee Sang Cheon Kim Chulhee | 2007 | Angew ChemInt Ed2007，46，9： | 1 |
| 10 | Regulation of IL- 18 production by IFN- 7 and PGE2 in mouse microglial cells: involvement of NF-κB pathway in the regulatory processes显示文摘 | Kyoungho S Sun YK Hocheol K | 2001 | Immunology Letters2001，77，2001： | 1 |
| 11 | Comparison of MOBILESa, MOBILE6, VT- MICRO and CMEM models for estimating hot- stabilized light -duty gasoline vehicle emission 显示文摘 | Hesham Rakha Kyoungho Alan Antonio Trani | 2003 | Canadian Journal of Civil Engineering2003，30，6： | 1 |
| 12 | Controlled release of guest molecules from mesoporous silica particles based on a pH-responsive polypseudorotaxane motif 显示文摘 | Kim Chulhee Lee Sang Cheon Oh Kyoungho Park Chiyoung | 2007 | Supramolecular Chemistry2007，46，9： | 1 |
| 13 | A field evaluation case study of the environmental and energy impacts of traffic calming 显示文摘 | Kyoungho Ahn Hesham Rakha | 2009 | Transportation Research2009，1，7： | 1 |
| 14 | Comparison of MOBILE5a,MOBILE6,VT-MICRO,and CMEM models for estimating hot-stabilized light-duty gasoline vehicle emissionsl显示文摘 | Hesham Rakha Kyoungho Ahn | 2003 | Canadian Journal of Civil Engineering2003，30，6： | 1 |
| 15 | Dependence of electrochemical properties of vanadium oxide films on their rtano-and mierostruetures显示文摘 | Lee Kyoungho Wang Ying Cao Guozhong | 2005 | The Journal of Physical Che- mistry B2005，109，16： | 1 |
| 16 | A context-aware workflow system for dynamic service Adaptation显示文摘 | Jongsun Choi Yongyun Cho Kyoungho Shin | 2007 | Computational Science and Its Applications ICCSA2007，2007，4705： | 1 |
| 17 | IFN-αsensitizes ME-180 human cervical cancer cells to TNF-induced apoptosis by inhibiting cytoprotective NF-kappa B activation显示文摘 | KYOUNGHO S KIM Y H CHANG I | 2001 | FEBS2001，，495： | 1 |
| 18 | 显示文摘 | Lee Kyoungho | 2005 | Phys Chem B2005，109，11： | 1 |
| 19 | The effects of route choice decisions on vehicle energy consumption and emissions 显示文摘 | Kyoungho A Hesham R | 2008 | Transportation Research Part D : Transport and Environment2008，13，3： | 1 |
| 20 | A numerical model study of barotropic subtidal water exchange between estuary and subestuaries (tributaries) in the Chesapeake Bay during northeaster events显示文摘 | GONG WENPING SHEN JIAN CHO KYOUNGHO | 2009 | Ocean Model2009，26，： | 1 |
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