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| 1 | Platelet-rich plasma for muscle injuries: A systematic review of the basic science literature显示文摘BACKGROUND Platelet-rich plasma(PRP) is an increasingly used biologic adjunct for muscle injuries, as it is thought to expedite healing. Despite its widespread use, little is known regarding the mechanisms by which PRP produces its efficacious effects in some patients.AIM To clarify the effects of PRP on muscular pathologies at the cellular and tissue levels by evaluating the basic science literature.METHODS A systematic review of PubMed/MEDLINE and EMBASE databases was performed using the Preferred Reporting Items for Systematic Reviews and MetaAnalyses(PRISMA) guidelines and checklist. Level III in vivo and in vitro studies examining PRP effects on muscles, myocytes and/or myoblasts were eligible for inclusion. Extracted data included PRP preparation methods and study results.RESULTS Twenty-three studies were included(15 in vivo, 6 in vitro, 2 in vitro/in vivo). Only one reported a complete PRP cytology(platelets, and red and white blood cell counts). Five in vitro studies reported increased cellular proliferation, four reported increased gene expression, and three reported increased cellular differentiation. Five in vivo studies reported increased gene expression, three reported superior muscle regeneration, and seven reported improved histological quality of muscular tissue.CONCLUSION The basic science literature on the use of PRP in muscle pathology demonstrates that PRP treatment confers several potentially beneficial effects on healing in comparison to controls. Future research is needed to determine optimal cytology,dosing, timing, and delivery methods of PRP for muscle pathologies. | Kyle N Kunze Charles P Hannon Jared D Fialkoff Rachel M Frank Brian J Cole | 2019 | World Journal of Orthopedics2019，10，7： | 6 |
| 2 | Targeting chronic lymphocytic leukemia cells in the tumor microenviroment: A review of the in vitro and clinical trials to date显示文摘Chronic lymphocytic leukemia(CLL) is the most common leukemia in the western world. Despite significantadvances in therapy over the last decade CLL remains incurable. Current front-line therapy often consists of chemoimmunotherapy-based regimens, most commonly the fludarabine, cyclophosphamide plus rituximab combination, but rates of relapse and refractory disease are high among these patients. Several key signaling pathways are now known to mediate the survival and proliferation of CLL cells in vivo, the most notable of which are the pathways mediated by the B-cell receptor(BCR) and cytokine receptors. A better understanding of the pathogenesis of the disease, the underlying biology of the CLL-cell and the roles of the tumour microenvironment has provided the rationale for trials of a range of novel, more targeted therapeutic agents. In particular, clinical trials of ibrutinib and idelalisib, which target the Brutons tyrosine kinase and the delta isoform of phosphoinositol-3 kinase components of the BCR signaling pathway respectively, have shown extremely promising results. Here we review the current literature on the key signaling pathways and interactions of CLL cells that mediate the survival and proliferation of the leukemic cells. For each we describe the results of the recent clinical trials and in vitro studies of novel therapeutic agents. | Kyle Crassini Stephen P Mulligan O Giles Best | 2015 | World Journal of Clinical Cases2015，3，8： | 5 |
| 3 | Car-bon nanomaterials in biosensors:should you use nanotubes orgraphene显示文摘 | Wenrong Yang Kyle R Ratinac Simon P Ringer | 2010 | Angewandte Chemie International Edition2010，49，12： | 1 |
| 4 | Analysis of trace elements including rare earth elements in fluid inclusion liquids 显示文摘 | Norman D I Kyle P R Baron C | 1989 | Econ Geol1989，84，1： | 1 |
| 5 | Microalgae as a source of fatty acids显示文摘 | BEHRENS P W KYLE D J | 1996 | Journal of Food Lipids1996，3，4： | 1 |
| 6 | Extending nodal aberration theory to include mount-induced aberrations with application to freeform surfaces显示文摘 | Kyle Fuerschbach Jannick P Rolland Kevin P Thompson | 2012 | Opt Express2012，20，20： | 1 |
| 7 | The impact of electric pas- senger transport technology under an economy -wide climate policy in the United States: Carbon dioxide emissions, coal use, and carbon di- oxide capture and storage 显示文摘 | Marshall W Kyle G P Dooley J J | 2010 | International Journal of Greenhouse Gas Control2010，，4： | 1 |
| 8 | Primary systemic amyloidisis: a rare complication of immunoglobulin M monoclonal gammopathies and Waldenstrom's macroglobulinemia显示文摘 | Gertz MA Kyle RA Noel P | 1993 | J Clin Oncol1993，11，5： | 1 |
| 9 | Analysis of trace elements including rare earth elements in fluid inclusion liquids 显示文摘 | Norman D I Kyle P R Baron C | 1989 | Economic Geology1989，84，： | 1 |
| 10 | Treatment of cachexia with recombinant growth hormone in a patient before lung transplantation: a case report显示文摘 | Kyle UG Jolliet P | 1999 | Crit Care Med1999，27，8： | 1 |
| 11 | Microalgaeas a sourceof fatty acid显示文摘 | BEHRENS P W KYLE D J | 1996 | Food Lipid1996，3，： | 1 |
| 12 | White Island volcano, New Zealand carbon dioxide and sulfur dioxide emission rates and melt inclusion studies 显示文摘 | Wardell L J Kyle P R Dunbar N | 2001 | Chemical Geology2001，177，： | 1 |
| 13 | Differential toxicity of silver and TiO2 nanoparticles on Drosophila melanogaster development, reproductive effort, and viability:Size, coatings and antioxidants matter显示文摘 | Ryan P Caitlin CM Kyle RM | 2011 | Chemosphere2011，85，1： | 1 |
| 14 | Effects of infusion time and addition of milk on content and absorption Of polyphcnols from black tea 显示文摘 | KYLE J A MORRICE P C MCNEILL G | 2007 | J Agric Food Chem2007，55，12： | 1 |
| 15 | Waldenstrom's macroglobulinaemia:a prospective study comparing daily with intermittent oral chlorambucil显示文摘 | KYLE R A GREIPP P R GERTZ M A | 2000 | Br J Haematol2000，108，： | 1 |
| 16 | Comparison of tools for nutritional assessment and screening at hospital admission:a population study显示文摘 | Kyle U G Kossovsky M P Karsegard V L | 2006 | Clin Nutr2006，25，3： | 1 |
| 17 | Review of trace toxic elements (Pb, Cd, Hg, As, Sb, Bi, Se, Te) and their deportment in gold processing: part II: deportment in gold ore processing by cyanidation 显示文摘 | Kyle J H Breuer P L Bunney K G | 2012 | Hydrometallurgy2012，111，： | 1 |
| 18 | Treatment of vasospastic disease with PGE1显示文摘 | Cliffered P C kyle V Pilger E | 1980 | Br Med J1980，281，： | 1 |
| 19 | El Nino and outgoing longwave radhtion:observations from Nimbus-7 ERB显示文摘 | Ardanuy P E Kyle H L | 1986 | Monthly Weather Review1986，114，： | 1 |
| 20 | Microalgaeas a source of fatty acid显示文摘 | BEHRENS P W KYLE D J | 1996 | Food Lipid1996，3，： | 1 |
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