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| 1 | 21世纪健康城市展望——上海的挑战显示文摘城市化为更好的生活与健康提供了前景。我们开始注意到由于未持续发展模式所造成的负面影响。全球化快速的变化使许多城市在物资、服务与人口流动上造成了困难,不论他们是旅游人员,农村流动人口,还是被迫离家的群体或难民。未来,保证城市的健康将成为保证整个人类社会健康的关键。为迎接21世纪的挑战,健康城市应提到全球健康的议程中,这一议程可称为“健康的城市化”,包括五个行动领域。对于上海来说,这是个很好去参与“健康的城市化”目标的时机。 | Wilfried Kreisel 戴俊明 | 2006 | 医学与哲学(A)2006，27，1： | 7 |
| 2 | Comprehensive lifestyle intervention vs soy protein-based meal regimen in non-alcoholic steatohepatitis显示文摘BACKGROUND Non-alcoholic steatohepatitis(NASH) has become one of the leading causes of liver disease in the western world. In obese patients weight reduction is recommended. Up to now there are no specific guidelines for weight loss in order to reduce hepatic fat content.AIM To investigate the effects of a 24-wk guided lifestyle intervention program compared to a meal replacement regimen based on soy protein.METHODS Twenty-six subjects with NASH participated in a randomized single-center study. They were randomly assigned to either meal replacement group(MR-G)with soy-yogurt-honey preparation or to guided lifestyle change group(LC-G)with endurance activity and nutrition counselling. Serum alanine transaminase(ALT), aspartate transaminase(AST), lipid parameters, and adipokines were measured. Liver fat content and lipid composition were determined by magnetic resonance imaging and magnetic resonance spectroscopy. Body fat mass and lean body mass were assessed using Bod Pod? device. Pre-and post-intervention monitoring of parameters was performed. Statistical analyses were conducted with SPSS software, results were expressed as median(interquartile range).RESULTS Twenty-two subjects(MR-G, n = 11 and LC-G, n = 11) completed the study(9 women, 13 men; age 52.1(15.0) years, body mass index(BMI) 32.3(3.3) kg/m^2).In both groups a significant weight loss was achieved(MR-G:-6.4(3.6) kg, P <0.01; LC-G:-9.1(10.4) kg, P < 0.01). BMI dropped in both groups(MR-G:-2.3(1.5)kg/m^2, P = 0.003; LC-G:-3.0(3.4) kg/m^2, P = 0.006). Internal fat and hepatic lipid content were markedly reduced in both groups in comparable amount. There was a strong correlation between reduction in liver fat and decrease in ALT.Likewise, both groups showed an improvement in glycemic control and lipid profile. Changes in adipokines, particularly in adiponectin and leptin were closely related to intrahepatic lipid changes.CONCLUSION Comprehensive lifestyle intervention and meal replacement regimen have comparable effects on body and liver fat, as well as decrease in markers of hepatic inflammation among NASH patients. | Peter Deibert Adhara Lazaro Denise Schaffner Aloys Berg Daniel Koenig Wolfgang Kreisel Manfred W Baumstark Daniel Steinmann Martin Buechert Thomas Lange | 2019 | World Journal of Gastroenterology2019，25，9： | 3 |
| 3 | Analysis of the nitric oxide-cyclic guanosine monophosphate pathway in experimental liver cirrhosis suggests phosphodiesterase-5 as potential target to treat portal hypertension显示文摘AIM To investigate the potential effect of inhibitors of phosphodiesterase-5(PDE-5) for therapy of portal hypertension in liver cirrhosis.METHODS In the rat model of thioacetamide-induced liver fibrosis/cirrhosis the nitric oxide-cyclic guanosine monophosphate(NO-cGMP) pathway was investigated. Expression and localization of PDE-5, the enzyme that converts vasodilating cGMP into inactive 5'-GMP, was in the focus of the study. Hepatic gene expression of key components of the NO-cGMP pathway was determined by qRT-PCR: Endothelial NO synthase(eNOS), inducible NO synthase(iNOS), soluble guanylate cyclase subunits α1 and β1(sGCa1, sGCb1), and PDE-5. Hepatic PDE-5 protein expression and localization were detected by immunohistochemistry. Serum cGMP concentrations were measured using ELISA. Acute effects of the PDE-5 inhibitor Sildenafil(0.1 mg/kg or 1.0 mg/kg) on portal and systemic hemodynamics were investigated using pressure transducers.RESULTS Hepatic gene expression of eNOS(2.2-fold; P = 0.003), sGCa1(1.7-fold; P = 0.003), sGCb1(3.0-fold; P = 0.003), and PDE-5(11-fold; P = 0.003) was increased in cirrhotic livers compared to healthy livers. Overexpression of PDE-5(7.7-fold; P = 0.006) was less pronounced in fibrotic livers. iNOS expression was only detected in fibrotic and cirrhotic livers. In healthy liver, PDE-5 protein was localized primarily in zone 3 hepatocytes and to a lesser extent in perisinusoidal cells. This zonation was disturbed in cirrhosis: PDE-5 protein expression in perisinusoidal cells was induced approximately 8-fold. In addition, PDE-5-expressing cells were also found in fibrous septa. Serum cGMP concentrations were reduced in rats with cirrhotic livers by approximately 40%. Inhibition of PDE-5 by Sildenafil caused a significant increase in serum cGMP concentrations [+ 64% in healthy rats(P = 0.024), + 85% in cirrhotic rats(P = 0.018)]. Concomitantly, the portal venous pressure was reduced by 19% in rats with liver cirrhosis. CONCLUSION Overexpression and abrogated zonation of PDE-5 likely contribute to the pathogenesis of cirrhotic portal hypertension. PDE-5 inhibition may therefore be a reasonable therapeutic approach for portal hypertension. | Denise Schaffner Adhara Lazaro Peter Deibert Peter Hasselblatt Patrick Stoll Lisa Fauth Manfred W Baumstark Irmgard Merfort Annette Schmitt-Graeff Wolfgang Kreisel | 2018 | World Journal of Gastroenterology2018，24，38： | 2 |
| 4 | Protein-losing pseudomembranous colitis with cap polyposis-like features显示文摘Protein-losing enteropathy(PLE) is characterized by loss of serum proteins into the gastrointestinal tract. It may lead to hypoproteinemia and clinically present as protein deficiency edema, ascites, pleural or pericardial effusion and/or malnutrition. In most cases the site of protein loss is the small intestine. Here we present an unusual case of severe PLE in a 55-year old female with a one-year history of recurrent diarrhea, crampy abdominal pain, and peripheral edema. Endoscopy and MRI showed a diffuse inflammatory thickening of the sigmoid colon and the rectum. Surgical resection of the involved colon was performed and the symptoms were significantly resolved. The final histologic evaluation confirmed a diagnosis of a pseudomembranous colitis with cap polyposis-like features. Such a cause of PLE has never been described before. | Wolfgang Kreisel Guenther Ruf Richard Salm Adhara Lazaro Bertram Bengsch Anna-Maria Globig Paul Fisch Silke Lassmann Annette Schmitt-Graeff | 2017 | World Journal of Gastroenterology2017，23，16： | 2 |
| 5 | Brain interleukin 1 mediates chronic stress-induced depression in mice via adrenocortical activation and hippocampal neurogenesis suppression显示文摘 | Goshen I Kreisel T Ben-Menachem-Zidon O | 2008 | Mol Psychiatry2008，13，7： | 1 |
| 6 | Deterioration of gait and balance over time: the effects of age-related white matter change--The LADIS Study显示文摘 | Kreisel SH Blahak C B | 2013 | Cerebrovasc Dis2013，35，6： | 1 |
| 7 | Preparation and characterization of titanium dioxide films for catalytic applications generated by anodic sparkdeposition 显示文摘 | MEYER S GORGES R KREISEL G | 2004 | Thin Solid Films2004，450，2： | 1 |
| 8 | Non-hematopoietic allograft cells directly activate CD8+T cells and trigger acute rejection:an alternative mechanism of allorecognition显示文摘 | Kreisel D Krupnick AS Gelman AE | 2002 | Nat Med2002，8，3： | 1 |
| 9 | Interleukin-1 signaling modulates stress-induced analgesia 显示文摘 | Wolf G Yirmiya R Kreisel T | 2007 | Brain Behav Immun2007，21，： | 1 |
| 10 | Donor antigen-presenting cells are important in the development of obliterative airway disease显示文摘 | Szeto WY Krasinskas AM Kreisel D | 2000 | J Thorac Cardiovasc Surg2000，120，6： | 1 |
| 11 | Oligosaccharide reprocessing and recycling of a cell surface glycoprotein in cultured rat hepatocytes 显示文摘 | Kreisel W Hildebrand H Mossner W | 1993 | Biol Chem Hoppe-Seyler1993，374，： | 1 |
| 12 | Predictors and earlyoutcome of hemorrhagic transformation after acute ischemic stroke显示文摘 | KABLAU M KREISEL SH SAUER T | 2011 | Cerebrovasc Dis2011，32，4： | 1 |
| 13 | Pragmatic management of hyperglycaemia in acute ischaemic stroke: safe- ty and feasibility of intensive intravenous insulin treatment 显示文摘 | Kreisel SH Berschin UM Hammes HP | 2009 | Cerebrovasc Dis2009，27，2： | 1 |
| 14 | Tunnel stability by convergence-confinement method显示文摘 | GESTA P KREISEL J LONDE P | 1980 | Underground Space1980，4，4： | 1 |
| 15 | A dual role for interleukin-1 in hippocampal-dependent memory processes显示文摘 | Goshen I Kreisel T Ounallah-Saad H | 2007 | Psychoneuroendocrinology2007，32，： | 1 |
| 16 | Preparation and Characterisation of Titanium Dioxide Films for Catalytic Applications Generated by Anodic Spark Deposition 显示文摘 | Meyer S Gorges R Kreisel G | 2004 | Thin Solid Films2004，450，2： | 1 |
| 17 | Predictors and early outcome of hemorrhagic transformation after acute ischcmic stroke 显示文摘 | Kablau M Kreisel SH Sauer T | 2011 | Cere- brovasc Dis2011，32，4： | 1 |
| 18 | A randomized, double-blind, double-dummy, multicenter trial of voriconazole and fluconazole in the treatment of esophageal candidiasis in immunocompromised patients显示文摘 | Schurmann D Kreisel W | 2001 | Clin Infect Dis2001，33，： | 1 |
| 19 | Complete remission of Crohn's disease after high - dose eyclophosphamide and autologous stem cell transplantation显示文摘 | Kreisel W Potthoff K Bertz H | 2003 | Bone Marrow Transplan12003，32，： | 1 |
| 20 | The case for robotic on-orbit servicing of spacecraft: spacecraft reliability is a myth 显示文摘 | ELLERY A KREISEL J SOMMER B | 2008 | Acta Astronautica2008，63，56： | 1 |
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