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| 1 | New treatment modalities in Alzheimer’s disease显示文摘Alzheimer’s disease (AD) is still a major public health challenge without an effective treatment to prevent or stop it. Routinely used acetylcholinesterase inhibitors and memantine seem to slow disease progression only to a limited extend. Therefore, many investigations on new drugs and other treatment modalities are ongoing in close association with increasing knowledge of the pathophysiology of the disease. Here, we review the studies about the new treatment modalities in AD with a classification based on their main targets, specifically pathologic structures of the disease, amyloid and tau, neural network dysfunction with special interest to the regulation of gamma oscillations, and attempts for the restoration of neural tissue via regenerative medicine. Additionally, we describe the evolving modalities related to gut microbiota, modulation, microglial function, and glucose metabolism. | Emel Koseoglu | 2019 | World Journal of Clinical Cases2019，7，14： | 7 |
| 2 | Gastric neuroendocrine neoplasms: A review显示文摘Gastric neuroendocrine neoplasms(g-NENs)or neuroendocrine tumors are generally slow-growing tumors with increasing incidence.They arise from enterochromaffin like cells and are divided into four types according to clinical characteristic features.Type 1 and 2 are gastrin dependent,whereas type 3 and 4 are sporadic.The reason for hypergastrinemia is atrophic gastritis in type 1,and gastrin releasing tumor(gastrinoma)in type 2 g-NEN.The diagnosis of g-NENs needs histopathological investigation taken by upper gastrointestinal endoscopy.g-NENs are positively stained with chomogranin A and synaptophysin.Grading is made with mitotic index and ki-67 proliferation index on histopathological analysis.It is crucial to discriminate between types of g-NENs,because the management,treatment and prognosis differ significantly between subtypes.Treatment options for g-NENs include endoscopic resection,surgical resection with or without antrectomy,medical treatment with somatostatin analogues,netazepide or chemotherapy regimens.Follow-up without excision is another option in appropriate cases.The prognosis of type 1 and 2 g-NENs are good,whereas the prognosis of type 3 and 4 g-NENs are close to the prognosis of gastric adenocancer. | Huseyin Koseoglu Tolga Duzenli Mesut Sezikli | 2021 | World Journal of Clinical Cases2021，9，27： | 2 |
| 3 | MRI measuremenes of water diffusion:impact of region of interest selection on ischemic quantifica- tion显示文摘 | Ozsunar Y Koseoglu K Huisman TA | 2004 | Eur J Radiol2004，51，3： | 1 |
| 4 | Identification of overexpression of orphan G protein coupled receptor GPR49 in human colon and ovarian primary tumors显示文摘 | MCCLANAHAN T KOSEOGLU S SMITH K | 2006 | Cancer Biol Ther2006，5，4： | 1 |
| 5 | Integrons显示文摘 | Koseoglu O | 2004 | Mikrobiyol Bul2004，38，3： | 1 |
| 6 | Crossflow surfactant-based ultrafiltration of heavy metals from waste streams显示文摘 | HUANG Y C BATCHELOR B KOSEOGLU S S | 1994 | Separate Science Technology1994，29，： | 1 |
| 7 | Endoscopic goniotomy with anterior chamber maintainer:surgical technique and one-year results显示文摘 | Bayraktar S Koseoglu T | 2001 | Ophthalmic Surg Lasers2001，32，6： | 1 |
| 8 | Boron removalfrom seawater using high rejection SWRO membranes -impactof pH,feed concentration, pressure,and cross-flow velocity显示文摘 | KOSEOGLU H KABAY N YUKSEL M | 2008 | Desalination2008，227，： | 1 |
| 9 | Relationship between the serum alanine aminotransferase level at the end of interferon treatment and histologic changes in wild-type and precore mutant hepatitis B virus infections显示文摘 | BAYRAKTAR Y KOSEOGLU T TEMIZER A | 1996 | J Viral Hepat1996，3，3： | 1 |
| 10 | Procalcitonin:Is it a predictor of noninvasive positive pressure ventilation necessity in acute chronic obstructive pulmonary disease exacerbation?显示文摘 | Pazarli A C Koseoglu H I Doruk S | 2012 | Journal of research in medical sciences:the official journal of Isfahan University of Medical Sciences2012，17，11： | 1 |
| 11 | The value of diffusion- weighted MRI in the diagnosis of malignant and benign urinary bladderlesions显示文摘 | Avcu S Koseoglu M N Ceylan K | 2011 | Br J Radiol2011，84，： | 1 |
| 12 | Comparison of blood gas and acid-base measurements in arterial and venous blood samples in patients witb uremic acidosis and diabetic ketoacidosis in the e mergency room显示文摘 | Gokel Y Paydas S Koseoglu Z | 2000 | Am J Nephrol2000，20，4： | 1 |
| 13 | Reduced aerobic capacity in patients with severe osteoporosis: a cross sectional study显示文摘 | Ordu Gokkaya NK Koseoglu F Albayrak N | 2008 | Eur J Phys Rehabil Med2008，44，2： | 1 |
| 14 | The role of jet inlet geometry in impinging jet heat transfer, modeling and experiments显示文摘 | KOSEOGLU M F BASKAYA S | 2010 | International Journal of Thermal Sci- ences2010，49，： | 1 |
| 15 | Hyperpigmented mycosis fungoides: a case report显示文摘 | Erbil H Sezer E Koseoglu D | 2007 | J Eur Acad Dermatol Venereol2007，21，7： | 1 |
| 16 | Treatment of a denimproducing textile industry wastewater using pilot-scale membranehioreactor显示文摘 | YIGIT N 0 UZAL N KOSEOGLU H | 2009 | Desalination2009，240，123： | 1 |
| 17 | Partial preoperative reduction of inguinal hernia through compression with an ultrasound transducter显示文摘 | Kutsi Koseoglu Yelda Ozsunar Fusun Taskin | 2003 | Journal of Clinical Uhrasound2003，31，7： | 1 |
| 18 | The use of deferoxamine infusions to enhance the response rate to interferon- alpha treatment of chronic viral hepatitis B 显示文摘 | Bayraktar Y Koseoglu T Somner C | 1996 | J Viral Hepal1996，3，3： | 1 |
| 19 | Membrane processing of crude vegetable oils: pilot plant scale removal of solvent from oil miscella 显示文摘 | KOSEOGLU S S LAWHON J F LUCAS E W | 1990 | J Am Oil Chem Soc1990，67，5： | 1 |
| 20 | Dissolution of root canal sealers in EDTA and NaOC1 solutions 显示文摘 | KELEA KOSEOGLU M | 2009 | J Am Dent Assoc2009，140，1： | 1 |
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