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| 1 | Hidden risks associated with conventional short intermittent hemodialysis:A call for action to mitigate cardiovascular risk and morbidity显示文摘The development of maintenance hemodialysis(HD)for end stage kidney disease patients is a success story that continues to save many lives.Nevertheless,intermittent renal replacement therapy is also a source of recurrent stress for patients.Conventional thrice weekly short HD is an imperfect treatment that only partially corrects uremic abnormalities,increases cardiovascular risk,and exacerbates disease burden.Altering cycles of fluid loading associated with cardiac stretching(interdialytic phase)and then fluid unloading(intradialytic phase)likely contribute to cardiac and vascular damage.This unphysiologic treatment profile combined with cyclic disturbances including osmotic and electrolytic shifts may contribute to morbidity in dialysis patients and augment the health burdenof treatment. As such, HD patients are exposed to multiple stressors including cardiocirculatory,inflammatory, biologic, hypoxemic, and nutritional. This cascade of events can be termed thedialysis stress storm and sickness syndrome. Mitigating cardiovascular risk and morbidityassociated with conventional intermittent HD appears to be a priority for improving patientexperience and reducing disease burden. In this in-depth review, we summarize the hidden effectsof intermittent HD therapy, and call for action to improve delivered HD and develop treatmentschedules that are better tolerated and associated with fewer adverse effects. | Bernard Canaud Jeroen P Kooman Nicholas M Selby Maarten Taal Andreas Maierhofer Pascal Kopperschmidt Susan Francis Allan Collins Peter Kotanko | 2022 | World Journal of Nephrology2022，11，2： | 2 |
| 2 | Causes and Consequences of Increased Sympathetic Activity in Renal Disease显示文摘 | Jaap A. Joles Hein A. Koomans | 2004 | Hypertension: Journal of the American Heart Association2004，，4： | 1 |
| 3 | Thrombosis and hemostasis in pineal disease 显示文摘 | RABELINK T J ZWAGINGA J J KOOMANS H A | 1994 | Kidney Int1994，46，2： | 1 |
| 4 | Role of the venous system in hemodynamics during ultrafihration and bicarbonate dialysis 显示文摘 | Kooman JP Gladziwa U Bocker G | 1992 | Kidney Int1992，42，3： | 1 |
| 5 | Spatialinhomogeneity of common carotid artery intima-media is increased in dialysis patients 显示文摘 | Hermans MH Kooman JP Brandenburg V | 2007 | Nephrol Dial Transpl2007，22，4： | 1 |
| 6 | Impaired renal clearance explains elevated troponin T fragments in hemodialysis patients显示文摘 | DIRIS J HACKENG C KOOMAN J | 2004 | Circulation2004，109，1： | 1 |
| 7 | Plasma volume recovery after uhrafihration in patients with chronic renal failure 显示文摘 | Koomans HA Geers AB Dorhout Mees EJ | 1984 | Kidney Int1984，26，6： | 1 |
| 8 | Effect of dialysate temperature on energy balance during hemodia- lysis: quantification of extracorporeal energy transfer 显示文摘 | VAN DER SANDE F M KOOMAN J P BUREMA J H | 1999 | Am J Kidney Dis1999，33，6： | 1 |
| 9 | Endothelin-induced vasopressor responses in essential hypertension显示文摘 | Kaasjager KAH Koomans HA Rabelink TJ | 1997 | Hypertension1997，30，1： | 1 |
| 10 | Fluid status in CAPDpatients is related to peritoneal transport and residual renal function:evidence from a longitudinal study显示文摘 | Konings CJ Kooman JP Schonck M | 2003 | Nephrology DialysisTransplantation2003，18，4： | 1 |
| 11 | Fluid status in CAPD patients is related to peritoneal transport and residual renal function: evidence from a longitudinal study 显示文摘 | Konings C J Kooman JP Schonck M | 2003 | Nephrol Dial Transplant2003，18，4： | 1 |
| 12 | Role of the venous system in hemodynamics during ultrafihration and bicarbonate dialysis显示文摘 | Kooman JP Gladziwa U Bocker G | 1992 | Kidney int1992，42，3： | 1 |
| 13 | Sympathetic hyperactivity in chronic renal failure: a wake-up call显示文摘 | Koomans HA Blankestijn PJ Joles JA | 2004 | J Am Soc Nephrol2004，15，： | 1 |
| 14 | Plasma and blood vol-ume in patients with the nephrotic syndrome显示文摘 | Geers AB Koomans HA Boer P | 1984 | Nephron1984，38，3： | 1 |
| 15 | Patho-physiology of edema formation in children with nephrotic syn-drome not due to minimal change disease显示文摘 | Vande Walle JG Donckerwolcke RA Koomans HA | 1999 | J AM Soc Nephrol1999，10，2： | 1 |
| 16 | New techniques to determine fluid status in hemodialyzed patients 显示文摘 | LEUNISSEN K M KOUW P KOOMAN J P | 1993 | Kidney Int Suppl1993，41，： | 1 |
| 17 | Hypoteasive periods during hemodialyaia显示文摘 | Kooman JP Sande FM Leunissen KM | 1999 | Ned Tijdschr Geneeskd1999，143，43： | 1 |
| 18 | Level of au- toimmune antibody in women with infertility: an analysis of 236 cases显示文摘 | Kooman J P Van der Sande F M Leunissen K M | 2013 | China Modem Doctor2013，51，3： | 1 |
| 19 | Acute renal failure after allogeneic myeloablative stem cell transplantation : retrospective analysis of incidence, risk factors and survival 显示文摘 | Kersting S Koomans HA Hen 6 RJ | 2007 | Bone Marrow Transplant2007，39，6： | 1 |
| 20 | A decline in residual glomerular filtration during the use of icodextrin may be due to underhydration显示文摘 | Konings CJ Kooman JP Gladziwa U | 2005 | Kidney Int2005，67，12： | 1 |
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