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| 1 | Music in depression: Neural correlates of emotional experience in remitted depression显示文摘AIM: To investigate neural and behavioral correlates of emotional experiences as potential vulnerability markers in remitted depression. METHODS: Fourteen remitted participants with a history of major depression and fourteen closely matched healthy control participants took part in the study. We used two psychiatric interviews(Hamilton Depression Rating Scale, Montgomery-Asberg Depression Rating Scale) and one self-report scale(Beck Depression Inventory) to assess remission. Healthy control participants were interviewed by an experienced psychiatrist to exclude those who showed any current or lifetime psychiatric or neurological disorders. To explore psychosocialand cognitive-interpersonal underpinnings of potential vulnerability markers of depression, early life stress, coping styles and alexithymia were also assessed. We induced pleasant and unpleasant emotional states using congruent combinations of music and human emotional faces to investigate neural and behavioral correlates of emotional experiences; neutral stimuli were used as a control condition. Brain responses were recorded using functional magnetic resonance imaging. Behavioral responses of pleasantness, arousal, joy and fear were measured via button-press inside the resonance imaging scanner. RESULTS: The mean age of the sample was 54.9(± 11.3) years. There were no differences between remitted depressed(RD)(n = 14; 9 females and 5 males) and healthy participants(n = 14; 8 females and 6 males) regarding age, current degree of depression, early life stress, coping styles and alexithymia. On a neural level, RD participants showed reduced activations in the pregenual anterior cingulate cortex(pg ACC) in response to pleasant [parameter estimates:-0.78 vs 0.32; t(26) =-3.41, P < 0.05] and unpleasant [parameter estimates:-0.88 vs 0.56; t(26)=-4.02, P < 0.05] emotional stimuli. Linear regression analysis revealed that pg ACC activity was modulated by early life stress [β =-0.48; R2 = 0.23, F(1,27) = 7.83, P < 0.01] and taskoriented coping style [β = 0.63; R2 = 0.37, F(1,27) = 16.91, P < 0.001]. Trait anxiety modulated hippocampal responses to unpleasant stimuli [β = 0.62; R2= 0.38, F(1,27) = 15.95, P < 0.001]. Interestingly, in their reported experiences of pleasantness, arousal, happiness and fear in response to pleasant, unpleasant and neutral stimuli, RD participants did not differ significantly from healthy control participants. Adding trait anxiety or alexithymia as a covariate did not change the results.CONCLUSION: The present study indicates that, in euthymic individuals, depression history alters neural correlates, but not the subjective dimension of pleasant and unpleasant emotional experiences. | Sabine Aust Karin Filip Stefan Koelsch Simone Grimm Malek Bajbouj | 2013 | World Journal of Psychiatry2013，3，2： | 3 |
| 2 | 特高压直流输电设备的设计显示文摘目前中国正在为各大水电站规划输电距离达2000km的大容量高压直流输电方案,800kV特高压直流是当前首选的方案。全球现有的高压直流输电系统的最高电压水平限制在500￣600 kV。因此,必须深入研究提高的稳态和暂态电压应力对特高压直流换流站主设备设计产生的影响。必须对现有技术水平和制造能力进行评估。将集中讨论特高压直流输电关键设备的特殊设计要求。 | HAEUSLER M KOELSCH H RAMASWAMI V | 2006 | 中国电力2006，39，2： | 3 |
| 3 | Towards a neural basis of music percep- tion显示文摘 | S Koelsch W A Siebel | 2005 | Trends Cogn Sci2005，9，12： | 1 |
| 4 | Music perception in cochlear implant users: an event--related potential study显示文摘 | Koelsch S Wittfoth M Wolf A | 2004 | Clin Neurophysiol2004，115，： | 1 |
| 5 | Atherogenic scavenger receptor modulation in the tubulointerstitium in response to chronic renal injury显示文摘 | Lopez-Guisa JM Koelsch K Collins S | 2007 | Am J Physiol Renal Physiol2007，293，： | 1 |
| 6 | An experimental route to Hofmeister显示文摘 | Patrick Koelsch Hubert Motschmann | 2004 | Curr Opin Coll Interface Sci2004，9，： | 1 |
| 7 | Structural locations and functional roles of new subsites S5,S6 and S7 in memapsin 2(Bsecretase)显示文摘 | Turner RT Hong L Koelsch G | 2004 | Biochemistry2004，，： | 1 |
| 8 | Biochemical and structural char aeterization of the interaction of memapsin2(β-secretase)cytosol to domain with the VHS domain of GGA proteins显示文摘 | He X Zhu G Koelsch G | 2003 | Biochemistry2003，42，12： | 1 |
| 9 | Dynamics of total, linear nonintegrated, and integrated HIV-1 DNA in vivo and in vitro 显示文摘 | Koelsch KK Liu L Haubrich R | 2008 | J Infect Dis2008，197，： | 1 |
| 10 | Memapsin 2 ( beta - secretase) as a therapeutic target 显示文摘 | Hong L Turner RT Koelsch G | 2002 | Biochem Soc Trans2002，30，4： | 1 |
| 11 | Distribution of TERTpromoter mutations in pediatric and adult tumors of the nervoussystem显示文摘 | Koelsche C Sahm F Capper D | 2013 | Acta Neuropathol2013，126，6： | 1 |
| 12 | Music perception in cochlear implant users: an event--related potential study显示文摘 | Koelsch S Wittfoth M Wolf A | 2004 | Clin Neurophysiol2004，115，： | 1 |
| 13 | Subsite specificity of memapsin 2 (beta-secretase):implications for inhibitor design显示文摘 | Turner RT 3rd Koelsch G Hong L | 2001 | Biochemistry2001，40，10： | 1 |
| 14 | Towards a neural basis of music-evoked emotions显示文摘 | Koelsch S | 2010 | Trends Cogn Sci2010，14，3： | 1 |
| 15 | Towards a neural basis of music-evoked emotions显示文摘 | Koelsch S | 2010 | Trends in Cognitive Sciences2010，14，3： | 1 |
| 16 | Hexanal formation via lipid oxidation as a function of oxygen concentration:Measurement and kinetics显示文摘 | Koelsch C M Downes T W Labuza T P | 1991 | Journal of Food Science1991，56，： | 1 |
| 17 | Node-positive duodenal car- cinoma is curable显示文摘 | Pickleman J Koelsch M Chejfec G | 1997 | Arch Surg1997，132，3： | 1 |
| 18 | Brain correlates of music-evoked emotions显示文摘 | Koelsch S | 2014 | Nature Reviews Neuroscience2014，15，3： | 1 |
| 19 | Investigating emotion with music:neuroscientific approaches显示文摘 | Koelsch S | 2005 | Annuals New York Academy of Sciences2005，1060，： | 1 |
| 20 | Structure of the protease domain of memapsin 2 (beta-secretase) complexed with inhibitor 显示文摘 | Hong L Koelsch G Lin X | 2000 | Science2000，290，5489： | 1 |
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