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	题名	作者	年代	出处	被引量
1	Evaluation of acoustic radiation force impulse imaging for determination of liver stiffness using transient elastography as a reference显示文摘AIM: To evaluate cut-off values and performance of acoustic radiation force impulse imaging (ARFI) using transient elastography [FibroScan■ (FS)] as a reference. METHODS: Six hundred and six patients were enrolled in this study.All patients underwent liver stiffness measurement with FS (FS-LS) and ARFI (with shear wave velocity quantification; ARFI-SWV) and the performance of ARFI in comparison to FS was determined. Sixtyeight patients underwent liver biopsy. RESULTS: Significantly higher success rates for the determination of liver stiffness were found using ARFI as compared to FS [604/606 (99.7%) vs 482/606 (79.5%); P < 0.001]. ARFI-SWV correlated significantly with FS-LS (r = 0.920, P < 0.001). ARFI-SWV increased significantly with the stage of fibrosis (1.09 ± 0.13 m/s for patients with no significant fibrosis (FS-LS < 7.6 kPa); 1.46 ± 0.27 m/s for patients with significant liver fibrosis (7.6 < FS-LS ≤ 13.0 kPa); and 2.55 ± 0.77 m/s for patients with liver cirrhosis (FS-LS > 13.0 kPa)). ARFI-SWV cut-off values were identified for no significant fibrosis (1.29 m/s; sensitivity 91.4% and specificity 92.6%) and for liver cirrhosis (1.60 m/s; sensitivity 92.3% and specificity 96.5%). The optimal cut-off value for predicting liver fibrosis (F ≥ 2) was 1.32 m/s (sensitivity 87.0% and specificity 80.0%) and for liver cirrhosis (F4) 1.62 m/s (sensitivity 100% and specificity 85.7%), for patients who underwent liver biopsy. An excellent inter-and intraobserver reproducibility was observed for ARFI-SWV determinations. CONCLUSION: An ARFI-SWV cut-off value of 1.29 m/s seems to be optimal for patients with no significant liver fibrosis and 1.60 m/s for patients with liver cirrhosis.	Gerald Kircheis Abdurrahman Sagir Christoph Vogt Stephan vom Dahl Ralf Kubitz Dieter Hussinger	2012	World Journal of Gastroenterology2012，18，10：	30
2	Voxel-based analyses of magnetization transfer imaging of the brain in hepatic encephalopathy显示文摘AIM: To evaluate the spatial distribution of cerebral abnormalities in cirrhotic subjects with and without hepatic encephalopathy (HE) found with magnetization transfer imaging (MTI).METHODS: Nineteen cirrhotic patients graded from neurologically normal to HE grade 2 and 18 healthy control subjects underwent magnetic resonance imaging. They gave institutional-review-board-approved written consent. Magnetization transfer ratio (MTR) maps were generated from MTI. We tested for significant differences compared to the control group using statistical non-parametric mapping (SnPM) for a voxelbased evaluation.RESULTS: The MTR of grey and white matter was lower in subjects with more severe HE. Changes were found in patients with cirrhosis without neurological defi cits in the basal ganglia and bilateral white matter. The loss in magnetization transfer increased in severity and spatial extent in patients with overt HE. Patients with HE grade 2 showed an MTR decrease in white and grey matter: the maximum loss of magnetization transfer effect was located in the basal ganglia [SnPM (pseudo-)t = 17.98, P = 0.0001].CONCLUSION: The distribution of MTR changes in HE points to an early involvement of basal ganglia and white matter in HE.	Falk R Miese Hans-Jrg Wittsack Gerald Kircheis Arne Holstein Christian Mathys Ulrich Mdder Mathias Cohnen	2009	World Journal of Gastroenterology2009，15，41：	2
3	Hepatic encephalopathy as a complication of liver disease显示文摘INTRODUCTIONHepatic encephalopathy ( HE) is a frequent complication of chronic liver disease .It is defined as a characteristic functional and reversible alteration of the mental state ,due to impaired liver function and / or increased portosystemic shunting .	Stephan vom Dahl Gerald Kircheis Dieter Haussinger	2001	World Journal of Gastroenterology2001，7，2：	2
4	Ernst Wagner Design and gene delivery activity of modified polyethylenimines显示文摘	Wightman L	2001	Adv Drug Deliv Rev2001，53，3：	1
5	Design and gene delivery activity of modified polyethylenimines 显示文摘	KIRCHEIS R WIGHTMAN L WAGNER E	2001	Adv Drug Deliv Rev2001，53，3：	1
6	polycation-based DNA complexes for tumor-targeted gene delivery in vivo 显示文摘	Kircheis R Schuller S Brunner S	1999	J Gene Med1999，1，2：	1
7	Therapeutic efficacy of L-ornithine- L-aspartate infusions in patients with cirrhosis and hepatic encephalopathy: results of a placebo-conltolled, double blind study 显示文摘	Kircheis G Nilins R Held C	1997	Hepatology1997，25，6：	1
8	Design and gene delivery activity of modified polyethylenimines 显示文摘	KIRCHEIS R WIGHTMAN L WAGNER E	2001	Ad- vanced Drug Delivery Reviews2001，53，：	1
9	Hepatic encephaiopathy显示文摘	Kircheis G Haussinger D	2012	Dtsch Med Wochenschr2012，137，4：	1
10	Design and gene delivery activity of modified polyethylenimines显示文摘	WIGHTMAN L WAGNER E	2001	Adv Drug Deliv Rev2001，53，3：	1
11	Hepatic Encephalopathy in Chronic Liver Disease:a Clinical Manifestation of Astrocyte Swelling and Low grade Cerebral Edema显示文摘	Haussinger D Kircheis G Fischer R	2000	J Hepatol2000，32，6：	1
12	Oral L - Ornithrone - L - aspartate therapy of chronic hepatic encephalopathy results of a placebo Controlled doubleblind Study显示文摘	Steuch S Kircheis G Adler G	1988	J Hepatol1988，28，：	1
13	Different behavior of branched and linear polyethylenimine for gene delivery in vitro and in vivo 显示文摘	Kircheis R Rssler V	2001	J Gene Med2001，3，4：	1
14	Design and gene delivery activity of modified polyethylenimines显示文摘	Kircheis R Wightman L Wagner E	2001	Adv Drug Deliv Rev2001，53，3：	1
15	Tumor targeting with surfaceshielded ligand-polycation DNA complexes显示文摘	Kircheis R Blessing T Brunner S	2001	J Control Release2001，72，13：	1
16	Nonviral gene transfer into fetal mouse livers( a comparison between the cationic polymer PEI and naked DNA) 显示文摘	Gharwan H Wightman L Kircheis R	2003	Gene Ther2003，10，：	1
17	Different behavior of branched and linear polyethylenimine for gene delivery in vitro and in vivo显示文摘	Wightman L Kircheis R Rossler V	2001	J Gene Med2001，3，4：	1
18	Tumor-targeted gene delivery: an attractive strategy to use highly active effector molecules in cancer treatment 显示文摘	Kircheis R Wightman L Kursa M	2002	Gene Ther2002，9，：	1
19	1H-MR Spectroscopy, Magnetization Transfer, and Diffusion-Weighted Imaging in Alcoholic and Nonalcoholic Patients with Cirrhosis with Hepatic Encephalopathy显示文摘	Miese F Kircheis G Wittsack H J	2006	AJNR2006，27，5：	1
20	Critical flicker frequency for quantification of low-grade hepatic encephalopathy 显示文摘	Kircheis G Wettstein M Timmermann L	2002	Hepatology2002，35，2：	1

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