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154篇 您的检索式：作者名="Kiley"

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	题名	作者	年代	出处	被引量
1	PI3K/Akt/mTOR inhibitors in breast cancer显示文摘Activation of the phosphoinositide 3 kinase(PI3K)/Akt/mammalian target of rapamycin(mTOR) pathway is common in breast cancer. There is preclinical data to support inhibition of the pathway, and phase Ⅰ to Ⅲ trials involving inhibitors of the pathway have been or are being conducted in solid tumors and breast cancer. Everolimus, an mTOR inhibitor, is currently approved for the treatment of hormone receptor(HR)-positive, human epidermal growth factor receptor 2(HER2)-negative breast cancer. In this review, we summarise the efficacy and toxicity findings from the randomised clinical trials, with simplified guidelines on the management of potential adverse effects. Education of healthcare professionals and patients is critical for safety and compliance. While there is some clinical evidence of activity of mTOR inhibition in HR-positive and HER2-positive breast cancers, the benefits may be more pronounced in selected subsets rather than in the overall population. Further development of predictive biomarkers will be useful in the selection of patients who will benefit from inhibition of the PI3K/Akt/mTOR(PAM) pathway.	Joycelyn JX Lee Kiley Loh Yoon-Sim Yap	2015	Cancer Biology & Medicine2015，12，4：	21
2	Self-assembling peptide detergents stabilize isolated photosystem 1 on a dry surface for an extended time显示文摘	Kiley P Zhao X J Vaughn M	2005	PLoS Biol2005，3，7：	1
3	Some Recent Advances in Nanostructure Preparation from Gold and Silver Particles: a Short Topical Review显示文摘	Brust M Kiley C J	2002	Colloids Surf a Physicochem Eng Aspects2002，202，：	1
4	The use of time to ignition data for characterizing the thermal inertia and the minimum (critical) heat flux for ignition or pyrolysis 显示文摘	DELICHATSIOS M A PANAGIOTOU T H KILEY F	1991	Combustion and Flame1991，84，：	1
5	Growth factor mediated phosphorylation of proapoptotic BAD reduce tubule cell death in vitro and in vivo显示文摘	KILEY S C THORNHILL B A TANG S S	2003	Kidney Int2003，63，1：	1
6	A pivotal role for the response regulato- r DegU in controlling multicellular be-haviour显示文摘	Murray E J Kiley T B Stanley-Walln R	2009	Microbiology2009，，：	1
7	Omeprazole-associated digoxin toxicity显示文摘	Cragin D J Roth B J	2007	South Med J2007，100，4：	1
8	Acute convexity subarachnoid haemorrhage:a cause of aura-like symptoms in the elderly显示文摘	Kleinig TJ Kiley M Thompson PD	2008	Cephalalgia2008，28，：	1
9	Team-based learning: a novel ap- proach to medical student education in family planning 显示文摘	I Mody SK Kiley J Gawron L	2012	Contra- ception2012，27，：	1
10	Pfiofitized research a- genda for prevention and control of chronic respiratory diseases 显示文摘	Bousquet J Kiley J Bateman ED	2010	Eur Respir J2010，36，5：	1
11	Protection of rhesus monkeys from Lassa virus by immunisation with closely related Arenavirus 显示文摘	Kiley MP Lange JV Johnson KM	1979	Lancet1979，2，8145：	1
12	Barriers to health and social services for street-based sex workers显示文摘	Kurtz SP Surratt HL Kiley MC Inciardi JA	2005	Journal of Health Care for the Poor and Underserved2005，16，2：	1
13	Protein kinase C delta involvement in mammary tumor cell metastasis 显示文摘	Kiley SC Clark K J Goodnough M	1999	Cancer Res1999，59，13：	1
14	Modeling,optimization,and control of magnetostrictive high force to mass ratio reaction mass actuators显示文摘	DOZOR J M ENGEL B B KILEY J E	1997	SPIE1997，3044，：	1
15	Designer short peptide surfactants stabilize G protein- coupled receptor bovine rhodopsin 显示文摘	Zhao X Nagai Y Reeves PJ Kiley P Khorana HG Zhang S	2006	Proc Natl Aead Sci U S A2006，103，17：	1
16	Self-assembling peptide detergents stabilize isolated photosystem I on a dry surface for an extended time 显示文摘	Kiley P Zhao X Vaughn M Baldo MA Bruce BD Zhang S	2005	PLoS Biol2005，3，：	1
17	The cyberspace database information overload显示文摘	Kiley K	1995	Catalog Age1995，12，9：	1
18	Intracranial hypertension in Sturge-Weber/Klippel-Trenaunay-Weber overlap syndrome due to impairment of cerebral venous outflow显示文摘	Kiley MA Oxbary JM Coley SC	2002	J Clin Neurosci2002，9，3：	1
19	Pattern formation in the Gray- Scott model 显示文摘	MCGOUGH J S KILEY K	2004	Nonlinear Anal Real World Appl2004，5，：	1
20	Effects of smoking intervention and the use of an inhaled anticholinergie bronehodilator on the rate of decline of FEV1 : the Lung Health Study显示文摘	Anthonisen NR Connett JE Kiley JP	1994	JAMA1994，272，19：	1

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