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| 1 | Current role of fenofibrate in the prevention and management of non-alcoholic fatty liver disease显示文摘Non-alcoholic fatty liver disease(NAFLD) is a common health problem with a high mortality burden due to its liver- and vascular-specific complications. It is associated with obesity, high-fat diet as well as with type 2 diabetes mellitus(T2DM) and metabolic syndrome(MetS).Impaired hepatic fatty acid(FA) turnover together with insulin resistance are key players in NAFLD pathogenesis. Peroxisome proliferator-activated receptors(PPARs)are involved in lipid and glucose metabolic pathways.The novel concept is that the activation of the PPARαsubunit may protect from liver steatosis. Fenofibrate, by activating PPARα, effectively improves the atherogenic lipid profile associated with T2DM and MetS. Experimental evidence suggested various protective effects of the drug against liver steatosis. Namely, fenofibraterelated PPARα activation may enhance the expression of genes promoting hepatic FA β-oxidation. Furthermore, fenofibrate reduces hepatic insulin resistance. It also inhibits the expression of inflammatory mediators involved in non-alcoholic steatohepatitis pathogenesis.These include tumor necrosis factor-α, intercellular cell adhesion molecule-1, vascular cell adhesion molecule-1and monocyte chemoattractant protein-1. Consequently, fenofibrate can limit hepatic macrophage infiltration. Other liver-protective effects include decreased oxidative stress and improved liver microvasculature function. Experimental studies showed that fenofibrate can limit liver steatosis associated with high-fat diet,T2DM and obesity-related insulin resistance. Few studies showed that these benefits are also relevant even in the clinical setting. However, these have certain limitations. Namely, these were uncontrolled, their sample size was small, fenofibrate was used as a part of multifactorial approach, while histological data were absent.In this context, there is a need for large prospective studies, including proper control groups and full assessment of liver histology. | Michael S Kostapanos Anastazia Kei Moses S Elisaf | 2013 | World Journal of Hepatology2013，5，9： | 16 |
| 2 | Developing a long-term local society design methodology towards a low carbon economy: An application to Shiga Prefecture in Japan 显示文摘 | Koji S Yoshitaka T Kei G | 2007 | Energy Policy2007，，35： | 1 |
| 3 | Periamullary tumors; high-spatial resolution MR imaging and histopathologic findings in ampullary region specimens显示文摘 | Reiji S Akemi F Kei I | 2004 | Radiology2004，231，3： | 1 |
| 4 | Sequence analysis of the genome of Bombyx mori nucleopolyhedrovirus显示文摘 | Gomi Sumiko Kei Majima Maeda S | 1999 | J Gen Virol1999，80，： | 1 |
| 5 | Secure group communications using key graphs显示文摘 | Chung Kei Wong Gouda M Lam S S | 2000 | IEEE/ACM Transactions on Networking2000，8，1： | 1 |
| 6 | Conductive hearing loss and middle ear pathology in young infants referred through a newborn universal hearing screening program in Australia显示文摘 | AITHAL S AITHAL V KEI J | 2012 | J Am Acad Audiol2012，23，： | 1 |
| 7 | Purpose- Built Anisotropic Metal Oxide Material:? 3D Highly Oriented Microrod Array of ZnO 显示文摘 | VAYSSIERES L KEIS K LINDQUIST S - E | 2001 | The Jour- nal of Physical Chemistry B2001，105，17： | 1 |
| 8 | Catalytic activity of lanthanide( Ⅲ) ions for the dehydration of hexo6e to 5 - hydroxymethyl- 2 -furaldehyde in water 显示文摘 | Kei - iehi S Yoshihisa I Hitoshi 1 | 2001 | Bull Chem Soe Jpn2001，74，6： | 1 |
| 9 | Brain natriuretic peptide (BNP) level is closely related to the extent of left ventricular sympathetic over activity in chronic ischemic heart failure显示文摘 | KAZUYUKI S KEI I NAO M | 2009 | In- ter Med2009，48，： | 1 |
| 10 | Glycosylation of capsaicin and 8-nordihydrocapsaicin by cultured cells of Catharanthus roseus显示文摘 | Kei S Soonil K Akiko U | 2007 | Phytochemistry2007，68，： | 1 |
| 11 | Sequence analysis of the genome of Bombyx mori nucleopolyhedrovirus显示文摘 | Gomi Sumiko Kei Majima Maeda S | 1999 | J Gen Virol1999，80，： | 1 |
| 12 | Sequence and expression of androgen receptor and estrogen receptor gene in the sex types of protognous wasse, Hahichoeres trimaculatus显示文摘 | Kei S J Ogasawara K Park J G | 2002 | Gen Comp Endocrinol2002，127，： | 1 |
| 13 | Lignin Depolymerization with Phenol via Redistribution Mechanism in Ionic Liquids 显示文摘 | Sepa N Antonio F P Kei S | 2014 | AmerieaJ1 Chemical Society2014，，2： | 1 |
| 14 | Modeling Visual Attention Via Selective Tuning显示文摘 | Tsotsos J K Culhane S M Kei Wai W Y | 1995 | Artificial intelligence1995，78，12： | 1 |
| 15 | Secure Group Communications Using Key Graphs显示文摘 | Chung Kei Gouda M Lam S S | 2000 | IEEE/ACM Transaction on Networking2000，8，1： | 1 |
| 16 | Effect of doping on thermoelectric properties of delafossite p-type oxide CuCrO2 显示文摘 | KEI H KENICHI S TOMOHIRO N | 2008 | Japanese J Appl Phys2008，1，9： | 1 |
| 17 | Periampullary tumors:high-spatial resolution MR imaging and histopathologic findings in ampullary region specimens显示文摘 | Reiji S Akemi F Kei I | 2004 | Radiology2004，231，： | 1 |
| 18 | Periamullary tumors:high-spatial resolution MR imaging and histopathologic findings in ampullary region specimens显示文摘 | Reiji S Akemi F Kei I | 2004 | Radiology2004，231，3： | 1 |
| 19 | Periamullary tumors;high spatial resolution MR imaging and histopathologlic findings in ampull- lary region specimens 显示文摘 | Reiji S Akemi F Kei I | 2004 | Radiology2004，231，3： | 1 |
| 20 | Purpose-built anisotropic metal oxide material : 3D Highly oriented microrod array of ZnO显示文摘 | VAYSSIERES L KEIS K LINDUIST S E | 2001 | Phys Chem B2001，105，： | 1 |
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