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| 1 | Notch signaling controls chondrocyte hypertrophy via indirect regulation of Sox9显示文摘RBPjk-dependent Notch signaling regulates both the onset of chondrocyte hypertrophy and the progression to terminal chondrocyte maturation during endochondral ossification. It has been suggested that Notch signaling can regulate Sox9 transcription, although how this occurs at the molecular level in chondrocytes and whether this transcriptional regulation mediates Notch control of chondrocyte hypertrophy and cartilage development is unknown or controversial. Here we have provided conclusive genetic evidence linking RBPjk-dependent Notch signaling to the regulation of Sox9 expression and chondrocyte hypertrophy by examining tissuespecific Rbpjk mutant(Prx1Cre;Rbpjkf/f), Rbpjk mutant/Sox9 haploinsufficient(Prx1Cre;Rbpjkf/f;Sox9f/1),and control embryos for alterations in SOX9 expression and chondrocyte hypertrophy during cartilage development. These studies demonstrate that Notch signaling regulates the onset of chondrocyte maturation in a SOX9-dependent manner, while Notch-mediated regulation of terminal chondrocyte maturation likely functions independently of SOX9. Furthermore, our in vitro molecular analyses of the Sox9 promoter and Notch-mediated regulation of Sox9 gene expression in chondrogenic cells identified the ability of Notch to induce Sox9 expression directly in the acute setting, but suppresses Sox9 transcription with prolonged Notch signaling that requires protein synthesis of secondary effectors. | Anat Kohn Timothy P Rutkowski Zhaoyang Liu Anthony J Mirando Michael J Zuscik Regis J O'Keefe Matthew J Hilton | 2015 | Bone Research2015，3，3： | 8 |
| 2 | Comments on chemical relationships among Zhamanshinites,Australasian tektites and Henbury impact glass显示文摘 | O'KEEF J A | 1980 | Geochim Cosmochim Acta1980，44，： | 1 |
| 3 | Deposition and characterization of cerium oxide conversion coatings on aluminum alloy 7075-T6 显示文摘 | RIVERA B F OHNSONB Y J O'KEEFE M J | 2004 | Surface and Coatings Technology2004，176，3： | 1 |
| 4 | Infrared optical properties and Ra man spectra of n-pentane and n-pentane-d12 显示文摘 | Keefe C D Scott J F | 2011 | Vibration al Spectroscopy2011，57，1： | 1 |
| 5 | Organizationstrategy and structural differences for radical versus in-cremental innovation显示文摘 | ETTLIE J BRIDGES W O'KEEFE R | 1984 | Management Science1984，30，6： | 1 |
| 6 | Dopamine D1 receptor binding in the anterior cingulated cortex of patients with obsessive-compulsive disorder 显示文摘 | OLVER J S O' KEEFE G JONES G R | 2010 | Psychiatry Res: Neuroimaging2010，183，1： | 1 |
| 7 | Cavity ringdown laser absorption spectroscopy: history, development, and application to pulsed mo- lecular beams显示文摘 | Scherer J J Paul J B O'keefe A | 1997 | ChemRev1997，97，1： | 1 |
| 8 | Plant expression of a bacterial cytochrome P450 that catalyzes activation of a sulfonylurea pro-herbicide 显示文摘 | O'Keefe D P Tepperman J M Dean C | 1994 | Plant Physiol1994，105，： | 1 |
| 9 | Periprosthetic osteolysis: an immunologist?s update显示文摘 | R John Looney Edward M Schwarz Allen Boyd Regis J O?Keefe | 2006 | Current Opinion in Rheumatology2006，，1： | 1 |
| 10 | Cancer chemotherapy - induced diarrhoea andconstipation : mechanisms of damage and prevention strategies显示文摘 | Gibson R J Keefe D M | 2006 | Sup-portive Care in Cancer2006，14，9： | 1 |
| 11 | Self-efficacy for Managing Pain, Symptoms, and Function in Patients with Lung Cancer and Their Informal Caregivers: Associations with Symptoms and Distress显示文摘 | Porter L S Keefe F J Garst J | 2008 | Pain2008，137，2： | 1 |
| 12 | Organization strategy and structural differences for radical versus incremental innovation 显示文摘 | Bridges W P O'Keefe R D | 1984 | Management Science1984，，6： | 1 |
| 13 | The hippocampus as a spatial map: preliminary evidence from unit activity in the freely-moving rat 显示文摘 | O'Keefe J Dostrovsky J | 1971 | Brain Res1971，34，1： | 1 |
| 14 | Analysis of crab meat volatiles as possible spoilage indicators for blue crab (callinectes sapidus)meat by gas chromatography-Mass spec- trometry显示文摘 | Sarnoski P J O'Keefe S F Jahncke M L | 2010 | Food Chemistry2010，122，3： | 1 |
| 15 | Self-efficacy for managing pain, symptoms, and function in patients with lung cancer and their informal caregivers:associations with symptoms and distress显示文摘 | Porter LS Keefe FJ Garst J | 2008 | Pain2008，137，2： | 1 |
| 16 | What is personalization?显示文摘 | Keefe J | 2007 | Phi Delta Kappan2007，，3： | 1 |
| 17 | Organization strategy and structural differences for radical versus incremental innovation显示文摘 | Ettlie J E Bridges W P O'Keefe R D | 1984 | Management Science1984，30，6： | 1 |
| 18 | Pharmacologic studies on radix puerariae: effect of puerarin on regional yocardial blood flow and cardiac hemodynamics in dogs with acute myocardial isochemia显示文摘 | Fan L L O'Keefe D D Powell W W J | 1985 | Chin Med J1985，98，： | 1 |
| 19 | Policy perspectives on occupational stress显示文摘 | O'KEEFE L C BROWN K C Christian B J | 2014 | Workplace Health Saf2014，62，10： | 1 |
| 20 | Fitting the jigsaw of citation: Information visualization in domain analy- sis显示文摘 | Chen C Paul R J Keefe B O | 2001 | Journal of the American Society for Infor- mation Science and Technology2001，52，4： | 1 |
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